2025
The landscape of suicide risk factors in Latin America
Cabrera-Mendoza B, Fries G, Polimanti R, Consortium S. The landscape of suicide risk factors in Latin America. Psychiatry Research 2025, 351: 116597. DOI: 10.1016/j.psychres.2025.116597.Peer-Reviewed Original ResearchLatin AmericaMental health care accessSocial determinants of suicideDevelopment of tailored interventionsCare-seeking behaviorHealth care accessSuicide ratesRisk factorsSuicide prevention strategiesTraditional gender normsMiddle-income countriesReduce suicide ratesCare accessSocial determinantsSuicide risk factorsTailored interventionsDeterminants of suicideImpact of religiosityGender normsFamily tiesLatin American populationsPrevention strategiesSignificant disparitiesSociocultural factorsLatinCardiovascular risk factors in myeloproliferative neoplasms: associations with survival and thrombotic outcomes
How J, Leiva O, Redd R, Marneth A, DeAngelo D, Dieli-Conwright C, El-Jawahri A, Kamaz B, Kim C, Lindsley R, Luskin M, Stahl M, Wazir M, Weeks L, Hobbs G. Cardiovascular risk factors in myeloproliferative neoplasms: associations with survival and thrombotic outcomes. Blood Vessels Thrombosis & Hemostasis 2025, 2: 100051. DOI: 10.1016/j.bvth.2025.100051.Peer-Reviewed Original ResearchMyeloproliferative neoplasm patientsCardiovascular risk factorsEssential thrombocythemiaMyeloproliferative neoplasmsPolycythemia veraThrombotic outcomesThrombotic riskRisk factorsDiagnosis of hematological malignanciesMyeloproliferative neoplasm subtypeIncreased risk of deathType 2 diabetes mellitusMyeloproliferative neoplasms diagnosisRetrospective cohort analysisSex-matched controlsManaging cardiovascular risk factorsAssociated with survivalImprove patient morbidityRisk of deathMF patientsHematologic malignanciesMPN diagnosisPatient morbidityDana-FarberArterial/venous thrombosisThe Impact of Cognitive Impairment on Cardiovascular Disease
Jamil Y, Krishnaswami A, Orkaby A, Stimmel M, Brown Iv C, Mecca A, Forman D, Rich M, Nanna M, Damluji A. The Impact of Cognitive Impairment on Cardiovascular Disease. Journal Of The American College Of Cardiology 2025, 85: 2472-2491. PMID: 40562512, DOI: 10.1016/j.jacc.2025.04.057.Peer-Reviewed Original ResearchConceptsImpact of cognitive impairmentCognitive impairmentCardiovascular diseaseHealth care utilizationOlder adult populationEvidence-based management strategiesMedical adverse eventsHealth literacyCare utilizationOlder adultsMitigate cognitive impairmentUnder-prescribedReduced participationU.S. populationTreatment of patientsAdult populationGuideline-directedExcess morbidityCardiac patientsRisk factorsOlder patientsAdverse eventsHealthMechanism of cognitive impairmentInterventional managementTirzepatide for reduction of morbidity and mortality in adults with obesity: rationale and design of the SURMOUNT‐MMO trial
Lam C, Rodriguez A, Aminian A, Ferrannini E, Heerspink H, Jastreboff A, Laffin L, Pandey A, Ray K, Ridker P, Sanyal A, Yki‐Jarvinen H, Mason D, Strzelecki M, Bartee A, Cui C, Hurt K, Linetzky B, Bunck M, Nissen S. Tirzepatide for reduction of morbidity and mortality in adults with obesity: rationale and design of the SURMOUNT‐MMO trial. Obesity 2025 PMID: 40545827, DOI: 10.1002/oby.24332.Peer-Reviewed Original ResearchSecondary cardiovascular disease preventionCardiovascular disease preventionCardiovascular diseaseGlucagon-like peptide-1 receptor agonistsGlucose-dependent insulinotropic polypeptide receptorPeptide-1 receptor agonistsMultiple cardiovascular risk factorsCardiovascular risk factorsHeart failure eventsNonfatal myocardial infarctionType 2 diabetesReduction of morbidityDisease preventionDouble-blindPrimary endpointReceptor agonistsClinical benefitImprove morbidityObesityCoronary revascularizationRisk factorsOutcome trialsTirzepatideMultiple outcomesSubstantial weight reductionCross-jurisdictional factors linked to gambling frequency in adolescents from 28 European countries: a machine learning approach
Testa G, Ruiz-Iniesta A, García O, Tarragón E, Soriano V, Benedetti E, Cerrai S, Molinaro S, Brand M, Potenza M, Mestre-Bach G. Cross-jurisdictional factors linked to gambling frequency in adolescents from 28 European countries: a machine learning approach. Psychiatry Research 2025, 351: 116602. PMID: 40578225, DOI: 10.1016/j.psychres.2025.116602.Peer-Reviewed Original ResearchSymptom Trajectories After COVID Hospitalization and Risk Factors for Symptom Burden in Older Persons: a Longitudinal Cohort Study
Pan Y, Cho G, Geda M, Gill T, Cohen A, Ferrante L, Hajduk A, Miner B. Symptom Trajectories After COVID Hospitalization and Risk Factors for Symptom Burden in Older Persons: a Longitudinal Cohort Study. The Journals Of Gerontology Series A 2025, glaf132. PMID: 40512177, DOI: 10.1093/gerona/glaf132.Peer-Reviewed Original ResearchHigh symptom burdenAssociated with high symptom burdenSymptom burdenGeriatric conditionsPsychosocial factorsOlder personsOlder adultsEdmonton Symptom Assessment SystemCommunity-dwelling older adultsSymptom trajectoriesModified Edmonton Symptom Assessment SystemYale New Haven Health SystemPost-COVID symptomsEvaluate symptom burdenImpairment of physical functionFemale sexMonths post-dischargeRisk factorsLongitudinal cohort studyMultinomial logistic regressionIdentified risk factorsPhysical functionHealth systemSocial supportPost-dischargeSafety overview and management of inavolisib alone and in combination therapies in PIK3CA-mutated, HR-positive, HER2-negative advanced breast cancer (GO39374)
Gambardella V, Accordino M, Bedard P, Cervantes A, Hamilton E, Italiano A, Kalinsky K, Krop I, Oliveira M, Saura C, Schmid P, Turner N, Varga A, Fernandez-Saranillo A, Jin Y, Royer-Joo S, Peters U, Shankar N, Schutzman J, Juric D, Jhaveri K. Safety overview and management of inavolisib alone and in combination therapies in PIK3CA-mutated, HR-positive, HER2-negative advanced breast cancer (GO39374). ESMO Open 2025, 10: 105303. PMID: 40513140, PMCID: PMC12205636, DOI: 10.1016/j.esmoop.2025.105303.Peer-Reviewed Original ResearchHER2-negative advanced breast cancerAdvanced breast cancerAdverse eventsCombination therapyPIK3CA-mutationsBreast cancerHormone receptor (HR)-positiveDiscontinued study treatmentBreast cancer therapyLong-term toleranceDose reductions/interruptionsAny-gradeData cutoffDose modificationTolerability profileHR-positiveProgressive diseaseStudy treatmentMetformin treatmentCancer therapyNo treatmentPatientsRisk factorsTherapyHyperglycemiaOver Two Decades of Experience in Aortic Arch Reoperations: Long-Term Outcomes and Mortality Risk Factors
Bozini N, Piber N, Vitanova K, Sideris K, Herold U, Guenzinger R, Amabile A, Georgescu T, Krane M, Prinzing A. Over Two Decades of Experience in Aortic Arch Reoperations: Long-Term Outcomes and Mortality Risk Factors. Journal Of Clinical Medicine 2025, 14: 4087. PMID: 40565833, PMCID: PMC12193799, DOI: 10.3390/jcm14124087.Peer-Reviewed Original ResearchAortic arch reoperationArch reoperationLong-term outcomesTemporary mechanical circulatory supportBleeding complicationsMechanical circulatory supportRisk factorsOverall survivalVentilation timeAdverse outcomesAssociated with significantly lower overall survivalSignificantly lower overall survivalAortic type B dissectionHistory of coronary artery diseaseMultivariate Cox regression analysisPredictor of adverse outcomesIncreased long-term survivalCirculatory supportAortic arch surgeryProlonged ventilation timeAssociated with high mortalityPreoperative risk factorsType B dissectionHigher mortalityTranscatheter aortic valve implantationUremic toxin receptor NR1H3 contributes to hyperlipidemia- and chronic kidney disease-accelerated vascular inflammation, which is partially suppressed by novel YBX2 anti-ROS pathway
Lu Y, Sun Y, Saaoud F, Xu K, Shao Y, Han B, Jiang X, Martinez L, Vazquez-Padron R, Mohsin S, Zhao H, Wang H, Yang X. Uremic toxin receptor NR1H3 contributes to hyperlipidemia- and chronic kidney disease-accelerated vascular inflammation, which is partially suppressed by novel YBX2 anti-ROS pathway. Redox Biology 2025, 85: 103724. PMID: 40505347, PMCID: PMC12182350, DOI: 10.1016/j.redox.2025.103724.Peer-Reviewed Original ResearchChronic kidney diseaseReactive oxygen speciesROS regulationNephrectomy-induced chronic kidney diseaseVascular inflammationRNA-binding proteinsReactive oxygen species regulationPromote vascular inflammationPromotion of inflammationCellular ROS levelsTrained immunityDisease progressionKidney diseaseMouse modelCytokine genesMouse aortaProinflammatory genesTranscription factorsRisk factorsRegulating inflammationHyperlipidemiaCardiovascular diseaseInflammationNegative feedback mechanismYBX2The incidence and trends of diving-related spine injuries in the United States and risk factors associated with spinal cord injury
Seddio A, Jabbouri S, Vasudevan R, Gouzoulis M, Day W, Maloy G, Varthi A, Rubio D, Grauer J. The incidence and trends of diving-related spine injuries in the United States and risk factors associated with spinal cord injury. Spinal Cord 2025, 1-7. PMID: 40490487, DOI: 10.1038/s41393-025-01098-6.Peer-Reviewed Original ResearchEstimated annual percentage changeSpine injuriesSpinal cord injuryRisk factorsLumbar spineInjury prevention programsAnnual percentage changePublic health initiativesCord injuryCervical spine surgeryMultivariate logistic regressionLog-linear regressionUnique risk factorsHealth initiativesUnited StatesCervical spondylolisthesisElixhauser Comorbidity IndexCervical spinePrevention programsAdministrative datasetsLogistic regressionSpine surgeryPercentage changeCervical stenosisOlder ageAssociation of Volume Overload With Kidney Function Outcomes Among Patients With Acute Decompensated Heart Failure
Moises A, Tighiouart H, Testani J, Tuttle M, Banlengchit R, Oka T, Lee K, Ferguson K, Sarnak H, Harding C, Kiernan M, Sarnak M, McCallum W. Association of Volume Overload With Kidney Function Outcomes Among Patients With Acute Decompensated Heart Failure. American Journal Of Kidney Diseases 2025 PMID: 40484339, DOI: 10.1053/j.ajkd.2025.03.026.Peer-Reviewed Original ResearchPulmonary capillary wedge pressureHigh central venous pressureCentral venous pressureAssociation of central venous pressureDecompensated heart failureRisk of dialysisVolume overloadInitiation of dialysisEGFR slopeHeart failureKidney functionDegree of volume overloadLow baseline kidney functionAcute decompensated heart failureRisk factorsAssociated with lower eGFRRight heart catheterizationCox proportional hazards regression modelsCapillary wedge pressureInitial central venous pressureAssociated with increased riskProportional hazards regression modelsBaseline kidney functionKidney function outcomesRestricted cubic splinesThe Brain Care Score and its associations with cardiovascular disease and cancer
Senff J, Rivier C, Tack R, Tan B, Kimball T, Brouwers H, Newhouse A, Fricchione G, Tanzi R, Yechoor N, Chemali Z, Anderson C, Rosand J, Falcone G, Singh S. The Brain Care Score and its associations with cardiovascular disease and cancer. Family Practice 2025, 42: cmaf034. PMID: 40464807, DOI: 10.1093/fampra/cmaf034.Peer-Reviewed Original ResearchConceptsLate-life depressionIncidence of cardiovascular diseaseCare scoresCardiovascular diseaseUK Biobank (UKBCases of cardiovascular diseaseRisk of dementiaHealth-related behaviorsIncident cardiovascular diseaseModifiable risk factorsCases of cancerCancer typesUKB participantsCox proportional hazards regression analysisProportional hazards regression analysisHazards regression analysisHealthy agingRisk factorsUKBDementiaRegression analysisFollow-upParticipantsAge-related brain diseasesBaselineRisk factors for perioperative nerve injury associated with total knee arthroplasty: Analysis of a national administrative database
Jayaram R, Kim L, Day W, Doshi R, Rubin L, Grauer J. Risk factors for perioperative nerve injury associated with total knee arthroplasty: Analysis of a national administrative database. PLOS ONE 2025, 20: e0324527. PMID: 40455711, PMCID: PMC12129142, DOI: 10.1371/journal.pone.0324527.Peer-Reviewed Original ResearchConceptsBody mass indexIndependent risk factorNerve injuryElixhauser Comorbidity IndexRisk factorsMultivariate analysisAssociated with nerve injuryInvestigate independent risk factorsOdds ratioRevision surgeryIncidence of nerve injuryRisk of nerve injuryPostoperative nerve injuryUnderweight body mass indexType of surgeryDay of surgeryAdministrative databasesNational administrative databaseTKA proceduresPatient ageRisk stratificationMass indexAdverse outcomesDecreased riskFemale sexPrevalence, Awareness, and Factors Associated with Hypertension Among Adults in Rural Southwestern Uganda: A Baseline Survey
Kansiime G, Nuwagira E, Obwoya P, Baluku J, Kanyesigye M, Twesiime C, Ssebutinde P, Muhindo R, Muyingo A, Kananura K, Tusingwire P, Atukunda E, Kalyesubula R, Bajunirwe F, Muiru A. Prevalence, Awareness, and Factors Associated with Hypertension Among Adults in Rural Southwestern Uganda: A Baseline Survey. International Journal Of General Medicine 2025, 18: 3289-3300. PMID: 40575767, PMCID: PMC12199733, DOI: 10.2147/ijgm.s522911.Peer-Reviewed Original ResearchFactors associated with hypertensionRural southwestern UgandaSouthwestern UgandaBaseline surveyWHO STEPS questionnaireServings of fruitsCommunity health workersPhysically active populationFactors of hypertensionBlood pressureRisk factorsRural sub-Saharan AfricaSTEPS questionnaireLifestyle behaviorsPhysical activityHealth workersHypertension prevalenceTargeted interventionsMbarara districtResearch assistantsPreventable deathsAntihypertensive useLogistic regressionSub-Saharan AfricaRural communitiesABS0315 TACKLING RHEUMATOLOGY WORKFORCE SHORTAGES WITH A CASE-BASED PRIMARY CARE RHEUMATOLOGY CURRICULUM
Cabrera D, Hsiao B, Koumpouras F. ABS0315 TACKLING RHEUMATOLOGY WORKFORCE SHORTAGES WITH A CASE-BASED PRIMARY CARE RHEUMATOLOGY CURRICULUM. Annals Of The Rheumatic Diseases 2025, 84: 1795-1796. DOI: 10.1016/j.ard.2025.06.1286.Peer-Reviewed Original ResearchPrimary care traineesWorkforce shortagesGeneral practitionersResidency programsFamily medicineKnowledge deficitsUrate-lowering therapyPostgraduate yearPrimary care trainingPrimary care residentsManagement of rheumatic diseasesPrimary care physiciansInternal medicine programsRheumatic diseasesPre-testRisk factorsPost-intervention testsInteractive learning sessionsRA risk factorsUnited StatesPrimary careCare trainingCare residentsPre-test scoresCare physiciansInhibitor development and clinical characteristics in children with severe hemophilia A in the ATHN 8 US Cohort Study
Thornburg C, van den Berg H, Chandler M, Malec L, Manuel M, O’Neill C, Recht M, Taggart E, Carpenter S, group A, Knoll C, Malec L, Wang M, Guerrera M, Tarango C, Sidonio R, Rodriguez N, Friedman K, Shapiro A, Yaish H, Carpenter S, Janbain M, Grabowski E, Pruthi R, Haley K, Thornburg C, Ahuja S, Simpson M, Reiss U, Lucas T, Balasa V, Wheeler A. Inhibitor development and clinical characteristics in children with severe hemophilia A in the ATHN 8 US Cohort Study. Blood Vessels Thrombosis & Hemostasis 2025, 100082. DOI: 10.1016/j.bvth.2025.100082.Peer-Reviewed Original ResearchClotting factor concentratesSevere hemophilia AHemophilia AInhibitor developmentExposure daysCohort studyAssociated with inhibitor developmentLow-titer inhibitorsReduce inhibitor developmentHigh-titer inhibitorsCox proportional hazards modelsEvaluate risk factorsClinically significant inhibitorUS cohort studyProportional hazards modelCongenital hemophiliaUntreated patientsSevere HAClinical characteristicsPrevent bleedingNeutralizing antibodiesModerate haemophiliaNonsense variantFactor concentrationsRisk factorsCancer care for adolescents and young adults under the age of 50 in Saudi Arabia: policy review, research gaps, and future directions
Alessy S, Alghamdi M, Al-Bawardy B, Alghamdi S, Al-Hamoudi W, Alomaim W, Abaalkhail F, Alqarni A, Alsharm A, Alqurashi Y, Bokhary M, Alqahtani S. Cancer care for adolescents and young adults under the age of 50 in Saudi Arabia: policy review, research gaps, and future directions. EClinicalMedicine 2025, 103188. DOI: 10.1016/j.eclinm.2025.103188.Peer-Reviewed Original ResearchCancer incidence ratesPatient-centred careIncreasing cancer incidence ratesPublic health challengeYoung adultsSurvivorship carePsychological well-beingCancer carePsychosocial needsCare providersCancer ratesYears of ageHealthcare institutionsHealth challengesIncidence rateAYACareSaudi ArabiaUnified treatment protocolRisk factorsPolicy developmentPolicy reviewResearch initiativesTargeted researchAdultsGenome-wide meta-analysis identifies nine loci to be associated with higher risk of hepatocellular carcinoma development.
Ghouse J, Gellert-Kristensen H, O’Rourke C, Seidelin A, Thorleifsson G, Sveinbjörnsson G, Tragante V, Konkwo C, Brancale J, Vilarinho S, Eyrich T, Ahlberg G, Bundgaard J, Rand S, Lundegaard P, Sørensen E, Mikkelsen C, Træholt J, Erikstrup C, Dinh K, Bruun M, Jensen B, Bay J, Brunak S, Banasik K, Ullum H, Consortium E, Laisk T, Mägi R, Nadauld L, Knowlton K, Knight S, Gluud L, Vistisen K, Björnsson E, Ulfarsson M, Sulem P, Holm H, Pedersen O, Ostrowski S, Gudbjartsson D, Rafnar T, Stefansson K, Lassen U, Pommergaard H, Hillingsø J, Andersen J, Bundgaard H, Stender S. Genome-wide meta-analysis identifies nine loci to be associated with higher risk of hepatocellular carcinoma development. JHEP Reports 2025, 101485. DOI: 10.1016/j.jhepr.2025.101485.Peer-Reviewed Original ResearchGenome-wide association studiesAssociated with higher riskGenome-wide statistical significanceIncident hepatocellular carcinomaMendelian randomization analysisGenome-wide meta-analysisIdentified variantsPer-allele effectsMeta-analysisMendelian randomizationGenetic risk lociPrevalent obesityRandomization analysisAlcohol intakeMeta-analysesRisk lociAssociation studiesRisk factorsGenetic variantsGenetic underpinningsRisk of hepatocellular carcinomaLociGenetic effectsCohortConcordant effectsExploring Ethnic Disparities in Hypospadias Incidence: A Meta-Analysis of Epidemiological Studies
Santoso B, Situmorang G, Wahyudi I, Rodjani A, Saraiva L, Al-Shafai K, Abbas T, Raharja P. Exploring Ethnic Disparities in Hypospadias Incidence: A Meta-Analysis of Epidemiological Studies. Journal Of Pediatric Urology 2025 DOI: 10.1016/j.jpurol.2025.06.015.Peer-Reviewed Original ResearchEthnic disparitiesMeta-analysis of epidemiological studiesMeta-analysisHypospadias incidenceImprove healthcare outcomesDiverse populationsIncidence of hypospadiasCross-sectional studyCongenital anomaly prevalenceCase-control studyHealthcare outcomesReduce disparitiesJBI toolsPerinatal determinantsNon-white groupsCitation tracingStudy selectionData extractionSystematic reviewBias riskManual searchEpidemiological studiesRisk factorsDisparitiesEthnic variationsInfection after CD19 chimeric antigen receptor T cell therapy for large B cell lymphoma: Real-world analysis from CIBMTR
Wudhikarn K, Herr M, Chen M, Martens M, Baird J, Gowda L, Rangarajan H, Abid M, Kharfan-Dabaja M, Williams K, Ganguly S, Young J, Sharma A, Fatobene G, Jain T, Kanakry C, Modi D, Grover N, Salem B, Batista M, Vergidis P, Yin D, Beitinjaneh A, Kelkar A, Nishihori T, Holter-Chakrabarty J, Gergis U, Smith M, El Boghdadly Z, Dandoy C, Murthy H, Huppler A, Perales M, Chemaly R, Hill J, Riches M, Auletta J. Infection after CD19 chimeric antigen receptor T cell therapy for large B cell lymphoma: Real-world analysis from CIBMTR. Blood Advances 2025 PMID: 40435511, DOI: 10.1182/bloodadvances.2025016141.Peer-Reviewed Original ResearchCD19 chimeric antigen receptorT-cell therapyCD19 chimeric antigen receptor T-cell therapyInfection-related mortalityCD19 CAR-T cellsCAR-T cellsT cellsSevere immune effector cell-associated neurotoxicity syndromeChimeric antigen receptor T-cell therapyImmune effector cell-associated neurotoxicity syndromeCD19 CAR T-cell therapyCAR-T cell therapySevere cytokine release syndromeRisk factorsChimeric antigen receptorInferior overall survivalMedian follow-upB-cell lymphomaCytokine release syndromeIndependent risk factorCause of morbidityDays post-infusionIncidence of infectionOutcome of infectionIncreased infection risk
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