2025
Single cell analysis identifies distinct CD4 + T cells associated with the pathobiology of pediatric obesity related asthma
Thompson D, Wabara Y, Duran S, Reichenbach A, Chen L, Collado K, Yon C, Greally DMed J, Rastogi D. Single cell analysis identifies distinct CD4 + T cells associated with the pathobiology of pediatric obesity related asthma. Scientific Reports 2025, 15: 6844. PMID: 40000680, PMCID: PMC11861978, DOI: 10.1038/s41598-025-88423-4.Peer-Reviewed Original ResearchConceptsCD4+ T cellsT cell subtypesT cellsSteroid resistanceTh1 inflammationObese asthmaTh1 responseCentral memory T cellsObese asthma phenotypeEffector T cellsMemory T cellsObesity-related asthmaCD4+ T cell subtypesPediatric obesity-related asthmaT helper 1Healthy-weight controlsPulmonary function deficitsCD4Th1Asthma phenotypesGlucocorticoid receptorSingle-cell transcriptomicsFunctional deficitsInflammationSteroidsβ-Ionone facilitates ex vivo airway smooth muscle relaxation via extraocular opsin-3 light receptor activation
Uribe S, Shany E, Zhang Y, Wu A, Dan W, Perez-Zoghbi J, Emala C, Yim P. β-Ionone facilitates ex vivo airway smooth muscle relaxation via extraocular opsin-3 light receptor activation. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2025, 328: l526-l537. PMID: 39937635, DOI: 10.1152/ajplung.00227.2024.Peer-Reviewed Original ResearchConceptsAirway smooth muscle relaxationOpsin 3Severity of asthma exacerbationsAirway smooth muscle cellsDose-dependent relaxationTherapeutic agentsAirways in vitroPrecision-cut lung slicesSmooth muscle relaxationSmooth muscle cellsAttenuated relaxationWire myographyDietary intakeDecreased relaxationAirway pathologyIncreased riskReceptor activationAsthma exacerbationsMuscle cellsLower airwaysLung slicesMRNA expressionMuscle relaxationTracheal ringsAirwayThe Interplay Between Respiratory Syncytial Virus and Asthma Inception: Insights Gained From the COVID‐19 Pandemic
Amram T, Duek O, Golan‐Tripto I, Goldbart A, Greenberg D, Hazan G. The Interplay Between Respiratory Syncytial Virus and Asthma Inception: Insights Gained From the COVID‐19 Pandemic. Pediatric Pulmonology 2025, 60: e27474. PMID: 39760467, PMCID: PMC11748096, DOI: 10.1002/ppul.27474.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusYears of ageSyncytial virusRespiratory syncytial virus bronchiolitisRespiratory syncytial virus infectionRespiratory syncytial virus exposureRSV-induced inflammationRespiratory syncytial virus activityMultivariate logistic regressionAirway changesAsthma inceptionRetrospective studyAsthma surrogateIncreased riskLogistic regressionAsthmaCause of asthmaCOVID-19 pandemicHealthcare organizationsPredispositionIncreased rateChildrenCOVID-19AgeVirus
2024
Research Priorities in Pediatric Asthma Morbidity: Addressing the Impacts of Systemic Racism on Children with Asthma in the United States. An Official American Thoracic Society Workshop Report
Lovinsky-Desir S, Riley I, Bryant-Stephens T, De Keyser H, Forno E, Kozik A, Louisias M, Matsui E, Sheares B, Thakur N, Apter A, Beck A, Bentley-Edwards K, Berkowitz C, Braxton C, Dean J, Jones C, Koinis-Mitchell D, Okelo S, Taylor-Cousar J, Teach S, Wechsler M, Gaffin J, Federico M. Research Priorities in Pediatric Asthma Morbidity: Addressing the Impacts of Systemic Racism on Children with Asthma in the United States. An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2024, 21: 1349-1364. PMID: 39352175, PMCID: PMC11451894, DOI: 10.1513/annalsats.202407-767st.Peer-Reviewed Original ResearchConceptsImpact of systemic racismAsthma morbidityChildhood asthmaSocial determinants of healthAsthma health outcomesPediatric asthma morbidityDeterminants of healthSystemic racismCommunity engagementDrivers of disparitiesEmergency department visitsResearch teamChildhood asthma outcomesImpact of interventionsMultidisciplinary research teamEffects of systemic racismInnovative study designsImpact of racismAsthma disparitiesSocial determinantsHealthcare accessAsthma outcomesHealth outcomesDepartment visitsEvaluate interventionsBeyond Air Pollution: Addressing Multifactorial Contributors to Asthma Disparities in Black and Latinx Populations.
Ou J, Yuan Y, Fu X, Sun Y. Beyond Air Pollution: Addressing Multifactorial Contributors to Asthma Disparities in Black and Latinx Populations. American Journal Of Respiratory And Critical Care Medicine 2024, 210: 696-697. PMID: 38935619, PMCID: PMC11389579, DOI: 10.1164/rccm.202405-1031le.Peer-Reviewed Original ResearchA common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma
Everman J, Sajuthi S, Liegeois M, Jackson N, Collet E, Peters M, Chioccioli M, Moore C, Patel B, Dyjack N, Powell R, Rios C, Montgomery M, Eng C, Elhawary J, Mak A, Hu D, Huntsman S, Salazar S, Feriani L, Fairbanks-Mahnke A, Zinnen G, Michel C, Gomez J, Zhang X, Medina V, Chu H, Cicuta P, Gordon E, Zeitlin P, Ortega V, Reisdorph N, Dunican E, Tang M, Elicker B, Henry T, Bleecker E, Castro M, Erzurum S, Israel E, Levy B, Mauger D, Meyers D, Sumino K, Gierada D, Hastie A, Moore W, Denlinger L, Jarjour N, Schiebler M, Wenzel S, Woodruff P, Rodriguez-Santana J, Pearson C, Burchard E, Fahy J, Seibold M. A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma. Nature Communications 2024, 15: 3900. PMID: 38724552, PMCID: PMC11082194, DOI: 10.1038/s41467-024-48034-5.Peer-Reviewed Original ResearchConceptsAirway epithelial cellsIntelectin-1Mucus pluggingGene expressionAirways of severe asthmaticsEpithelial cellsHuman airway epithelial cellsAirway epithelial brushingsMucus secretory cellsT2-high asthmaFormation of mucus plugsAssociated with protectionC-terminusGenetic variantsAirway mucus pluggingMolecular roleSecretory cellsSecreted componentsEpithelial brushingsT2-lowIL-13Mucus obstructionTarget pathwaysSevere asthmaticsClinical significanceImplementing Antiinflammatory Reliever Strategies in Asthma The Evolving Paradigm of Asthma Management
Zaeh S, Eakin M, Chupp G. Implementing Antiinflammatory Reliever Strategies in Asthma The Evolving Paradigm of Asthma Management. CHEST Journal 2024, 165: 250-252. PMID: 38336438, DOI: 10.1016/j.chest.2023.09.004.Peer-Reviewed Original Research
2023
Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma
Gautam S, Chu J, Cohen A, Kaur R, Lee S, Wilson G, Liu Q, Gomez J, Rajaveen H, Yan X, Cohn L, Clark B, Chupp G. Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma. Allergy 2023, 78: 3274-3277. PMID: 37874609, PMCID: PMC10842366, DOI: 10.1111/all.15915.Peer-Reviewed Original ResearchEpigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma
Recto K, Kachroo P, Huan T, Van Den Berg D, Lee G, Bui H, Lee D, Gereige J, Yao C, Hwang S, Joehanes R, Weiss S, Consortium N, Abe N, Abecasis G, Aguet F, Albert C, Almasy L, Alonso A, Ament S, Anderson P, Anugu P, Applebaum-Bowden D, Ardlie K, Arking D, Arnett D, Ashley-Koch A, Aslibekyan S, Assimes T, Auer P, Avramopoulos D, Ayas N, Balasubramanian A, Barnard J, Barnes K, Barr R, Barron-Casella E, Barwick L, Beaty T, Beck G, Becker D, Becker L, Beer R, Beitelshees A, Benjamin E, Benos T, Bezerra M, Bielak L, Bis J, Blackwell T, Blangero J, Blue N, Boerwinkle E, Bowden D, Bowler R, Brody J, Broeckel U, Broome J, Brown D, Bunting K, Burchard E, Bustamante C, Buth E, Cade B, Cardwell J, Carey V, Carrier J, Carson A, Carty C, Casaburi R, Romero J, Casella J, Castaldi P, Chaffin M, Chang C, Chang Y, Chasman D, Chavan S, Chen B, Chen W, Chen Y, Cho M, Choi S, Chuang L, Chung M, Chung R, Clish C, Comhair S, Conomos M, Cornell E, Correa A, Crandall C, Crapo J, Cupples L, Curran J, Curtis J, Custer B, Damcott C, Darbar D, David S, Davis C, Daya M, de Andrade M, de las Fuentes L, de Vries P, DeBaun M, Deka R, DeMeo D, Devine S, Dinh H, Doddapaneni H, Duan Q, Dugan-Perez S, Duggirala R, Durda J, Dutcher S, Eaton C, Ekunwe L, Boueiz A, Ellinor P, Emery L, Erzurum S, Farber C, Farek J, Fingerlin T, Flickinger M, Fornage M, Franceschini N, Frazar C, Fu M, Fullerton S, Fulton L, Gabriel S, Gan W, Gao S, Gao Y, Gass M, Geiger H, Gelb B, Geraci M, Germer S, Gerszten R, Ghosh A, Gibbs R, Gignoux C, Gladwin M, Glahn D, Gogarten S, Gong D, Goring H, Graw S, Gray K, Grine D, Gross C, Gu C, Guan Y, Guo X, Gupta N, Haessler J, Hall M, Han Y, Hanly P, Harris D, Hawley N, He J, Heavner B, Heckbert S, Hernandez R, Herrington D, Hersh C, Hidalgo B, Hixson J, Hobbs B, Hokanson J, Hong E, Hoth K, Hsiung C, Hu J, Hung Y, Huston H, Hwu C, Irvin M, Jackson R, Jain D, Jaquish C, Johnsen J, Johnson A, Johnson C, Johnston R, Jones K, Kang H, Kaplan R, Kardia S, Kelly S, Kenny E, Kessler M, Khan A, Khan Z, Kim W, Kimoff J, Kinney G, Konkle B, Kooperberg C, Kramer H, Lange C, Lange E, Lange L, Laurie C, Laurie C, LeBoff M, Lee J, Lee S, Lee W, LeFaive J, Levine D, Levy D, Lewis J, Li X, Li Y, Lin H, Lin H, Lin X, Liu S, Liu Y, Liu Y, Loos R, Lubitz S, Lunetta K, Luo J, Magalang U, Mahaney M, Make B, Manichaikul A, Manning A, Manson J, Martin L, Marton M, Mathai S, Mathias R, May S, McArdle P, McDonald M, McFarland S, McGarvey S, McGoldrick D, McHugh C, McNeil B, Mei H, Meigs J, Menon V, Mestroni L, Metcalf G, Meyers D, Mignot E, Mikulla J, Min N, Minear M, Minster R, Mitchell B, Moll M, Momin Z, Montasser M, Montgomery C, Muzny D, Mychaleckyj J, Nadkarni G, Naik R, Naseri T, Natarajan P, Nekhai S, Nelson S, Neltner B, Nessner C, Nickerson D, Nkechinyere O, North K, O'Connell J, O'Connor T, Ochs-Balcom H, Okwuonu G, Pack A, Paik D, Palmer N, Pankow J, Papanicolaou G, Parker C, Peloso G, Peralta J, Perez M, Perry J, Peters U, Peyser P, Phillips L, Pleiness J, Pollin T, Post W, Becker J, Boorgula M, Preuss M, Psaty B, Qasba P, Qiao D, Qin Z, Rafaels N, Raffield L, Rajendran M, Ramachandran V, Rao D, Rasmussen-Torvik L, Ratan A, Redline S, Reed R, Reeves C, Regan E, Reiner A, Reupena M, Rice K, Rich S, Robillard R, Robine N, Roden D, Roselli C, Rotter J, Ruczinski I, Runnels A, Russell P, Ruuska S, Ryan K, Sabino E, Saleheen D, Salimi S, Salvi S, Salzberg S, Sandow K, Sankaran V, Santibanez J, Schwander K, Schwartz D, Sciurba F, Seidman C, Seidman J, Sériès F, Sheehan V, Sherman S, Shetty A, Shetty A, Sheu W, Shoemaker M, Silver B, Silverman E, Skomro R, Smith A, Smith J, Smith J, Smith N, Smith T, Smoller S, Snively B, Snyder M, Sofer T, Sotoodehnia N, Stilp A, Storm G, Streeten E, Su J, Sung Y, Sylvia J, Szpiro A, Taliun D, Tang H, Taub M, Taylor K, Taylor M, Taylor S, Telen M, Thornton T, Threlkeld M, Tinker L, Tirschwell D, Tishkoff S, Tiwari H, Tong C, Tracy R, Tsai M, Vaidya D, Van Den Berg D, VandeHaar P, Vrieze S, Walker T, Wallace R, Walts A, Wang F, Wang H, Wang J, Watson K, Watt J, Weeks D, Weinstock J, Weir B, Weiss S, Weng L, Wessel J, Willer C, Williams K, Williams L, Williams S, Wilson C, Wilson J, Winterkorn L, Wong Q, Wu B, Wu J, Xu H, Yanek L, Yang I, Yu K, Zekavat S, Zhang Y, Zhao S, Zhao W, Zhu X, Ziv E, Zody M, Zoellner S, O’Connor G, Levy D, DeMeo D. Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma. EBioMedicine 2023, 95: 104758. PMID: 37598461, PMCID: PMC10462855, DOI: 10.1016/j.ebiom.2023.104758.Peer-Reviewed Original ResearchConceptsMethylation quantitative trait lociAssociation studiesNovel epigenetic signatureIdentifies novel targetsQuantitative trait lociTranscription factor bindingEpigenome-wide association studiesGene ontology analysisWide association studyClosest genesTrait lociCausal regulatorsDrug target analysisTranscription patternsOntology analysisDNA methylationEpigenetic signaturesFactor bindingGene expressionMolecular mechanismsMendelian randomizationCosta Rica StudyPotential therapeutic targetNovel targetGenetic epidemiologyDifferences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19
Liu Y, Rajeevan H, Simonov M, Lee S, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Ortega H, Zaeh S, Gomez J, Cohn L, Gautam S, Chupp G. Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3383-3390.e3. PMID: 37454926, PMCID: PMC10787810, DOI: 10.1016/j.jaip.2023.07.006.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseType 2 inflammationCOVID-19 severitySOFA scoreAirway diseaseNoneosinophilic asthmaSequential Organ Failure Assessment scoreOrgan Failure Assessment scoreSevere coronavirus disease 2019Higher SOFA scoreMedian SOFA scoreRetrospective cohort studyObstructive pulmonary diseaseOdds of mortalityLower SOFA scoresCells/μLCOVID-19 outcomesCoronavirus disease 2019Logistic regression analysisCOVID-19Clinical confoundersAsthma patientsCohort studyImmunological factorsClinical featuresIs there a best strategy to prevent asthma exacerbations in inner-city patients with asthma?
Zaeh S, Chupp G, Eakin M. Is there a best strategy to prevent asthma exacerbations in inner-city patients with asthma? Annals Of Allergy Asthma & Immunology 2023, 132: 11-12. PMID: 37433383, PMCID: PMC10774450, DOI: 10.1016/j.anai.2023.07.003.Commentaries, Editorials and LettersEfficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of the PATHWAY and NAVIGATOR Clinical Trials
Corren J, Menzies-Gow A, Chupp G, Israel E, Korn S, Cook B, Ambrose C, Hellqvist Å, Roseti S, Molfino N, Llanos J, Martin N, Bowen K, Griffiths J, Parnes J, Colice G. Efficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of the PATHWAY and NAVIGATOR Clinical Trials. American Journal Of Respiratory And Critical Care Medicine 2023, 208: 13-24. PMID: 37015033, PMCID: PMC10870853, DOI: 10.1164/rccm.202210-2005oc.Peer-Reviewed Original ResearchConceptsAsthma exacerbation rateUncontrolled asthmaExacerbation rateSecondary outcomesClinical trialsOverall populationRelevant subgroupsMeaningful reductionEfficacy of tezepelumabExacerbation-related hospitalizationsSafety of tezepelumabPlacebo-controlled trialEmergency department visitsInflammatory biomarker levelsNitric oxide levelsAdverse eventsAllergy statusBaseline bloodClinical characteristicsDepartment visitsPooled analysisNAVIGATOR trialBiomarker levelsOxide levelsTezepelumabEffect of tezepelumab on healthcare utilization in patients with severe, uncontrolled asthma The NAVIGATOR study
Menzies-Gow A, Bourdin A, Chupp G, Israel E, Hellqvist Å, Hunter G, Roseti S, Ambrose C, Llanos J, Cook B, Corren J, Colice G. Effect of tezepelumab on healthcare utilization in patients with severe, uncontrolled asthma The NAVIGATOR study. Annals Of Allergy Asthma & Immunology 2023, 131: 343-348.e2. PMID: 37263380, DOI: 10.1016/j.anai.2023.05.028.Peer-Reviewed Original ResearchConceptsExacerbation-related hospitalizationsHealthcare utilizationUncontrolled asthmaNAVIGATOR studyAsthma-related healthcare utilizationEffect of tezepelumabPatient healthcare utilizationRecipients of placeboThymic stromal lymphopoietinHealth-related qualityIntensive care daysHuman monoclonal antibodySubcutaneous tezepelumabAsthma controlAsthma exacerbationsLung functionSpecialist visitsEmergency departmentCare daysOverall burdenTezepelumabMAIN OUTCOMEPlaceboAmbulance transportHospitalizationDupilumab improves long‐term outcomes in patients with uncontrolled, moderate‐to‐severe GINA‐based type 2 asthma, irrespective of allergic status
Rabe K, Pavord I, Busse W, Chupp G, Izuhara K, Altincatal A, Gall R, Pandit‐Abid N, Deniz Y, Rowe P, Jacob‐Nara J, Radwan A. Dupilumab improves long‐term outcomes in patients with uncontrolled, moderate‐to‐severe GINA‐based type 2 asthma, irrespective of allergic status. Allergy 2023, 78: 2148-2156. PMID: 37073882, DOI: 10.1111/all.15747.Peer-Reviewed Original ResearchConceptsParent study baselineType 2 inflammationPre-bronchodilator FEVAsthma exacerbation rateType 2 asthmaAllergic asthmaExacerbation rateSevere asthma exacerbation ratesSevere type 2 asthmaAsthma Control Questionnaire scoreACQ-5 scoresReduced exacerbation ratesLong-term outcomesLong-term treatmentAllergic statusDupilumab efficacyGINA guidelinesQUEST studyWeek 96Asthma controlUncontrolled asthmaWeek 48Allergic phenotypeLung functionQuestionnaire scoresGenetic analyses of chr11p15.5 region identify MUC5AC-MUC5B associated with asthma-related phenotypes
Li X, Li H, Christenson S, Castro M, Denlinger L, Erzurum S, Fahy J, Gaston B, Israel E, Jarjour N, Levy B, Mauger D, Moore W, Zein J, Kaminski N, Wenzel S, Woodruff P, Bleecker E, Meyers D, Program F. Genetic analyses of chr11p15.5 region identify MUC5AC-MUC5B associated with asthma-related phenotypes. Journal Of Asthma 2023, 60: 1824-1835. PMID: 36946148, PMCID: PMC10524756, DOI: 10.1080/02770903.2023.2193631.Peer-Reviewed Original ResearchRemission outcomes in severe eosinophilic asthma with mepolizumab therapy: Analysis of the REDES study
Pavord I, Gardiner F, Heaney L, Domingo C, Price R, Pullan A, Oppenheimer J, Brusselle G, Nagase H, Chupp G, Pizzichini E, Bañas-Conejero D, Howarth P. Remission outcomes in severe eosinophilic asthma with mepolizumab therapy: Analysis of the REDES study. Frontiers In Immunology 2023, 14: 1150162. PMID: 37122713, PMCID: PMC10131245, DOI: 10.3389/fimmu.2023.1150162.Peer-Reviewed Original ResearchConceptsSevere eosinophilic asthmaClinical remissionEosinophilic asthmaRemission definitionsClinical practiceAsthma Control Test scoresBetter ACT scoresProportion of patientsSubset of patientsACT scoreMepolizumab therapyMepolizumab treatmentOral corticosteroidsPrior exacerbationsOC useSevere asthmaBaseline characteristicsExpiratory volumeLung functionRemission outcomesMedical recordsDisease progressionTreatment outcomesRemissionTreatment goalsLow CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity.
Li X, Guerra S, Ledford JG, Kraft M, Li H, Hastie AT, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Zein J, Kaminski N, Wenzel SE, Woodruff PG, Meyers DA, Bleecker ER. Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 438-451. PMID: 36066606, PMCID: PMC9940145, DOI: 10.1164/rccm.202206-1230oc.Peer-Reviewed Original ResearchConceptsBronchial epithelial cellsMRNA expression levelsAsthma severityT2 biomarkersAsthma susceptibilityT2 inflammationExpression levelsSevere Asthma Research ProgramSystemic corticosteroid useLower pulmonary functionEpithelial cellsAsthma-related phenotypesCorticosteroid useAsthma exacerbationsPulmonary functionAsthma developmentAsthma endotypesAsthma progressionInflammation biomarkersInflammation genesHost defenseCC16Th2 genesSeverityBiomarkersValidated anxiety assessments among pediatric patients with peanut allergy on oral immunotherapy
Kaman K, Dhodapkar M, Shabanova V, McCollum S, Factor J, Leeds S. Validated anxiety assessments among pediatric patients with peanut allergy on oral immunotherapy. Annals Of Allergy Asthma & Immunology 2023, 130: 657-663. PMID: 36738780, DOI: 10.1016/j.anai.2023.01.028.Peer-Reviewed Original ResearchConceptsPeanut oral immunotherapyOral immunotherapyNon-white racePeanut allergyAnxiety scoresOlder cohortProspective cross-sectional cohort studyCross-sectional cohort studyHigher mean anxiety scoresMean anxiety scoreDiagnosable anxietyCohort studyMale patientsPediatric patientsFemale patientsFood allergySimilar patientsHigh prevalenceHigher scoresLife measuresLow prevalencePatientsSeparation anxiety scoresElectronic survey questionnaireAllergyPsoriasis associated with asthma and allergic rhinitis: a US-based cross-sectional study using the All of US Research Program
Joel M, Fan R, Damsky W, Cohen J. Psoriasis associated with asthma and allergic rhinitis: a US-based cross-sectional study using the All of US Research Program. Archives Of Dermatological Research 2023, 315: 1823-1826. PMID: 36707438, DOI: 10.1007/s00403-023-02539-z.Peer-Reviewed Original ResearchConceptsAllergic rhinitisUS adultsUs Research ProgramCommon chronic inflammatory diseaseMultivariable logistic regression modelNationwide longitudinal cohortImmunopathogenesis of psoriasisBody mass indexChronic inflammatory diseaseCases of asthmaCross-sectional studyLogistic regression modelsMultivariable analysisSmoking statusMass indexInflammatory pathwaysSubgroup analysisInflammatory diseasesLongitudinal cohortHigh prevalenceAsthmaPsoriasisPotential associationDiverse cohortSociodemographic variablesType 2 cytokine genes as allergic asthma risk factors after viral bronchiolitis in early childhood
Dong Z, Myklebust Å, Johnsen I, Jartti T, Døllner H, Risnes K, DeWan A. Type 2 cytokine genes as allergic asthma risk factors after viral bronchiolitis in early childhood. Frontiers In Immunology 2023, 13: 1054119. PMID: 36685501, PMCID: PMC9852873, DOI: 10.3389/fimmu.2022.1054119.Peer-Reviewed Original ResearchConceptsAllergic asthmaViral bronchiolitisRisk factorsViral infectionDetailed lung function testsAllergic asthma developmentHistory of bronchiolitisHuman Metapneumovirus InfectionVariable airway obstructionAsthma risk factorsType 2 cytokinesDevelopment of asthmaLung function testsGenetic variantsCohort of childrenSpecific viral infectionsEarly childhoodType 2 cytokine genesSchool agePotential candidate targetAirway obstructionMetapneumovirus infectionMedian ageAsthma developmentFunction tests
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