2025
Prognostic and Predictive Insights From Genomic Assays for Breast Cancer in Diverse Populations
Abdou Y, Kantor O, Racz J, Newman L, Pierce L, Winer E. Prognostic and Predictive Insights From Genomic Assays for Breast Cancer in Diverse Populations. JAMA Oncology 2025, 11: 655-663. PMID: 40178824, DOI: 10.1001/jamaoncol.2025.0178.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorBreast NeoplasmsFemaleGene Expression ProfilingGenomicsHealthcare DisparitiesHumansPrognosisConceptsEthnic disparitiesBreast cancer mortality ratesBreast cancerGenomic assaysCancer mortality ratesBiological characteristics of tumorsPredictive valueDiverse populationsGenomic assay resultsBreast cancer outcomesPersonalized clinical decision-makingBasal-like subtypeAggressive tumor phenotypeBreast cancer recurrenceCharacteristics of tumorsRandomized clinical trialsEthnic groupsSocial determinantsClinical decision-makingMultigene assaysLuminal BCancer outcomesDistribution of risk estimatesSurvival outcomesMolecular subtypesReduced sociodemographic disparities in surgical outcomes after spine surgery for spinal epidural abscess
Elsamadicy A, Ghanekar S, Serrato P, Mitre L, Kolb L, Lo S, Sciubba D. Reduced sociodemographic disparities in surgical outcomes after spine surgery for spinal epidural abscess. Journal Of Clinical Neuroscience 2025, 137: 111351. PMID: 40446558, DOI: 10.1016/j.jocn.2025.111351.Peer-Reviewed Original ResearchConceptsNon-Hispanic blacksNon-Hispanic whitesAmerican College of SurgeonsLength of stayNational Surgical Quality Improvement ProgramNon-routine dischargeRacial disparitiesSpinal epidural abscessSpine surgeryReduce racial disparitiesHispanic (HISHighest proportion of individualsQuality Improvement ProgramSurgical Quality Improvement ProgramHealth disparitiesMultivariate logistic regression analysisEpidural abscessSociodemographic disparitiesHealth outcomesLogistic regression analysisProportion of individualsRetrospective cohort studyAdverse eventsCollege of SurgeonsSpinal epidural abscess patientsCounty Incarceration Rate and Stroke Death: A Cross‐Sectional Study of the Influence of Physical Environment, Health Care Access, and Community Mental Distress
Sonderlund A, Wang E, Williams N, Horowitz C, Schoenthaler A, Holaday L. County Incarceration Rate and Stroke Death: A Cross‐Sectional Study of the Influence of Physical Environment, Health Care Access, and Community Mental Distress. Journal Of The American Heart Association 2025, 14: e039065. PMID: 40357666, PMCID: PMC12184567, DOI: 10.1161/jaha.124.039065.Peer-Reviewed Original ResearchConceptsPrimary care physiciansStroke deathsMental distressFood environmentImprisonment ratesRacial disparitiesPrimary care physician accessIncarceration ratesWhite populationHealth care accessMental health providersBlack populationCross-sectional designCross-sectional studyCare accessHealth providersCare physiciansPhysician accessAdjusted modelsTesting pathwayInfluence of physical environmentResults complement evidenceTest mediationDistressViolent crimeUnited States racial/ethnic disparities in PGT-A use: an analysis of 2014–2020 SART CORS database
Mason-Otey A, Seifer D. United States racial/ethnic disparities in PGT-A use: an analysis of 2014–2020 SART CORS database. Reproductive Biology And Endocrinology 2025, 23: 66. PMID: 40349066, PMCID: PMC12065204, DOI: 10.1186/s12958-025-01399-8.Peer-Reviewed Original ResearchConceptsPGT-AMultiple logistic regressionART cyclesHispanic womenAsian womenSociety for Assisted Reproductive Technology Clinic Outcome Reporting SystemWhite womenSelection of euploid embryosPreimplantation genetic testingRetrospective cohort studyOutcome Reporting SystemAutologous ART cyclesSART CORS databaseEuploid embryosSART CORSAutologous cyclesCohort studyGenetic testingMinority womenLogistic regressionWomenBackgroundThe useResultsThis studyUnited StatesRacial/ethnic disparitiesPredictors and Uptake of Lung Cancer Screening in the US: An Integrative Literature Review
Sarkar S, Choa E, Manzo L, Richman I, Batten J, Raziani Y, Poghosyan H. Predictors and Uptake of Lung Cancer Screening in the US: An Integrative Literature Review. Lung Cancer 2025, 203: 108529. PMID: 40253942, DOI: 10.1016/j.lungcan.2025.108529.Peer-Reviewed Original ResearchMeSH KeywordsEarly Detection of CancerHealthcare DisparitiesHumansLung NeoplasmsMass ScreeningTomography, X-Ray ComputedUnited StatesConceptsLung cancer screeningCancer screeningUptake of lung cancer screeningLung cancer screening utilizationLung cancer mortalityOrganizational-level policiesIntegrative literature reviewUS-based studiesCancer mortalityUninsured individualsDecision-making resourcesOvid MEDLINEInclusion criteriaOvid EmbaseMedical librariansExclusion criteriaDisparitiesOvidEarly detectionLiterature reviewCINAHLScreeningLung cancerMEDLINEEmbaseHospital Performance, Nursing Resources, and Health Inequities During the COVID-19 Pandemic
Kutney-Lee A, Golinelli D, Feder S, Amenyedor K, Lasater K, McHugh M, Carthon J. Hospital Performance, Nursing Resources, and Health Inequities During the COVID-19 Pandemic. Nursing Research 2025, 74: 280-287. PMID: 40127111, PMCID: PMC12188792, DOI: 10.1097/nnr.0000000000000821.Peer-Reviewed Original ResearchMeSH KeywordsAgedCOVID-19FemaleHealthcare DisparitiesHospital MortalityHospitalsHumansIllinoisMaleNew YorkNursing Staff, HospitalPandemicsSARS-CoV-2Social VulnerabilityConceptsLow-performing hospitalsHigh-performing hospitalsNursing resourcesHospital performanceLower patient-to-nurse ratiosCOVID-19 mortalityFavorable nursing work environmentsPatient-to-nurse ratioInpatient mortalityNursing work environmentHospitalized older adultsSocial Vulnerability Index quartilesFuture public health emergenciesSocially vulnerable patientsProportion of admissionsNurse surveyAdmitted to hospitalMortality disparitiesHealth inequalitiesHealth disparitiesPublic health emergencyAverage mortality rateOlder adultsNursesClaims dataRacial disparities in HIV pre-exposure prophylaxis (PrEP) awareness and uptake among white, Black, and Indigenous men in Canada: Analysis of data from the I’m Ready national HIV self-testing study
Ajiboye W, Tharao W, Owino M, Soje L, Tian J, Ly A, Piyesis M, McLeod A, Fleury M, McBain K, Massaquoi N, Mosugu T, Swidrovich J, Tan D, Nelson L, Rourke S. Racial disparities in HIV pre-exposure prophylaxis (PrEP) awareness and uptake among white, Black, and Indigenous men in Canada: Analysis of data from the I’m Ready national HIV self-testing study. Canadian Journal Of Public Health 2025, 116: 243-253. PMID: 40106208, PMCID: PMC12075050, DOI: 10.17269/s41997-025-01009-5.Peer-Reviewed Original ResearchConceptsPrEP awarenessPrEP eligibilityWhite participantsPrEP cascadeIndigenous menFunded health care systemHIV pre-exposure prophylaxisIncrease PrEP awarenessRural communitiesRacial differencesHealth care systemPublic health interventionsAssess racial differencesPre-exposure prophylaxisBinary logistic regressionCross-sectional dataPrEP carePrEP uptakeHealth interventionsCare systemDisproportionate burdenRacial disparitiesBlack participantsSecondary analysisPrEPDisparities in use of physical restraint and chemical sedation in the emergency department by patient housing status
Robinson L, Ryus C, Nath B, Kumar A, Desai R, Shah D, Faustino I, Wong A. Disparities in use of physical restraint and chemical sedation in the emergency department by patient housing status. PLOS ONE 2025, 20: e0319286. PMID: 40080507, PMCID: PMC11906057, DOI: 10.1371/journal.pone.0319286.Peer-Reviewed Original ResearchConceptsPatient's housing statusEmergency departmentHousing statusPhysical restraintSedative usePsychiatric emergency careAdverse health outcomesCross-sectional studyLogistic regression modelsRestraint ordersEmergency careHealth outcomesED visitsPatient raceYears of ageDescriptive statisticsHealthcare networkRegional healthcare networkChemical sedationHoused patientsDemographic factorsMarginalized populationsRegression modelsCareChief complaintMediators of Racial Inequities in Non‐Small Cell Lung Cancer Care
Hamid S, Lee D, Herrin J, Yu J, Pollack C, Dean L, Gaddy J, Oladele C, Feder S, Canavan M, Nunez-Smith M, Soulos P, Gross C. Mediators of Racial Inequities in Non‐Small Cell Lung Cancer Care. Cancer Medicine 2025, 14: e70757. PMID: 40052387, PMCID: PMC11886416, DOI: 10.1002/cam4.70757.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancer carePhase of careSocioeconomic statusNon-small cell lung cancerIndividual-level socioeconomic statusNeighborhood-level socioeconomic statusMedicare-Medicaid dual eligibilityWhite patientsHealth care accessLung cancer careNon-Hispanic blacksIndirect effects of mediatorsDiagnosis stageStage-appropriate treatmentTwo-year survivalCancer careCare accessEffects of raceOptimal careDual eligiblesCareStructural racismRacial inequalityBlack patientsInadequate evaluationRacial/Ethnic Differences and Effects of Clinical/Socioeconomic Factors on Time from Diagnosis to Treatment in Pancreatic Cancer
Sridharan A, Dotan E, Dorta M, Vemula N, Handorf E, Deng M, Renning A, Sorice K, Laderman L, Whittington K, Cukierman E, Astsaturov I, Vijayvergia N, Meyer J, Reddy S, Lynch S. Racial/Ethnic Differences and Effects of Clinical/Socioeconomic Factors on Time from Diagnosis to Treatment in Pancreatic Cancer. Journal Of Gastrointestinal Cancer 2025, 56: 67. PMID: 39954184, PMCID: PMC11829832, DOI: 10.1007/s12029-025-01188-x.Peer-Reviewed Original ResearchConceptsSocioeconomic statusHazard ratioConfidence intervalsSocioeconomic status populationsCancer CenterComprehensive cancer centerDiagnosis to first treatmentPatient-level variablesAcademic cancer centerCox proportional hazards regressionReceipt of chemotherapyMultivariable Cox proportional hazards regressionProportional hazards regressionT2TCancer disparitiesNeighborhood deprivationRace/ethnic disparitiesDisparity indicatorsRacial/ethnic differencesHospital settingEffects of racePatient raceDiagnosis to treatmentUS CensusMetastatic PDACExploring sociodemographic disparities in diagnostic problems and mistakes in the quest for diagnostic equity: insights from a national survey of patient experiences
McDonald K, Gleason K, Grob R, Yuan C, Dhingra I, Evered J, Warne E, Schlesinger M. Exploring sociodemographic disparities in diagnostic problems and mistakes in the quest for diagnostic equity: insights from a national survey of patient experiences. Frontiers In Public Health 2025, 13: 1444005. PMID: 40017549, PMCID: PMC11865055, DOI: 10.3389/fpubh.2025.1444005.Peer-Reviewed Original ResearchConceptsNational survey of patient experiencesSurvey of patient experienceU.S. population-based surveysPopulation-based surveyLower household incomeNationally representative sampleWorking full-timePatient experienceSociodemographic disparitiesSociodemographic characteristicsSociodemographic predictorsSociodemographic groupsEpidemiological researchDiagnostic disparitiesRepresentative sampleU.S. populationHousehold incomeMultivariate regression analysisDiagnostic experienceNational surveyAnalysis of dataOutcome estimatesYounger ageCis femaleFull-timeRacial and ethnic disparities in conversion to mastectomy following lumpectomy
Khubchandani J, KC M, Dey P, Proussaloglou E, Valero M, Berger E, Park T, Gross C, Butler P, Fayanju O, Winer E, Golshan M, Greenup R. Racial and ethnic disparities in conversion to mastectomy following lumpectomy. Breast Cancer Research And Treatment 2025, 211: 99-110. PMID: 39937397, DOI: 10.1007/s10549-025-07625-6.Peer-Reviewed Original ResearchConceptsConversion to mastectomyNeoadjuvant chemotherapyBreast conservationStage 0-III breast cancerWhite womenBreast cancerBlack womenBreast cancer careNational Cancer DatabaseMultivariate logistic regression modelEvaluate contemporary trendsLogistic regression modelsCancer careImprove disparitiesEthnic disparitiesDiagnosis yearInitial lumpectomySocio-demographicCancer DatabaseClinical factorsMastectomyLumpectomySurgeryResultsThe studyTreatment sequenceClosing the Gap: Digital Innovations to Address Hypertension Disparities
Shanab B, Gaffey A, Schwamm L, Zawalich M, Sarpong D, Pérez-Escamilla R, Dorney J, Cooperman C, Schafer R, Lipkind H, Lu Y, Onuma O, Spatz E. Closing the Gap: Digital Innovations to Address Hypertension Disparities. Current Cardiology Reports 2025, 27: 23. PMID: 39812880, DOI: 10.1007/s11886-024-02171-x.Peer-Reviewed Original ResearchMeSH KeywordsBlood Pressure Monitoring, AmbulatoryHealthcare DisparitiesHumansHypertensionSocial Determinants of HealthTelemedicineConceptsHypertension disparitiesCare teamSocial determinants of healthCommunity health workersDeterminants of healthRemote blood pressure monitoringIncrease patient empowermentBlood pressure controlMultidisciplinary care teamBlood pressure machineIntegration of servicesHealth equityHealth inequalitiesHealth disparitiesPatient empowermentPatient engagementInfluence blood pressure controlSocial determinantsHealth workersTelehealth visitsPayment modelsHypertension managementPressure controlHypertension DetectionPatient outcomesQuality of gastrointestinal surgical oncology care according to insurance status
Butensky S, Kerekes D, Bakkila B, Billingsley K, Ahuja N, Johnson C, Khan S. Quality of gastrointestinal surgical oncology care according to insurance status. Journal Of Gastrointestinal Surgery 2025, 29: 101961. PMID: 39800081, DOI: 10.1016/j.gassur.2025.101961.Peer-Reviewed Original ResearchConceptsMedicare-insured patientsNational Cancer DatabaseAdequate lymphadenectomyNegative marginsCancer DatabaseRetrospective study of adult patientsStudy of adult patientsSurvival analysisInsurance statusReceipt of lymphadenectomyCurative-intent resectionGastrointestinal (GI) cancersIncreased risk of deathMultivariate survival analysisAdequacy of lymphadenectomyCox proportional hazards modelsRisk of deathProportional hazards modelResection marginsSurgical oncology careAdjuvant therapyRetrospective studyAdult patientsBiliary organismsLymphadenectomy
2024
Who feels safe calling 911: are prior experiences of anti-Black racial discrimination associated with hesitancy seeking emergency medical services in the event of accidental drug overdose? – a study protocol
Hall O, Trimble C, Garcia S, Grayson S, Joseph L, Entrup P, Jegede O, Martel J, Tetrault J, Mathis M, Jordan A. Who feels safe calling 911: are prior experiences of anti-Black racial discrimination associated with hesitancy seeking emergency medical services in the event of accidental drug overdose? – a study protocol. Annals Of Medicine 2024, 57: 2439540. PMID: 39697058, PMCID: PMC11660366, DOI: 10.1080/07853890.2024.2439540.Peer-Reviewed Original ResearchConceptsEmergency medical servicesExperiences of racial discriminationCross-sectional surveyMedical servicesAccidental drug overdoseGroup-Based Medical Mistrust ScaleAssociated with health disparitiesDrug overdoseGroup-based medical mistrustMedical Mistrust ScaleEveryday Discrimination ScaleBlack AmericansNon-parametric partial correlationsMedical discriminationRacial discriminationFatal drug overdosesHealth disparitiesQuestionnaire measuring perceptionsRelated health problemsMedical mistrustExploratory factor analysisBlack adultsSociodemographic informationCronbach's alphaGroup-basedFrom Simulation to Bedside: The Journey to Provide Equitable Patient Care.
Vora S, Dahlen B, Bryant K, Kou M. From Simulation to Bedside: The Journey to Provide Equitable Patient Care. Pediatric Annals 2024, 53: e414-e419. PMID: 39495632, DOI: 10.3928/19382359-20240908-03.Peer-Reviewed Original ResearchMeSH KeywordsClinical CompetenceHealth EquityHealthcare DisparitiesHumansPediatricsSimulation TrainingConceptsSimulation-based educationHealth equityHealth care disparitiesEquitable patient careHealth care trainingHealth care professionalsCare disparitiesCare trainingCare professionalsPatient careImplementing action stepsCultural humilityPatient outcomesCommunity engagementHealthEnhance skillsSystem issuesAction stepsUnintentional harmClinical practiceRobust evaluationPotential benefitsTeam commitmentHidden curriculumSkillsGlobal Disparities in the Characteristics and Outcomes of Leukemia Clinical Trials: A Cross-Sectional Study of the ClinicalTrials.gov Database.
Alhajahjeh A, Rotter L, Stempel J, Grimshaw A, Bewersdorf J, Blaha O, Kewan T, Podoltsev N, Shallis R, Mendez L, Stahl M, Zeidan A. Global Disparities in the Characteristics and Outcomes of Leukemia Clinical Trials: A Cross-Sectional Study of the ClinicalTrials.gov Database. JCO Global Oncology 2024, 10: e2400316. PMID: 39621951, DOI: 10.1200/go-24-00316.Peer-Reviewed Original ResearchMeSH KeywordsClinical Trials as TopicCross-Sectional StudiesDatabases, FactualDeveloped CountriesDeveloping CountriesHealthcare DisparitiesHumansLeukemiaResearch Priorities in Pediatric Asthma Morbidity: Addressing the Impacts of Systemic Racism on Children with Asthma in the United States. An Official American Thoracic Society Workshop Report
Lovinsky-Desir S, Riley I, Bryant-Stephens T, De Keyser H, Forno E, Kozik A, Louisias M, Matsui E, Sheares B, Thakur N, Apter A, Beck A, Bentley-Edwards K, Berkowitz C, Braxton C, Dean J, Jones C, Koinis-Mitchell D, Okelo S, Taylor-Cousar J, Teach S, Wechsler M, Gaffin J, Federico M. Research Priorities in Pediatric Asthma Morbidity: Addressing the Impacts of Systemic Racism on Children with Asthma in the United States. An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2024, 21: 1349-1364. PMID: 39352175, PMCID: PMC11451894, DOI: 10.1513/annalsats.202407-767st.Peer-Reviewed Original ResearchConceptsImpact of systemic racismAsthma morbidityChildhood asthmaSocial determinants of healthAsthma health outcomesPediatric asthma morbidityDeterminants of healthSystemic racismCommunity engagementDrivers of disparitiesEmergency department visitsResearch teamChildhood asthma outcomesImpact of interventionsMultidisciplinary research teamEffects of systemic racismInnovative study designsImpact of racismAsthma disparitiesSocial determinantsHealthcare accessAsthma outcomesHealth outcomesDepartment visitsEvaluate interventionsDisparities in Dual-energy X-ray Absorptiometry Scan Utilization Across Race/Ethnic Groups Before and After Hip Fractures
Rudisill K, Ratnasamy P, Sanchez J, Grauer J. Disparities in Dual-energy X-ray Absorptiometry Scan Utilization Across Race/Ethnic Groups Before and After Hip Fractures. JAAOS Global Research And Reviews 2024, 8: e24.00052. PMID: 39303221, PMCID: PMC11419421, DOI: 10.5435/jaaosglobal-d-24-00052.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptiometry, PhotonAgedAged, 80 and overBone DensityEthnicityFemaleHealthcare DisparitiesHip FracturesHumansMaleMedicareRacial GroupsUnited StatesConceptsHip fracture populationHip fractureDEXA scanRace/ethnic groupsElixhauser Comorbidity IndexLesser oddsPatient ageFracture populationScan utilizationComorbidity indexTime of hip fractureBefore hip fractureStudy revealed disparitiesImprove medication accessDual x-ray absorptiometryHip fracture patientsGeriatric hip fracturesX-ray absorptiometryHip fragility fracturesMedication accessNon-white categorySentinel eventsHealthcare systemFragility fracturesFracture patientsAdaptation of the socioecological model to address disparities in engagement of Black men in prostate cancer genetic testing
Leader A, Rebbeck T, Oh W, Patel A, Winer E, Bailey L, Gomella L, Lumpkins C, Garraway I, Aiello L, Baskin M, Cheng H, Cooney K, Ganzak A, George D, Halabi S, Hathaway F, Healy C, Kim J, Leapman M, Loeb S, Maxwell K, McNair C, Morgan T, Prindeville B, Soule H, Steward W, Suttiratana S, Taplin M, Yamoah K, Fortune T, Bennett K, Blanding-Godbolt J, Gross L, Giri V. Adaptation of the socioecological model to address disparities in engagement of Black men in prostate cancer genetic testing. BMC Public Health 2024, 24: 2533. PMID: 39289635, PMCID: PMC11409532, DOI: 10.1186/s12889-024-20008-8.Peer-Reviewed Original ResearchMeSH KeywordsAfricaBlack or African AmericanBlack PeopleDelphi TechniqueGenetic TestingHealthcare DisparitiesHumansMaleProstatic NeoplasmsUnited StatesConceptsSocioecological modelGermline testingHealthcare institutionsCancer genetic testingHereditary cancer implicationsEquity frameworkBlack malesCancer screeningReduce disparitiesBackgroundBlack menCommunity liaisonCommunity stakeholdersMixed-methods approachOvercome barriersImprovement PartnershipCommunity eventsCascade testingModified Delphi modelRate of prostate cancerGenetic testingCancer implicationsEducation programsBlack menEquitable strategiesIncreased engagement
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