2025
Association of clinical manifestations and immune alterations with genetic variants of uncertain significance in patients concerned for inborn errors of immunity
Novotny S, Yoo N, Chen J, Granoth M, Kohli-Pamnani A, Hsu F, Rodenas M, Steele R, Kaman K, Soffer G, Price C, Kuster J, Kang I, Osmani L, Shin J. Association of clinical manifestations and immune alterations with genetic variants of uncertain significance in patients concerned for inborn errors of immunity. Clinical Immunology 2025, 277: 110513. PMID: 40354868, DOI: 10.1016/j.clim.2025.110513.Peer-Reviewed Original ResearchInborn errors of immunityErrors of immunityGenetic variantsInborn errorsAssociation of clinical manifestationsGene clusterGene functionStudy evaluated associationsImmune alterationsDiagnostic challengeClinical manifestationsImmunological profileGenetic testingVUSGenesImmunological characteristicsImmune functionLaboratory dataImmunityVariantsAssociationPatientsCCL17 Influences Borrelia burgdorferi Infection in the Heart
Tang X, Yu Q, Cui Y, Hart T, Rivas-Giorgi F, Calloway K, Mohapatra A, Fikrig E. CCL17 Influences Borrelia burgdorferi Infection in the Heart. The Journal Of Infectious Diseases 2025, jiaf011. PMID: 39777514, DOI: 10.1093/infdis/jiaf011.Peer-Reviewed Original ResearchSerum levels of proinflammatory cytokinesLevels of proinflammatory cytokinesVector-borne pathogensB. burgdorferiReduce pathogen loadImmune alterationsMacrophage infiltrationProinflammatory cytokinesCCL17B. burgdorferi infectionIxodes ticksPathogen loadControl animalsChemokinesBorrelia burgdorferiInfectious diseasesInfectionDiverse illnessesKnockoutLyme diseaseDisease
2023
Mucosal immune alterations at the early onset of tissue destruction in chronic obstructive pulmonary disease
de Fays C, Geudens V, Gyselinck I, Kerckhof P, Vermaut A, Goos T, Vermant M, Beeckmans H, Kaes J, Van Slambrouck J, Mohamady Y, Willems L, Aversa L, Cortesi E, Hooft C, Aerts G, Aelbrecht C, Everaerts S, McDonough J, De Sadeleer L, Gohy S, Ambroise J, Janssens W, Ceulemans L, Van Raemdonck D, Vos R, Hackett T, Hogg J, Kaminski N, Gayan-Ramirez G, Pilette C, Vanaudenaerde B. Mucosal immune alterations at the early onset of tissue destruction in chronic obstructive pulmonary disease. Frontiers In Immunology 2023, 14: 1275845. PMID: 37915582, PMCID: PMC10616299, DOI: 10.3389/fimmu.2023.1275845.Peer-Reviewed Original ResearchConceptsCD8+ T cell accumulationT cell accumulationImmune alterationsTerminal bronchiolesTissue destructionCOPD lungsCD4+ T cellsMyeloid antigen-presenting cellsAntigen-presenting cellsSmall airway changesTissue destructive processesChronic airway inflammationInnate immune alterationsB cell activationMucosal immune defenseAdaptive immune responsesChronic obstructive pulmonary diseaseObstructive pulmonary diseaseIncreased mucus productionAlveolar surface densityAirway changesT cellsAirway inflammationImmune cellsB cells
2022
Alterations in high‐dimensional T‐cell profile and gene signature of immune aging in HIV‐infected older adults without viremia
Shin MS, Park H, Salahuddin S, Montgomery RR, Emu B, Shaw AC, Kang I. Alterations in high‐dimensional T‐cell profile and gene signature of immune aging in HIV‐infected older adults without viremia. Aging Cell 2022, 21: e13702. PMID: 36036630, PMCID: PMC9577958, DOI: 10.1111/acel.13702.Peer-Reviewed Original ResearchConceptsOlder human immunodeficiency virusPeripheral blood mononuclear cellsHuman immunodeficiency virusAntiretroviral therapyT cellsDetectable viremiaMemory CD8HIV infectionAge-associated immune alterationsYoung human immunodeficiency virusReplication-competent HIV-1Combination antiretroviral therapyEffector memory CD8T-cell countsSubset of CD4T cell profileBlood mononuclear cellsAgeing-associated genesEM CD8Immune alterationsMemory CD4Immune agingImmunodeficiency virusInflammatory moleculesMononuclear cells
2020
Immunological and Clinical Phenotyping in Primary Antibody Deficiencies: a Growing Disease Spectrum
Shin JJ, Liauw D, Siddiqui S, Lee J, Chung EJ, Steele R, Hsu FI, Price C, Kang I. Immunological and Clinical Phenotyping in Primary Antibody Deficiencies: a Growing Disease Spectrum. Journal Of Clinical Immunology 2020, 40: 592-601. PMID: 32239366, PMCID: PMC7260109, DOI: 10.1007/s10875-020-00773-y.Peer-Reviewed Original ResearchConceptsCommon variable immunodeficiencyInterstitial lung diseasePrimary antibody deficiencyConnective tissue diseaseAntibody deficiencyLow NK cell countHematopoietic malignanciesNon-infectious complicationsNon-infectious manifestationsNK cell countsNatural killer cellsPneumococcal vaccine responsesElectronic medical recordsResultsAll patientsImmune alterationsVaccine responsesKiller cellsTissue diseaseImmunoglobulin levelsVariable immunodeficiencyLung diseasePAD groupIgG deficiencyImmunological profileMedical records
2017
Brain Ischemia Suppresses Immunity in the Periphery and Brain via Different Neurogenic Innervations
Liu Q, Jin WN, Liu Y, Shi K, Sun H, Zhang F, Zhang C, Gonzales RJ, Sheth KN, La Cava A, Shi FD. Brain Ischemia Suppresses Immunity in the Periphery and Brain via Different Neurogenic Innervations. Immunity 2017, 46: 474-487. PMID: 28314594, DOI: 10.1016/j.immuni.2017.02.015.Peer-Reviewed Original ResearchConceptsPost-stroke infectionsBrain ischemiaMiddle cerebral artery occlusionCell-mediated immune defenseAdrenal axis leadsNK cell numbersCerebral artery occlusionNK cell responsesNK cell functionNatural killer cellsExpression of SOCS3Infectious complicationsArtery occlusionImmune alterationsIschemic strokeSplenic atrophyKiller cellsImmune functionCell responsesGenetic ablationIschemiaImmune defenseBrainCell functionInnervation
2014
Case Report
Magid-Bernstein J, Mahajan K, Lincoln J, Ming X, Rohowsky-Kochan C. Case Report. Journal Of Child Neurology 2014, 30: 386-390. PMID: 24736120, DOI: 10.1177/0883073814529821.Peer-Reviewed Original ResearchConceptsT cellsCytokine profileInterleukin-17T cell cytokine profilesT-cell abnormalitiesT regulatory (Treg) cellsGender-matched controlsImmune alterationsRegulatory cellsDifferent comorbiditiesMultiple sclerosisCase reportNeurodevelopmental disordersMonozygotic twinsComorbiditiesInterferonAutism spectrum disorderDisordersHigh percentageSpectrum disorderCells
2012
40. Antidepressant effects of macrophage migration inhibitory factor using a knockout mouse approach
Bay-Richter C, Janelidze S, Bucala R, Deierborg T, Brundin L. 40. Antidepressant effects of macrophage migration inhibitory factor using a knockout mouse approach. Brain Behavior And Immunity 2012, 26: s11-s12. DOI: 10.1016/j.bbi.2012.07.064.Peer-Reviewed Original ResearchSucrose preference testAntidepressant effectsIL-1βIL-6Male KOMacrophage migration inhibitory factorClear antidepressant effectMIF knockout miceLevels of IFNBrain mRNA expressionMigration inhibitory factorSuppression of IFNIL-6 mRNAIL-12p70Immune alterationsIL-10Female KOPlasma levelsSwim testKO miceSucrose preferenceDepressed patientsWildtype miceKO animalsWildtype littermatesEvidence for an association between tumor necrosis factor-alpha levels and lithium response
Guloksuz S, Altinbas K, Cetin E, Kenis G, Gazioglu S, Deniz G, Oral E, van Os J. Evidence for an association between tumor necrosis factor-alpha levels and lithium response. Journal Of Affective Disorders 2012, 143: 148-152. PMID: 22749155, DOI: 10.1016/j.jad.2012.04.044.Peer-Reviewed Original ResearchConceptsTNF-α levelsBipolar patientsLithium responsePartial responseTumor necrosis factor-alpha levelsBipolar disorderTreatment-resistant bipolar patientsNecrosis factor-alpha levelsRole of inflammationPotential pathophysiological mechanismsAdditional inflammatory markersAssessment of responseGood responseEnzyme-linked immunosorbentEuthymic bipolar patientsImmune imbalanceImmune alterationsInflammatory markersImmune changesPathophysiological mechanismsPotential confoundersLithium therapyNatural coursePoor responseTreatment response
1973
Immune Alterations in Hodgkin's Disease: Effect of Delayed Hypersensitivity and Lymphocyte Transformation on Course and Survival
Young R, Corder M, Berard C, DeVita V. Immune Alterations in Hodgkin's Disease: Effect of Delayed Hypersensitivity and Lymphocyte Transformation on Course and Survival. JAMA Internal Medicine 1973, 131: 446-454. DOI: 10.1001/archinte.1973.00320090136016.Peer-Reviewed Original ResearchHodgkin's diseaseLymphocyte transformationDelayed hypersensitivityFrequency of relapsesSkin test reactivityFive-year followSkin test antigensPeripheral leukocyte culturesRemission durationUntreated patientsImmune alterationsHistologic typeSkin testSystemic symptomsTest reactivityTest antigenLeukocyte culturesDiseaseHypersensitivitySurvivalDinitrochlorobenzeneCourseRelapseMumpsPatientsImmune alterations in Hodgkin's disease. Effect of delayed hypersensitivity and lymphocyte transformation on course and survival.
Young R, Corder M, Berard C, DeVita V. Immune alterations in Hodgkin's disease. Effect of delayed hypersensitivity and lymphocyte transformation on course and survival. JAMA Internal Medicine 1973, 131: 446-54. PMID: 4574227, DOI: 10.1001/archinte.131.3.446.Peer-Reviewed Original Research
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply