2025
Association of clinical manifestations and immune alterations with genetic variants of uncertain significance in patients concerned for inborn errors of immunity
Novotny S, Yoo N, Chen J, Granoth M, Kohli-Pamnani A, Hsu F, Rodenas M, Steele R, Kaman K, Soffer G, Price C, Kuster J, Kang I, Osmani L, Shin J. Association of clinical manifestations and immune alterations with genetic variants of uncertain significance in patients concerned for inborn errors of immunity. Clinical Immunology 2025, 277: 110513. PMID: 40354868, DOI: 10.1016/j.clim.2025.110513.Peer-Reviewed Original ResearchInborn errors of immunityErrors of immunityGenetic variantsInborn errorsAssociation of clinical manifestationsGene clusterGene functionStudy evaluated associationsImmune alterationsDiagnostic challengeClinical manifestationsImmunological profileGenetic testingVUSGenesImmunological characteristicsImmune functionLaboratory dataImmunityVariantsAssociationPatientsThe five senses of immunity
Nixon D, Bachtel N, Hupert N, Eleftherianos I. The five senses of immunity. Trends In Immunology 2025, 46: 361-363. PMID: 40251093, PMCID: PMC12172028, DOI: 10.1016/j.it.2025.03.005.Peer-Reviewed Original Research
2024
Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma
Lu B, Lucca L, Lewis W, Wang J, Nogueira C, Heer S, Rayon-Estrada V, Axisa P, Reeves S, Buitrago-Pocasangre N, Pham G, Kojima M, Wei W, Aizenbud L, Bacchiocchi A, Zhang L, Walewski J, Chiang V, Olino K, Clune J, Halaban R, Kluger Y, Coyle A, Kisielow J, Obermair F, Kluger H, Hafler D. Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma. Nature Immunology 2024, 26: 82-91. PMID: 39609626, DOI: 10.1038/s41590-024-02023-4.Peer-Reviewed Original ResearchCD8+ T cellsAnti-tumor immunityRegulatory T cellsT cellsSubpopulation of CD8+ T cellsCytotoxic CD8+ T cellsHuman CD8+ T cellsTumor antigen-specific CD8Impaired anti-tumor immunityTumor antigen-specificPoor overall survivalTumor rejectionKIR expressionOverall survivalTumor antigensImmune evasionCellular mediatorsHuman cancersCD8MelanomaTumorTranscriptional programsFunctional heterogeneityImmunityPatientsA model of proximate protection against pathogenic infection through shared immunity
Nixon D, Kyza-Karavioti M, Mallick S, Daley L, Hupert N, Bachtel N, Eleftherianos I. A model of proximate protection against pathogenic infection through shared immunity. MBio 2024, 15: e03046-24. PMID: 39526781, PMCID: PMC11633142, DOI: 10.1128/mbio.03046-24.Peer-Reviewed Original ResearchDrosophila melanogaster</i>Host immune defenseTransforming biomedical researchMicrobial signalsPathogen infectionPathogen challengeAdult fliesImmunological primingInsect pathogensImmune defenseInfected hostsInnate immune primingImmune primingHostPathogensInfluence immunityBiomedical researchHealthy individualsFliesPrimed hostsProtective effectLethal doseImmunityBacteriaSpecific chemicalsTwo-dose priming immunization amplifies humoral immunity by synchronizing vaccine delivery with the germinal center response
Bhagchandani S, Yang L, Lam J, Maiorino L, Ben-Akiva E, Rodrigues K, Romanov A, Suh H, Aung A, Wu S, Wadhera A, Chakraborty A, Irvine D. Two-dose priming immunization amplifies humoral immunity by synchronizing vaccine delivery with the germinal center response. Science Immunology 2024, 9: eadl3755-eadl3755. PMID: 39303017, PMCID: PMC11492009, DOI: 10.1126/sciimmunol.adl3755.Peer-Reviewed Original ResearchConceptsDendritic cellsGerminal centersHumoral immunityAntigen-specific germinal centerGerminal center responseSubunit vaccineFollicular dendritic cellsPrimary immune responseIncreased T<sub>rDose 7 daysPrime immunizationGC responseImmune responseVaccine deliveryCenter responseAdministered vaccinesImmunityVaccineRegimensAdjuvant vaccineDoseCellsHIVResponseBolusBeta Spike-Presenting SARS-CoV-2 Virus-like Particle Vaccine Confers Broad Protection against Other VOCs in Mice
Ullah I, Symmes K, Keita K, Zhu L, Grunst M, Li W, Mothes W, Kumar P, Uchil P. Beta Spike-Presenting SARS-CoV-2 Virus-like Particle Vaccine Confers Broad Protection against Other VOCs in Mice. Vaccines 2024, 12: 1007. PMID: 39340037, PMCID: PMC11435481, DOI: 10.3390/vaccines12091007.Peer-Reviewed Original ResearchImmune responseVirus-like particlesBeta spikesCross-protective immune responsesSARS-CoV-2 immunitySARS-CoV-2Effective immune responseEffective humoral immune responseHumoral immune responseAncestral spikeT cellsVaccination regimenSARS-CoV-2 virus-like particlesVaccine platformMouse modelVariant spike proteinsOmicron spikeBeta variantDisease burdenNon-infectiousReduce virus spreadImmunityVariant spikesFusion glycoproteinSpike proteinDeterminants of undervaccination of routine childhood immunization in Argentina: A cross-sectional study
Melchinger H, Winters M, Christie S, Arias N, Lirman L, Abeyesekera S, Thomson A, Omer S. Determinants of undervaccination of routine childhood immunization in Argentina: A cross-sectional study. Vaccine 2024, 42: 126235. PMID: 39182313, DOI: 10.1016/j.vaccine.2024.126235.Peer-Reviewed Original ResearchConceptsRoutine childhood immunizationChildhood immunizationRoutine immunizationAdverse side effectsCross-sectional studyOfficial health organizationsRoutine immunization coverageSide effectsVaccination scheduleTarget parentsImmunization coverageParental concernsImmunityVaccineUnder-vaccinationVaccination adviceHealth OrganizationEvidence to dateOlder parentsInfectious diseasesCaspase-4/11 promotes hyperlipidemia and chronic kidney disease-accelerated vascular inflammation by enhancing trained immunity
Sun Y, Lu Y, Liu L, Saaoud F, Shao Y, Xu K, Drummer C, Cueto R, Shan H, Jiang X, Zhao H, Wang H, Yang X. Caspase-4/11 promotes hyperlipidemia and chronic kidney disease-accelerated vascular inflammation by enhancing trained immunity. JCI Insight 2024, 9: e177229. PMID: 39024553, PMCID: PMC11343595, DOI: 10.1172/jci.insight.177229.Peer-Reviewed Original ResearchChronic kidney diseaseTrained immunityAortic endothelial cellsVascular inflammationEndothelial cellsRecruitment of macrophagesIL-1b levelsHuman aortic endothelial cellsHigh-fat dietMembrane expressionN-terminal gasdermin DCytokine secretionPathological analysisIL-1BKidney diseaseNeointima hyperplasiaCaspase-4/11HyperlipidemiaInflammationCytosolic lipopolysaccharideCaspase-11RNA sequencingGasdermin DImmunityLipopolysaccharideFrom metabolic to epigenetic: Insight into trained macrophages in atherosclerosis (Review)
Li T, Feng W, Yan W, Wang T. From metabolic to epigenetic: Insight into trained macrophages in atherosclerosis (Review). Molecular Medicine Reports 2024, 30: 145. PMID: 38904193, DOI: 10.3892/mmr.2024.13269.Peer-Reviewed Original ResearchConceptsTrained immunityTrained macrophagesAbundant immune cellsCharacteristics of innate immunityChronic inflammatory diseaseAtherosclerotic plaquesProgression of ASImmune cellsInflammatory diseasesImmune responseTherapeutic approachesClinical strategiesEpigenetic reprogrammingDeposition of lipoproteinsCardiovascular diseaseInnate immunityMacrophagesAtherosclerosisImmunityDiseasePlaqueCellsComplex mechanismsDEPDC5 protects CD8+ T cells from ferroptosis by limiting mTORC1-mediated purine catabolism
Li S, Ouyang X, Sun H, Jin J, Chen Y, Li L, Wang Q, He Y, Wang J, Chen T, Zhong Q, Liang Y, Pierre P, Zou Q, Ye Y, Su B. DEPDC5 protects CD8+ T cells from ferroptosis by limiting mTORC1-mediated purine catabolism. Cell Discovery 2024, 10: 53. PMID: 38763950, PMCID: PMC11102918, DOI: 10.1038/s41421-024-00682-z.Peer-Reviewed Original ResearchCD8+ T cellsPeripheral CD8+ T cellsAnti-tumor immunityT cellsTumor-infiltrating CD8+ T cellsCD8+ T cell homeostasisCD8+ T cell numbersImpaired anti-tumor immunityT cell numbersT-cell protectionT cell homeostasisCancer patient survivalLevels of xanthine oxidasePatient survivalCD8Epilepsy patientsDEPDC5Suppression of ferroptosisMTORC1 signalingFerroptosisMolecular mechanismsImmunityXanthine oxidasePurine catabolismExpressionThe Benjamin Button effect on stem cells: Reversing the clock on aging immunity.
Conde L, Lucas C. The Benjamin Button effect on stem cells: Reversing the clock on aging immunity. Science Immunology 2024, 9: eadq0013. PMID: 38701191, DOI: 10.1126/sciimmunol.adq0013.Peer-Reviewed Original ResearchAdiposity, immunity, and inflammation: interrelationships in health and disease: a report from 24th Annual Harvard Nutrition Obesity Symposium, June 2023
Burak M, Stanley T, Lawson E, Campbell S, Lynch L, Hasty A, Domingos A, Dixit V, Hotamışlıgil G, Sheedy F, Dixon A, Brinkley T, Hill J, Donath M, Grinspoon S. Adiposity, immunity, and inflammation: interrelationships in health and disease: a report from 24th Annual Harvard Nutrition Obesity Symposium, June 2023. American Journal Of Clinical Nutrition 2024, 120: 257-268. PMID: 38705359, PMCID: PMC11347817, DOI: 10.1016/j.ajcnut.2024.04.029.Peer-Reviewed Original ResearchLow-grade systemic inflammationChronic low-grade inflammationLocal immune environmentAdipose tissueLow-grade inflammationEffect of obesityObesity Research CenterPro-inflammatory pathwaysOutcome of metabolic diseasesImmune environmentSystemic inflammationHealth and DiseaseTreatment therapiesInflammationMultifaceted effectsDisease severityMetabolic diseasesImmunometabolic diseasesImmunityAdiposeDiseaseReduced disease severityObesityTissueDisrupting cellular homeostasisEx Vivo Immunization: A Strategy for Immunization Against SARS-CoV-2
Singh H, Nuthalapati P, Yendapalli P, Sahu D. Ex Vivo Immunization: A Strategy for Immunization Against SARS-CoV-2. 2024, 258-271. DOI: 10.1039/bk9781837672813-00258.Peer-Reviewed Original ResearchPeripheral blood mononuclear cellsNatural killer cellsCell-mediated immunityBlood mononuclear cellsEnhanced immune responseNaive lymphocytesDendritic cellsKiller cellsT cellsAntigen presentationB cellsMononuclear cellsImmune responseSARS-nCoV-2Human hostSignaling cascadesSARS-CoV-2Global pandemic coronavirus diseaseVirion particlesImmunityMass immunizationAdverse effectsCoronavirus 2Pandemic coronavirus disease
2023
Breast milk oxytocin and s-IgA modulate infant biomarkers and social engagement; The role of maternal anxiety
Zagoory-Sharon O, Yirmiya K, Peleg I, Shimon-Raz O, Sanderlin R, Feldman R. Breast milk oxytocin and s-IgA modulate infant biomarkers and social engagement; The role of maternal anxiety. Comprehensive Psychoneuroendocrinology 2023, 17: 100219. PMID: 38187086, PMCID: PMC10765300, DOI: 10.1016/j.cpnec.2023.100219.Peer-Reviewed Original ResearchBreast milkInfant salivaS-IgAInfant biomarkersMaternal anxietyBreast milk compositionMaternal mental healthMother-infant dyadsInfant social behaviorInfant immunityInfant healthSecretory immunoglobulinS-IgA.Mother-infant bondSame biomarkersMental healthAbundant antibodyBiomarkersOxytocinSalivaMental developmentImmunityAssociationDegree of stressHealthBacterial antigens unleash tumor-targeting immunity
Boeck N, Trajanoski Z, Galluzzi L. Bacterial antigens unleash tumor-targeting immunity. Cell Host & Microbe 2023, 31: 1945-1947. PMID: 38096784, PMCID: PMC11075005, DOI: 10.1016/j.chom.2023.11.001.Peer-Reviewed Original ResearchTargeting interleukin (IL)-4/IL-13 in immune checkpoint inhibitor-induced bullous pemphigoid: a cautionary note on the beneficial effect of T helper 2 immunity in melanoma and immunotherapy: reply from the authors
Shipman W, Singh K, Cohen J, Leventhal J, Damsky W, Tomayko M. Targeting interleukin (IL)-4/IL-13 in immune checkpoint inhibitor-induced bullous pemphigoid: a cautionary note on the beneficial effect of T helper 2 immunity in melanoma and immunotherapy: reply from the authors. British Journal Of Dermatology 2023, 190: 138-138. PMID: 37947404, DOI: 10.1093/bjd/ljad342.Peer-Reviewed Original Research1025 Tumor-specific CD8+ T cells epigenetically licensed by IL-7R are critical for anti-tumor immunity in melanoma
Micevic G, Daniels A, Flem-Karlsen K, Park K, Talty R, McGeary M, Mirza H, Blackburn H, Sefik E, Cheung J, Hornick N, Aizenbud L, Joshi N, Kluger H, Iwasaki A, Bosenberg M, Flavell R. 1025 Tumor-specific CD8+ T cells epigenetically licensed by IL-7R are critical for anti-tumor immunity in melanoma. 2023, a1133-a1133. DOI: 10.1136/jitc-2023-sitc2023.1025.Peer-Reviewed Original ResearchDiverging humoral and cellular immune responses due to Omicron—a national study from the Faroe Islands
Petersen M, Pérez-Alós L, Kongsstovu S, Eliasen E, Hansen C, Larsen S, Hansen J, Bayarri-Olmos R, Fjallsbak J, Weihe P, Garred P. Diverging humoral and cellular immune responses due to Omicron—a national study from the Faroe Islands. Microbiology Spectrum 2023, 11: e00865-23. PMID: 37909772, PMCID: PMC10714973, DOI: 10.1128/spectrum.00865-23.Peer-Reviewed Original ResearchConceptsT cell responsesOmicron infectionHumoral responseUnvaccinated individualsImmune responseRobust T cell responsesSARS-CoV-2 Omicron variantPositive T-cell responsesDetectable humoral responseLow humoral responseLower humoral immune responseT cell immunityCellular immune responsesHumoral immune responsePrior vaccinationThird doseHumoral immunityImmune evasionOmicron variantInfectionInfection statusImmunityVaccinationNational studyResponseMolecular Mechanism of Fasting-Mimicking Diet in Inhibiting Colorectal Cancer Progression: Implications for Immune Therapy and Metabolic Regulation.
Bush C, Perry R. Molecular Mechanism of Fasting-Mimicking Diet in Inhibiting Colorectal Cancer Progression: Implications for Immune Therapy and Metabolic Regulation. Cancer Research 2023, 83: 3493-3494. PMID: 37908187, DOI: 10.1158/0008-5472.can-23-2257.Commentaries, Editorials and LettersConceptsFasting-mimicking dietColorectal cancer progressionIgA class switchingColorectal cancerCancer progressionB cellsClass switchingFatty acid oxidationAnticancer immunityAntitumor immunityImmune therapyMolecular mechanismsTumor regressionMouse modelCaloric restrictionAnticancer effectsMetabolic reprogrammingProgressionDietCancerAcid oxidationCancer researchImmunityMetabolic regulationCellsIron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection
Spiga L, Fansler R, Perera Y, Shealy N, Munneke M, David H, Torres T, Lemoff A, Ran X, Richardson K, Pudlo N, Martens E, Folta-Stogniew E, Yang Z, Skaar E, Byndloss M, Chazin W, Zhu W. Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection. Cell Host & Microbe 2023, 31: 1639-1654.e10. PMID: 37776864, PMCID: PMC10599249, DOI: 10.1016/j.chom.2023.08.018.Peer-Reviewed Original ResearchConceptsLipocalin-2Nutritional immunityProtein lipocalin 2Role of commensalIntestinal inflammationInflamed gutSalmonella infectionHost nutritional immunityImmunityGut bacteriaIron metabolismHost-pathogen interactionsGut commensal Bacteroides thetaiotaomicronPathogensBacteroides thetaiotaomicronSalmonellaInflammationInfectionHost sequestration
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