2025
Association of clinical manifestations and immune alterations with genetic variants of uncertain significance in patients concerned for inborn errors of immunity
Novotny S, Yoo N, Chen J, Granoth M, Kohli-Pamnani A, Hsu F, Rodenas M, Steele R, Kaman K, Soffer G, Price C, Kuster J, Kang I, Osmani L, Shin J. Association of clinical manifestations and immune alterations with genetic variants of uncertain significance in patients concerned for inborn errors of immunity. Clinical Immunology 2025, 277: 110513. PMID: 40354868, DOI: 10.1016/j.clim.2025.110513.Peer-Reviewed Original ResearchInborn errors of immunityErrors of immunityGenetic variantsInborn errorsAssociation of clinical manifestationsGene clusterGene functionStudy evaluated associationsImmune alterationsDiagnostic challengeClinical manifestationsImmunological profileGenetic testingVUSGenesImmunological characteristicsImmune functionLaboratory dataImmunityVariantsAssociationPatients
2024
Clinical Interpretation of Serum Troponin in the Era of High-Sensitivity Testing
Maayah M, Grubman S, Allen S, Ye Z, Park D, Vemmou E, Gokhan I, Sun W, Possick S, Kwan J, Gandhi P, Hu J. Clinical Interpretation of Serum Troponin in the Era of High-Sensitivity Testing. Diagnostics 2024, 14: 503. PMID: 38472975, PMCID: PMC10930800, DOI: 10.3390/diagnostics14050503.Peer-Reviewed Original ResearchAcute coronary syndromeTn elevationCoronary syndromeTreatment of acute coronary syndromesNon-cardiac etiologyManagement of myocardial injuryEvaluation of patientsHigh-sensitivity assaySerum troponinHighly sensitive testPrognostic implicationsCardiac troponinMyocardial injuryPhysical examMyocardial ischemiaPoor specificityLaboratory dataClinical judgmentClinical interpretationTroponinSyndromeAnalytical sensitivityTN measurementsPresentationElevation
2023
The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A resource for research on the aging brain and Alzheimer’s disease and related dementias
Crane P, Lind B, Dodd T, Lyons M, Macuiba J, Gray S, Meyers K, Kelley A, Nemerever L, Covey J, Campbell C, Lederman B, Sheridan L, Tom S, Larson E, Nelson J, LaCroix A, Renz A. The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A resource for research on the aging brain and Alzheimer’s disease and related dementias. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.079041.Peer-Reviewed Original ResearchMedical recordsClinical dataMedical conditionsAlzheimer's diseaseAdult ChangesElectronic medical record dataProspective cohort studyClinical-pathological correlationChart review dataLaboratory dataMedical record dataLongitudinal clinical dataAutopsy cohortCerebrovascular accidentCohort studyBlood pressureMedication dataPharmacy dataDementia statusCardiovascular conditionsNeurological conditionsDementia diagnosisAbstract medical recordsPsychiatric conditionsAnalysis of association
2022
3D CT-Inclusive Deep-Learning Model to Predict Mortality, ICU Admittance, and Intubation in COVID-19 Patients
Di Napoli A, Tagliente E, Pasquini L, Cipriano E, Pietrantonio F, Ortis P, Curti S, Boellis A, Stefanini T, Bernardini A, Angeletti C, Ranieri S, Franchi P, Voicu I, Capotondi C, Napolitano A. 3D CT-Inclusive Deep-Learning Model to Predict Mortality, ICU Admittance, and Intubation in COVID-19 Patients. Journal Of Imaging Informatics In Medicine 2022, 36: 603-616. PMID: 36450922, PMCID: PMC9713092, DOI: 10.1007/s10278-022-00734-4.Peer-Reviewed Original ResearchConceptsIntensive care unit admittanceIntensive care unit admissionIntensive care unitCOVID-19 patientsDeep learning modelsChest CTLaboratory dataPatient mortalityCT imagesRetrospective multicentre studyReal-time reverse transcriptase polymerase chain reactionHospital admissionReverse transcriptase polymerase chain reactionTranscriptase polymerase chain reactionDeep learningPredictive of mortalityChest CT imagesClinical featuresValidation cohortMulticentre studyPolymerase chain reactionDense neural networkTest cohortLung damageInternal validity
2020
Physician and patient prediction of adherence to antiretroviral therapy in HIV positive people in Saint-Petersburg, Russia
Vetrova M, Aleksandrova O, Paschenko A, Toropov S, Rassokhin V, Abyshev R, Levina O, Niccolai L, Heimer R. Physician and patient prediction of adherence to antiretroviral therapy in HIV positive people in Saint-Petersburg, Russia. AIDS Care 2020, 33: 473-477. PMID: 32148065, DOI: 10.1080/09540121.2020.1738005.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyHIV-positive peopleART initiationPositive peopleHIV viral suppressionPatient predictionsAccuracy of providerReview of pharmacyART retentionHIV physiciansViral suppressionPhysicians' predictionsTreatment outcomesART outcomesPatientsAdherenceLaboratory dataTherapyLongitudinal analysisOutcomesProvidersInitiationPhysiciansCare
2019
A simple real-time model for predicting acute kidney injury in hospitalized patients in the US: A descriptive modeling study
Simonov M, Ugwuowo U, Moreira E, Yamamoto Y, Biswas A, Martin M, Testani J, Wilson FP. A simple real-time model for predicting acute kidney injury in hospitalized patients in the US: A descriptive modeling study. PLOS Medicine 2019, 16: e1002861. PMID: 31306408, PMCID: PMC6629054, DOI: 10.1371/journal.pmed.1002861.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAged, 80 and overConnecticutDecision Support TechniquesElectronic Health RecordsFemaleHospital MortalityHumansInpatientsMaleMiddle AgedPatient AdmissionPredictive Value of TestsPrognosisRenal DialysisRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsConceptsAcute kidney injuryImminent acute kidney injuryElectronic health recordsKidney injuryHospital 1Prediction of AKIRenal replacement therapyOptimal treatment strategyLaboratory dataReceiver operator characteristic curveInternal validation setAKI occurrenceAKI severityHospitalized adultsMedical comorbiditiesOverall cohortAdverse eventsHospitalized patientsSurgical wardsSignificant morbidityReplacement therapyExternal validation data setsHospital 2Hospital 3Study hospitalDiagnosing acute interstitial nephritis: considerations for clinicians
Nussbaum E, Perazella M. Diagnosing acute interstitial nephritis: considerations for clinicians. Clinical Kidney Journal 2019, 12: 808-813. DOI: 10.1093/ckj/sfz080.Peer-Reviewed Original ResearchAcute interstitial nephritisAcute kidney injuryAcute tubular necrosisInterstitial nephritisCommon causeDirect further managementKidney injuryMost patientsTubular necrosisKidney biopsyClinical historyFurther managementCliniciansLaboratory dataNephritisPatientsInjuryDiagnosisSingle testCauseBiopsyNecrosisBiomarkersMo1984 – Symptom Profiles, Gluten Free Diet Adherence, and Laboratory Data Do Not Reliably Predict Duodenal Mucosal Healing in Follow Up Biopsies from Patients with Celiac Disease in a Multinational Pathology Based Cohort
Patel N, Atsawarungruangkit A, Leffler D, Hart J, Olivas A, Vieth M, Melcher B, Al-toma A, Mulder C, Salomao M, Pai R, Bronner M, Prats M, Naini B, Meyerson C, Elli L, del Gobbo A, Kakar S, Choi W, Gopal P, Westerhoff M, Cheng J, Robert M. Mo1984 – Symptom Profiles, Gluten Free Diet Adherence, and Laboratory Data Do Not Reliably Predict Duodenal Mucosal Healing in Follow Up Biopsies from Patients with Celiac Disease in a Multinational Pathology Based Cohort. Gastroenterology 2019, 156: s-911. DOI: 10.1016/s0016-5085(19)39247-9.Peer-Reviewed Original Research
2018
Correlation between quantitative liver and spleen volumes and disease severity in primary sclerosing cholangitis as determined by Mayo risk score
Khoshpouri P, Ameli S, Ghasabeh M, Pandey A, Zarghampour M, Varzaneh F, Jacob A, Pandey P, Luo Y, Kamel I. Correlation between quantitative liver and spleen volumes and disease severity in primary sclerosing cholangitis as determined by Mayo risk score. European Journal Of Radiology 2018, 108: 254-260. PMID: 30396665, DOI: 10.1016/j.ejrad.2018.10.006.Peer-Reviewed Original ResearchConceptsMayo risk scorePrimary sclerosing cholangitisLiver volume ratioHigh-risk groupSpleen volumeRisk scoreSclerosing cholangitisSeverity of primary sclerosing cholangitisLeft lobeSingle center retrospective studyPrimary sclerosing cholangitis patientsROC analysisIntermediate risk groupDisease severityTotal liver volumeLiver volumeRetrospective studyCohort studyRisk groupsImaging studiesMayoLaboratory dataSpleenCholangitisAbsolute volumeAdolescent type 2 diabetes: Comparing the Pediatric Diabetes Consortium and Germany/Austria/Luxemburg Pediatric Diabetes Prospective registries
Klingensmith GJ, Lanzinger S, Tamborlane WV, Hofer SE, Cheng P, de Beaufort C, Gal RL, Reinehr T, Kollman C, Holl RW. Adolescent type 2 diabetes: Comparing the Pediatric Diabetes Consortium and Germany/Austria/Luxemburg Pediatric Diabetes Prospective registries. Pediatric Diabetes 2018, 19: 1156-1163. PMID: 29923263, DOI: 10.1111/pedi.12712.Peer-Reviewed Original ResearchConceptsDiabetes durationClinical characteristicsBody mass index SDSAdolescent type 2Onset of T2DPediatric Diabetes ConsortiumShorter diabetes durationMost recent visitType 2 diabetesYears of ageProspective registryTreatment of youthAdverse eventsDiabetes complicationsHigher HbA1cOffice visitsHigher hemoglobinUnited States databaseVs 3.2Diabetes testingType 2RegistryLaboratory dataTreatment differencesFurther studies
2017
Hypertension and Type 2 Diabetes Are Associated With Decreased Inhibition of Dipeptidyl Peptidase-4 by Sitagliptin
Wilson JR, Shuey MM, Brown NJ, Devin JK. Hypertension and Type 2 Diabetes Are Associated With Decreased Inhibition of Dipeptidyl Peptidase-4 by Sitagliptin. Journal Of The Endocrine Society 2017, 1: 1168-1178. PMID: 29264572, PMCID: PMC5686657, DOI: 10.1210/js.2017-00312.Peer-Reviewed Original ResearchDPP4 activityHealthy controlsSitagliptin doseSystolic blood pressurePeptidase-4 inhibitorsType 2 diabetesDipeptidyl peptidase-4Blood pressureCrossover fashionMetabolic syndromeCrossover studyMultivariable analysisDPP4 inhibitionDPP4 inhibitorsHypertensionPlaceboPeptidase-4High dosesSitagliptinT2DMDecreased inhibitionPatientsLaboratory dataInfluences responseDiabetes
2016
Characterizing Readmissions After Bariatric Surgery
Garg T, Rosas U, Rogan D, Hines H, Rivas H, Morton JM, Azagury D. Characterizing Readmissions After Bariatric Surgery. Journal Of Gastrointestinal Surgery 2016, 20: 1797-1801. PMID: 27613733, DOI: 10.1007/s11605-016-3247-3.Peer-Reviewed Original ResearchConceptsBariatric surgeryIndex hospital lengthAdjustable gastric bandMultivariable logistic regressionSingle academic institutionHospital lengthHospital LOSLaparoscopic RouxGastric bandGastric bypassIndex procedureImportant quality metricGastrointestinal issuesCommon causeReadmissionSurgeryLogistic regressionPatientsMean timeLaboratory dataLRYGBDaysGastrectomyRouxStay
2015
Development and Performance of an Algorithm to Estimate the Child-Turcotte-Pugh Score From a National Electronic Healthcare Database
Kaplan DE, Dai F, Aytaman A, Baytarian M, Fox R, Hunt K, Knott A, Pedrosa M, Pocha C, Mehta R, Duggal M, Skanderson M, Valderrama A, Taddei TH, Group V. Development and Performance of an Algorithm to Estimate the Child-Turcotte-Pugh Score From a National Electronic Healthcare Database. Clinical Gastroenterology And Hepatology 2015, 13: 2333-2341.e6. PMID: 26188137, PMCID: PMC4655141, DOI: 10.1016/j.cgh.2015.07.010.Peer-Reviewed Original ResearchConceptsCTP scoreAdministrative databasesChild-TurcottePugh scoreVeterans Health Administration Corporate Data WarehouseLaboratory dataCox proportional hazards regressionSeverity of ascitesTransplant-free survivalSeverity IndexInternational normalized ratioClinical laboratory valuesHarrell's C-statisticProportional hazards regressionDiseases version 9U.S. Veterans Health AdministrationVeterans Health AdministrationMulticenter collaborative studyLarge administrative databaseLong-term survivalDisease severity scoreValidity of diagnosesCorporate Data WarehouseElectronic healthcare databasesCommon Procedural Terminology
2014
Borrelia burgdorferi Promotes the Establishment of Babesia microti in the Northeastern United States
Dunn JM, Krause PJ, Davis S, Vannier EG, Fitzpatrick MC, Rollend L, Belperron AA, States SL, Stacey A, Bockenstedt LK, Fish D, Diuk-Wasser MA. Borrelia burgdorferi Promotes the Establishment of Babesia microti in the Northeastern United States. PLOS ONE 2014, 9: e115494. PMID: 25545393, PMCID: PMC4278703, DOI: 10.1371/journal.pone.0115494.Peer-Reviewed Original ResearchConceptsB. microtiB. burgdorferiBabesia microtiLyme diseaseRespective causative agentsSpread of babesiosisI. scapularis larvaeInfected micePrimary reservoir hostHigh prevalenceLeucopus miceMiceHuman babesiosisBorrelia burgdorferiLaboratory dataLarval burdenCausative agentMicrotiBurgdorferiCoinfectionReservoir hostsDiseaseR0 modelBasic reproduction numberEnzootic cycleDifferentiating HIV-associated Nephropathy from Antiretroviral Drug-Induced Nephropathy: A Clinical Challenge
Kumar N, Perazella M. Differentiating HIV-associated Nephropathy from Antiretroviral Drug-Induced Nephropathy: A Clinical Challenge. Current HIV/AIDS Reports 2014, 11: 202-211. PMID: 24924830, DOI: 10.1007/s11904-014-0209-9.Peer-Reviewed Original ResearchConceptsHIV-associated nephropathyKidney diseaseConcurrent co-morbiditiesHIV-infected patientsAdverse renal effectsEtiology of kidney diseaseCo-morbid diseasesDrug-induced nephropathyAntiretroviral therapyKidney biopsyRenal effectsClinical challengeCo-morbiditiesKidney lesionsNephropathyLaboratory dataClinical practiceNon-infectiousKidneyDiseaseNephrotoxicityCliniciansBiopsyComplicationsTherapyThe VACS Index Predicts Mortality in a Young, Healthy HIV Population Starting Highly Active Antiretroviral Therapy
Bebu I, Tate J, Rimland D, Mesner O, Macalino GE, Ganesan A, Okulicz JF, Bavaro M, Weintrob AC, Justice AC, Agan BK. The VACS Index Predicts Mortality in a Young, Healthy HIV Population Starting Highly Active Antiretroviral Therapy. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 65: 226-230. PMID: 24226058, PMCID: PMC4091811, DOI: 10.1097/qai.0000000000000045.Peer-Reviewed Original ResearchConceptsVACS IndexActive antiretroviral therapyCause mortalityAntiretroviral therapyHIV populationVeterans Aging Cohort Study (VACS) IndexActive antiretroviral therapy (HAART) initiationAntiretroviral therapy initiationPrediction of mortalityGood discriminationNHS subjectsTherapy initiationDifferent time pointsStudy cohortSimilar patientsClinical variablesEarly risk assessmentMedical historyVAC indexHealthy populationMortalityStudy indicesOutcome predictionTime pointsLaboratory data
2013
Validation of an algorithm to identify antiretroviral‐naïve status at time of entry into a large, observational cohort of HIV‐infected patients
Gandhi NR, Tate JP, Rodriguez‐Barradas M, Rimland D, Goetz MB, Gibert C, Brown ST, Mattocks K, Justice AC. Validation of an algorithm to identify antiretroviral‐naïve status at time of entry into a large, observational cohort of HIV‐infected patients. Pharmacoepidemiology And Drug Safety 2013, 22: 1019-1025. PMID: 23836591, PMCID: PMC3831617, DOI: 10.1002/pds.3476.Peer-Reviewed Original ResearchConceptsART-naïve patientsViral load thresholdMedical record reviewAntiretroviral treatmentMedical recordsHIV cohortObservational cohortRecord reviewVeterans Aging Cohort Study Virtual CohortVirtual cohortPrevious antiretroviral treatmentLaboratory dataPatients' medical recordsPositive predictive value 87Cohort entryAdverse eventsHIV outcomesRandomized trialsRetrospective studyAdverse reactionsTime of entryCopies/ART treatmentTreatment statusTreatment history
2011
Interstitial Lung Disease in Older Patients
Antin-Ozerkis D. Interstitial Lung Disease in Older Patients. Respiratory Medicine 2011, 201-226. DOI: 10.1007/978-1-60761-727-3_11.Peer-Reviewed Original ResearchInterstitial lung diseaseDiffuse parenchymal lung diseaseLung diseaseOlder patientsRespiratory statusTerm interstitial lung diseasePatient's respiratory statusParenchymal lung diseaseDetailed physical examinationYounger patientsPathologic featuresCareful historyPhysical examinationLung disordersMedical conditionsSpecific diagnosisPhysiologic studiesDiagnostic approachMultidisciplinary conferenceDiseasePatientsPathologic tissueHeterogeneous groupLaboratory dataCertain diseasesPrevalence, Incidence, and Recurrence of Oral Lesions Among HIV-Infected Patients on HAART in Alabama
Tamí-Maury IM, Willig JH, Jolly PE, Vermund S, Aban I, Hill JD, Wilson CM, Kempf MC. Prevalence, Incidence, and Recurrence of Oral Lesions Among HIV-Infected Patients on HAART in Alabama. Southern Medical Journal 2011, 104: 561-566. PMID: 21886064, DOI: 10.1097/smj.0b013e318224a15f.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAIDS-Related Opportunistic InfectionsAlabamaAntiretroviral Therapy, Highly ActiveCandidiasis, OralFemaleHIV InfectionsHumansIncidenceLeukoplakia, HairyLongitudinal StudiesMaleMiddle AgedMouth DiseasesOffice VisitsOral UlcerPrevalenceRecurrenceRetrospective StudiesStomatitis, HerpeticYoung AdultConceptsOral lesionsOropharyngeal candidiasisPeriod prevalenceOral conditionsActive antiretroviral therapyAvailability of HAARTLaboratory dataYears of agePatient's laboratory dataAntiretroviral therapyChart reviewHIV infectionRetrospective studyFrequent manifestationIncidence rateMedical careHAARTNew casesPatientsRecurrencePrevalenceIncident rateUniversity of AlabamaHIVLesionsCerebrovascular Accidents Associated with Sorafenib in Hepatocellular Carcinoma
Saif MW, Isufi I, Peccerillo J, Syrigos KN. Cerebrovascular Accidents Associated with Sorafenib in Hepatocellular Carcinoma. Gastroenterology Research And Practice 2011, 2011: 616080. PMID: 21687621, PMCID: PMC3113260, DOI: 10.1155/2011/616080.Peer-Reviewed Original ResearchHepatocellular carcinomaCerebrovascular accidentVenous thrombotic eventsNormal systolic functionCases of patientsHead CT scanPrompt discontinuationAcute abnormalitiesCerebrovascular eventsNeurologic symptomsSystolic functionThrombotic eventsSecond patientCarotid ultrasoundSignificant stenosisRisk factorsMultikinase inhibitorCT scanLeft ventriclePatientsSorafenibAngiogenetic agentsHeart chambersCarcinomaLaboratory data
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