2025
Timing of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study
Dribin T, Sampson H, Zhang Y, Boyd S, Zhang N, Michelson K, Neuman M, Brousseau D, Mistry R, Freedman S, Aronson P, Bergmann K, Boswell B, Chinta S, Chua W, Cohen A, Cohen J, Daggett A, Davis J, Freeman J, Khanna K, Knoles C, Kwan K, Larsen C, Lee J, Lubell T, Metcalf A, Moake M, Nesiama J, Ngo T, Pulcini C, Russo C, Singh N, Srivastava G, Strutt J, Thapar V, Vander Wyst C, Walsh P, Wolnerman Y, Schnadower D, Academy of Pediatrics P, Kanngiesser A, McGarghan F, Dulchavsky A, Costalez J, DesPain A, Armanious M, Haghnazarian E, Brown-Whitehorn T, Weigert R, Dayan P, Meltzer J, Chowdhury N, Benedetti J, Sinziana C, Handorf A, Ruthford M, Devens M, Mecham C, Holland J, Casas T, Brown J, Panda P, Morrow A, Maready M, Nathani Y, Stevens M, Abraham G, Yen K, Cooper-Sood J, Woolf S. Timing of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study. The Lancet Child & Adolescent Health 2025, 9: 484-496. PMID: 40506197, DOI: 10.1016/s2352-4642(25)00139-7.Peer-Reviewed Original ResearchConceptsElectronic medical recordsEmergency departmentRetrospective cohort studyCohort studyMedical recordsDocumentation of symptomsCardiovascular involvementHealth-care facilitiesEpinephrine doseAcute allergic reactionsNational Institutes of HealthCumulative incidenceNational Center for Advancing Translational SciencesInstitutes of HealthChildren aged 6 monthsClinical ModificationHospital wardsIncidence rateICD-10Observation periodPrimary outcomeAllergic reactionsSecondary to medicationsInitiation to discontinuationKaplan-Meier analysisRace Comparisons in Patients With Cardiac Sarcoidosis: Insights From the Cardiac Sarcoidosis Consortium.
Trongtorsak A, De La Rosa Martinez J, Crawford T, Bogun F, Gu X, Purroll E, Ellenbogen K, Chicos A, Roukoz H, Zimetbaum P, Kalbfleisch S, Murgatroyd F, Steckman D, Rosenfeld L, Soejima K, Bhan A, Vedantham V, Dickfeld T, De Lurgio D, Platonov P, Zipse M, Nishiuchi S, Ortman M, Narasimhan C, Patton K, Rosenthal D, Mukerji S, Hoogendoorn J, Zeppenfeld K, Torosoff M, Judson M, Martin K, Madias C, Hermel M, Nour K, Torbey E, Sauer W, Kron J. Race Comparisons in Patients With Cardiac Sarcoidosis: Insights From the Cardiac Sarcoidosis Consortium. Circulation Arrhythmia And Electrophysiology 2025, e013670. PMID: 40557494, DOI: 10.1161/circep.124.013670.Peer-Reviewed Original ResearchLeft ventricular ejection fractionCardiac sarcoidosisVentricular ejection fractionBlack patientsEjection fractionNo significant differenceClinical outcomesPrimary outcomeWhite patientsImplantable cardioverter defibrillator therapyLeft ventricular assist device implantationSignificant differenceVentricular assist device implantationComposite end pointChronic kidney diseaseChronic obstructive pulmonary diseaseAll-cause mortalityAssist device implantationRates of lungRates of hypertensionObstructive pulmonary diseaseImplantable cardioverter defibrillatorExtracardiac involvementEye involvementHeart transplantationSerotonin Norepinephrine Reuptake Inhibitor Is Associated With Lower Mortality Among Patients Presenting With Takotsubo Cardiomyopathy.
Shamaki G, Anuforo A, Safiriyu I, Corteville D, Sanghavi M, Shah S, Clark K. Serotonin Norepinephrine Reuptake Inhibitor Is Associated With Lower Mortality Among Patients Presenting With Takotsubo Cardiomyopathy. Journal Of The American Heart Association 2025, 14: e037951. PMID: 40551298, DOI: 10.1161/jaha.124.037951.Peer-Reviewed Original ResearchConceptsSerotonin-norepinephrine reuptake inhibitorsDiagnosis of takotsubo cardiomyopathyTakotsubo cardiomyopathyPropensity score matchingReuptake inhibitorsClinical outcomes of patientsNorepinephrine reuptake inhibitorsReuptake of serotoninScore matchingOutcomes of patientsOpioid-related disordersCocaine-related disordersAssociated with lower mortalityLower mortalityTriNetX Research NetworkTreatment of depressionAssociated with lowered mortalityAcute myocardial infarctionNeuropathic painPresynaptic reuptakeClinical outcomesCardiac arrestPrimary outcomeSecondary outcomesVentricular fibrillationDiabetes Deprescribing in Older Adults
Grant R, Peterson I, McCloskey J, Lipska K, Nugent J, Karter A, Gilliam L. Diabetes Deprescribing in Older Adults. JAMA Internal Medicine 2025, 185 PMID: 40549370, PMCID: PMC12186576, DOI: 10.1001/jamainternmed.2025.2015.Peer-Reviewed Original ResearchPrimary care physiciansType 2 diabetesMedication deprescribingParticipating primary care physiciansAD sessionsOlder patientsRandomized clinical trialsDeprescribing ratesCompare physiciansCare physiciansDeprescribing strategiesOlder AdultsDeprescribingMain OutcomesPrevisitSevere hypoglycemia episodesPrimary outcomeClinical trialsHemoglobin A1cActive armMonths of follow-upStatistically significant differencePhysiciansDiabetesFollow-upIntravenous thrombolysis for acute ischemic stroke patients with cerebral amyloid angiopathy
Chen H, Colasurdo M, Khunte M, Malhotra A, Gandhi D. Intravenous thrombolysis for acute ischemic stroke patients with cerebral amyloid angiopathy. Journal Of The Neurological Sciences 2025, 475: 123586. PMID: 40561725, DOI: 10.1016/j.jns.2025.123586.Peer-Reviewed Original ResearchAssociated with significantly higher oddsSignificantly higher oddsHigher oddsMultivariate logistic regressionAcute ischemic stroke patientsIn-hospital mortalityAcute ischemic strokeLogistic regressionAssociated with higher oddsIntravenous thrombolysisDatabase of hospitalizationsAssociated with older agePropensity score matchingSelf-careBalanced treatment groupsIschemic stroke patientsIntracerebral hemorrhageHome dischargeStroke patientsSecondary outcomesCerebral amyloid angiopathyPrimary outcomeOddsScore matchingHemorrhagic cerebrovascular diseaseTreatment outcomes of successful M1 versus M2 thrombectomy for low-ASPECTS stroke patients.
Chen H, Colasurdo M, Matsukawa H, Cunningham C, Maier I, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Shaban A, Goyal N, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Crosa R, Grandhi R, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Daglioglu E, Williamson R, Navia P, Chowdhry S, Altschul D, Spiotta A, Kan P. Treatment outcomes of successful M1 versus M2 thrombectomy for low-ASPECTS stroke patients. Interventional Neuroradiology 2025, 15910199251343283. PMID: 40530425, PMCID: PMC12176791, DOI: 10.1177/15910199251343283.Peer-Reviewed Original ResearchLow Alberta Stroke Program Early CT ScoreAlberta Stroke Program Early CT ScoreEffect of endovascular thrombectomyM2 occlusionsIntracranial hemorrhageM2 patientsAssociated with intracranial hemorrhageOdds of all-cause mortalityMulticenter retrospective studyOdds of poor outcomeMultivariate logistic regression modelAll-cause mortalityMiddle cerebral arteryStroke patientsM1 patientsM1 occlusionCT scoreRetrospective studyLogistic regression modelsPoor outcomeMultivariable adjustmentPrimary outcomeCerebral arteryTreatment outcomesEndovascular thrombectomyAssociation between hyperkalemia and outcomes in hospitalized patients with acute kidney injury
Wang W, Yang H, Wilson F, Gallagher M, Feng Y. Association between hyperkalemia and outcomes in hospitalized patients with acute kidney injury. Intensive And Critical Care Nursing 2025, 90: 104118. PMID: 40554252, DOI: 10.1016/j.iccn.2025.104118.Peer-Reviewed Original ResearchAcute kidney injuryNadir of riskPrimary outcomeSerum potassiumKidney injuryAKI progressionAssociated with AKI progressionOdds ratioHospitalized patientsAcute kidney injury durationAcute kidney injury patientsAssociation of hyperkalemiaMeasured serum potassiumOutcomes of hospitalized patientsSerum potassium levelsRestricted cubic spline regressionDays of randomizationAcute kidney injury progressionConfidence intervalsCubic spline regressionDose-response relationshipDischarged to homeOutcomes of interestsComposite outcomeHyperkalemiaUltrasound‐Guided Nerve Block for Pediatric Femur Fractures in the Emergency Department: A Prospective Multi‐Center Study
Binder Z, Ng C, Klekowski N, Lawson S, Riera A, Toney A, Pade K, Saint The T, Shaahinfar A, Chaudoin L, Lauer E, Snelling P, Moake M. Ultrasound‐Guided Nerve Block for Pediatric Femur Fractures in the Emergency Department: A Prospective Multi‐Center Study. Academic Emergency Medicine 2025 PMID: 40524602, DOI: 10.1111/acem.70084.Peer-Reviewed Original ResearchPediatric emergency medicineFascia iliaca compartment nerve blockEmergency departmentPediatric femur fracturesFemur fracturesPain intensityPediatric emergency medicine physiciansSelf-reported pain intensityFaces Pain Scale-RevisedFracture pain managementPain scoresChildren aged 4Pain score reductionEmergency medicinePost-enrollmentAdverse eventsNerve blockPain managementSecondary outcomesOpioid medicationsPrimary outcomeOral morphine equivalentsProcedure useUltrasound-guided nerve blockProspective multi-center studyLate Permissive Hypercapnia for Mechanically Ventilated Preterm Infants: A Randomized Trial
Travers C, Gentle S, Shukla V, Aban I, Yee A, Armstead K, Benz R, Laney D, Ambalavanan N, Carlo W. Late Permissive Hypercapnia for Mechanically Ventilated Preterm Infants: A Randomized Trial. Pediatric Pulmonology 2025, 60: e71165. PMID: 40525736, PMCID: PMC12172392, DOI: 10.1002/ppul.71165.Peer-Reviewed Original ResearchConceptsPostnatal day 7Permissive hypercapniaPreterm infantsInstitutional review boardDay 7Ventilator-freeMechanically ventilated preterm infantsSingle-center randomized clinical trialReduced mechanical ventilation durationWeeks postmenstrual ageMechanical ventilation durationRespiratory distress syndromeVentilator-free daysRandomized clinical trialsPostmenstrual ageGestational ageWeeks gestationDistress syndromeVentilation durationBirth weightLung protectionRandomized trialsClinical trialsPrimary outcomeInfantsSystematic Review and Meta‐Analysis of Dual‐Layered Stents Versus Single‐Layered Stents for Carotid Artery Stenosis
Mari T, Moeed A, Siddiqui A, Abbasi A, Arif Z, Jannat A, Akman Z, Rossi R, Unnar H, Bhatti H, Batool R, Khan M, Ali M, Batool F, Minahil, Iqbal J, Mena‐Hurtado C, Nanna M. Systematic Review and Meta‐Analysis of Dual‐Layered Stents Versus Single‐Layered Stents for Carotid Artery Stenosis. Catheterization And Cardiovascular Interventions 2025 PMID: 40518749, DOI: 10.1002/ccd.31684.Peer-Reviewed Original ResearchCarotid artery stentingCarotid artery stenosisSingle-layer stentsDual-layer stentsAll-cause mortalityPost-procedural strokeArtery stenosisRandomized controlled trialsStent occlusionHigher risk of peri-procedural strokePostprocedural strokeMeta-analysisRisk of peri-procedural strokeRisk ratioHigh riskCarotid artery stenting proceduresStroke riskPeri-procedural strokeRandom-effects meta-analysisPredictors of strokeTreat carotid artery stenosisLipid-rich carotid plaquesTreatment optionsArtery stentingPrimary outcomeInpatient Outcomes for Patients With Peripheral Artery Disease Hospitalized for Acute Myocardial Infarction.
Gusdorf J, Faridi K, Wang T, Mena-Hurtado C, Smolderen K, Rymer J, Curtis J, Li S, Secemsky E. Inpatient Outcomes for Patients With Peripheral Artery Disease Hospitalized for Acute Myocardial Infarction. Journal Of The American Heart Association 2025, 14: e040526. PMID: 40497502, DOI: 10.1161/jaha.124.040526.Peer-Reviewed Original ResearchConceptsAcute myocardial infarction typesPeripheral arterial diseaseAcute myocardial infarctionIn-hospital mortalityPeripheral artery disease hospitalizationsIn-hospital outcomesAcute myocardial infarction hospitalizationsCardiac arrestHigh-risk populationAssociated with increased ratesLong-term riskRevascularized patientsInpatient outcomesMultivariable adjustmentHeart failureArtery diseasePrimary outcomeAdverse cardiovascular outcomesUS sitesHeightened riskAge groupsSecondary end pointsSubgroup analysisDialysis initiationCoronary artery diseaseDiagnostic Accuracy of Point-of-Care Ultrasound for Hip Effusion: A Multicenter Diagnostic Study
Jones R, Malia L, Snelling P, Riera A, Mak W, Moote D, Brimacombe M, Chicaiza H. Diagnostic Accuracy of Point-of-Care Ultrasound for Hip Effusion: A Multicenter Diagnostic Study. Annals Of Emergency Medicine 2025 PMID: 40481828, DOI: 10.1016/j.annemergmed.2025.04.033.Peer-Reviewed Original ResearchPediatric emergency physiciansAccuracy of point-of-care ultrasoundPoint-of-care ultrasoundDiagnostic accuracy of point-of-care ultrasoundPediatric emergency departmentRadiology-performed ultrasoundEmergency physiciansHip effusionDiagnostic accuracyAged 2 monthsEmergency departmentMulticenter diagnostic studyTrained individualsPhysiciansPrimary outcomeHip analysisHipClinical presentationHip ultrasoundProspective studyParticipantsMeasurement definitionsAccurate diagnosisEffusionDiagnostic studiesAssociation of Primary Language with Treatment and Outcomes in Inflammatory Bowel Disease.
Sahyoun L, Chavez V, Vasudevan J, Kogan L, Mukkamala B, Ochi M, Anand T, Ahmed Z, Tang Z, Feagins L, Gaidos J. Association of Primary Language with Treatment and Outcomes in Inflammatory Bowel Disease. Clinical And Translational Gastroenterology 2025 PMID: 40478247, DOI: 10.14309/ctg.0000000000000868.Peer-Reviewed Original ResearchCorticosteroid-free clinical remissionInflammatory bowel diseaseAdvanced therapiesClinical remissionDisease activityCohort study of adult patientsBowel diseaseStudy of adult patientsElevated fecal calprotectinBaseline disease activityPhysician global assessmentIBD disease activityRates of inflammatory bowel diseaseFecal calprotectinAdult patientsTherapy useCohort studyPrimary outcomeMultivariate analysisSecondary outcomesMulti-centerClinic visitsDisease outcomePatientsBaseline differencesThe Effect of Prophylactic Use of Antifibrinolytics During Pediatric Non‐Cardiac Surgeries on Bleeding and Transfusions: A Systematic Review and Meta‐Analysis
Hickey K, Smith M, Karam O, Demetres M, Faraoni D, Duron V, Wu Y, Nellis M. The Effect of Prophylactic Use of Antifibrinolytics During Pediatric Non‐Cardiac Surgeries on Bleeding and Transfusions: A Systematic Review and Meta‐Analysis. Pediatric Anesthesia 2025 PMID: 40476647, DOI: 10.1111/pan.15137.Peer-Reviewed Original ResearchEstimated blood lossNon-cardiac surgeryBlood lossP-value <Tranexamic acidScoliosis surgeryAminocaproic acidBlood transfusionCraniofacial surgeryProphylactic administration of tranexamic acidMeta-analysisEfficacy of tranexamic acidAdministration of tranexamic acidIntraoperative blood transfusionIntraoperative blood lossAdministration of antifibrinolyticsIntraoperative tranexamic acidSystematic reviewP-valueReduce transfusionsDosing regimensProphylactic administrationCraniosynostosis surgeryPediatric surgeryPrimary outcomeGender Differences in Medicare Practice and Payment of Neuroradiologists.
Malhotra A, Lee C, Khunte M, Futela D, Moily R, Payabvash S, Gandhi D, Wintermark M. Gender Differences in Medicare Practice and Payment of Neuroradiologists. American Journal Of Neuroradiology 2025, 46: 1093-1099. PMID: 40461255, PMCID: PMC12152790, DOI: 10.3174/ajnr.a8633.Peer-Reviewed Original ResearchMetabolic and bariatric surgery outcomes in patients with gastroparesis: a retrospective analysis of the 2016 to 2022 Nationwide Readmissions Database
Hamid S, Graetz E, Schneider E, Schwartz J, Ghiassi S, Gibbs K. Metabolic and bariatric surgery outcomes in patients with gastroparesis: a retrospective analysis of the 2016 to 2022 Nationwide Readmissions Database. Journal Of Gastrointestinal Surgery 2025, 29: 102107. PMID: 40466804, DOI: 10.1016/j.gassur.2025.102107.Peer-Reviewed Original ResearchRoux-en-Y gastric bypassLength of stayNationwide Readmissions DatabaseReoperation rateReadmissions DatabaseRoux-en-YBariatric surgery outcomesPostoperative eventsSleeve gastrectomyGastric bypassBariatric surgeryClinical factorsSurgery outcomesRetrospective analysisProcedure typeCounseling patientsReoperationMBS patientsPrimary outcomeGastroparesisObesity treatmentSecondary outcomesPatientsReadmission ratesReadmissionImpact of static and dynamic risk assessment in HMA-treated MDS patients undergoing stem cell transplantation.
Aguirre L, Kim H, Elmariah H, Frumm S, Kelkar A, Ho V, Gooptu M, Antin J, Soiffer R, Shimony S, Luskin M, Garcia J, Chen E, Winer E, Stone R, DeAngelo D, Al Ali N, Cutler C, Komrokji R, Stahl M. Impact of static and dynamic risk assessment in HMA-treated MDS patients undergoing stem cell transplantation. Journal Of Clinical Oncology 2025, 43: 6568-6568. DOI: 10.1200/jco.2025.43.16_suppl.6568.Peer-Reviewed Original ResearchIPSS-MHypomethylating agentsStem cell transplantationPre-HSCTCell transplantationPost-hematopoietic stem cell transplantationResponse to HMATreated with hypomethylating agentsIPSS-R scorePost-HSCT outcomesProgression-free survivalHigh-risk diseaseCytoreductive therapyMUD donorsIPSS-RMDS patientsIncreased blastsSurvival benefitNo significant differencePre-HCTPrognostic accuracyDana-FarberHSCTPrimary outcomeResponse evaluationPOS0507 RANDOMIZED CONTROL TRIAL OF THE CARE RA PEER COACH INTERVENTION TO IMPROVE CARDIOVASCULAR RISK ASSESSMENT IN PATIENTS WITH RHEUMATOID ARTHRITIS
Madrigal V, Garcia D, Brown M, Paez Y, Sydnor-Campbell T, Allen A, Fritz S, Weiner J, Jabri A, Curtis J, Lui G, Venkatachalam S, Fraenkel L, Young S, Hernandez N, Safford M, Navarro-Millan I. POS0507 RANDOMIZED CONTROL TRIAL OF THE CARE RA PEER COACH INTERVENTION TO IMPROVE CARDIOVASCULAR RISK ASSESSMENT IN PATIENTS WITH RHEUMATOID ARTHRITIS. Annals Of The Rheumatic Diseases 2025, 84: 723-724. DOI: 10.1016/j.ard.2025.05.889.Peer-Reviewed Original ResearchPrimary care physiciansCardiovascular disease riskCardiovascular disease risk assessmentCardiovascular risk assessmentCholesterol testingControl armPeer coachingSecondary outcomesPatient activationCardiovascular diseaseBaseline characteristics of peoplePrimary care physician appointmentPatient activation interventionPrimary outcomeCardiovascular disease risk reductionCardiovascular disease deathsRisk reduction guidelinesComprehensive CVD risk assessmentPrimary CVD preventionHistory of cardiovascular diseaseCVD risk assessmentCardiovascular disease preventionLipid lowering therapyAssess CVD riskPatient-reported outcomesCareer transitions and practice patterns among international medical graduates in oncology workforce: A US nationwide analysis.
Xing J, Wang Q, Tang Y, Lu C, Chen F, Roy A, Deng L, Neupane K, Ardeshir Larijani F, Bekaii-Saab T, Aggarwal C, Lee A, Owonikoko T, Chavez Mac Gregor M, Bakouny Z, Gandhi S, Dizman N, Choueiri T, Perimbeti S, Jiang C. Career transitions and practice patterns among international medical graduates in oncology workforce: A US nationwide analysis. Journal Of Clinical Oncology 2025, 43: 9009-9009. DOI: 10.1200/jco.2025.43.16_suppl.9009.Peer-Reviewed Original ResearchInternational medical graduatesRural-Urban Continuum CodesCancer care deliveryOncology workforceMedical graduatesCare deliveryMedical oncologistsUS graduatesNCI-designated cancer centersDesignated cancer centersCross-sectional studyNon-metropolitan areasContinuum CodesWorkforce disparitiesUnderserved regionsSystemic barriersCareer stagesChi-square testPrimary specialtyPracticing medical oncologistsNCI centersStratified analysisAcademic affiliationPractice patternsPrimary outcomePublication and data sharing of completed NCI cooperative group trials.
Cueto L, Huang S, Ghali F, Abgafe V, Ubachukwu T, Winer E, Ross J, Gross C. Publication and data sharing of completed NCI cooperative group trials. Journal Of Clinical Oncology 2025, 43: 11023-11023. DOI: 10.1200/jco.2025.43.16_suppl.11023.Peer-Reviewed Original ResearchCooperative group trialsIndividual patient dataPhase III trialsYear of study completionPrimary outcomeIII trialsGroup trialAvailability of individual patient dataEastern Cooperative Oncology GroupStudy completionAnalysis of phase III trialsCooperative Oncology GroupClinical trial dataPatient dataCooperative groupsPrimary outcome dataPhase IIOncology GroupNRG OncologySubgroup analysisOnline archivesNIH trialData sharingPrimary outcome findingsOutcome data
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