2025
Bridging Radiotherapy Prior to Chimeric Antigen Receptor T-Cells for B-Cell Lymphomas: An ILROG Multicenter Study
Yegya-Raman N, Plastaras J, Wright C, Chelius M, Zhang S, Baron J, Hubbeling H, Sim A, Robinson T, Jain M, Imber B, Fregonese B, Yahalom J, Ladbury C, Dandapani S, Pinnix C, Gunther J, Fang P, Wu S, Dabaja B, Yang J, Chew J, Braunstein S, Sinha S, Delinger N, Sun S, Terezakis S, Sakthivel G, Constine L, Chowdhry A, Reagan P, Burke S, Tseng Y, LaRiviere M, Maity A, Schuster S, Chong E, Figura N. Bridging Radiotherapy Prior to Chimeric Antigen Receptor T-Cells for B-Cell Lymphomas: An ILROG Multicenter Study. Blood Advances 2025, 9: 3293-3303. PMID: 40203192, DOI: 10.1182/bloodadvances.2025015855.Peer-Reviewed Original ResearchConceptsChimeric antigen receptor T-cell therapyImmune effector cell-associated neurotoxicity syndromeSuperior progression-free survivalProgression-free survivalB-cell lymphomaCytokine release syndromeAssociated with superior progression-free survivalOverall survivalTwo-year progression-free survivalChimeric antigen receptor T cellsLactate dehydrogenaseRelapsed/refractory B-cell lymphomaLactate dehydrogenase normalizationAmerican Society for TransplantationT-cell therapyBaseline lactate dehydrogenaseMedian follow-upRetrospectively reviewed patientsAdvanced-stage diseaseHigh-risk cohortAxicabtagene ciloleucelBrexucabtagene autoleucelSystemic therapyMulticenter studyT cellsFunctional Correlates of Atypical Visuoperceptual Organization in a Multisite Clinical High-Risk Sample
Pokorny V, Tran T, Williams T, Kenney J, Silverstein S, Gold J, Waltz J, Schiffman J, Ellman L, Strauss G, Walker E, Woods S, Powers A, Corlett P, Mittal V. Functional Correlates of Atypical Visuoperceptual Organization in a Multisite Clinical High-Risk Sample. Journal Of Psychopathology And Clinical Science 2025, 134: 527-539. PMID: 40193439, PMCID: PMC12162206, DOI: 10.1037/abn0000992.Peer-Reviewed Original ResearchConceptsClinical high riskPsychotic-like Experiences groupClinical high-risk statusClinical high-risk samplesMeasures of cognitive abilityClinical high-risk groupHigh-risk sampleMeasuring perceptual organizationFaces taskPsychotic disordersPerceptual priorsCognitive abilitiesCognitive functionClinical groupsPerceptual organizationHealthy control groupContext-sensitiveSocial functioningTwo-tone imagesTarget circleSymbolic codeEbbinghausFunctional correlatesTaskParticipantsTiming of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study
Dribin T, Sampson H, Zhang Y, Boyd S, Zhang N, Michelson K, Neuman M, Brousseau D, Mistry R, Freedman S, Aronson P, Bergmann K, Boswell B, Chinta S, Chua W, Cohen A, Cohen J, Daggett A, Davis J, Freeman J, Khanna K, Knoles C, Kwan K, Larsen C, Lee J, Lubell T, Metcalf A, Moake M, Nesiama J, Ngo T, Pulcini C, Russo C, Singh N, Srivastava G, Strutt J, Thapar V, Vander Wyst C, Walsh P, Wolnerman Y, Schnadower D, Academy of Pediatrics P, Kanngiesser A, McGarghan F, Dulchavsky A, Costalez J, DesPain A, Armanious M, Haghnazarian E, Brown-Whitehorn T, Weigert R, Dayan P, Meltzer J, Chowdhury N, Benedetti J, Sinziana C, Handorf A, Ruthford M, Devens M, Mecham C, Holland J, Casas T, Brown J, Panda P, Morrow A, Maready M, Nathani Y, Stevens M, Abraham G, Yen K, Cooper-Sood J, Woolf S. Timing of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study. The Lancet Child & Adolescent Health 2025, 9: 484-496. PMID: 40506197, DOI: 10.1016/s2352-4642(25)00139-7.Peer-Reviewed Original ResearchConceptsElectronic medical recordsEmergency departmentRetrospective cohort studyCohort studyMedical recordsDocumentation of symptomsCardiovascular involvementHealth-care facilitiesEpinephrine doseAcute allergic reactionsNational Institutes of HealthCumulative incidenceNational Center for Advancing Translational SciencesInstitutes of HealthChildren aged 6 monthsClinical ModificationHospital wardsIncidence rateICD-10Observation periodPrimary outcomeAllergic reactionsSecondary to medicationsInitiation to discontinuationKaplan-Meier analysisCarcinogenic Industrial Air Emissions and Lung Cancer Risk in a Cohort of 440,000 Americans.
Madrigal J, Fisher J, Pruitt C, Liao L, Graubard B, Ward M, Silverman D, Jones R. Carcinogenic Industrial Air Emissions and Lung Cancer Risk in a Cohort of 440,000 Americans. American Journal Of Respiratory And Critical Care Medicine 2025, 211: 1241-1252. PMID: 40315142, DOI: 10.1164/rccm.202409-1738oc.Peer-Reviewed Original ResearchConceptsLung cancer riskCancer riskAssociated with riskNIH-AARP DietEvaluate lung cancer riskLung carcinogensAssociated with lung cancerCox proportional hazards modelsNIH-AARPHealth StudyProportional hazards modelSquamous cell carcinomaStrong associationsAssociated with benzeneHazards modelIndustrial air emissionsEnrollment residenceCell carcinomaOverall riskLung cancer developmentSmokingAssociationRiskHistological subtypesLung cancerIntratumoral IL12 mRNA administration activates innate and adaptive pathways in checkpoint inhibitor-resistant tumors resulting in complete responses
Lakshmipathi J, Santha S, Li M, Qian Y, Roy S, Luheshi N, Politi K, Bosenberg M, Eyles J, Muthusamy V. Intratumoral IL12 mRNA administration activates innate and adaptive pathways in checkpoint inhibitor-resistant tumors resulting in complete responses. Cancer Immunology, Immunotherapy 2025, 74: 250. PMID: 40560386, PMCID: PMC12198101, DOI: 10.1007/s00262-025-04105-0.Peer-Reviewed Original ResearchConceptsAnti-tumor immune responseTumor-associated macrophagesCytotoxic T cellsImmune responseActivity of checkpoint inhibitorsAnti-PD-L1 antibodyPhagocytosis of tumor cellsAnti-PD-L1Enhanced anti-tumorAntigen presentation machineryCell-based immune responsesMurine tumor modelsTh1-type cytokinesColorectal carcinoma tumorsICI resistanceMurine IL12Checkpoint inhibitorsPresentation machineryIntratumoral deliveryResistant tumorsAdvanced diseaseCarcinoma tumorsTumor microenvironmentMurine tumorsT cellsThe Impact and Safety of GLP‐1 Agents and Breast Cancer
Parsons K, Montalvo M, Fischbach N, Taylor M, Alfaro S, Lustberg M. The Impact and Safety of GLP‐1 Agents and Breast Cancer. Cancer Medicine 2025, 14: e70932. PMID: 40552446, PMCID: PMC12186097, DOI: 10.1002/cam4.70932.Peer-Reviewed Original ResearchConceptsBreast cancer patientsGLP-1 receptor agonistsBreast cancerBreast cancer-specific mortalityCancer patientsBreast cancer incidenceBreast cancer ratesWeight management interventionsProportion of breast cancer patientsNon-cancer populationObese post-menopausal womenReceptor agonistsBreast cancer outcomesBreast cancer progressionWeight loss interventionWeight management strategiesEffective weight managementGLP-1Quality of lifeAll-cause mortalityCancer-specific mortalityImprove patient outcomesObesity prevalenceWeb of ScienceCancer incidenceA Vaccine to Block Plasmodium falciparum Transmission.
Healy S, Sagara I, Assadou M, Katile A, Kone M, Imeru A, Kwan J, Swihart B, Fintzi J, Potter G, Zeguimé A, Dolo A, Diarra B, Narum D, Rausch K, MacDonald N, Zhu D, Mohan R, Thera I, Morrison R, Zaidi I, Doritchamou J, Sylla D, Hume J, Coulibaly M, Morelle D, Lievens M, Doumbo O, Duffy P. A Vaccine to Block Plasmodium falciparum Transmission. NEJM Evidence 2025, 4: evidoa2400188. PMID: 40552966, DOI: 10.1056/evidoa2400188.Peer-Reviewed Original ResearchConceptsStandard membrane feeding assayPfs230D1-EPASafety trialsAntibody responseEnd pointsSkin feeding assaysTransmission-reducing activityWeeks of follow-upMembrane feeding assaysAs-treated populationPrimary efficacy analysisSecondary end pointsPrimary end pointInfected mosquitoesEnzyme-linked immunosorbent assayMalian adultsMalaria vaccineComparator-controlledDouble-blindProportion of infected mosquitoesDosing regimensEfficacy analysisThird doseYears postvaccinationBlock disease transmissionSulopenem versus Amoxicillin/Clavulanate for the Treatment of Uncomplicated Urinary Tract Infection.
Puttagunta S, Aronin S, Gupta J, Das A, Gupta K, Dunne M. Sulopenem versus Amoxicillin/Clavulanate for the Treatment of Uncomplicated Urinary Tract Infection. NEJM Evidence 2025, 4: evidoa2400414. PMID: 40552968, DOI: 10.1056/evidoa2400414.Peer-Reviewed Original ResearchConceptsUrinary tract infectionUncomplicated urinary tract infectionsIntent-to-treat populationSusceptible to amoxicillin/clavulanateTract infectionsUrine cultureAdverse eventsTreatment of uncomplicated urinary tract infectionsCombined population of patientsPatients treated with amoxicillin/clavulanateTreatment-emergent adverse eventsBaseline urine culturePositive urine cultureMild adverse eventsPopulation of patientsTreatment of adult womenClasses of antibioticsMicrobiological eradicationBaseline pathogensClinical cureDouble-blindMedian ageTrial medicationAmoxicillin/clavulanateAntimicrobial resistanceThe distal nephron biomarkers associate with diabetic kidney disease progression
Tamargo C, Coca S, Philbrook H, Hu D, Ix J, Shlipak M, Fried L, Gutierrez O, Waikar S, Schrauben S, Schelling J, Ganz P, Kimmel P, Greenberg J, Deo R, Takakura A, Vasan R, Bonventre J, Parikh C. The distal nephron biomarkers associate with diabetic kidney disease progression. JCI Insight 2025, 10: e186836. PMID: 40548378, DOI: 10.1172/jci.insight.186836.Peer-Reviewed Original ResearchConceptsDiabetic kidney disease progressionUrine albumin-to-creatinine ratioDiabetic kidney diseaseRisk of DKD progressionEpidermal growth factorDKD progressionMedian urine albumin-to-creatinine ratioUrinary epidermal growth factorBiomarker levelsAlbumin-to-creatinine ratioDistal tubule markerPredicting diabetic kidney diseaseMedian follow-upDistal tubular markersKidney disease progressionCox regression modelsBaseline biomarker levelsNational Institute of DiabetesType 2 diabetesEGFR changeTubular markersUrinary biomarkersFollow-upClinical trialsDisease progressionSerotonin Norepinephrine Reuptake Inhibitor Is Associated With Lower Mortality Among Patients Presenting With Takotsubo Cardiomyopathy.
Shamaki G, Anuforo A, Safiriyu I, Corteville D, Sanghavi M, Shah S, Clark K. Serotonin Norepinephrine Reuptake Inhibitor Is Associated With Lower Mortality Among Patients Presenting With Takotsubo Cardiomyopathy. Journal Of The American Heart Association 2025, 14: e037951. PMID: 40551298, DOI: 10.1161/jaha.124.037951.Peer-Reviewed Original ResearchConceptsSerotonin-norepinephrine reuptake inhibitorsDiagnosis of takotsubo cardiomyopathyTakotsubo cardiomyopathyPropensity score matchingReuptake inhibitorsClinical outcomes of patientsNorepinephrine reuptake inhibitorsReuptake of serotoninScore matchingOutcomes of patientsOpioid-related disordersCocaine-related disordersAssociated with lower mortalityLower mortalityTriNetX Research NetworkTreatment of depressionAssociated with lowered mortalityAcute myocardial infarctionNeuropathic painPresynaptic reuptakeClinical outcomesCardiac arrestPrimary outcomeSecondary outcomesVentricular fibrillationPatterns of sialyl-Lewis X expression predict gastric histopathology
Vargas N, Quiroga A, Chaves J, Bolaños H, Nalbantoglu I, Astaiza C, Wu Y, Sáenz J. Patterns of sialyl-Lewis X expression predict gastric histopathology. Diagnostic Pathology 2025, 20: 76. PMID: 40551130, PMCID: PMC12183862, DOI: 10.1186/s13000-025-01673-8.Peer-Reviewed Original ResearchConceptsChronic atrophic gastritisChronic non-atrophic gastritisGastric pathologyAssociated with chronic atrophic gastritisIntestinal metaplasiaProgression to gastric cancerSLex expressionPre-cancerous lesionsNon-atrophic gastritisGastric pre-cancerous lesionsHistological diagnosisPre-cancerous changesGlandular distributionAntrum biopsiesAdult patientsGastric corpusAtrophic gastritisChronic inflammationGastric cancerHistological markersHistological assessmentGastric histopathologyGastric epitheliumIntroductionGastric cancerBiopsyHealth Services Usage in Patients Receiving Buprenorphine for Opioid Use Disorder or Long-Term Opioid Therapy for Chronic Pain: Retrospective Cohort Study
Savitz S, Stevens M, Nath B, D'Onofrio G, Melnick E, Jeffery M. Health Services Usage in Patients Receiving Buprenorphine for Opioid Use Disorder or Long-Term Opioid Therapy for Chronic Pain: Retrospective Cohort Study. JMIR Formative Research 2025, 9: e66596. PMID: 40537088, DOI: 10.2196/66596.Peer-Reviewed Original ResearchConceptsIncidence rate ratiosLong-term opioid therapyIn-person careMental illness cohortOpioid use disorderIn-personTelemedicine visitsChronic painPain medicineOpioid therapyEmergency medicineMental healthFamily practiceHealth service usageChronic opioidsPercentage of visitsIn-person visitsIn-person treatmentPoor outcomeAdministrative claims dataUse disorderMedicare Advantage patientsOptumLabs Data WarehouseVulnerable patient populationCare deliveryStatistical Methods for Chemical Mixtures: A Roadmap for Practitioners Using Simulation Studies and a Sample Data Analysis in the PROTECT Cohort
Hao W, Cathey A, Aung M, Boss J, Meeker J, Mukherjee B. Statistical Methods for Chemical Mixtures: A Roadmap for Practitioners Using Simulation Studies and a Sample Data Analysis in the PROTECT Cohort. Environmental Health Perspectives 2025, 133: 067019. PMID: 40392783, PMCID: PMC12178341, DOI: 10.1289/ehp15305.Peer-Reviewed Original ResearchConceptsEnvironmental risk scoreMixtures researchBirth outcomesSummary scoreSimulation studyBirth cohortIllustrative data analysisData analysisPolycyclic aromatic hydrocarbonsRisk scoreBinary outcomesEpidemiological studiesHealth impactsRisk stratificationCumulative measureInferential goalsIntegrated R packagePractitionersChemical mixturesImprove risk stratificationPROTECT cohortSimulation settingsCohortScoresExposure to chemical mixturesRisk Factors for Serious Bacterial Infections Among Young Infants With Hypothermia: Protocol for a Multicenter, Retrospective Case-Control Study
Ramgopal S, Aronson P, Lorenz D, Rogers A, Cruz A. Risk Factors for Serious Bacterial Infections Among Young Infants With Hypothermia: Protocol for a Multicenter, Retrospective Case-Control Study. JMIR Research Protocols 2025, 14: e66722. PMID: 40536806, DOI: 10.2196/66722.Peer-Reviewed Original ResearchConceptsEpidemiology of SBIHerpes simplex virusCase-control studyEmergency departmentYoung infantsMultivariable prediction modelRetrospective nested case-control studyBacterial infectionsRetrospective case-control studyManagement of young infantsNested case-control studyUrinary tract infectionOptimal cutoff valueSerious bacterial infectionsSoft tissue infectionsOutcome measuresPediatric Emergency Medicine Collaborative Research CommitteeReceiver operating characteristic curvePediatric emergency departmentOperating characteristics curveUS children's hospitalsMixed effects logistic regressionHSV-positiveBlood culturesPredicting SBIAmino acid patterns predict white matter integrity measures in the brain in patients across the Alzheimer’s disease continuum
Goharmanesh F, Masmoie M, Nasiri H, Sadat-Madani S, Namin S, Damizadeh M, Shakeri S, Sodeifian F, Rajabpour-Sanati A, Bahrainian B, Mohammadi Y, Shushtari A, Mayeli M. Amino acid patterns predict white matter integrity measures in the brain in patients across the Alzheimer’s disease continuum. Metabolic Brain Disease 2025, 40: 227. PMID: 40531346, DOI: 10.1007/s11011-025-01647-1.Peer-Reviewed Original ResearchConceptsWhite matter integrityMean diffusivityDiffusion tensor imagingFractional anisotropyAlzheimer's Disease Neuroimaging InitiativeAxial diffusivityAA metabolic pathwaysReduced white matter integrityDisease continuumDTI-derived metricsWhite matter integrity measuresWhite matter microstructural integrityAD patientsCross-sectional studyUltra-high performance liquid chromatographyPotential therapeutic targetRadial diffusivityDecreased FAIncreased MDStudy groupEarly diagnosisProgression markersAlzheimer's disease continuumAmino acidsMild cognitive impairmentLatent Health Status Trajectories in Individuals With New or Worsening Claudication Symptoms.
Grubman S, Romain G, Cleman J, Scierka L, Pajarillo C, Kluger J, Mena-Hurtado C, Smolderen K. Latent Health Status Trajectories in Individuals With New or Worsening Claudication Symptoms. Journal Of The American Heart Association 2025, 14: e039455. PMID: 40530482, DOI: 10.1161/jaha.124.039455.Peer-Reviewed Original ResearchConceptsHealth status trajectoriesPeripheral artery disease careStatus trajectoriesDisease careHealth statusClaudication symptomsTrajectory subgroupsPeripheral Artery QuestionnaireVascular specialty clinicsPeripheral artery questionnaire scoresHierarchical multivariable logistic regressionImprove health statusMultivariate logistic regressionClinically meaningful thresholdsRegistry of patientsPsychosocial factorsBiopsychosocial modelDepressive symptomsSpecialty clinicsAlcohol use disorderQuestionnaire scoresRecovery trajectoriesLogistic regressionHealthLatent trajectory modelsCriminal Justice-Involved Veterans Not Engaged in Primary Care in the Veterans Health Administration.
Tsai J, Lampros A, Clark S, Dunn A, O'Toole T. Criminal Justice-Involved Veterans Not Engaged in Primary Care in the Veterans Health Administration. Journal Of Primary Care & Community Health 2025, 16: 21501319251348134. PMID: 40525421, PMCID: PMC12174793, DOI: 10.1177/21501319251348134.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationPrimary care visitsPrimary careJustice-involved veteransCare visitsHealth AdministrationVeterans Health Administration medical recordsMental health/substance use treatmentVeterans Health Administration facilitiesIntegrated care initiativesVA primary careOutpatient medical careMilitary sexual traumaCare initiativesService useAssociated with useCriminal justice systemHealthcare needsService utilizationNon-HispanicRetrospective cohort studySubstance use disordersBehavioral healthcareMental healthSociodemographic characteristicsImmune Subtyping Identifies Patients With Hormone Receptor–Positive Early-Stage Breast Cancer Who Respond to Neoadjuvant Immunotherapy (IO): Results From Five IO Arms of the I-SPY2 Trial
Wolf D, Yau C, Campbell M, Glas A, Barcaru A, Mittempergher L, Kuilman M, Brown-Swigart L, Hirst G, Basu A, Magbanua M, Sayaman R, Huppert L, Delson A, Investigators I, Symmans W, Borowsky A, Pohlmann P, Rugo H, Clark A, Yee D, DeMichele A, Perlmutter J, Petricoin E, Chien J, Stringer-Reasor E, Shatsky R, Liu M, Han H, Soliman H, Isaacs C, Nanda R, Hylton N, Pusztai L, Esserman L, van ‘t Veer L, Mukhtar R, Melisko M, Wallace A, Yeung K, Albain K, Robinson P, Lo S, Olopade F, Potter D, Beckwith H, Blaes A, Boughey J, Haddad T, Elias A, Isaacs C, Mitri Z, Kemmer K, Lu J, Lang J, Thomas A, Trivedi M, Hershman D, Meisel J, Kalinsky K, Vaklavas C, Williams N, Ellis E, Sanford A, Sanft T, Viscusi R, Arora M, Falkson C, Northfelt D, Murthy R, Haley B, Yung R, Mayer I, Khan Q, Edmiston K. Immune Subtyping Identifies Patients With Hormone Receptor–Positive Early-Stage Breast Cancer Who Respond to Neoadjuvant Immunotherapy (IO): Results From Five IO Arms of the I-SPY2 Trial. JCO Precision Oncology 2025, 9: e2400776. PMID: 40526879, PMCID: PMC12184982, DOI: 10.1200/po-24-00776.Peer-Reviewed Original ResearchConceptsPCR ratePredicting pathologic complete responseTriple-negative breast cancerNeoadjuvant immunotherapyTumor gradeHormone receptor-positive early-stage breast cancerHuman epidermal growth factor receptor 2-negativeBreast cancerEarly-stage triple-negative breast cancerImmune-related adverse eventsControl armEarly-stage breast cancerMammaPrint-high riskHormone receptor-positivePathological complete responseResponse to IOI-SPY2 trialStandard of careER-lowComplete responseNeoadjuvant therapyReceptor-positiveHER2+I-SPY2Adverse eventsTranslation and cultural adaptation of tools to assess diverse Asian American and Asian Canadian subgroups: The Asian Cohort for Alzheimer's Disease (ACAD) Study
Lee H, Tzuang M, Chow T, Kang Y, Tee B, Li C, Lam E, Gu Y, Lee S, Ho P, Peavy G, Seo E, Kim K, Tran B, Chae W, Nguyen D, Vo N, Dang D, Spat‐Lemus J, Choi Y, Feldman H, Jun G, Wang L, Yu W, Park V, Study T. Translation and cultural adaptation of tools to assess diverse Asian American and Asian Canadian subgroups: The Asian Cohort for Alzheimer's Disease (ACAD) Study. Alzheimer's & Dementia 2025, 21: e70311. PMID: 40528300, PMCID: PMC12173839, DOI: 10.1002/alz.70311.Peer-Reviewed Original ResearchConceptsCultural adaptationWorld Health OrganizationPromote health literacyCanadian older adultsAsian cohortCulturally appropriate translationCognitive assessment toolsLanguage backgroundAsian languagesAppropriate translationAssessment of cognitive functionHealth literacyStudy materialQuality healthcareCanadian adultsAlzheimer's diseaseTranslation processTranslation guidelinesOlder adultsSociocultural backgroundTranslation methodologyCanadian populationLanguage versionsAdaptation of toolsAssessment toolLate Permissive Hypercapnia for Mechanically Ventilated Preterm Infants: A Randomized Trial
Travers C, Gentle S, Shukla V, Aban I, Yee A, Armstead K, Benz R, Laney D, Ambalavanan N, Carlo W. Late Permissive Hypercapnia for Mechanically Ventilated Preterm Infants: A Randomized Trial. Pediatric Pulmonology 2025, 60: e71165. PMID: 40525736, PMCID: PMC12172392, DOI: 10.1002/ppul.71165.Peer-Reviewed Original ResearchConceptsPostnatal day 7Permissive hypercapniaPreterm infantsInstitutional review boardDay 7Ventilator-freeMechanically ventilated preterm infantsSingle-center randomized clinical trialReduced mechanical ventilation durationWeeks postmenstrual ageMechanical ventilation durationRespiratory distress syndromeVentilator-free daysRandomized clinical trialsPostmenstrual ageGestational ageWeeks gestationDistress syndromeVentilation durationBirth weightLung protectionRandomized trialsClinical trialsPrimary outcomeInfants
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