2025
Bridging Radiotherapy Prior to Chimeric Antigen Receptor T-Cells for B-Cell Lymphomas: An ILROG Multicenter Study
Yegya-Raman N, Plastaras J, Wright C, Chelius M, Zhang S, Baron J, Hubbeling H, Sim A, Robinson T, Jain M, Imber B, Fregonese B, Yahalom J, Ladbury C, Dandapani S, Pinnix C, Gunther J, Fang P, Wu S, Dabaja B, Yang J, Chew J, Braunstein S, Sinha S, Delinger N, Sun S, Terezakis S, Sakthivel G, Constine L, Chowdhry A, Reagan P, Burke S, Tseng Y, LaRiviere M, Maity A, Schuster S, Chong E, Figura N. Bridging Radiotherapy Prior to Chimeric Antigen Receptor T-Cells for B-Cell Lymphomas: An ILROG Multicenter Study. Blood Advances 2025, 9: 3293-3303. PMID: 40203192, DOI: 10.1182/bloodadvances.2025015855.Peer-Reviewed Original ResearchConceptsChimeric antigen receptor T-cell therapyImmune effector cell-associated neurotoxicity syndromeSuperior progression-free survivalProgression-free survivalB-cell lymphomaCytokine release syndromeAssociated with superior progression-free survivalOverall survivalTwo-year progression-free survivalChimeric antigen receptor T cellsLactate dehydrogenaseRelapsed/refractory B-cell lymphomaLactate dehydrogenase normalizationAmerican Society for TransplantationT-cell therapyBaseline lactate dehydrogenaseMedian follow-upRetrospectively reviewed patientsAdvanced-stage diseaseHigh-risk cohortAxicabtagene ciloleucelBrexucabtagene autoleucelSystemic therapyMulticenter studyT cellsFunctional Correlates of Atypical Visuoperceptual Organization in a Multisite Clinical High-Risk Sample
Pokorny V, Tran T, Williams T, Kenney J, Silverstein S, Gold J, Waltz J, Schiffman J, Ellman L, Strauss G, Walker E, Woods S, Powers A, Corlett P, Mittal V. Functional Correlates of Atypical Visuoperceptual Organization in a Multisite Clinical High-Risk Sample. Journal Of Psychopathology And Clinical Science 2025, 134: 527-539. PMID: 40193439, PMCID: PMC12162206, DOI: 10.1037/abn0000992.Peer-Reviewed Original ResearchConceptsClinical high riskPsychotic-like Experiences groupClinical high-risk statusClinical high-risk samplesMeasures of cognitive abilityClinical high-risk groupHigh-risk sampleMeasuring perceptual organizationFaces taskPsychotic disordersPerceptual priorsCognitive abilitiesCognitive functionClinical groupsPerceptual organizationHealthy control groupContext-sensitiveSocial functioningTwo-tone imagesTarget circleSymbolic codeEbbinghausFunctional correlatesTaskParticipantsDebate 1: Radical Prostatectomy For the Right Patient With High-Risk Prostate Cancer
Sundaresan V, Leapman M. Debate 1: Radical Prostatectomy For the Right Patient With High-Risk Prostate Cancer. Seminars In Radiation Oncology 2025, 35: 385-392. PMID: 40516973, DOI: 10.1016/j.semradonc.2025.05.001.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyRadical prostatectomyProstate cancerDeprivation therapyHigh riskEffect of long-term androgen-deprivation therapyLong-term androgen deprivation therapyAdequate randomized clinical trialsLong-term cancer controlHigh-risk prostate cancerRisk of gastrointestinal toxicityDisease-related survivalProportion of patientsDegrees of metastatic potentialResponse to treatmentRandomized clinical trialsCourse of treatmentSequence of surgeryLocal salvageRadiation therapySecondary malignanciesGastrointestinal toxicityInitial surgeryMultimodal treatmentHealth-related quality of lifeTiming of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study
Dribin T, Sampson H, Zhang Y, Boyd S, Zhang N, Michelson K, Neuman M, Brousseau D, Mistry R, Freedman S, Aronson P, Bergmann K, Boswell B, Chinta S, Chua W, Cohen A, Cohen J, Daggett A, Davis J, Freeman J, Khanna K, Knoles C, Kwan K, Larsen C, Lee J, Lubell T, Metcalf A, Moake M, Nesiama J, Ngo T, Pulcini C, Russo C, Singh N, Srivastava G, Strutt J, Thapar V, Vander Wyst C, Walsh P, Wolnerman Y, Schnadower D, Academy of Pediatrics P, Kanngiesser A, McGarghan F, Dulchavsky A, Costalez J, DesPain A, Armanious M, Haghnazarian E, Brown-Whitehorn T, Weigert R, Dayan P, Meltzer J, Chowdhury N, Benedetti J, Sinziana C, Handorf A, Ruthford M, Devens M, Mecham C, Holland J, Casas T, Brown J, Panda P, Morrow A, Maready M, Nathani Y, Stevens M, Abraham G, Yen K, Cooper-Sood J, Woolf S. Timing of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study. The Lancet Child & Adolescent Health 2025, 9: 484-496. PMID: 40506197, DOI: 10.1016/s2352-4642(25)00139-7.Peer-Reviewed Original ResearchConceptsElectronic medical recordsEmergency departmentRetrospective cohort studyCohort studyMedical recordsDocumentation of symptomsCardiovascular involvementHealth-care facilitiesEpinephrine doseAcute allergic reactionsNational Institutes of HealthCumulative incidenceNational Center for Advancing Translational SciencesInstitutes of HealthChildren aged 6 monthsClinical ModificationHospital wardsIncidence rateICD-10Observation periodPrimary outcomeAllergic reactionsSecondary to medicationsInitiation to discontinuationKaplan-Meier analysisCarcinogenic Industrial Air Emissions and Lung Cancer Risk in a Cohort of 440,000 Americans.
Madrigal J, Fisher J, Pruitt C, Liao L, Graubard B, Ward M, Silverman D, Jones R. Carcinogenic Industrial Air Emissions and Lung Cancer Risk in a Cohort of 440,000 Americans. American Journal Of Respiratory And Critical Care Medicine 2025, 211: 1241-1252. PMID: 40315142, DOI: 10.1164/rccm.202409-1738oc.Peer-Reviewed Original ResearchConceptsLung cancer riskCancer riskAssociated with riskNIH-AARP DietEvaluate lung cancer riskLung carcinogensAssociated with lung cancerCox proportional hazards modelsNIH-AARPHealth StudyProportional hazards modelSquamous cell carcinomaStrong associationsAssociated with benzeneHazards modelIndustrial air emissionsEnrollment residenceCell carcinomaOverall riskLung cancer developmentSmokingAssociationRiskHistological subtypesLung cancerA Vaccine to Block Plasmodium falciparum Transmission.
Healy S, Sagara I, Assadou M, Katile A, Kone M, Imeru A, Kwan J, Swihart B, Fintzi J, Potter G, Zeguimé A, Dolo A, Diarra B, Narum D, Rausch K, MacDonald N, Zhu D, Mohan R, Thera I, Morrison R, Zaidi I, Doritchamou J, Sylla D, Hume J, Coulibaly M, Morelle D, Lievens M, Doumbo O, Duffy P. A Vaccine to Block Plasmodium falciparum Transmission. NEJM Evidence 2025, 4: evidoa2400188. PMID: 40552966, DOI: 10.1056/evidoa2400188.Peer-Reviewed Original ResearchConceptsStandard membrane feeding assayPfs230D1-EPASafety trialsAntibody responseEnd pointsSkin feeding assaysTransmission-reducing activityWeeks of follow-upMembrane feeding assaysAs-treated populationPrimary efficacy analysisSecondary end pointsPrimary end pointInfected mosquitoesEnzyme-linked immunosorbent assayMalian adultsMalaria vaccineComparator-controlledDouble-blindProportion of infected mosquitoesDosing regimensEfficacy analysisThird doseYears postvaccinationBlock disease transmissionSpecificities of Mental Functioning and Referential Process in Body Dysmorphic Disorder: A Single Case Study Using the Psychodynamic Diagnostic Manual (PDM-2)
Christian C, Bincoletto A, Mariani R, Negri A, Lingiardi V, Tanzilli A. Specificities of Mental Functioning and Referential Process in Body Dysmorphic Disorder: A Single Case Study Using the Psychodynamic Diagnostic Manual (PDM-2). Journal Of Psycholinguistic Research 2025, 54: 46. PMID: 40553242, DOI: 10.1007/s10936-025-10162-4.Peer-Reviewed Original ResearchConceptsBody dysmorphic disorderPsychodynamic Diagnostic ManualDiagnostic manualsDysmorphic disorderSevere body dysmorphic disorderMental functioningSchizoid personality disorderStages of psychotherapySelf-esteem regulationPersonality disorderReferential processLanguage measuresTherapist interventionsPDM-2Emotional experienceRelational intimacyEmotional activationSingle case studyPsychodynamicsAnalysis of languageClinical implicationsTherapeutic actionSymbolic processingTreatment sessionsDisordersThe distal nephron biomarkers associate with diabetic kidney disease progression
Tamargo C, Coca S, Philbrook H, Hu D, Ix J, Shlipak M, Fried L, Gutierrez O, Waikar S, Schrauben S, Schelling J, Ganz P, Kimmel P, Greenberg J, Deo R, Takakura A, Vasan R, Bonventre J, Parikh C. The distal nephron biomarkers associate with diabetic kidney disease progression. JCI Insight 2025, 10: e186836. PMID: 40548378, DOI: 10.1172/jci.insight.186836.Peer-Reviewed Original ResearchConceptsDiabetic kidney disease progressionUrine albumin-to-creatinine ratioDiabetic kidney diseaseRisk of DKD progressionEpidermal growth factorDKD progressionMedian urine albumin-to-creatinine ratioUrinary epidermal growth factorBiomarker levelsAlbumin-to-creatinine ratioDistal tubule markerPredicting diabetic kidney diseaseMedian follow-upDistal tubular markersKidney disease progressionCox regression modelsBaseline biomarker levelsNational Institute of DiabetesType 2 diabetesEGFR changeTubular markersUrinary biomarkersFollow-upClinical trialsDisease progressionSerotonin Norepinephrine Reuptake Inhibitor Is Associated With Lower Mortality Among Patients Presenting With Takotsubo Cardiomyopathy.
Shamaki G, Anuforo A, Safiriyu I, Corteville D, Sanghavi M, Shah S, Clark K. Serotonin Norepinephrine Reuptake Inhibitor Is Associated With Lower Mortality Among Patients Presenting With Takotsubo Cardiomyopathy. Journal Of The American Heart Association 2025, 14: e037951. PMID: 40551298, DOI: 10.1161/jaha.124.037951.Peer-Reviewed Original ResearchConceptsSerotonin-norepinephrine reuptake inhibitorsDiagnosis of takotsubo cardiomyopathyTakotsubo cardiomyopathyPropensity score matchingReuptake inhibitorsClinical outcomes of patientsNorepinephrine reuptake inhibitorsReuptake of serotoninScore matchingOutcomes of patientsOpioid-related disordersCocaine-related disordersAssociated with lower mortalityLower mortalityTriNetX Research NetworkTreatment of depressionAssociated with lowered mortalityAcute myocardial infarctionNeuropathic painPresynaptic reuptakeClinical outcomesCardiac arrestPrimary outcomeSecondary outcomesVentricular fibrillationPatterns of sialyl-Lewis X expression predict gastric histopathology
Vargas N, Quiroga A, Chaves J, Bolaños H, Nalbantoglu I, Astaiza C, Wu Y, Sáenz J. Patterns of sialyl-Lewis X expression predict gastric histopathology. Diagnostic Pathology 2025, 20: 76. PMID: 40551130, PMCID: PMC12183862, DOI: 10.1186/s13000-025-01673-8.Peer-Reviewed Original ResearchConceptsChronic atrophic gastritisChronic non-atrophic gastritisGastric pathologyAssociated with chronic atrophic gastritisIntestinal metaplasiaProgression to gastric cancerSLex expressionPre-cancerous lesionsNon-atrophic gastritisGastric pre-cancerous lesionsHistological diagnosisPre-cancerous changesGlandular distributionAntrum biopsiesAdult patientsGastric corpusAtrophic gastritisChronic inflammationGastric cancerHistological markersHistological assessmentGastric histopathologyGastric epitheliumIntroductionGastric cancerBiopsyHealth Services Usage in Patients Receiving Buprenorphine for Opioid Use Disorder or Long-Term Opioid Therapy for Chronic Pain: Retrospective Cohort Study
Savitz S, Stevens M, Nath B, D'Onofrio G, Melnick E, Jeffery M. Health Services Usage in Patients Receiving Buprenorphine for Opioid Use Disorder or Long-Term Opioid Therapy for Chronic Pain: Retrospective Cohort Study. JMIR Formative Research 2025, 9: e66596. PMID: 40537088, DOI: 10.2196/66596.Peer-Reviewed Original ResearchConceptsIncidence rate ratiosLong-term opioid therapyIn-person careMental illness cohortOpioid use disorderIn-personTelemedicine visitsChronic painPain medicineOpioid therapyEmergency medicineMental healthFamily practiceHealth service usageChronic opioidsPercentage of visitsIn-person visitsIn-person treatmentPoor outcomeAdministrative claims dataUse disorderMedicare Advantage patientsOptumLabs Data WarehouseVulnerable patient populationCare deliveryRisk Factors for Serious Bacterial Infections Among Young Infants With Hypothermia: Protocol for a Multicenter, Retrospective Case-Control Study
Ramgopal S, Aronson P, Lorenz D, Rogers A, Cruz A. Risk Factors for Serious Bacterial Infections Among Young Infants With Hypothermia: Protocol for a Multicenter, Retrospective Case-Control Study. JMIR Research Protocols 2025, 14: e66722. PMID: 40536806, DOI: 10.2196/66722.Peer-Reviewed Original ResearchConceptsEpidemiology of SBIHerpes simplex virusCase-control studyEmergency departmentYoung infantsMultivariable prediction modelRetrospective nested case-control studyBacterial infectionsRetrospective case-control studyManagement of young infantsNested case-control studyUrinary tract infectionOptimal cutoff valueSerious bacterial infectionsSoft tissue infectionsOutcome measuresPediatric Emergency Medicine Collaborative Research CommitteeReceiver operating characteristic curvePediatric emergency departmentOperating characteristics curveUS children's hospitalsMixed effects logistic regressionHSV-positiveBlood culturesPredicting SBIAmino acid patterns predict white matter integrity measures in the brain in patients across the Alzheimer’s disease continuum
Goharmanesh F, Masmoie M, Nasiri H, Sadat-Madani S, Namin S, Damizadeh M, Shakeri S, Sodeifian F, Rajabpour-Sanati A, Bahrainian B, Mohammadi Y, Shushtari A, Mayeli M. Amino acid patterns predict white matter integrity measures in the brain in patients across the Alzheimer’s disease continuum. Metabolic Brain Disease 2025, 40: 227. PMID: 40531346, DOI: 10.1007/s11011-025-01647-1.Peer-Reviewed Original ResearchConceptsWhite matter integrityMean diffusivityDiffusion tensor imagingFractional anisotropyAlzheimer's Disease Neuroimaging InitiativeAxial diffusivityAA metabolic pathwaysReduced white matter integrityDisease continuumDTI-derived metricsWhite matter integrity measuresWhite matter microstructural integrityAD patientsCross-sectional studyUltra-high performance liquid chromatographyPotential therapeutic targetRadial diffusivityDecreased FAIncreased MDStudy groupEarly diagnosisProgression markersAlzheimer's disease continuumAmino acidsMild cognitive impairmentLatent Health Status Trajectories in Individuals With New or Worsening Claudication Symptoms.
Grubman S, Romain G, Cleman J, Scierka L, Pajarillo C, Kluger J, Mena-Hurtado C, Smolderen K. Latent Health Status Trajectories in Individuals With New or Worsening Claudication Symptoms. Journal Of The American Heart Association 2025, 14: e039455. PMID: 40530482, DOI: 10.1161/jaha.124.039455.Peer-Reviewed Original ResearchConceptsHealth status trajectoriesPeripheral artery disease careStatus trajectoriesDisease careHealth statusClaudication symptomsTrajectory subgroupsPeripheral Artery QuestionnaireVascular specialty clinicsPeripheral artery questionnaire scoresHierarchical multivariable logistic regressionImprove health statusMultivariate logistic regressionClinically meaningful thresholdsRegistry of patientsPsychosocial factorsBiopsychosocial modelDepressive symptomsSpecialty clinicsAlcohol use disorderQuestionnaire scoresRecovery trajectoriesLogistic regressionHealthLatent trajectory modelsCriminal Justice-Involved Veterans Not Engaged in Primary Care in the Veterans Health Administration.
Tsai J, Lampros A, Clark S, Dunn A, O'Toole T. Criminal Justice-Involved Veterans Not Engaged in Primary Care in the Veterans Health Administration. Journal Of Primary Care & Community Health 2025, 16: 21501319251348134. PMID: 40525421, PMCID: PMC12174793, DOI: 10.1177/21501319251348134.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationPrimary care visitsPrimary careJustice-involved veteransCare visitsHealth AdministrationVeterans Health Administration medical recordsMental health/substance use treatmentVeterans Health Administration facilitiesIntegrated care initiativesVA primary careOutpatient medical careMilitary sexual traumaCare initiativesService useAssociated with useCriminal justice systemHealthcare needsService utilizationNon-HispanicRetrospective cohort studySubstance use disordersBehavioral healthcareMental healthSociodemographic characteristicsTranslation and cultural adaptation of tools to assess diverse Asian American and Asian Canadian subgroups: The Asian Cohort for Alzheimer's Disease (ACAD) Study
Lee H, Tzuang M, Chow T, Kang Y, Tee B, Li C, Lam E, Gu Y, Lee S, Ho P, Peavy G, Seo E, Kim K, Tran B, Chae W, Nguyen D, Vo N, Dang D, Spat‐Lemus J, Choi Y, Feldman H, Jun G, Wang L, Yu W, Park V, Study T. Translation and cultural adaptation of tools to assess diverse Asian American and Asian Canadian subgroups: The Asian Cohort for Alzheimer's Disease (ACAD) Study. Alzheimer's & Dementia 2025, 21: e70311. PMID: 40528300, PMCID: PMC12173839, DOI: 10.1002/alz.70311.Peer-Reviewed Original ResearchConceptsCultural adaptationWorld Health OrganizationPromote health literacyCanadian older adultsAsian cohortCulturally appropriate translationCognitive assessment toolsLanguage backgroundAsian languagesAppropriate translationAssessment of cognitive functionHealth literacyStudy materialQuality healthcareCanadian adultsAlzheimer's diseaseTranslation processTranslation guidelinesOlder adultsSociocultural backgroundTranslation methodologyCanadian populationLanguage versionsAdaptation of toolsAssessment toolLate Permissive Hypercapnia for Mechanically Ventilated Preterm Infants: A Randomized Trial
Travers C, Gentle S, Shukla V, Aban I, Yee A, Armstead K, Benz R, Laney D, Ambalavanan N, Carlo W. Late Permissive Hypercapnia for Mechanically Ventilated Preterm Infants: A Randomized Trial. Pediatric Pulmonology 2025, 60: e71165. PMID: 40525736, PMCID: PMC12172392, DOI: 10.1002/ppul.71165.Peer-Reviewed Original ResearchConceptsPostnatal day 7Permissive hypercapniaPreterm infantsInstitutional review boardDay 7Ventilator-freeMechanically ventilated preterm infantsSingle-center randomized clinical trialReduced mechanical ventilation durationWeeks postmenstrual ageMechanical ventilation durationRespiratory distress syndromeVentilator-free daysRandomized clinical trialsPostmenstrual ageGestational ageWeeks gestationDistress syndromeVentilation durationBirth weightLung protectionRandomized trialsClinical trialsPrimary outcomeInfantsCollege Community–Based Physical Activity Support at a Public University During the COVID-19 Pandemic: Retrospective Longitudinal Analysis of Intra- Versus Interpersonal Components for Uptake and Outcome Association
Ash G, Mak S, Haughton A, Augustine M, Bodurtha P, Axtell R, Borsari B, Liu J, Lou S, Xin X, Fucito L, Jeon S, Stults-Kolehmainen M, Gerstein M. College Community–Based Physical Activity Support at a Public University During the COVID-19 Pandemic: Retrospective Longitudinal Analysis of Intra- Versus Interpersonal Components for Uptake and Outcome Association. JMIR MHealth And UHealth 2025, 13: e51707. PMID: 40523272, PMCID: PMC12209730, DOI: 10.2196/51707.Peer-Reviewed Original ResearchConceptsPA promotion programsPhysical activityPromotion programsPhysical activity supportLow physical activityCollege studentsInterpersonal componentsEngagement frequencyRetrospective longitudinal analysisPA interventionsPA outcomesPA supportCOVID-19 pandemicIntervention componentsApp engagementUndergraduate studentsApp useInterpersonal supportAssociated with longer retentionImplementation strategiesStaff membersLong-term trajectoriesOutcome associationsLongitudinal analysisStaffVisceral pain-related acute actions of cerulein on mouse and human sensory neurons.
Goyal S, Zurek N, Ehsanian R, Goyal S, Jones D, Shilling M, Desir G, Gorelick F, Westlund K, Alles S. Visceral pain-related acute actions of cerulein on mouse and human sensory neurons. Molecular Pain 2025, 21: 17448069251353346. PMID: 40524328, DOI: 10.1177/17448069251353346.Peer-Reviewed Original ResearchConceptsDorsal root gangliaDRG neuronsPain behaviorCCK-AAcute pancreatitisHuman DRGWhole-cell patch-clamp electrophysiologyIncreased excitabilityHuman dorsal root gangliaDorsal root ganglia neuronsHuman sensory neuronsThoracic DRG neuronsVon Frey testAssess pain behaviorCCK-A receptorsInduce acute pancreatitisPatch-clamp electrophysiologyCCK-B receptorsPre-clinical studiesResponse to ceruleinComplaints of patientsAntagonist of cholecystokininMechanical hypersensitivityPancreatic painCholecystokinin systemsCost Efficiency of fMRI Studies Using Resting‐State Vs. Task‐Based Functional Connectivity
Zhang X, Hulvershorn L, Constable T, Zhao Y, Wang S. Cost Efficiency of fMRI Studies Using Resting‐State Vs. Task‐Based Functional Connectivity. Human Brain Mapping 2025, 46: e70260. PMID: 40543060, PMCID: PMC12182254, DOI: 10.1002/hbm.70260.Peer-Reviewed Original ResearchConceptsNeuroimaging studiesNeuropsychological outcomesFMRI conditionsGradual-onset continuous performance taskCognitive control outcomesN-back memory taskContinuous performance taskNegative emotional outcomesFMRI taskMemory taskFMRI studyPerformance tasksTask conditionsEmotional outcomesFMRITaskFunctional fingerprintsPower differentialsSociabilityOutcomesControl outcomes
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