2025
CFTR dictates monocyte adhesion by facilitating integrin clustering but not activation
Younis D, Marosvari M, Liu W, Pulikkot S, Cao Z, Zhou B, Vella A, McArdle S, Hu L, Chen Y, Gan W, Yu J, Bruscia E, Fan Z. CFTR dictates monocyte adhesion by facilitating integrin clustering but not activation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2412717122. PMID: 39813254, PMCID: PMC11760921, DOI: 10.1073/pnas.2412717122.Peer-Reviewed Original ResearchConceptsIntegrin clusteringCF transmembrane conductance regulatorCystic fibrosisAdhesion defectsPathogenesis of cystic fibrosisClinically relevant disease modelsMembrane recruitmentTransmembrane conductance regulatorIntegrin activationTherapeutic strategy designRelevant disease modelsIntegrinCF monocytesCell adhesionMonocyte dysfunctionPatients' monocytesTissue infectionsConductance regulatorSuperresolution microscopyCortex formationLeukocyte-dependent inflammationInflammatory pathogenesisLeukocyte adhesionMonocytesInflammation
2016
GG-06 Single cell gene expression studies in lupus patient monocytes reveal novel patterns reflecting disease activity, interferon, and medical treatment
Jin Z, Fan W, Jensen M, Dorschner J, Vsetecka D, Amin S, Makol A, Ernste F, Osborn T, Moder K, Chowdhary V, Niewold T. GG-06 Single cell gene expression studies in lupus patient monocytes reveal novel patterns reflecting disease activity, interferon, and medical treatment. Lupus Science & Medicine 2016, 3: a30. DOI: 10.1136/lupus-2016-000179.58.Peer-Reviewed Original ResearchNon-classical monocytesSLE patientsDisease activityClassical monocytesPatients' monocytesCell gene expressionAnti-dsDNA titersHigh disease activityHigher IFN scoresSLE patient groupAnti-inflammatory genesMonocyte gene expressionPrednisone useGene expressionMedication useClinical featuresInterferon signatureC3 complementIFN scorePatient groupImmunologic characteristicsUnsupervised hierarchical clusteringMedical treatmentPatients
2015
ID: 209 Single cell interferon signatures in lupus patient monocytes reveal a differential impact of interferon signaling between monocyte subtypes
Jin Z, Fan W, Jensen M, Dorschner J, Vsetecka D, Amin S, Makol A, Ernste F, Osborn T, Moder K, Chowdhary V, Niewold T. ID: 209 Single cell interferon signatures in lupus patient monocytes reveal a differential impact of interferon signaling between monocyte subtypes. Cytokine 2015, 76: 102-103. DOI: 10.1016/j.cyto.2015.08.213.Peer-Reviewed Original ResearchSystemic lupus erythematosusHigher IFN scoresClassical monocytesIFN scoreI interferonPatients' monocytesCD16 expressionEffects of IFNHuman systemic lupus erythematosusNon-classical subtypesPrimary pathogenic factorImmune cell populationsNon-classical monocytesCell populationsSingle immune cellsType I interferonPatient blood samplesSLE patientsLupus erythematosusMonocyte subtypesInflammatory mediatorsIFN signatureImmune cellsPathogenic factorsBlood samplesTHU0022 Single Cell Interferon Signatures in Lupus Patient Monocytes Reveal a Differential Impact of Interferon Signaling Between Monocyte Subtypes
Jin Z, Fan W, Jensen M, Dorschner J, Vsetecka D, Amin S, Makol A, Ernste F, Osborn T, Moder K, Chowdhary V, Niewold T. THU0022 Single Cell Interferon Signatures in Lupus Patient Monocytes Reveal a Differential Impact of Interferon Signaling Between Monocyte Subtypes. Annals Of The Rheumatic Diseases 2015, 74: 200. DOI: 10.1136/annrheumdis-2015-eular.5326.Peer-Reviewed Original ResearchSystemic lupus erythematosusHigher IFN scoresClassical monocytesIFN scoreI interferonSLE patientsCD16 expressionEffects of IFNHuman systemic lupus erythematosusNon-classical subtypesPrimary pathogenic factorImmune cell populationsNon-classical monocytesCell populationsSingle immune cellsType I interferonPatient blood samplesLupus erythematosusMonocyte subtypesInflammatory mediatorsInterferon signatureIndividual monocytesPatients' monocytesIFN signatureImmune cells
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