Emanuela Bruscia, PhD

Associate Professor of Pediatrics (Respiratory)

Research Interests

Cystic Fibrosis; Lung; Macrophages; Pediatrics; Respiration Disorders; Cystic Fibrosis Transmembrane Conductance Regulator

Research Organizations

Pediatrics: Pediatric Pulmonology, Allergy, Immunology & Sleep Medicine

CPIRT - Pulmonary Infection Research and Treatment

Office of Cooperative Research

Research Summary

Our research aims to understand how CFTR--the gene that, when mutated, causes Cystic Fibrosis (CF)--affects innate immunity and how this will impact the progression of CF lung disease. We have performed pioneering studies demonstrating that CFTR expression is necessary for the normal function of an important player of the innate immune response: macrophages. Using in vitro and in vivo models, we are dissecting the molecular mechanisms by which CFTR affects these cells.

Specialized Terms: Cystic Fibrosis; Lung inflammation; Macrophages

Selected Publications

Full List of PubMed Publications

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Contact Info

Emanuela Bruscia, PhD
Mailing Address
Pediatric Pulmonology, Allergy, Immunology & Sleep MedicinePO Box 208064
New Haven, CT 06520-8064