2025
Toll-like receptors in B cells and obesity
Wang P, Hou C, Wong F, Wen L. Toll-like receptors in B cells and obesity. Trends In Molecular Medicine 2025 PMID: 40527636, DOI: 10.1016/j.molmed.2025.05.005.Peer-Reviewed Original ResearchToll-like receptorsPathogen-associated molecular patternsB cellsDendritic cellsFunction of Toll-like receptorsActivation of dendritic cellsActivation of TLR signalingExcessive adipose tissue accumulationSignaling mechanisms of Toll-like receptorsT cell differentiationAdipose tissue accumulationContext of obesityMechanisms of Toll-like receptorsChronic inflammationInflammatory activityAdaptive immunityImmune responseMetabolic dysregulationTLR signalingImmune functionObesityTissue accumulationMetabolic diseasesMolecular patternsSignaling mechanismsAssociation of clinical manifestations and immune alterations with genetic variants of uncertain significance in patients concerned for inborn errors of immunity
Novotny S, Yoo N, Chen J, Granoth M, Kohli-Pamnani A, Hsu F, Rodenas M, Steele R, Kaman K, Soffer G, Price C, Kuster J, Kang I, Osmani L, Shin J. Association of clinical manifestations and immune alterations with genetic variants of uncertain significance in patients concerned for inborn errors of immunity. Clinical Immunology 2025, 277: 110513. PMID: 40354868, DOI: 10.1016/j.clim.2025.110513.Peer-Reviewed Original ResearchInborn errors of immunityErrors of immunityGenetic variantsInborn errorsAssociation of clinical manifestationsGene clusterGene functionStudy evaluated associationsImmune alterationsDiagnostic challengeClinical manifestationsImmunological profileGenetic testingVUSGenesImmunological characteristicsImmune functionLaboratory dataImmunityVariantsAssociationPatientsSupervised fine-tuning of pre-trained antibody language models improves antigen specificity prediction
Wang M, Patsenker J, Li H, Kluger Y, Kleinstein S. Supervised fine-tuning of pre-trained antibody language models improves antigen specificity prediction. PLOS Computational Biology 2025, 21: e1012153. PMID: 40163503, PMCID: PMC12013870, DOI: 10.1371/journal.pcbi.1012153.Peer-Reviewed Original ResearchConceptsSupervised fine-tuningImmune responseMolecular basis of antigen recognitionSARS-CoV-2 spike proteinLanguage modelSARS-CoV-2 vaccinesAdaptive immune responsesSpecific predictionsMolecular basisSpike proteinAntibody-based therapeuticsFine-tuningAntibody-antigen specificitySpecific to antigensInfluenza hemagglutininVaccine designAntigen recognitionModel embeddingsImmune functionLanguage model embeddingsSARS-CoV-2AntibodiesAntigenInfluenzaVaccineComposition and function of AChR chimeric autoantibody receptor T cells for antigen-specific B cell depletion in myasthenia gravis
Oh S, Khani-Habibabadi F, O'Connor K, Payne A. Composition and function of AChR chimeric autoantibody receptor T cells for antigen-specific B cell depletion in myasthenia gravis. Science Advances 2025, 11: eadt0795. PMID: 40020066, PMCID: PMC11870065, DOI: 10.1126/sciadv.adt0795.Peer-Reviewed Original ResearchConceptsChimeric autoantibody receptorsMyasthenia gravisAnti-AChRChimeric autoantibody receptor T cellsSurface expressionSustained surface expressionTarget cell eliminationB-cell depletionT cell cytotoxicityB-cell outgrowthSevere muscle weaknessMouse xenograft modelSuppress immune functionCellular immunotherapyAChR-MGMg therapyT cellsB cellsXenograft modelMuscle weaknessImmune functionNeuromuscular transmissionCell eliminationCD28GravisSorafenib Alters Interstitial Proton and Sodium Levels in the Tumor Microenvironment: A 1H/23Na Spectroscopic Imaging Study
Khan M, Walsh J, Kurdi S, Mishra S, Mihailović J, Coman D, Hyder F. Sorafenib Alters Interstitial Proton and Sodium Levels in the Tumor Microenvironment: A 1H/23Na Spectroscopic Imaging Study. NMR In Biomedicine 2025, 38: e5319. PMID: 39764672, DOI: 10.1002/nbm.5319.Peer-Reviewed Original ResearchConceptsU87 tumorsSorafenib-treated tumorsUpregulated aerobic glycolysisSodium-potassium pumpInterstitial spaceTumor microenvironmentIntracellular NaTumor growthSpectroscopic imaging studiesTumor invasionGlioblastoma modelSodium levelsTumorGlioblastoma therapyImaging studiesPlaceboSorafenibMetabolic changesImmune functionCancer hallmarksAerobic glycolysisProliferative stateMeasure treatment effectsIonic changesProliferation rate
2024
Vitamin D for very preterm infants—determining the how, when, and why
Taylor S. Vitamin D for very preterm infants—determining the how, when, and why. Pediatric Research 2024, 1-2. PMID: 39496874, DOI: 10.1038/s41390-024-03685-4.Peer-Reviewed Original ResearchGENETIC VARIANTS OF UNCERTAIN SIGNIFICANCE IN PATIENTS WITH PRESENTATIONS CONCERNING FOR INBORN ERRORS OF IMMUNITY
Novotny S, Yoo N, Granoth M, Chen J, Osmani L, Kang I, Shin J. GENETIC VARIANTS OF UNCERTAIN SIGNIFICANCE IN PATIENTS WITH PRESENTATIONS CONCERNING FOR INBORN ERRORS OF IMMUNITY. Annals Of Allergy Asthma & Immunology 2024, 133: s60. DOI: 10.1016/j.anai.2024.08.200.Peer-Reviewed Original ResearchInborn errors of immunityClinical presentationOrganelle biogenesisGenetic resultsT cellsAssociated with distinct clinical presentationInborn errors of immunity patientsGenetic testingClinical presentation of patientsDiagnosis of inborn errors of immunityImmune functionImmune thrombocytopenic purpuraReviewed electronic medical recordsT cell immunityErrors of immunityPresentation of patientsB cell immunityGene groupsCytomegalovirus infectionVariable immunodeficiencyThrombocytopenic purpuraRate of rheumatoid arthritisPediatric patientsGenetic variantsB cellsMicroglia-mediated neuroimmune suppression in PTSD is associated with anhedonia
Bonomi R, Hillmer A, Woodcock E, Bhatt S, Rusowicz A, Angarita G, Carson R, Davis M, Esterlis I, Nabulsi N, Huang Y, Krystal J, Pietrzak R, Cosgrove K. Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406005121. PMID: 39172786, PMCID: PMC11363315, DOI: 10.1073/pnas.2406005121.Peer-Reviewed Original ResearchConceptsPTSD groupPrefrontal-limbic circuitsNeuroimmune responseAssociated with anhedoniaPosttraumatic stress disorderPositron emission tomography brain imagingTranslocator protein availabilityBrain immune functionAnhedonic symptomsStress disorderPeripheral immune dysfunctionPTSDGroup differencesSeverity of symptomsPsychiatric diseasesTranslocator proteinBrain imagingAdministration of lipopolysaccharideSymptomsMicroglial markersLPS-induced increaseCompared to controlsImmune functionSickness symptomsAnhedoniaA metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance
Mertens R, Misra A, Xiao P, Baek S, Rone J, Mangani D, Sivanathan K, Arojojoye A, Awuah S, Lee I, Shi G, Petrova B, Brook J, Anderson A, Flavell R, Kanarek N, Hemberg M, Nowarski R. A metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance. Immunity 2024, 57: 2077-2094.e12. PMID: 38906145, DOI: 10.1016/j.immuni.2024.06.001.Peer-Reviewed Original ResearchFatty acid oxidationStimulator of interferon genesMetabolic switchIL-18Immune toleranceIntestinal toleranceRelease of mitochondrial DNAActivation of stimulator of interferon genesSusceptibility to inflammationIL-18 stimulationIL-18 activityMitochondrial DNATolerogenic macrophagesChronic inflammationInterleukin-18Immune stateInflammatory challengeInflammatory responseMetabolic programmingSodium influxMacrophage-derivedImmune functionInterferon genesBistable switchAcid oxidationCancer cell metabolism and antitumour immunity
De Martino M, Rathmell J, Galluzzi L, Vanpouille-Box C. Cancer cell metabolism and antitumour immunity. Nature Reviews Immunology 2024, 24: 654-669. PMID: 38649722, PMCID: PMC11365797, DOI: 10.1038/s41577-024-01026-4.Peer-Reviewed Original ResearchCell-extrinsic mechanismsCancer cell-extrinsic mechanismsCancer cell-intrinsicAntitumour immune responseAdverse microenvironmental conditionsIncreased proliferative potentialAccelerated disease progressionAdaptive immune functionMetabolic rewiringAnticancer immunityMalignant cellsAlteration of metabolismTumor progressionCell-intrinsicMicroenvironmental conditionsDisease progressionProliferative potentialImmune responseCancer cellsImmune functionTherapeutic purposesCancerAlterationsCellsTumor
2023
Neurophysin I is an analytically robust surrogate biomarker for oxytocin
MacLean E, Carranza E, Gnanadesikan G, King K, Allen A, Linde-Krieger L, Feldman R, White-Traut R, Hammock E, Carter C, Leng G, Tecot S, Bell A. Neurophysin I is an analytically robust surrogate biomarker for oxytocin. Psychoneuroendocrinology 2023, 161: 106951. PMID: 38194845, PMCID: PMC10872509, DOI: 10.1016/j.psyneuen.2023.106951.Peer-Reviewed Original ResearchSurrogate biomarkerOxytocin concentrationsUseful surrogate biomarkerRegulation of appetitePlasma oxytocin concentrationsNP-1Late pregnancyImmune functionKnockout micePleiotropic neuropeptideUrine samplesPlasma oxytocinCardiovascular repairOxytocinBiomarkersSandwich immunoassayStudy of vasopressinEquimolar concentrationsHuman plasmaImaging the brain’s immune response to alcohol with [11C]PBR28 TSPO Positron Emission Tomography
Raval N, Angarita G, Matuskey D, Miller R, Drake L, Kapinos M, Nabulsi N, Huang Y, Carson R, O’Malley S, Cosgrove K, Hillmer A. Imaging the brain’s immune response to alcohol with [11C]PBR28 TSPO Positron Emission Tomography. Molecular Psychiatry 2023, 28: 3384-3390. PMID: 37532797, PMCID: PMC10743097, DOI: 10.1038/s41380-023-02198-6.Peer-Reviewed Original ResearchConceptsVolume of distributionBlood alcohol levelsPositron emission tomographyBrain immune responseImmune responseAlcohol challengeEmission tomographyPeak blood alcohol levelsMultilinear analysis 1Peripheral immune functionVivo human evidenceLaboratory alcohol challengeTSPO positron emission tomographyBinge levelsPlasma cytokinesImmune dysfunctionNeuroimmune systemIL-6MCP-1Cytokines TNFAcute effectsScan dayArterial bloodHuman evidenceImmune functionImplications of Toll-like receptors (TLRs) and their signaling mechanisms in human cancers
Chandrasekar S, Palaniyandi T, Parthasarathy U, Surendran H, Viswanathan S, Wahab M, Baskar G, Natarajan S, Ranjan K. Implications of Toll-like receptors (TLRs) and their signaling mechanisms in human cancers. Pathology - Research And Practice 2023, 248: 154673. PMID: 37453359, DOI: 10.1016/j.prp.2023.154673.Peer-Reviewed Original ResearchToll-like receptorsActivation of TLRsHuman cancersEssential pattern recognition receptorsInnate immune functionNew therapeutic targetsPattern recognition receptorsControl of cancerTLRs 2Inflammatory responseInflammatory microenvironmentEffector functionsImmune functionTherapeutic targetHepatic cancerEpithelial markersCancerHuman lungMost cancersTLR genesReceptorsCancer biomarkersMajor mechanismGene expressionSuch deregulationThree-dimensional imaging of vascular development in the mouse epididymis.
Damon-Soubeyrand C, Bongiovanni A, Chorfa A, Goubely C, Pirot N, Pardanaud L, Piboin-Fragner L, Vachias C, Bravard S, Guiton R, Thomas J, Saez F, Kocer A, Tardivel M, Drevet J, Henry-Berger J. Three-dimensional imaging of vascular development in the mouse epididymis. ELife 2023, 12 PMID: 37310207, PMCID: PMC10264076, DOI: 10.7554/elife.82748.Peer-Reviewed Original ResearchConceptsProtection of spermatozoaComplex immune functionsAccessory tubulesVascular developmentMouse epididymisCellular levelSecretory roleImportant playersMale fertilityMale reproductive systemOrgan clearingMature adult miceReproductive systemTransgenic mouse modelFunctional maturationPeripheral toleranceBlood markersImmune responseLymphatic networkImmune functionKey determinantMouse modelSurvival of spermatozoaAdult miceImmune systemSodium perturbs mitochondrial respiration and induces dysfunctional Tregs
Côrte-Real B, Hamad I, Arroyo Hornero R, Geisberger S, Roels J, Van Zeebroeck L, Dyczko A, van Gisbergen M, Kurniawan H, Wagner A, Yosef N, Weiss S, Schmetterer K, Schröder A, Krampert L, Haase S, Bartolomaeus H, Hellings N, Saeys Y, Dubois L, Brenner D, Kempa S, Hafler D, Stegbauer J, Linker R, Jantsch J, Müller D, Kleinewietfeld M. Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs. Cell Metabolism 2023, 35: 299-315.e8. PMID: 36754020, DOI: 10.1016/j.cmet.2023.01.009.Peer-Reviewed Original ResearchConceptsHuman TregsPro-inflammatory featuresLong-term dysfunctionPro-inflammatory signatureMetabolic reprogrammingLong-term functionDysfunctional TregsFoxp3 downregulationPeripheral toleranceMitochondrial respirationMetabolic disturbancesTregsImmune functionAutoimmunityMetabolic fitnessIntracellular NaMitochondrial NaHigh saltMitochondrial metabolismElectron transport chainTranscriptional changesFoxp3DysfunctionBlockade
2022
Implication of IL-7 receptor alpha chain expression by CD8+ T cells and its signature in defining biomarkers in aging
Shin M, Park H, Young J, Kang I. Implication of IL-7 receptor alpha chain expression by CD8+ T cells and its signature in defining biomarkers in aging. Immunity & Ageing 2022, 19: 66. PMID: 36544153, PMCID: PMC9768896, DOI: 10.1186/s12979-022-00324-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsT cellsImmune agingHost defenseIL-7 receptor alpha chainFrequencies of naïveT cell subsetsAlpha chain expressionAssociation of CD8Age-associated conditionsReceptor alpha chainMemory CD8Treatment of illnessCell subsetsInflammatory disordersIL-7RαCD8High riskImmune functionTherapeutic interventionsImmune systemPotential biomarkersGene signatureChain expressionOlder adultsBiomarkersIsotope tracing reveals distinct substrate preference in murine melanoma subtypes with differing anti-tumor immunity
Zhang X, Halberstam A, Zhu W, Leitner B, Thakral D, Bosenberg M, Perry R. Isotope tracing reveals distinct substrate preference in murine melanoma subtypes with differing anti-tumor immunity. Cancer & Metabolism 2022, 10: 21. PMID: 36457136, PMCID: PMC9714036, DOI: 10.1186/s40170-022-00296-7.Peer-Reviewed Original ResearchTumor microenvironmentAnti-tumor immunityPotential prognostic factorsObesity-associated cancersPotential prognostic predictorPatient RNA-seq dataSubset of studiesImmunogenic tumorsCancer Genome AtlasLymphocyte infiltrationMelanoma cell linesPrognostic factorsPrognostic predictorMetabolic therapyMelanoma subtypesMurine modelImmune functionMetabolic gene expressionMelanoma progressionMelanomaSubstrate metabolismMetabolic flux studiesGene expressionGenome AtlasCell linesEvolving concepts of host–pathobiont interactions in autoimmunity
Pereira M, Kriegel M. Evolving concepts of host–pathobiont interactions in autoimmunity. Current Opinion In Immunology 2022, 80: 102265. PMID: 36444784, DOI: 10.1016/j.coi.2022.102265.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAutoimmune diseasesSecondary lymphoid tissuesUnconventional therapeutic approachesAutoimmune pathwaysMucosal sitesLymphoid tissueMultistep pathogenesisTherapeutic approachesImmune functionMultifactorial diseaseDiseasePathobiontsSecretion of metabolitesNon-gut tissuesHuman microbiomeTissueAutoimmunityAutoantigensPathogenesisEnvironmental factorsSecretionSingle-cell RNA-seq uncovers cellular heterogeneity and provides a signature for paediatric sleep apnoea.
Cortese R, Adams T, Cataldo K, Hummel J, Kaminski N, Kheirandish-Gozal L, Gozal D. Single-cell RNA-seq uncovers cellular heterogeneity and provides a signature for paediatric sleep apnoea. European Respiratory Journal 2022, 61: 2201465. PMID: 36356973, DOI: 10.1183/13993003.01465-2022.Peer-Reviewed Original ResearchConceptsObstructive sleep apnoeaSleep apnoeaImpact of OSASystemic immune functionMononuclear cell compositionMolecular signaturesCell-specific markersSystemic inflammationCardiovascular dysfunctionImmune cellsImmune functionSingle-cell transcriptomic analysisPaediatric sleep apnoeaUndescribed cell typePrevalent diseaseMajor causeCellular compositionApnoeaCell compositionRNA expression datasetsDiagnostic settingCell typesCell lineagesMolecular diagnostic settingScRNA-seqInsomnia symptoms and risk of bloodstream infections: prospective data from the prospective population‐based Nord‐Trøndelag Health Study (HUNT), Norway
Thorkildsen MS, Laugsand LE, Nilsen TIL, Mohus RM, Høvik LH, Rogne T, Solligård E, Damås JK, Gustad LT. Insomnia symptoms and risk of bloodstream infections: prospective data from the prospective population‐based Nord‐Trøndelag Health Study (HUNT), Norway. Journal Of Sleep Research 2022, 32: e13696. PMID: 36068650, PMCID: PMC10078600, DOI: 10.1111/jsr.13696.Peer-Reviewed Original ResearchConceptsFirst-time bloodstream infectionNord-Trøndelag Health StudyHazard ratioBloodstream infectionsInsomnia symptomsProspective dataHealth StudyConfidence intervalsNorwegian Nord-Trøndelag Health StudyRisk of BSIPopulation-based prospective studyPopulation-based Nord-Trøndelag Health StudyFrequent insomnia symptomsNon-restorative sleepRisk of infectionCox regressionProspective studyAbove symptomsImmune functionSymptomsInfectionMortalitySleepRiskParticipants
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