2025
MAP kinase phosphatases in metabolic diseases
Hota A, Bennett A. MAP kinase phosphatases in metabolic diseases. Trends In Endocrinology And Metabolism 2025 PMID: 40555575, DOI: 10.1016/j.tem.2025.05.002.Peer-Reviewed Original ResearchMitogen-activated protein kinaseInactivate mitogen-activated protein kinasesMAP kinase phosphatasesRegulation of MAPK signaling pathwaysMetabolic diseasesMAPK signaling pathwayRegulatory residuesInsulin signalingProtein kinaseSignaling pathwayCellular responsesKey pathwaysLipid metabolismGlucose homeostasisTherapeutic targetPathwayMetabolismKinaseResiduesHomeostasisMKPRegulationPhosphataseAutonomic modulation of the immune response and implications for CNS malignancies
Wachsmuth L, Srinivasan E, Puviindran B, Haskell-Mendoza A, DeSpenza T, Fecci P. Autonomic modulation of the immune response and implications for CNS malignancies. Npj Precision Oncology 2025, 9: 168. PMID: 40483275, PMCID: PMC12145445, DOI: 10.1038/s41698-025-00957-y.Peer-Reviewed Original ResearchCentral nervous systemAntitumor immune responseImmune responseAutonomic nervous systemNervous systemCentral nervous system malignanciesCentral nervous system inflammationModulation of immune responsesCentral nervous system inputImmune cell functionRegulate immune responsesIntracranial malignanciesImmune cellsMalignancyAutonomic modulationNeuro-immunologyCell functionImmune organsSignaling pathwayGlobal physiological processesTripartite interactionResponseInflammationCancerPhysiological processesExploring dopamine as the master regulator of brain circuitry and mental health genome
Blum K, Braverman E, Sharafshah A, Elman I, Lewandrowski K, Bowirrat A, Pinhasov A, Thanos P, Gold M, Dennen C, Modestino E, Badgaiyan R, Baron D, Fuehrlein B, Sipple D, Ashford J, Sunder K, Makale M, Murphy K, Jafari N, Zeine F, Pollack A, Lewandowski P, Khalsa J. Exploring dopamine as the master regulator of brain circuitry and mental health genome. Gene & Protein In Disease 2025, 0: 6557. DOI: 10.36922/gpd.6557.Peer-Reviewed Original ResearchBrain circuitryDopamine transmissionDopaminergic activityPsychiatric disordersDopamineBrain functionCircuitryLong-term influenceNeurobiologyAddictionImmediate effectsIntracellular signaling pathwaysPotential therapeutic targetDisordersNeurotransmitterBrainClinical relevanceTherapeutic targetSignaling pathwaySubstancesSteamed panax notoginseng mitigates CA-MRSA USA300-induced necroptosis in human neutrophils
Zhang L, Feng X, An H, Yang W, Xia Y, Wen B, Zheng H, Chen Y, Cheng Y, Jiang C, Lu C, Tan Y. Steamed panax notoginseng mitigates CA-MRSA USA300-induced necroptosis in human neutrophils. Frontiers In Pharmacology 2025, 16: 1546652. PMID: 40520183, PMCID: PMC12163054, DOI: 10.3389/fphar.2025.1546652.Peer-Reviewed Original ResearchCA-MRSAVirulence factorsCommunity-associated methicillin-resistant <i>Staphylococcus aureus</i> (CAQuorum-sensing signaling pathwayPolymorphonuclear neutrophil countMethicillin-resistant <i>Staphylococcus aureus</i> (MRPhagocytic function of polymorphonuclear neutrophilsGenes of MRSAPolymorphonuclear neutrophilsSignaling pathwayCA-MRSA infectionsHost innate immune responseBacterial virulence factorsDrug-resistant bacterial infectionsMCP-1IL-1BIL-8Pro-inflammatory cytokines IL-1bDisrupt innate immunityInnate immune responseRNA-seqFunctions of polymorphonuclear neutrophilsPathogenic microbial infectionsPanax notoginsengCytokines IL-1bRBM15-MKL1 fusion protein promotes leukemia via m6A methylation and WNT pathway activation
Mayday M, Biancon G, Wei M, Ramirez C, Moratti I, Pintado-Urbanc A, Espinosa J, Chen M, Wang L, Simon M, Ofir-Rosenfeld Y, Rausch O, Tebaldi T, Halene S, Krause D. RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and WNT pathway activation. Blood 2025 PMID: 40435410, DOI: 10.1182/blood.2024027712.Peer-Reviewed Original ResearchRNA fateM6A modificationFusion proteinWnt pathway activationFrizzled genesFunctions of RBM15Dysregulation of m6A modificationRBM15-MKL1Pathway activationMulti-omics approachInduced apoptosis in vitroWnt signaling pathwayApoptosis in vitroM6A depositionRNA bindingSpecific RNAGrowth in vitroM6A methylationMRNA targetsSignaling pathwayWnt pathwayWnt signalingM6A modifiersM6A-dependent mechanismRNAAPOBEC affects tumor evolution and age at onset of lung cancer in smokers
Zhang T, Sang J, Hoang P, Zhao W, Rosenbaum J, Johnson K, Klimczak L, McElderry J, Klein A, Wirth C, Bergstrom E, Díaz-Gay M, Vangara R, Colon-Matos F, Hutchinson A, Lawrence S, Cole N, Zhu B, Przytycka T, Shi J, Caporaso N, Homer R, Pesatori A, Consonni D, Imielinski M, Chanock S, Wedge D, Gordenin D, Alexandrov L, Harris R, Landi M. APOBEC affects tumor evolution and age at onset of lung cancer in smokers. Nature Communications 2025, 16: 4711. PMID: 40394004, PMCID: PMC12092836, DOI: 10.1038/s41467-025-59923-8.Peer-Reviewed Original ResearchConceptsLung cancerTumor evolutionMulti-omics profilingLung tumor samplesCell of originProgenitor-like cellsMulti-omicsMutagenic processesMutational processesOff-target activityTP53 mutationsMutational burdenSignaling pathwayKRAS mutationsMutagenesisAPOBEC mutagenesisSomatic mutationsSolid tumorsTumor samplesClonal expansionDNA damageTumor developmentCell typesMutationsStemness markersRottlerin inhibits macropinocytosis of Porcine Reproductive and Respiratory Syndrome Virus through the PKCδ-Cofilin signaling pathway
Kang Y, Choi J, Lee J, Park S, Oh C. Rottlerin inhibits macropinocytosis of Porcine Reproductive and Respiratory Syndrome Virus through the PKCδ-Cofilin signaling pathway. PLOS ONE 2025, 20: e0324500. PMID: 40392868, PMCID: PMC12091787, DOI: 10.1371/journal.pone.0324500.Peer-Reviewed Original ResearchConceptsRespiratory syndrome virusPorcine ReproductiveLIM domain kinase 1Actin dynamicsPRRSV replicationPRRSV entryPRRSVSignaling pathwayDecreased actin polymerizationActin polymerizationCofilin activityEffects of rottlerinHost cellsKinase 1Enveloped virusesRottlerin treatmentInhibit viral replicationAntiviral moleculesReplicationRottlerinVirusMacropinocytosisEntry pathwayViral replicationPathwayDysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation
Bathla S, Datta D, Bolat D, Woo E, Duque A, Arellano J, Arnsten A, Nairn A. Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation. Frontiers In Aging Neuroscience 2025, 17: 1549770. PMID: 40365352, PMCID: PMC12069431, DOI: 10.3389/fnagi.2025.1549770.Peer-Reviewed Original ResearchTau pathologyTau hyperphosphorylationAlzheimer's diseaseAssociated with tau hyperphosphorylationSoluble phosphorylated tauSporadic Alzheimer's diseaseCalcium signalingDysregulated calcium signalingTau etiologyEarly stages of ADHyperphosphorylationSignaling pathwayHuman ADInflammatory signaling pathwaysCalpain-2Stages of ADMolecular processesHydrolyze cAMPTauEntorhinal cortexCarboxypeptidase IIGlutamate carboxypeptidase IIDephosphorylationPancreatic β-cell apoptosis caused by apolipoprotein C3-rich low-density lipoprotein is attenuated by kansuinine A through oxidative stress inhibition
Lulji Taraqaz B, Hsu Y, Tsai P, Li Y, Chen F, Yang W, Shen M. Pancreatic β-cell apoptosis caused by apolipoprotein C3-rich low-density lipoprotein is attenuated by kansuinine A through oxidative stress inhibition. Biomedicine & Pharmacotherapy 2025, 187: 118066. PMID: 40262236, DOI: 10.1016/j.biopha.2025.118066.Peer-Reviewed Original ResearchConceptsB cell apoptosisRat pancreatic B-cellsLow-density lipoproteinPathway analysisSignaling pathwayOxidative stressApoptosisImproved cell viabilityRIN-m5FB cellsLectin-like oxidized low-density lipoprotein receptor-1Pancreatic B-cellsHigh-fat dietCell viabilityInsulin toleranceAntiapoptotic propertiesKansuinine AMitigated apoptosisMechanism of actionMolecular dockingStress inhibitionPathwayLow-density lipoprotein receptor-1Improved glucoseHigh-fat4-Anilinoquinolinylchalcone derivatives mediate antifibrotic effects through ERK/MRTF—a signaling pathway crosstalk
Selvam P, Tseng C, Wang C, Sun Y, Chen Y, Kao Y, Dahms H, Cheng C. 4-Anilinoquinolinylchalcone derivatives mediate antifibrotic effects through ERK/MRTF—a signaling pathway crosstalk. Environmental Science And Pollution Research 2025, 32: 11685-11696. PMID: 40234319, DOI: 10.1007/s11356-025-36382-8.Peer-Reviewed Original ResearchConceptsSide effectsAbnormal liver functionAnti-fibrosisSevere side effectsGroup of drugsAnti-inflammatory responseHuman immune systemSkin rashGenitourinary cancersMechanism of actionAntifibrotic effectsBreast cancerScreened 6Immunomodulatory qualitiesLiver functionPharmacological profileImmune systemSignaling pathwaySignaling pathway crosstalkQuinolone analoguesCancerAnti-cancerDerivativesBleedingRashTSC-mTORC1 Pathway in Postnatal V-SVZ Neurodevelopment
Feliciano D, Bordey A. TSC-mTORC1 Pathway in Postnatal V-SVZ Neurodevelopment. Biomolecules 2025, 15: 573. PMID: 40305300, PMCID: PMC12024678, DOI: 10.3390/biom15040573.Peer-Reviewed Original ResearchConceptsMTOR pathwayNeural stem cellsVentricular-subventricular zoneTranscriptional programsMTOR pathway signalingPathway signalingSignaling pathwayNutrient sufficiencyPathwayOlfactory bulb circuitryMTORNeurodevelopmental disordersFunctional cellsGrowth factorNeurogenesisCellsRodent brainStem cellsNarrative reviewThe molecular determinants regulating redox signaling in diabetic endothelial cells
Srivastava S, Kopasz-Gemmen O, Thurman A, Rajendran B, Selvam M, Kumar S, Srivastava R, Suresh M, Kumari R, Goodwin J, Inoki K. The molecular determinants regulating redox signaling in diabetic endothelial cells. Frontiers In Pharmacology 2025, 16: 1563047. PMID: 40290438, PMCID: PMC12023289, DOI: 10.3389/fphar.2025.1563047.Peer-Reviewed Original ResearchReactive oxygen speciesProcess of oxidative phosphorylationAberrant activation of mTOR signalingNutrient-sensing kinaseCellular signaling pathwaysCellular ROS levelsLoss of AMPKOxygen speciesActivation of mTOR signalingReactive oxygen species productionIncreased ROSTranscription of pro-inflammatory cytokinesActivation of MAPKCell powerhouseGenerate ATPCell oxidative statusRenal endothelial cellsOxidative phosphorylationRedox signalingDamaged DNASignaling pathwayMolecular determinantsMTOR signalingPI3KAberrant activationIdentification of potential hub genes and drugs in septic kidney injury: a bioinformatic analysis with preliminary experimental validation
Sun S, Ding Y, Yang D, Shen J, Zhang T, Song G, Chen X, Lin Y, Chen R. Identification of potential hub genes and drugs in septic kidney injury: a bioinformatic analysis with preliminary experimental validation. Frontiers In Medicine 2025, 12: 1502189. PMID: 40166075, PMCID: PMC11955678, DOI: 10.3389/fmed.2025.1502189.Peer-Reviewed Original ResearchHub genesSeptic kidney injuryAcute kidney injurySignaling pathwayDrug-gene interaction databaseKidney injuryAssociated with hub genesGene Ontology biological processesProtein-protein interactionsIntensive care unitPotential hub genesDrug-gene interactionsCandidate genesKEGG pathwaysCytoscape softwareDrug-geneSTRING databaseInfiltration of immune cellsBioinformatics analysisGene screeningSerum creatinine levelsInteraction databasesRelated genesBiological processesGenesEnhanced insights into the genetic architecture of 3D cranial vault shape using pleiotropy-informed GWAS
Goovaerts S, Naqvi S, Hoskens H, Herrick N, Yuan M, Shriver M, Shaffer J, Walsh S, Weinberg S, Wysocka J, Claes P. Enhanced insights into the genetic architecture of 3D cranial vault shape using pleiotropy-informed GWAS. Communications Biology 2025, 8: 439. PMID: 40087503, PMCID: PMC11909261, DOI: 10.1038/s42003-025-07875-6.Peer-Reviewed Original ResearchConceptsCranial vault shapeVault shapeGenomic lociGenetic discovery effortsSNP discoveryCraniofacial developmentGenetic architectureGWAS dataGWAS studiesTranscription factorsGenetic studiesCranial vaultGenetic understandingShape variationSignaling pathwayBrain shapeExperimental biologyBrain shape variationCraniofacial complexFDR methodLociDiscovery effortsFacial shapeWealth of knowledgeGWASMultifaceted analysis of noncoding and coding de novo variants implicates NOTCH signaling pathway in tetralogy of Fallot in Chinese population
Lin Q, Zhang D, Gruber P, Tam P, Lui V, Wu Z, Hong H, Chien K, Sham P, Tang C. Multifaceted analysis of noncoding and coding de novo variants implicates NOTCH signaling pathway in tetralogy of Fallot in Chinese population. Human Genetics And Genomics Advances 2025, 6: 100414. PMID: 39921258, PMCID: PMC11910093, DOI: 10.1016/j.xhgg.2025.100414.Peer-Reviewed Original ResearchPediatric Cardiac Genomics ConsortiumProtein-protein interactionsNoncoding variantsCoding de novo variantsNotch signalingPopulation genetic heterogeneityEvidence of genetic contributionEtiology of TOFDysregulated gene expressionNotch signaling pathwayNotch signaling genesDysregulation of Notch signalingChinese populationTetralogy of FallotCyanotic heart defectsCandidate genesOutflow tract morphogenesisGenetic heterogeneitySignaling genesGenomics ConsortiumBioinformatics analysisGene expressionCo-expressionGenetic contributionSignaling pathwayModulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology
Stem A, Michel C, Harris P, Rogers K, Gibb M, Roncal-Jimenez C, Reisdorph R, Johnson R, Roede J, Fritz K, Brown J. Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology. Particle And Fibre Toxicology 2025, 22: 3. PMID: 39910563, PMCID: PMC11800628, DOI: 10.1186/s12989-025-00619-8.Peer-Reviewed Original ResearchMeSH KeywordsBasic Helix-Loop-Helix Transcription FactorsCell LineChronic Kidney Diseases of Uncertain EtiologyHumansKidney Tubules, ProximalNanoparticlesOccupational ExposureOxidation-ReductionOxidative StressProteomeProteomicsReactive Oxygen SpeciesReceptors, Aryl HydrocarbonRenal Insufficiency, ChronicSaccharumSilicon DioxideSulfhydryl CompoundsConceptsProximal convoluted tubulesActivation of aryl hydrocarbon receptorExposure to silica nanoparticlesDisease of unknown etiologyReactive oxygen speciesKidney proximal convoluted tubuleIncreased reactive oxygen species generationChronic kidney diseaseSignaling pathwayIntroductionChronic kidney diseaseHK-2 cellsReactive oxygen species generationProfile in vitroPotential mechanisms of toxicityMembrane hyperpolarizationCKD progressionUnknown etiologyGeneration of reactive oxygen speciesMitochondrial membrane hyperpolarizationOxygen species generationAryl hydrocarbon receptorEnergy metabolismKidney diseaseConvoluted tubulesMechanisms of toxicityStructural basis for the interaction between the Drosophila RTK Sevenless (dROS1) and the GPCR BOSS
Zhang J, Tsutsui Y, Li H, Li T, Wang Y, Laraki S, Alarcon-Frias S, Stayrook S, Klein D. Structural basis for the interaction between the Drosophila RTK Sevenless (dROS1) and the GPCR BOSS. Nature Communications 2025, 16: 808. PMID: 39827240, PMCID: PMC11743138, DOI: 10.1038/s41467-025-55943-6.Peer-Reviewed Original ResearchConceptsFibronectin type IIIExtracellular regionReceptor tyrosine kinasesR7 photoreceptor cellsN-terminal domainCryo-EM structureC-terminal peptideDownstream signaling pathwaysDrosophila homologueBeta-strandsHelical hairpinHuman orthologHydrogen-deuterium exchange mass spectrometryMutagenesis studiesStructural basisRegulatory functionsSignaling pathwayTyrosine kinaseLigand bindingSevenlessComplex predictionBinding epitopeHDX-MSPhotoreceptor cellsBinding interactionsLupus and inflammatory bowel disease share a common set of microbiome features distinct from other autoimmune disorders
Zhou H, Balint D, Shi Q, Vartanian T, Kriegel M, Brito I. Lupus and inflammatory bowel disease share a common set of microbiome features distinct from other autoimmune disorders. Annals Of The Rheumatic Diseases 2025, 84: 93-105. PMID: 39874239, PMCID: PMC11868722, DOI: 10.1136/ard-2024-225829.Peer-Reviewed Original ResearchProtein-protein interaction analysisMicrobial signaturesMicrobial profilesEffector-like proteinsSignaling pathwayInterleukin-12 signaling pathwayDisease mechanismsBacteria-derived proteinsMetagenomic datasetsMicrobiome featuresMicrobial underpinningsFunctional genesMicrobial biomarkersInteraction analysisMicrobial influenceInflammatory bowel diseaseMicrobial mechanismsGlucocorticoid signalingProteinGlucocorticoid receptorCritical roleAutoimmune diseasesPathwayBowel diseasePotential importanceOlanzapine Induces Adipogenesis and Glucose Uptake by Activating Glycolysis and Synergizing with the PI3K-AKT Pathway
Li S, Fu Y, Wang W, Qiu J, Huang Y, Li X, Yang K, Yu X, Ma Y, Zhang Y, Zhang M, Li J, Li W. Olanzapine Induces Adipogenesis and Glucose Uptake by Activating Glycolysis and Synergizing with the PI3K-AKT Pathway. Current Neuropharmacology 2025, 23: 412-425. PMID: 39150031, PMCID: PMC12105311, DOI: 10.2174/1570159x22666240815120547.Peer-Reviewed Original ResearchAdministration of olanzapineTreated with olanzapineReactive oxygen speciesDownstream PI3K-Akt signal pathwayAssociated with obesityActive glycolysisAssessed body weightWeight gainDifferentiated 3T3-L1 preadipocytesLiver fat levelsPI3K-Akt pathwayOlanzapineDrug doseFemale miceDietary patternsMetabolic markersPI3K-AktFood intakeGlucose uptakeMouse modelGlycolipid abnormalitiesRodent modelsBody weightGAPDH expressionSignaling pathwayThe evolving understanding of systemic mechanisms in organ-specific IgA nephropathy: a focus on gut-kidney crosstalk
Wang X, Zhou X, Qiao X, Falchi M, Liu J, Zhang H. The evolving understanding of systemic mechanisms in organ-specific IgA nephropathy: a focus on gut-kidney crosstalk. Theranostics 2025, 15: 656-681. PMID: 39744688, PMCID: PMC11671385, DOI: 10.7150/thno.104631.Peer-Reviewed Original ResearchConceptsGut-kidney crosstalkExploration of gut microbiotaGut microbiotaKidney diseaseMechanism of IgANIntestinal microbiomeSignaling pathwayIgA nephropathyInter-organ crosstalkEfficient therapeutic strategiesPrognosis of patientsProgression of IgANElaborate mechanismsTherapeutic strategiesIgAN pathogenesisIgANCrosstalkMicrobiomeMicrobiotaMultiple organsKidneyProbioticsNephropathyDiseaseMechanism
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