2025
16 Metabolic Syndrome and Obesity
Alonso W, Canapari C. 16 Metabolic Syndrome and Obesity. 2025, 175-184. DOI: 10.1016/b978-0-323-75566-5.00016-2.Peer-Reviewed Original ResearchMetabolic syndromeComponents of metabolic syndromeInvolvement of adipocytokinesSleep-disordered breathingIncreased sympathetic activityElevated blood pressureCardiovascular risk factorsRates of obesityIntermittent hypoxemiaTruncal obesityDysregulation of glucose metabolismSleep fragmentationSympathetic activityBlood pressureSleep curtailmentRisk factorsSyndromeObesityShort sleepGlucose metabolismCircadian factorsSleepHypoxemiaDyslipidemiaAdipocytokines
2024
Unveiling Inequities: Racial Disparities in Risk-Reducing Mastectomy for Breast Cancer Prevention
Knoedler S, Diatta F, Klimitz F, Noel O, Kempa J, Obed D, Song S, Mayer H, Kim B, Kauke-Navarro M, Pomahac B, Butler P. Unveiling Inequities: Racial Disparities in Risk-Reducing Mastectomy for Breast Cancer Prevention. Clinical Breast Cancer 2024, 25: e312-e320. PMID: 39743397, DOI: 10.1016/j.clbc.2024.12.004.Peer-Reviewed Original ResearchRisk-reducing mastectomyMinority patientsRacial minority patientsBreast cancer preventionRacial disparitiesQuality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramWhite patientsCancer preventionStudy investigates racial disparitiesBreast cancer riskEquitable healthcare accessBlack patientsRates of obesityPrevalence of obesityBlack/African American womenImprovement programsPostoperative outcomesOutpatient surgeryAmerican College of Surgeons National Surgical Quality Improvement ProgramSurgeons National Surgical Quality Improvement ProgramHealth equityBreast cancer treatmentHealthcare accessThe Impact of Obesity on the Prevalence and Complications of Perianal Fistulas of Crohn’s Disease
Youn J, Hsia K, Khadilkar S, Zeina T, Rai P, Rastogi A, Hussani S, Spence S, Adavelly P, Yanes J, Kotlier J, Sweigart B, Levy A, Friedman S. The Impact of Obesity on the Prevalence and Complications of Perianal Fistulas of Crohn’s Disease. Digestive Diseases And Sciences 2024, 70: 323-332. PMID: 39548039, DOI: 10.1007/s10620-024-08729-7.Peer-Reviewed Original ResearchPerianal fistulasPerianal surgeryImpact of obesityComplex fistulasCrohn's perianal fistulasFecal diversionCrohn's diseaseInflammatory bowel diseaseMedian timeBMI categoriesBackgroundThe incidence of obesityHistory of perianal fistulaIncreasing BMI categoryTertiary care centerPerianal fistula surgeryIncidence of obesityRates of obesityCross-sectional studyFistula surgeryAnal surgeryNo significant differenceBackgroundThe incidenceCD patientsFistulaMaximum BMIGender Differences in “Making Weight” Behaviors Among U.S. Iraq and Afghan War Veterans: Implications for Future Health
Cary A, Neff K, Buta E, Fenn L, Ramsey C, Snow J, Haskell S, Masheb R. Gender Differences in “Making Weight” Behaviors Among U.S. Iraq and Afghan War Veterans: Implications for Future Health. Journal Of Women's Health 2024, 34: 314-321. PMID: 39510825, DOI: 10.1089/jwh.2024.0246.Peer-Reviewed Original ResearchFemale service membersEating pathologyMental healthAfghanistan war era veteransLevels of dietary restraintMeasures of eating behaviorPosttraumatic stress disorderService membersGender differencesWeight behaviorPotential gender differencesRates of obesityAssociated with female genderStress disorderFood addictionProportion of womenDietary restraintEmotional eatingEra veteransU.S.-IraqWar veteransExcessive exerciseFuture healthMilitary populationVeteransUnited States Long-Term Trends in Adult BMI (1959–2018): Unraveling the Roots of the Obesity Epidemic
Banas J, Cook A, Raygoza-Cortez K, Davila D, Irwin M, Ferrucci L, Humphries D. United States Long-Term Trends in Adult BMI (1959–2018): Unraveling the Roots of the Obesity Epidemic. International Journal Of Environmental Research And Public Health 2024, 21: 73. PMID: 38248537, PMCID: PMC10815706, DOI: 10.3390/ijerph21010073.Peer-Reviewed Original ResearchNational Health Examination SurveyExamination SurveyObesity epidemicBody mass index (BMI) trendsOngoing obesity epidemicCritical public health challengeNutrition Examination SurveyHealth Examination SurveyRates of obesityPublic health challengePopulation-level interventionsBMI growth rateEffective population-level interventionsRace/ethnicityAverage BMIAdult BMINational HealthBMI trendsHigh school educationWhite adultsAge groupsBlack adultsHealth challengesBMIRacial disparities
2022
Smooth muscle cell FTO regulates contractile function
Luse M, Krüger N, Good M, Biwer L, Serbulea V, Salamon A, Deaton R, Leitinger N, Gödecke A, Isakson B. Smooth muscle cell FTO regulates contractile function. AJP Heart And Circulatory Physiology 2022, 323: h1212-h1220. PMID: 36306211, PMCID: PMC9678421, DOI: 10.1152/ajpheart.00427.2022.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsThird-order mesenteric arteriesMuscle cellsObesity genesSmooth muscle contractilityRates of obesityHuman coronary arteriesCardiac myocyte contractilityPlasma reninBlood pressureMesenteric arteryMyogenic toneCoronary arteryFat massContractile functionMyocyte contractilityMuscle contractilityHeart rateSerum response factorMuscle depolarizationMouse body massContractilitySignificant decreaseCell deletionMiceOvercoming Therapy Resistance in Colon Cancer by Drug Repurposing
Zarif T, Yibirin M, De Oliveira-Gomes D, Machaalani M, Nawfal R, Bittar G, Bahmad H, Bitar N. Overcoming Therapy Resistance in Colon Cancer by Drug Repurposing. Cancers 2022, 14: 2105. PMID: 35565237, PMCID: PMC9099737, DOI: 10.3390/cancers14092105.Peer-Reviewed Original ResearchColorectal cancerDecreases chemotherapy toxicityTreatment of colorectal cancerOvercome therapy resistanceDevelopment of promising therapiesRates of obesityMetastatic settingChemotherapy toxicityStandard screening methodTherapy resistanceAnti-diabetic agentsAdjuvant roleColon cancerSurvival rateAnti-malarialsPromising therapiesDrug repurposingIncreased life expectancyPoor dietCancerGeneral populationAnti-hypertensiveDrugAnti-inflammatoryComorbiditiesObstructive Sleep Apnea and Polycystic Ovary Syndrome
Chu Y, Hilbert J, Mohsenin V. Obstructive Sleep Apnea and Polycystic Ovary Syndrome. 2022, 393-409. DOI: 10.1007/978-3-030-92589-5_20.Peer-Reviewed Original ResearchPolycystic ovary syndromeObstructive sleep apneaCardiovascular outcomesOvary syndromeSleep apneaPathogenesis of OSAPrevalence of OSARepetitive upper airway obstructionsUntreated sleep-disordered breathingExcess of androgensUpper airway obstructionImproved cardiovascular outcomesSleep-disordered breathingSleep breathing disordersWeight-matched controlsImproved sleep qualityRates of obesityAirway obstructionNorepinephrine levelsCentral adiposityAtypical symptomsInsulin resistanceTreatment optionsSex hormonesTreatment benefitRadiation therapy in the definitive management of medically inoperable endometrial cancer
Chin C, Damast S. Radiation therapy in the definitive management of medically inoperable endometrial cancer. International Journal Of Gynecological Cancer 2022, 32: 323-331. PMID: 35256419, DOI: 10.1136/ijgc-2021-002532.Peer-Reviewed Original ResearchConceptsMultiparametric magnetic resonance imagingInoperable patientsEndometrial cancerImage-guided brachytherapyRadiation therapySystemic anti-tumor immune responseAnti-tumor immune responseThree-dimensional image-guided brachytherapyInoperable endometrial cancerDefinitive radiation therapyPoor surgical candidatesNovel systemic agentsRecent consensus guidelinesHigh-volume centersExtent of tumorRates of obesityMagnetic resonance imagingMedical inoperabilityLate morbiditySurgical candidatesSystemic agentsClinical stagingDefinitive managementOngoing trialsUterine size
2021
Physical Activity, Weight, and Outcomes in Patients Receiving Chemotherapy for Metastatic Breast Cancer (C40502/Alliance)
Ligibel JA, Huebner L, Rugo HS, Burstein HJ, Toppmeyer DL, Anders CK, Ma C, Barry WT, Suman V, Carey LA, Partridge AH, Hudis CA, Winer EP. Physical Activity, Weight, and Outcomes in Patients Receiving Chemotherapy for Metastatic Breast Cancer (C40502/Alliance). JNCI Cancer Spectrum 2021, 5: pkab025-. PMID: 33981951, PMCID: PMC8103727, DOI: 10.1093/jncics/pkab025.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntineoplastic Agents, ImmunologicalAntineoplastic Combined Chemotherapy ProtocolsBevacizumabBody HeightBody Mass IndexBody WeightBreast NeoplasmsEpothilonesExerciseFemaleHumansMiddle AgedObesityPaclitaxelProgression-Free SurvivalProportional Hazards ModelsTreatment OutcomeYoung AdultConceptsProgression-free survivalMetastatic breast cancerBody mass indexOverall survivalPhysical activityBreast cancerMass indexMET hoursFirst-line taxane-based chemotherapyHormone receptor-positive cancersBaseline body mass indexFirst-line chemotherapyTaxane-based chemotherapyReceptor-positive cancersRecreational physical activityRates of obesityMetastatic diseaseCox modelingMedian ageOverall mortalityRandomized trialsTask hoursMetabolic equivalentsPatientsCancer
2018
A Home Visiting Parenting Program and Child Obesity: A Randomized Trial
Ordway M, Sadler L, Holland M, Slade A, Close N, Mayes L. A Home Visiting Parenting Program and Child Obesity: A Randomized Trial. 2018, 117-126. DOI: 10.1542/9781610022781-a_home.Peer-Reviewed Original ResearchObesity-related morbidityRates of obesityMTB programIntervention groupProspective longitudinal cohort studyMaternal mental healthLongitudinal cohort studyYoung childrenMTB interventionCohort studyChildhood overweightHealthy BMINational prevalenceChild obesityObesityOverweightControl groupHispanic mothersMental healthHispanic childrenYoung mothersMore childrenUnderserved communitiesMorbidityChildrenA Home Visiting Parenting Program and Child Obesity: A Randomized Trial
Ordway MR, Sadler LS, Holland ML, Slade A, Close N, Mayes LC. A Home Visiting Parenting Program and Child Obesity: A Randomized Trial. 2018, 141: e20171076. PMID: 29339565, PMCID: PMC5810599, DOI: 10.1542/peds.2017-1076.Peer-Reviewed Original ResearchConceptsObesity-related morbidityRates of obesityMTB programIntervention groupProspective longitudinal cohort studyMaternal mental healthLongitudinal cohort studyYoung childrenMTB interventionCohort studyChildhood overweightHealthy BMINational prevalenceChild obesityObesityOverweightControl groupHispanic mothersMental healthHispanic childrenYoung mothersMore childrenUnderserved communitiesMorbidityChildren
2017
Differential Associations Between Excess Body Weight and Psychiatric Disorders in Men and Women
Husky MM, Mazure CM, Ruffault A, Flahault C, Kovess-Masfety V. Differential Associations Between Excess Body Weight and Psychiatric Disorders in Men and Women. Journal Of Women's Health 2017, 27: 183-190. PMID: 28686068, DOI: 10.1089/jwh.2016.6248.Peer-Reviewed Original ResearchConceptsExcess body weightExcess weightPsychiatric disordersBody weightMajor depressionWeight statusFirst large-scale population-based studyComposite International Diagnostic Interview Short FormLarge-scale population-based studyCo-occurring psychiatric disordersPast-year psychiatric disordersBody mass indexPopulation-based studyRates of obesityCommon psychiatric disordersExcess weight statusCross-sectional general population surveyGeneral population surveyNormal weightMass indexObsessive-compulsive disorderPsychiatric assessmentPanic disorderObesityPsychiatric conditions
2013
Investigating the safety and efficacy of naltrexone for anti-psychotic induced weight gain in severe mental illness: study protocol of a double-blind, randomized, placebo-controlled trial
Tek C, Guloksuz S, Srihari VH, Reutenauer EL. Investigating the safety and efficacy of naltrexone for anti-psychotic induced weight gain in severe mental illness: study protocol of a double-blind, randomized, placebo-controlled trial. BMC Psychiatry 2013, 13: 176. PMID: 23805859, PMCID: PMC3702521, DOI: 10.1186/1471-244x-13-176.Peer-Reviewed Original ResearchConceptsSevere mental illnessEfficacy of naltrexoneWeight gainOutcome measurementsHealth problemsMental illnessGreater New Haven areaTumor necrosis factor alphaWeight lossCurrent available medicationsPlacebo-controlled trialHigh-sensitivity CRPOpioid receptor antagonistSecondary outcome measuresSerum lipid profilePrimary outcome measurementBody mass indexD2 receptor blockadeEffects of naltrexoneNovel pharmacological optionsNecrosis factor alphaDoses of naltrexoneMajor health problemRates of obesitySignificant weight lossObesity among Chronically Homeless Adults: Is it a Problem?
Tsai J, Rosenheck RA. Obesity among Chronically Homeless Adults: Is it a Problem? Public Health Reports 2013, 128: 29-36. PMID: 23277657, PMCID: PMC3514718, DOI: 10.1177/003335491312800105.Peer-Reviewed Original ResearchConceptsHomeless adultsFood insecurity-obesity paradoxMental healthPrevalence of obesityHealth service useRates of obesityHealth care providersMultivariate regression analysisNormal weightLess exerciseService useObesityWeight groupParticular riskAdultsObeseOverweightRegression analysisCommunity sampleHomeless populationExerciseHealthPrevalenceSociodemographicsRange of factors
2012
The effect of dietary and physical activity pattern on metabolic profile in individuals with schizophrenia: a cross-sectional study
Ratliff JC, Palmese LB, Reutenauer EL, Liskov E, Grilo CM, Tek C. The effect of dietary and physical activity pattern on metabolic profile in individuals with schizophrenia: a cross-sectional study. Comprehensive Psychiatry 2012, 53: 1028-1033. PMID: 22425530, PMCID: PMC3380150, DOI: 10.1016/j.comppsych.2012.02.003.Peer-Reviewed Original ResearchConceptsPhysical activity habitsActivity habitsPhysical activityNational HealthMetabolic profileSelf-reported physical activity questionnaireDiastolic blood pressureBody mass indexPhysical Activity QuestionnaireAdverse metabolic profileFourth Edition diagnosisNutrition Examination SurveyModerate physical activityBurden of diseasePhysical activity patternsCross-sectional studyRates of obesityVigorous physical activityDaily energy intakeBlood pressureWaist circumferenceMass indexDiet recallExamination SurveyActivity Questionnaire
2007
Disappointing Weight Loss among Shift Workers after Laparoscopic Gastric Bypass Surgery
Ketchum ES, Morton JM. Disappointing Weight Loss among Shift Workers after Laparoscopic Gastric Bypass Surgery. Obesity Surgery 2007, 17: 581. PMID: 17658014, DOI: 10.1007/s11695-007-9100-8.Peer-Reviewed Original ResearchConceptsShift workersWeight lossBariatric surgeryExcess body weight lossLaparoscopic gastric bypass surgeryPostoperative excess weight lossShift workAltered sleep physiologyExcess weight lossBariatric surgery patientsGastric bypass surgeryPostoperative weight lossRetrospective chart reviewWeight loss outcomesBody weight lossRates of obesityT-testPatterns of sleepStudent's t-testPreoperative BMIGastric bypassLaparoscopic RouxBypass surgeryChart reviewPostoperative period
2005
224 Increased Prevalence of Obesity in Children with Functional Constipation with and Without Fecal Incontinence
Loening-Baucke V, Pashankar D. 224 Increased Prevalence of Obesity in Children with Functional Constipation with and Without Fecal Incontinence. Pediatric Research 2005, 58: 392-392. DOI: 10.1203/00006450-200508000-00253.Peer-Reviewed Original ResearchFecal incontinencePrevalence of obesityYears of ageMorbid obesityFunctional constipationMorbid obeseWell-child visitsRates of obesityObesity clinicConstipated childrenChildren's HospitalMean agePediatric clinicChild visitsHigh prevalenceConstipationIncontinenceHormonal influencesObesityControl groupPrevalenceActivity levelsGender ratioControl boysObeseNumber of children and the risk of obesity in older women
Bastian LA, West NA, Corcoran C, Munger RG, From the Cache County Study on Memory H. Number of children and the risk of obesity in older women. Preventive Medicine 2005, 40: 99-104. PMID: 15530586, DOI: 10.1016/j.ypmed.2004.05.007.Peer-Reviewed Original ResearchConceptsRisk of obesityOlder womenNumber of childrenLive birthsConfounding factorsAdditional live birthSocioeconomic statusPopulation-based cohortRates of obesityDose-response relationshipTelephone-based interviewsHigh rateHormone therapyHysterectomy statusNulliparous womenOral contraceptivesObesity riskReproductive factorsPhysical activityObesityHealth behaviorsAge 18CohortWomenMarital status
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