As a physician scientist, I have strived to improve outcomes in children and adolescent with cancer along the entire cancer journey from diagnosis through the decades after therapy ends. My work has helped to document the high rates of chronic medical and psychosocial conditions caused by previous cancer therapy. I established the regional Yale HEROS multidisciplinary research and clinical program for long-term survivors of childhood cancer survivors in 2003 as the first of its kind in Connecticut and one of the first in the United States. My research and clinical work are intertwined and directly inform each other. Specifically, the HEROS program has functioned as a testbed for pilot studies that I then expanded to large, multi-institution studies. In recent years, I have progressed from documenting the incidence and severity of late complications of cancer therapy to developing innovative interventions to prevent or ameliorate these conditions. I have been the PI of several multi-site studies funded by NIH and the American Cancer Society. I have investigated novel interventions to increase cardiopulmonary health through physical activity interventions, increase health knowledge in childhood cancer survivors, and engage primary care physicians in survivorship care. In the national and international arena, I serve on the Children’s Oncology Group Survivorship Steering Committee, International Harmonization of Long-term Follow-up Guidelines, and special task forces at the National Cancer Institute. As part of my commitment to optimize cancer outcomes, I serve as the Yale Cancer Center Disease Aligned Research Team Leader for Childhood Cancer to oversee and also am the Yale site PI for the Children’s Oncology Group Clinical Trials consortium.