2025
Moving Beyond Desensitization to Tolerance in Food Allergy
Flom J, Shreffler W, Perrett K. Moving Beyond Desensitization to Tolerance in Food Allergy. The Journal Of Allergy And Clinical Immunology In Practice 2025, 13: 741-744. PMID: 40010566, DOI: 10.1016/j.jaip.2025.02.014.Peer-Reviewed Original ResearchManagement of IgE-mediated food allergyFood allergyIgE-mediated food allergyStages of clinical developmentSide effect profileMode of deliveryGoal of therapeuticsSustained unresponsivenessDosing regimensDose protocolProactive therapyAllergen-specificClinical developmentActive therapyPatient populationSide effectsTherapyPassive therapyPatient-specificDesensitizationClinical contextPatientsDoseAllergyDegree of protection
2021
Wheat oral immunotherapy
Leeds S, Liu EG, Nowak-Wegrzyn A. Wheat oral immunotherapy. Current Opinion In Allergy And Clinical Immunology 2021, 21: 269-277. PMID: 33840798, DOI: 10.1097/aci.0000000000000743.Peer-Reviewed Original ResearchConceptsWheat oral immunotherapyOral immunotherapyMaintenance dosesSevere reactionsFood allergy epidemiologyLow maintenance dosesNonrandomized clinical trialRisk of reactionSustained unresponsivenessSuccessful desensitizationAdjunct therapeuticsFood allergyTrial protocolClinical trialsAllergic reactionsAllergy epidemiologyHuman trialsSafety outcomesHead comparisonAugmenting factorSmall sample sizeTrialsFood modificationImmunotherapyDoses
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