2024
Ezrin drives adaptation of monocytes to the inflamed lung microenvironment
Gudneppanavar R, Di Pietro C, H Öz H, Zhang P, Cheng E, Huang P, Tebaldi T, Biancon G, Halene S, Hoppe A, Kim C, Gonzalez A, Krause D, Egan M, Gupta N, Murray T, Bruscia E. Ezrin drives adaptation of monocytes to the inflamed lung microenvironment. Cell Death & Disease 2024, 15: 864. PMID: 39613751, PMCID: PMC11607083, DOI: 10.1038/s41419-024-07255-8.Peer-Reviewed Original ResearchConceptsActivation of focal adhesion kinaseExtracellular matrixActin-binding proteinsFocal adhesion kinaseLung extracellular matrixKnock-out mouse modelProtein kinase signalingCortical cytoskeletonLoss of ezrinKinase signalingPlasma membraneCell migrationSignaling pathwayEzrinResponse to lipopolysaccharideTissue-resident macrophagesMouse modelLipopolysaccharideCytoskeletonEzrin expressionLung microenvironmentKinaseMonocyte recruitmentProteinAkt
2021
Microenvironment controls inflammatory response in macrophages
Zhou X, Pope S, Medzhitov R. Microenvironment controls inflammatory response in macrophages. The Journal Of Immunology 2021, 206: 111.03-111.03. DOI: 10.4049/jimmunol.206.supp.111.03.Peer-Reviewed Original ResearchInflammatory gene expressionInflammatory responseInflammatory response to lipopolysaccharideGene expressionModulate immune functionResponse to lipopolysaccharideControlling inflammatory gene expressionControlling inflammatory responsesTissue environmentPH-sensing receptorImmune cellsInflammatory conditionsInflammatory programGene-specific mannerTissue dysfunctionImmune functionNF-kBTissue microenvironmentPathway activationNarrow homeostatic rangeChromatin landscapeGene classesTissue homeostasisTranscriptional circuitsChromatin remodeling
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