2025
16 Metabolic Syndrome and Obesity
Alonso W, Canapari C. 16 Metabolic Syndrome and Obesity. 2025, 175-184. DOI: 10.1016/b978-0-323-75566-5.00016-2.Peer-Reviewed Original ResearchMetabolic syndromeComponents of metabolic syndromeInvolvement of adipocytokinesSleep-disordered breathingIncreased sympathetic activityElevated blood pressureCardiovascular risk factorsRates of obesityIntermittent hypoxemiaTruncal obesityDysregulation of glucose metabolismSleep fragmentationSympathetic activityBlood pressureSleep curtailmentRisk factorsSyndromeObesityShort sleepGlucose metabolismCircadian factorsSleepHypoxemiaDyslipidemiaAdipocytokines
2023
Intermittent Hypoxemia and Bronchopulmonary Dysplasia with Pulmonary Hypertension in Preterm Infants.
Gentle S, Travers C, Nakhmani A, Indic P, Carlo W, Ambalavanan N. Intermittent Hypoxemia and Bronchopulmonary Dysplasia with Pulmonary Hypertension in Preterm Infants. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 899-907. PMID: 36449386, PMCID: PMC10111996, DOI: 10.1164/rccm.202203-0580oc.Peer-Reviewed Original ResearchConceptsBronchopulmonary dysplasia-associated pulmonary hypertensionIntermittent hypoxemiaHypoxemic eventsReceiver operating characteristicPreterm infantsPulmonary hypertensionControl subjectsWeeks 6 daysExtremely preterm infantsWeeks 0 daysHigher risk of deathIdentification of infantsCase-control studyRisk of deathBronchopulmonary dysplasiaDesaturation frequencyEchocardiographic dataPostnatal dayBedside biomarkersIH eventsHigh riskInfantsHypoxemiaHypertensionLong duration
2018
Environmental or Nasal Cannula Supplemental Oxygen for Preterm Infants: A Randomized Cross-Over Trial
Travers C, Carlo W, Nakhmani A, Bhatia S, Gentle S, Amperayani V, Indic P, Aban I, Ambalavanan N. Environmental or Nasal Cannula Supplemental Oxygen for Preterm Infants: A Randomized Cross-Over Trial. The Journal Of Pediatrics 2018, 200: 98-103. PMID: 29705116, PMCID: PMC6109600, DOI: 10.1016/j.jpeds.2018.03.010.Peer-Reviewed Original ResearchConceptsEpisodes of intermittent hypoxemiaPreterm infantsNasal cannulaIntermittent hypoxemiaSupplemental oxygenRandomized cross-over trialCross-over trialGestational agePostnatal dayBirth weightPretermHypoxemiaDecreased episodesInfantsOxygen saturationCannulaHoursPatient monitoringPatientsBirthWeeksTrials
2017
Patterns of Oxygenation, Mortality, and Growth Status in the Surfactant Positive Pressure and Oxygen Trial Cohort
Di Fiore J, Martin R, Li H, Morris N, Carlo W, Finer N, Walsh M, Health A, Jobe A, Caplan M, Polin R, Laptook R, Oh W, Hensman A, Gingras D, Barnett S, Lillie S, Francis K, Andrews D, Angela K, Fanaroff A, Newman N, Siner B, Zadell A, Schibler K, Donovan E, Bridges K, Alexander B, Grisby C, Mersmann M, Mincey H, Hessling J, Goldberg R, Cotten C, Wallace D, Freedman S, Auten K, Fisher K, Foy K, Stoll B, Piazza A, Buchter S, Carlton D, Hutchinson A, Hale E, Higgins R, Archer S, Poindexter B, Lemons J, Hamer F, Herron D, Miller L, Wilson L, Berberich M, Blaisdell C, Gail D, Kiley J, Gantz M, Das A, Crawford M, Hastings B, Irene A, Auman J, Huitema C, Pickett J, Wallace D, Zaterka-Baxter K, Van Meurs K, Stevenson D, Ball M, Proud M, Frantz I, Fiascone J, Furey A, MacKinnon B, Nylen E, Ambalavanan N, Collins M, Cosby S, Phillips V, Rasmussen M, Wozniak P, Rich W, Arnell K, Bridge R, Demetrio C, Bell E, Widness J, Klein J, Johnson K, Duara S, Everett-Thomas R, Watterberg K, Ohls R, Rohr J, Lacy C, Phelps D, Laroia N, Markowitz G, Reubens L, Burnell E, Sánchez P, Rosenfeld C, Salhab W, Allen J, Grau L, Guzman A, Hensley G, Lepps M, Martin M, Miller N, Solis A, Vasil D, Wilder K, Kennedy K, Tyson J, Morris B, Harris B, Lis A, Martin S, McDavid G, Tate P, Wright S, Yoder B, Faix R, Burnett J, Jensen J, Osborne K, Spencer C, Weaver-Lewis K, O'Shea T, Peters N, Shankaran S, Sood B, Bara R, Billian E, Johnson M, Ehrenkranz R, Narendran V, Bhandari V, Jacobs H, Cervone P, Gettner P, Konstantino M, Poulsen J, Taft J. Patterns of Oxygenation, Mortality, and Growth Status in the Surfactant Positive Pressure and Oxygen Trial Cohort. The Journal Of Pediatrics 2017, 186: 49-56.e1. PMID: 28279433, PMCID: PMC5484739, DOI: 10.1016/j.jpeds.2017.01.057.Peer-Reviewed Original ResearchConceptsDays of lifeIntermittent hypoxemia eventsOxygen saturation targetsOxygen saturationHypoxemia eventsSaturation targetsGestational ageHigher oxygen saturation targetsExtremely preterm infantsMedian oxygen saturationWeeks of gestationLowest oxygen saturationPositive pressureOxygen saturation levelsPatterns of oxygenationIntermittent hypoxemiaPreterm infantsTrial cohortSupplemental oxygenLowest quartileHigh incidenceTarget infantsInfantsSGASurvival
2013
Hypertension and endothelial dysfunction in obstructive sleep apnea (OSA) – Is it related to hypoxia?
Mohsenin V, Jafari B. Hypertension and endothelial dysfunction in obstructive sleep apnea (OSA) – Is it related to hypoxia? Sleep Medicine 2013, 14: e210. DOI: 10.1016/j.sleep.2013.11.503.Peer-Reviewed Original ResearchObstructive sleep apneaEndothelial dysfunctionSFlt-1Fms-like tyrosine kinase-1Endothelial-dependent vasodilatory capacitySevere obstructive sleep apneaAngiogenic inhibitorsN-OSACardiovascular adverse outcomesNon-OSA patientsNormotensive OSAS patientsTarget organ damageApnea-hypopnea indexDevelopment of hypertensionArterial oxygen saturationTyrosine kinase-1Significant inverse correlationImpaired FMDIntermittent hypoxemiaSEng concentrationsVasodilatory capacityOSA patientsSympathetic toneIntermittent hypoxiaOrgan damage
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