2025
Prevalence and Phenotype of Food Allergy in Children with Cystic Fibrosis
Nguyen H, Shabanova V, McCollum S, Polk B, Lee T, Whittington K, Cunha P, Bruscia E, Egan M, Emmenegger M, Leeds S. Prevalence and Phenotype of Food Allergy in Children with Cystic Fibrosis. Annals Of Allergy Asthma & Immunology 2025 PMID: 40550267, DOI: 10.1016/j.anai.2025.06.024.Peer-Reviewed Original ResearchCystic fibrosisCF patientsFood allergyUS pediatric populationElectronic medical recordsPediatric populationPhenotypes of food allergyRetrospective pediatric cohort studyPrevalence of FAFA prevalenceCystic Fibrosis Foundation RegistryMale CF patientsUnited StatesPediatric CF patientsPancreatic enzyme replacementPediatric cohort studyIgE-mediated FACohort studyEstimated prevalenceInclusion criteriaMedical informationDevelopment of FAMedical recordsFA diagnosisPrevalencePediatric Fellows and Their Ability to Meet Minimum Supervision Levels at Graduation.
Weiss P, Schwartz A, Boyer D, Chess P, Fussell J, McGann K, Moffatt M, Herman B, Turner D, Pitts S, Langhan M, High P, James S, Karnik R, Aye T, Stafford D, Rama J, Robinson B, Hsu D, Sauer C, Mehta J, Atlas M, Curran M, Mahan J, McFadden V, Kamin D, Kesselheim J, Czaja A, Dammann C, George R, Lopez M, Torres O, Mink R. Pediatric Fellows and Their Ability to Meet Minimum Supervision Levels at Graduation. 2025, 156 PMID: 40518135, DOI: 10.1542/peds.2025-070682.Peer-Reviewed Original ResearchConceptsEntrustable professional activitiesPediatric fellowsSupervision levelPediatric subspecialty fellowsAmerican Board of PediatricsCertificate dataClinical competency committeeSubspecialty board certificationPatient careCertification ratesSubspecialty fellowsBoard certificationProgram directorsCompetency committeeAmerican BoardSubspecialty certification examinationsCertification examinationSubspecialtyGraduating fellowsPediatricFellowGraduatesSupervisionReadinessCareSocial Determinants of Health and Healthcare Utilization in Infants With Bronchopulmonary Dysplasia
Urbach H, Ostfeld‐Johns S, McCollum S, Weiss P, Kandil S, Brumer E. Social Determinants of Health and Healthcare Utilization in Infants With Bronchopulmonary Dysplasia. Pediatric Pulmonology 2025, 60: e71153. PMID: 40504047, DOI: 10.1002/ppul.71153.Peer-Reviewed Original ResearchConceptsSocial determinants of healthChildhood Opportunity IndexArea Deprivation IndexHealthcare utilizationED visitsImpact of social determinants of healthSocial determinants of health variablesInfluence of social determinants of healthEmergency departmentAssociated with fewer ED visitsAssociated with increased ED visitsHigh-deprivation neighborhoodsDeterminants of healthBronchopulmonary dysplasiaAdverse health outcomesMediation analysisDeprivation indexHealthcare useSocial determinantsNo significant associationHealth outcomesFollow-upHospital utilizationNeighborhood disadvantageRacial/ethnic differencesSystemic in utero gene editing as a treatment for cystic fibrosis
Ricciardi A, Barone C, Putman R, Quijano E, Gupta A, Nguyen R, Mandl H, Piotrowski-Daspit A, Lopez-Giraldez F, Luks V, Freedman-Weiss M, Farrelly J, Ahle S, Lynn A, Glazer P, Saltzman W, Stitelman D, Egan M. Systemic in utero gene editing as a treatment for cystic fibrosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2418731122. PMID: 40493185, PMCID: PMC12184489, DOI: 10.1073/pnas.2418731122.Peer-Reviewed Original ResearchConceptsUtero gene editingCystic fibrosisCF transmembrane conductance regulatorTreat CF patientsTransmembrane conductance regulatorWild-type miceIrreversible organ damageNormal organ developmentTreat monogenic diseasesCFTR activityCF patientsConductance regulatorDisease-causing genesMultiorgan diseaseDisease improvementOrgan damageGene editingMonogenic diseasesMutation correctionPolymeric nanoparticlesGastrointestinal tissuesDiseaseBirthFibrosisReproductive systemENaC contributes to macrophage dysfunction in cystic fibrosis
Moran J, Pugh C, Brown N, Thomas A, Zhang S, McCauley E, Cephas A, Shrestha C, Partida-Sanchez S, Bai S, Bruscia E, Kopp B. ENaC contributes to macrophage dysfunction in cystic fibrosis. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2025, 329: l61-l69. PMID: 40454714, PMCID: PMC12181047, DOI: 10.1152/ajplung.00009.2025.Peer-Reviewed Original ResearchConceptsCystic fibrosis transmembrane conductance regulatorCystic fibrosis transmembrane conductance regulator modulatorsMonocyte-derived macrophagesEpithelial sodium channelTransmembrane conductance regulatorCystic fibrosisImmune cellsProinflammatory cytokine productionENaC modulationENaC expressionConductance regulatorCystic fibrosis transmembrane conductance regulator inhibitionCytokine productionSodium channelsCF airway epithelial cellsReduced proinflammatory cytokine productionDecreased proinflammatory cytokine productionSodium channel expressionInfection controlTherapeutic targetAirway epithelial cellsIon channel dysfunctionReactive oxygen speciesIon channelsCFTR expressionPrevention and Management of Food Allergy in Infants
Mathew M, Wong K, Munoz J, Leeds S. Prevention and Management of Food Allergy in Infants. Immunology And Allergy Clinics Of North America 2025 DOI: 10.1016/j.iac.2025.04.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsThe clinical and socioeconomic aspects of t-cell receptor excision circle based newborn screening for severe combined immunodeficiency in Southeast and East Asia
Yoo N, Kim S, Kim J, Ahn J, Kang I, Shin J. The clinical and socioeconomic aspects of t-cell receptor excision circle based newborn screening for severe combined immunodeficiency in Southeast and East Asia. Frontiers In Immunology 2025, 16: 1549768. PMID: 40458401, PMCID: PMC12127307, DOI: 10.3389/fimmu.2025.1549768.Peer-Reviewed Original ResearchAssociation of clinical manifestations and immune alterations with genetic variants of uncertain significance in patients concerned for inborn errors of immunity
Novotny S, Yoo N, Chen J, Granoth M, Kohli-Pamnani A, Hsu F, Rodenas M, Steele R, Kaman K, Soffer G, Price C, Kuster J, Kang I, Osmani L, Shin J. Association of clinical manifestations and immune alterations with genetic variants of uncertain significance in patients concerned for inborn errors of immunity. Clinical Immunology 2025, 277: 110513. PMID: 40354868, DOI: 10.1016/j.clim.2025.110513.Peer-Reviewed Original ResearchInborn errors of immunityErrors of immunityGenetic variantsInborn errorsAssociation of clinical manifestationsGene clusterGene functionStudy evaluated associationsImmune alterationsDiagnostic challengeClinical manifestationsImmunological profileGenetic testingVUSGenesImmunological characteristicsImmune functionLaboratory dataImmunityVariantsAssociationPatientsWhen Stridor Persists: A Case of Pulmonary Artery Sling Masquerading as Viral Croup
Chandrasekar L, Clifton E, Huertas M, Canapari C, Maurrasse S, Jauhari A, Brumer E. When Stridor Persists: A Case of Pulmonary Artery Sling Masquerading as Viral Croup. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a4421-a4421. DOI: 10.1164/ajrccm.2025.211.abstracts.a4421.Peer-Reviewed Original ResearchThe LEARN (Learning Educator's Anaphylaxis Response Needs) Early Project
Kaman K, Lahoud A, Flessner C, Butler K, Lowery S, Hoyt A. The LEARN (Learning Educator's Anaphylaxis Response Needs) Early Project. Annals Of Allergy Asthma & Immunology 2025, 134: 694-699. PMID: 40164281, DOI: 10.1016/j.anai.2025.03.018.Peer-Reviewed Original ResearchSelf-reported preparednessHead Start centersFood allergy emergencyUnderserved communitiesImprove health care outcomesAllergy emergencyHealth care outcomesHealth care managementFeelings of preparednessPublic health problemCare outcomesFood allergy knowledgeIdentified multiple areasFood allergy trainingRates of food allergyPreparedness questionnaireCare managementFood allergyMultiple barriersCenter staffAllergy trainingKnowledge testAllergy knowledgeEarly childhood education centersHealth problemsUpdate on the utilization of complementary therapies by adolescents with asthma in an urban population
Soffer G, Feinberg T, Kroll H, Reznik M. Update on the utilization of complementary therapies by adolescents with asthma in an urban population. Journal Of Asthma 2025, ahead-of-print: 1-9. PMID: 40040497, DOI: 10.1080/02770903.2025.2475451.Peer-Reviewed Original ResearchAsthma Control TestCAM useUtilization of complementary therapiesPrevalence of CAM usePrescription adherenceEfficacy of CAMHealth-promoting behaviorsPrimary care clinicsElectronic health recordsCAM utilizationCare clinicsActivity prescriptionHealth recordsAlternative medicineComplementary therapyAsthma managementLack of associationOutpatient specialtyAsthma controlSelf-reportAsthma severityLogistic regressionMind-bodyUrban adolescentsDemographic informationLabeling Barriers to Delabeling Penicillin Allergy: An Intersectional Case Study of Gender Identity, Race, and Syphilis
Ochuba O, Novotny S, Wong K, Canarie J, Sarpong D, Belmont A. Labeling Barriers to Delabeling Penicillin Allergy: An Intersectional Case Study of Gender Identity, Race, and Syphilis. The Journal Of Allergy And Clinical Immunology In Practice 2025, 13: 1210-1211. PMID: 40049316, PMCID: PMC12064391, DOI: 10.1016/j.jaip.2025.02.038.Peer-Reviewed Original ResearchMoving Beyond Desensitization to Tolerance in Food Allergy
Flom J, Shreffler W, Perrett K. Moving Beyond Desensitization to Tolerance in Food Allergy. The Journal Of Allergy And Clinical Immunology In Practice 2025, 13: 741-744. PMID: 40010566, DOI: 10.1016/j.jaip.2025.02.014.Peer-Reviewed Original ResearchManagement of IgE-mediated food allergyFood allergyIgE-mediated food allergyStages of clinical developmentSide effect profileMode of deliveryGoal of therapeuticsSustained unresponsivenessDosing regimensDose protocolProactive therapyAllergen-specificClinical developmentActive therapyPatient populationSide effectsTherapyPassive therapyPatient-specificDesensitizationClinical contextPatientsDoseAllergyDegree of protectionPrevalence of Food Allergy in Children with Cystic Fibrosis
Nguyen H, Whittington K, McCollum S, Shabanova V, Polk B, Lee T, Bruscia E, Egan M, Leeds S. Prevalence of Food Allergy in Children with Cystic Fibrosis. Journal Of Allergy And Clinical Immunology 2025, 155: ab41. DOI: 10.1016/j.jaci.2024.12.132.Peer-Reviewed Original ResearchDecreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome
Shin J, Shin H, Gutierrez A, Yoo N, Par-Young J, Osmani L, Shin M, Sanchez-Lara P, Bucala R, Soffer G, Kang I. Decreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome. EBioMedicine 2025, 112: 105578. PMID: 39891996, PMCID: PMC11840234, DOI: 10.1016/j.ebiom.2025.105578.Peer-Reviewed Original ResearchConceptsCD4<sup>+</sup> T cellsRecurrent sinopulmonary infectionsT cell functionRNA-seq analysisT cellsHealthy controlsSinopulmonary infectionsRNA-seqT-betIFN-gFrequency of CD4<sup>+</sup> T cellsCD4<sup>+</sup> T cell functionTh1 transcription factor T-betDeletion syndromeFlow cytometryCompared to age-matched healthy controlsTranscription factor T-betDecreased T-betUrinary tract abnormalitiesAge-matched healthy controlsMultiplex assayDownstream effector cytokinesEffector cytokinesRecurrent infectionsTh17 cytokinesEfficacy of a Pediatrician-Led Food Allergy Education Program for Elementary School Students and Teachers
Butler K, Kaman K. Efficacy of a Pediatrician-Led Food Allergy Education Program for Elementary School Students and Teachers. Journal Of Allergy And Clinical Immunology 2025, 155: ab312. DOI: 10.1016/j.jaci.2024.12.963.Peer-Reviewed Original ResearchAlternative, complementary, and integrative medicine approaches to allergic rhinitis
Soffer G, Myers C, Weinstock M, Hand M. Alternative, complementary, and integrative medicine approaches to allergic rhinitis. Annals Of Allergy Asthma & Immunology 2025, 135: 5-6. PMID: 39870210, DOI: 10.1016/j.anai.2025.01.021.Peer-Reviewed Original ResearchMedical School Curriculum Evaluation to Improve Health Equity Education
Nguemeni Tiako M, Sundaresh R, Nunez-Smith M, Shenson D, Sheares B. Medical School Curriculum Evaluation to Improve Health Equity Education. Journal Of General Internal Medicine 2025, 1-5. PMID: 39843676, DOI: 10.1007/s11606-024-09347-9.Peer-Reviewed Original ResearchHealth equity curriculumEquity educationStudent focus groupsHealth equityEducation policyUndergraduate medical educationClassroom teachingCurriculum evaluationResponsive to community needsCurriculumSocial justiceCourse directorsPhysician-patient relationshipEducationAxes of oppressionYale School of MedicineNational reviewFocus groupsStudentsMedical educationSchool of MedicineBlack Lives MatterMedical studentsStructural competencyCommunity needsAssociation of delayed asthma diagnosis with asthma exacerbations in children
Wi C, Ryu E, King K, Kwon J, Bublitz J, Park M, Chiarella S, Greenwood J, Pongdee T, Myers L, Nordlund B, Sohn S, Sagheb E, Kshatriya B, Watson D, Liu H, Sheares B, Davis C, Schulz W, Juhn Y. Association of delayed asthma diagnosis with asthma exacerbations in children. Journal Of Allergy And Clinical Immunology Global 2025, 4: 100409. PMID: 40008091, PMCID: PMC11851198, DOI: 10.1016/j.jacig.2025.100409.Peer-Reviewed Original ResearchElectronic health recordsDiagnosis of asthmaAsthma diagnosisAsthma exacerbationsRisk of AEPredetermined Asthma CriteriaDiagnosis of childhood asthmaChildhood asthma managementIncreased riskCox proportional hazards modelsIncreased risk of AECare qualityAsthma outcomesHealth recordsProportional hazards modelAsthma managementChildhood asthmaBirth cohortAsthma severityDiagnosis statusIndex dateIdentifying childrenPrimary outcomeNatural language processing algorithmsHazards modelMapping Pediatric Pulmonary Milestones 2.0 to Entrustable Professional Activities
Stevens E, Chiel L, Collins M, Rama J, Esther C, Richard K, Nelson B, Weiss P, Nuncio B, Turner D, Boyer D. Mapping Pediatric Pulmonary Milestones 2.0 to Entrustable Professional Activities. ATS Scholar 2025, 6: 30-35. PMID: 39904503, PMCID: PMC11984644, DOI: 10.34197/ats-scholar.2024-0105br.Peer-Reviewed Original Research
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