2025
B-cell immune repertoire sequencing in tobacco cigarette smoking, vaping, and chronic obstructive pulmonary disease in the COPDGene cohort
Moll M, Xu Z, Boueiz A, Ryu M, Silverman E, Cho M, Hersh C, Sauler M, Polverino F, Kinney G, Curtis J, Crotty-Alexander L, Vollmers C, Castaldi P. B-cell immune repertoire sequencing in tobacco cigarette smoking, vaping, and chronic obstructive pulmonary disease in the COPDGene cohort. Frontiers In Immunology 2025, 16: 1508786. PMID: 40386772, PMCID: PMC12082042, DOI: 10.3389/fimmu.2025.1508786.Peer-Reviewed Original ResearchConceptsB cell activationB cell functionB cellsCigarette smokingClonal expansionClass switchingB cell clonal expansionImpaired B-cell functionIncreased B cell activationImpact of e-cigarette useSecretory IgA productionB cell receptor sequencesTobacco cigarette smokingChronic obstructive pulmonary diseaseE-cigarette useImmune repertoire sequencingIncreased infection riskObstructive pulmonary diseaseBCR-seqResponse to infectionBlood RNA samplesAssessed multivariable associationsBenjamini-Hochberg methodDual usersMultiple alterationsA ventilated perfused lung model platform to dissect the response of the lungs to viral infection
Derman I, Alioglu M, Moses J, Chroneos Z, Yilmaz Y, Banerjee D, Koff J, Rizvi S, Klunk D, Celik N, Pochareddy S, Umstead T, Namli I, Holton S, Mikacenic C, Thompson J, Castaneda D, Hickey D, Nagamine M, Warang P, Schotsaert M, Chen P, Peeples M, Palucka K, Ozbolat I. A ventilated perfused lung model platform to dissect the response of the lungs to viral infection. Trends In Biotechnology 2025 PMID: 40280814, DOI: 10.1016/j.tibtech.2025.03.012.Peer-Reviewed Original ResearchRespiratory syncytial virusViral infectionEpithelial barrier functionAir-liquid interfaceResponse to ventilationResponse to viral infectionTight-junction formationResponse to infectionViral responseProinflammatory chemokinesSyncytial virusRespiratory infectionsPulmonary physiologyViral recognitionLung physiologyEpithelial layerRespiratory cyclePerfusion modelBarrier functionAlveolar epithelial layerVascular componentInfectionViral spreadLung modelVentilationHost-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients
Pickering H, Schaenman J, Phan H, Maguire C, Tsitsiklis A, Rouphael N, Higuita N, Atkinson M, Brakenridge S, Fung M, Messer W, Salehi-rad R, Altman M, Becker P, Bosinger S, Eckalbar W, Hoch A, Doni Jayavelu N, Kim-Schulze S, Jenkins M, Kleinstein S, Krammer F, Maecker H, Ozonoff A, Diray-Arce J, Shaw A, Baden L, Levy O, Reed E, Langelier C. Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients. Nature Communications 2025, 16: 586. PMID: 39794319, PMCID: PMC11723965, DOI: 10.1038/s41467-025-55823-z.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsOrgan transplant recipientsTransplant recipientsInduction of pro-inflammatory genesSenescent T cellsTransitional B cellsImpaired viral clearanceImmune response to infectionAnti-spike IgG levelsNon-transplanted controlsFeatures of COVID-19Innate immune signaling pathwaysResponse to infectionPro-inflammatory genesSerum chemokinesViral clearanceImmune dysregulationT cellsImmune signaling pathwaysB cellsImmune featuresSex-matchedIgG levelsSevere diseaseTransplantation
2024
Maresin-1 Ameliorates Sepsis-Induced Microglial Activation Through Modulation of the P38 MAPK Pathway
Dai M, Sun S, Dai Y, Dou X, Yang J, Chen X, Yang D, Lin Y. Maresin-1 Ameliorates Sepsis-Induced Microglial Activation Through Modulation of the P38 MAPK Pathway. Neurochemical Research 2024, 50: 26. PMID: 39565476, DOI: 10.1007/s11064-024-04280-z.Peer-Reviewed Original ResearchConceptsSepsis-induced neuroinflammationM1-type microgliaPro-inflammatory markersPhosphorylation of p38 MAPKP38 MAPK pathwayP38 MAPKDysregulated immune response to infectionMouse cecum ligationImmune response to infectionExpression of pro-inflammatory markersInhibited phosphorylation of p38 MAPKInduce neuronal degenerationMAPK pathwayPuncture (CLP)-induced sepsis modelPotential therapeutic roleP38 MAPK inhibitor SB203580Combination of SB203580Response to infectionMicroglial cell markersLife-threatening diseaseMAPK inhibitor SB203580Co-administrationCell markersCLP modelCecum ligationLeishmania major surface components and DKK1 signalling via LRP6 promote migration and longevity of neutrophils in the infection site
Ihedioha O, Marcarian H, Sivakoses A, Beverley S, McMahon-Pratt D, Bothwell A. Leishmania major surface components and DKK1 signalling via LRP6 promote migration and longevity of neutrophils in the infection site. Frontiers In Immunology 2024, 15: 1473133. PMID: 39502693, PMCID: PMC11534728, DOI: 10.3389/fimmu.2024.1473133.Peer-Reviewed Original ResearchParasite-infected miceBALB/c miceDickkopf-1Infection siteInfected BALB/c micePathogen-associated molecular patternsWild-type BALB/c miceLevels of apoptosisNull mutantsLeishmania infectionDickkopf-1 levelsDraining lymph nodesNeutrophil-platelet aggregatesLeukocyte-platelet aggregatesInfiltration of neutrophilsReduced neutrophil activationDay 3 PIResponse to infectionSignaling pathwayHost-related factorsMolecular patternsMembrane componentsLRP6Lymph nodesTh2 differentiationCCR2+ monocytes are dispensable to resolve acute pulmonary Pseudomonas aeruginosa infections in WT and cystic fibrosis mice
Öz H, Braga C, Gudneppanavar R, Di Pietro C, Huang P, Zhang P, Krause D, Egan M, Murray T, Bruscia E. CCR2+ monocytes are dispensable to resolve acute pulmonary Pseudomonas aeruginosa infections in WT and cystic fibrosis mice. Journal Of Leukocyte Biology 2024, 117: qiae218. PMID: 39365279, PMCID: PMC11953069, DOI: 10.1093/jleuko/qiae218.Peer-Reviewed Original ResearchLung tissue damageCystic fibrosisTissue damageMonocyte recruitmentImmune responsePulmonary Pseudomonas aeruginosa infectionHyper-inflammatory immune responseCystic fibrosis micePropagate tissue damagePseudomonas aeruginosaLungs of patientsChronic neutrophilic inflammationImmunological response to infectionHost immune responseMonocyte-derived macrophagesTarget monocyte recruitmentSite of injuryResponse to infectionCFTR modulatorsPA infectionChronic inflammatory disease conditionsReduced bactericidal activityAdjunctive therapyClinical outcomesEradicate infectionACLY and ACSS2 link nutrient-dependent chromatin accessibility to CD8 T cell effector responses
Kaymak I, Watson M, Oswald B, Ma S, Johnson B, DeCamp L, Mabvakure B, Luda K, H. E, Lau K, Fu Z, Muhire B, Kitchen-Goosen S, Vander Ark A, Dahabieh M, Samborska B, Vos M, Shen H, Fan Z, Roddy T, Kingsbury G, Sousa C, Krawczyk C, Williams K, Sheldon R, Kaech S, Roy D, Jones R. ACLY and ACSS2 link nutrient-dependent chromatin accessibility to CD8 T cell effector responses. Journal Of Experimental Medicine 2024, 221: e20231820. PMID: 39150482, PMCID: PMC11329787, DOI: 10.1084/jem.20231820.Peer-Reviewed Original ResearchConceptsAcyl-CoA synthetase short-chain family member 2Acetyl-CoA productionATP citrate lyaseChromatin accessibilityAcetyl-CoAEnzyme ATP citrate lyaseFamily member 2Function in vivoCoordination of cellular metabolismTCA cycleMetabolic nodesGene locusCitrate lyaseT cell effector responsesHistone acetylationCellular metabolismEffector functionsCD8 T cellsResponse to infectionMember 2ChromatinEffector responsesMetabolic substratesT cell response to infectionT cellsMesenchymal stem cell-derived small extracellular vesicles alleviate the immunometabolic dysfunction in murine septic encephalopathy
Koutroulis I, Kratimenos P, Hoptay C, O’Brien W, Sanidas G, Byrd C, Triantafyllou M, Goldstein E, Jablonska B, Bharadwaj M, Gallo V, Freishtat R. Mesenchymal stem cell-derived small extracellular vesicles alleviate the immunometabolic dysfunction in murine septic encephalopathy. IScience 2024, 27: 110573. PMID: 39165840, PMCID: PMC11334791, DOI: 10.1016/j.isci.2024.110573.Peer-Reviewed Original ResearchCentral nervous systemSeptic encephalopathyStem cell (MSC)-derived small extracellular vesiclesSmall extracellular vesiclesDysregulated host response to infectionRestored aerobic metabolismLife-threatening organ dysfunctionLong-term sequelaeHost response to infectionExtracellular vesiclesMesenchymal stem cell-derived small extracellular vesiclesPro-inflammatory cytokinesCell-derived small extracellular vesiclesResponse to infectionStem cell-derived small extracellular vesiclesImmune dysregulationOrgan dysfunctionSusceptible to injurySeptic miceClinical symptomsClinical severityImmunometabolic dysfunctionIntravenous administrationDisease outcomeInfectious processMacrophage Migration Inhibitory Factor (MIF) and D-Dopachrome Tautomerase (DDT): Pathways to Tumorigenesis and Therapeutic Opportunities
Valdez C, Sánchez-Zuno G, Bucala R, Tran T. Macrophage Migration Inhibitory Factor (MIF) and D-Dopachrome Tautomerase (DDT): Pathways to Tumorigenesis and Therapeutic Opportunities. International Journal Of Molecular Sciences 2024, 25: 4849. PMID: 38732068, PMCID: PMC11084905, DOI: 10.3390/ijms25094849.Peer-Reviewed Original ResearchConceptsInhibition of MIFResponse to infectionNon-canonical signaling pathwaysClinical studiesCancer patientsClinical trialsInflammatory cytokinesDriving tumorigenesisClinical explorationCancer typesCancerDual inhibitionTherapeutic targetIn vivoIn vitroSignaling pathwayMIFAntitumor candidateBinding partnersSeptic Shock
Abdel‐Razeq S. Septic Shock. 2024, 665-695. DOI: 10.1002/9781119820260.ch38.Peer-Reviewed Original ResearchSeptic shockDysregulated inflammatory response to infectionPhysiological adaptations to pregnancyDiagnosis of septic shockInflammatory response to infectionClinical presentation of shockAdaptation to pregnancyIntravenous fluid resuscitationEarly diagnosis of septic shockInadequate tissue oxygenationIntensive care unitPresentation of shockResponse to infectionFetal outcomesClinical presentationClammy skinFluid resuscitationMetabolic acidosisCirculatory failureBiochemical abnormalitiesEarly diagnosisClinical syndromeFluid homeostasisCare unitImprove outcomesExploring new perspectives in immunology
Medzhitov R, Iwasaki A. Exploring new perspectives in immunology. Cell 2024, 187: 2079-2094. PMID: 38670066, DOI: 10.1016/j.cell.2024.03.038.Peer-Reviewed Original ResearchAdvances in understanding bat infection dynamics across biological scales
Sánchez C, Phelps K, Frank H, Geldenhuys M, Griffiths M, Jones D, Kettenburg G, Lunn T, Moreno K, Mortlock M, Vicente-Santos A, Víquez-R L, Kading R, Markotter W, Reeder D, Olival K. Advances in understanding bat infection dynamics across biological scales. Proceedings Of The Royal Society B 2024, 291: 20232823. PMID: 38444339, PMCID: PMC10915549, DOI: 10.1098/rspb.2023.2823.Peer-Reviewed Original ResearchMaresins as novel anti-inflammatory actors and putative therapeutic targets in sepsis
Sun Y, Sun S, Chen P, Dai Y, Yang D, Lin Y, Yi L. Maresins as novel anti-inflammatory actors and putative therapeutic targets in sepsis. Pharmacological Research 2024, 202: 107113. PMID: 38387744, DOI: 10.1016/j.phrs.2024.107113.Peer-Reviewed Original ResearchInflammatory response associated with sepsisIntensive care unit admissionDiagnosis of sepsisManagement of patientsHost response to infectionSuboptimal treatment strategyResponse to infectionFamily of lipid mediatorsUnit admissionUnfavorable outcomeTreatment strategiesSepsisClinical syndromeInflammatory processSepsis treatmentInflammation resolutionLipid mediatorsTherapeutic targetInaccurate diagnosisMaresinsDocosahexaenoic acidTermination of inflammatory processes
2022
Diversity and distribution of MHC class I and II alleles in chicken populations worldwide
Martin R, Tregaskes C, Kaufman J. Diversity and distribution of MHC class I and II alleles in chicken populations worldwide. Molecular Immunology 2022, 150: 27. DOI: 10.1016/j.molimm.2022.05.092.Peer-Reviewed Original ResearchMinimal essential MHCClass II lociPeptide binding specificityPopulation bottlenecksClass II genesFancy breedsIllumina MiSeqPopulation geneticsLinkage disequilibriumCommercial flocksLow diversityChicken populationsArtificial selectionBinding specificityFree-range local chickensExon 2Genetic associationII lociHaplotypesResponse to infectionTapasin geneII genesTranslocation specificityExpress class II genesMHC alleles
2021
SysInflam HuDB, a Web Resource for Mining Human Blood Cells Transcriptomic Data Associated with Systemic Inflammatory Responses to Sepsis
Toufiq M, Huang S, Boughorbel S, Alfaki M, Rinchai D, Saraiva L, Chaussabel D, Garand M. SysInflam HuDB, a Web Resource for Mining Human Blood Cells Transcriptomic Data Associated with Systemic Inflammatory Responses to Sepsis. The Journal Of Immunology 2021, 207: 2195-2202. PMID: 34663591, PMCID: PMC8525868, DOI: 10.4049/jimmunol.2100697.Peer-Reviewed Original ResearchConceptsPublic transcriptome dataGene expression changesTranscriptome dataTranscriptomic datasetsBlood transcriptome datasetsSystemic inflammatory response to sepsisDisease susceptibilityResponse to infectionBlood gene signaturesExpression changesClinical metadataHost inflammatory responseInflammatory responseSystemic infectionDysregulated host inflammatory responseInflammatory response to sepsisGene signatureSystemic inflammatory responseMechanistic discoveriesSystemic inflammatory diseaseResponse to sepsisHeterogeneous diseaseWeb-based interfaceSepsis biomarkersInflammatory diseases
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