2025
16 Metabolic Syndrome and Obesity
Alonso W, Canapari C. 16 Metabolic Syndrome and Obesity. 2025, 175-184. DOI: 10.1016/b978-0-323-75566-5.00016-2.Peer-Reviewed Original ResearchMetabolic syndromeComponents of metabolic syndromeInvolvement of adipocytokinesSleep-disordered breathingIncreased sympathetic activityElevated blood pressureCardiovascular risk factorsRates of obesityIntermittent hypoxemiaTruncal obesityDysregulation of glucose metabolismSleep fragmentationSympathetic activityBlood pressureSleep curtailmentRisk factorsSyndromeObesityShort sleepGlucose metabolismCircadian factorsSleepHypoxemiaDyslipidemiaAdipocytokines
2024
Shock prediction with dipeptidyl peptidase-3 and renin (SPiDeR) in hypoxemic patients with COVID-19
Busse L, Teixeira J, Schaich C, Lohuis C, Nielsen N, Sturek J, Merck L, Self W, Puskarich M, Khan A, Semler M, Moskowitz A, Hager D, Duggal A, Rice T, Ginde A, Tiffany B, Iovine N, Chen P, Safdar B, Gibbs K, Javaheri A, de Wit M, Harkins M, Joly M, Collins S, Investigators F. Shock prediction with dipeptidyl peptidase-3 and renin (SPiDeR) in hypoxemic patients with COVID-19. Journal Of Critical Care 2024, 85: 154950. PMID: 39546997, PMCID: PMC11697573, DOI: 10.1016/j.jcrc.2024.154950.Peer-Reviewed Original ResearchRenin levelsVasopressor initiationAssociated with organ dysfunctionHigher 28-day mortalityVasopressor-free daysAssociated with increased riskBaseline plasma levelsAt-risk patientsOnset of shockAccelerating COVID-19 Therapeutic InterventionsVasopressor requirementsHypoxemic patientsAcute hypoxemiaOrgan dysfunctionBaseline hypotensionOdds ratioHypotensive eventsReninPlasma samplesPatientsTherapeutic interventionsHypoxemiaMortalityPlatform trialsBaselineThe Critical Challenge of Neonatal Airway Management: An Overview
Johnston L, Sawyer T. The Critical Challenge of Neonatal Airway Management: An Overview. 2024, 3-10. DOI: 10.1007/978-3-031-71946-2_1.Peer-Reviewed Original ResearchNeonatal airway managementAirway managementNeonatal intensive care unitAirway management techniquesIntensive care unitLaryngeal mask airwayAirway management proceduresDelivery roomPatient managementCare unitVideo laryngoscopyAirwayNeonatesSystemic factorsHypoxemiaBradycardiaPatientsInfantsLaryngoscopyPremedication
2023
Intermittent Hypoxemia and Bronchopulmonary Dysplasia with Pulmonary Hypertension in Preterm Infants.
Gentle S, Travers C, Nakhmani A, Indic P, Carlo W, Ambalavanan N. Intermittent Hypoxemia and Bronchopulmonary Dysplasia with Pulmonary Hypertension in Preterm Infants. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 899-907. PMID: 36449386, PMCID: PMC10111996, DOI: 10.1164/rccm.202203-0580oc.Peer-Reviewed Original ResearchConceptsBronchopulmonary dysplasia-associated pulmonary hypertensionIntermittent hypoxemiaHypoxemic eventsReceiver operating characteristicPreterm infantsPulmonary hypertensionControl subjectsWeeks 6 daysExtremely preterm infantsWeeks 0 daysHigher risk of deathIdentification of infantsCase-control studyRisk of deathBronchopulmonary dysplasiaDesaturation frequencyEchocardiographic dataPostnatal dayBedside biomarkersIH eventsHigh riskInfantsHypoxemiaHypertensionLong durationSleep-related hypoventilation and hypoxemia due to neuromuscular and chest wall disorders
Mansour W, Thapa S, Hilbert J. Sleep-related hypoventilation and hypoxemia due to neuromuscular and chest wall disorders. 2023, 201-213. DOI: 10.1016/b978-0-12-822963-7.00238-3.Peer-Reviewed Original ResearchSleep-disordered breathingSleep-related hypoventilationChest wall disordersNoninvasive positive pressure ventilationDiurnal respiratory failureRestrictive thoracic disordersFirst-line therapyPositive pressure ventilationRespiratory failureLine therapyRespiratory insufficiencyClinical presentationPressure ventilationSleep apneaThoracic disordersNormal sleepNeuromuscular diseaseHypoventilationSpecific disordersBreathingDisordersHypoxemiaTherapyVentilationApnea
2022
The Association of Teamwork and Adverse Tracheal Intubation–Associated Events in Advanced Airway Management in the PICU
Jennings J, Nett S, Umoren R, Murray R, Kessel A, Napolitano N, Adu-Darko M, Biagas K, Jung P, Spear D, Parsons S, Breuer R, Meyer K, Malone M, Shenoi A, Lee A, Mallory P, Al-Subu A, Tarquinio K, Glater L, Toal M, Lee J, Pinto M, Polikoff L, Own E, Toedt-Pingel I, Kasagi M, Ducharme-Crevier L, Motomura M, Gima M, Kelly S, Panisello J, Nuthall G, Gladen K, Shults J, Nadkarni V, Nishisaki A, Network F. The Association of Teamwork and Adverse Tracheal Intubation–Associated Events in Advanced Airway Management in the PICU. Journal Of Pediatric Intensive Care 2022 DOI: 10.1055/s-0042-1756715.Peer-Reviewed Original ResearchTracheal intubationTeamwork scoresPoor teamworkNational Emergency Airway RegistryPediatric intensive care unitAdverse tracheal intubationNeuromuscular blockade usePeri-intubation hypoxemiaIntensive care unitAdvanced airway managementHigh-risk procedureAirway RegistryHigher occurrenceCare unitAirway managementNeuromuscular blockadeIll childrenRetrospective analysisHigher oddsProvider typeTeamwork assessment toolsHypoxemiaIntubationTeamwork ratingsScoresAssociation of obstructive sleep apnea and nocturnal hypoxemia with all-cancer incidence and mortality: a systematic review and meta-analysis.
Tan B, Teo Y, Tan N, Yap D, Sundar R, Lee C, See A, Toh S. Association of obstructive sleep apnea and nocturnal hypoxemia with all-cancer incidence and mortality: a systematic review and meta-analysis. Journal Of Clinical Sleep Medicine 2022, 18: 1427-1440. PMID: 34755597, PMCID: PMC9059590, DOI: 10.5664/jcsm.9772.Peer-Reviewed Original ResearchConceptsAssociation of obstructive sleep apneaObstructive sleep apneaAll-cancer riskAll-cancer incidenceSevere nocturnal hypoxemiaNocturnal hypoxemiaSleep apneaAll-cancer mortalityModerate obstructive sleep apneaNo/mild OSASevere obstructive sleep apneaObstructive sleep apnea diagnosisObstructive sleep apnea treatmentOxygen desaturation indexMeta-analysisNewcastle-Ottawa ScaleSystematic reviewRandom-effects meta-analysesQuality of evidenceArousal indexDesaturation indexNormoxemic patientsRandomized studyHypoxemiaEvaluated study biasProlonged Unconsciousness is Common in COVID‐19 and Associated with Hypoxemia
Waldrop G, Safavynia S, Barra M, Agarwal S, Berlin D, Boehme A, Brodie D, Choi J, Doyle K, Fins J, Ganglberger W, Hoffman K, Mittel A, Roh D, Mukerji S, Der Nigoghossian C, Park S, Schenck E, Salazar‐Schicchi J, Shen Q, Sholle E, Velazquez A, Walline M, Westover M, Brown E, Victor J, Edlow B, Schiff N, Claassen J. Prolonged Unconsciousness is Common in COVID‐19 and Associated with Hypoxemia. Annals Of Neurology 2022, 91: 740-755. PMID: 35254675, PMCID: PMC9082460, DOI: 10.1002/ana.26342.Peer-Reviewed Original ResearchConceptsCessation of mechanical ventilationAssociated with hypoxemiaMedian timeMechanical ventilationAssociated with more severe hypoxemiaDays of hypoxemiaEvidence of structural brain injurySevere coronavirus disease 2019Cox proportional hazards modelsArterial partial pressure of oxygenImpairment of consciousnessSevere COVID-19Survivors of severe COVID-19Proportional hazards modelArterial partial pressureBrain injuryStructural brain injurySevere hypoxemiaCohort studyLife-sustaining therapyEndotracheal intubationHypoxemiaProlonged unconsciousnessPartial pressure of oxygenPatientsSelf-reported Race/Ethnicity and Intraoperative Occult Hypoxemia: A Retrospective Cohort Study
Burnett G, Stannard B, Wax D, Lin H, Pyram-Vincent C, DeMaria S, Levin M. Self-reported Race/Ethnicity and Intraoperative Occult Hypoxemia: A Retrospective Cohort Study. Anesthesiology 2022, 136: 688-696. PMID: 35231085, DOI: 10.1097/aln.0000000000004153.Peer-Reviewed Original ResearchConceptsOccult hypoxemiaSpO2 rangeWhite race/ethnicityArterial blood gasesArterial oxygen saturationMeasurement of arterial oxygen saturationHypoxemiaMultivariate analysisSelf-reported race/ethnicityHispanic race/ethnicityUnique patientsBlood gasesOxygen saturationPatientsSaO2 valuesPulse oximetryImpact of skin pigmentationSpO2 valuesSelf-reportNoninvasive measurementSkin pigmentationPrevalenceAnesthesiaRace/ethnicitySpO2Pulmonary Hypertension in Adults with Congenital Heart Disease
Goldstein S, Krasuski R. Pulmonary Hypertension in Adults with Congenital Heart Disease. Cardiology Clinics 2022, 40: 55-67. PMID: 34809917, DOI: 10.1016/j.ccl.2021.08.006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPAH-CHDPulmonary arterial hypertension related to congenital heart diseaseSystemic-to-pulmonary shuntAssociated with significant morbidityCongenital heart diseasePulmonary vascular resistancePulmonary vascular remodelingShunt reversalEisenmenger syndromePulmonary hypertensionCentral cyanosisPrimary management strategySignificant morbidityMedical therapySevere elevationVascular resistanceDefect closureSevere phenotypeVascular remodelingHeart diseasePathological processesShuntCyanosisAdultsHypoxemia
2021
Pulmonary Hypertension in Obstructive Sleep Apnea
Mohsenin V. Pulmonary Hypertension in Obstructive Sleep Apnea. 2021, 69-76. DOI: 10.1007/978-3-030-57942-5_6.Peer-Reviewed Original ResearchMean pulmonary artery pressurePulmonary hypertensionChronic obstructive pulmonary diseaseMild pulmonary arterial hypertensionPulmonary artery pressurePulmonary arterial hypertensionThird of patientsChronic lung diseaseObstructive pulmonary diseaseObstructive sleep apneaTreatment of OSADaytime hypoxemiaArterial hypertensionArtery pressureObesity hypoventilationHeart failurePulmonary diseaseSleep apneaLung diseaseHypertensionOSAPatientsDiseaseCurrent definitionHypoxemiaHypoventilation Associated with Scoliosis
Thapa S, Hilbert J. Hypoventilation Associated with Scoliosis. 2021, 153-163. DOI: 10.1007/978-3-030-57942-5_14.Peer-Reviewed Original ResearchNoninvasive positive pressure ventilationPolysomnographic findingsRapid eye movement (REM) sleepRestrictive ventilatory impairmentPositive pressure ventilationEye movement sleepVentilatory impairmentPressure ventilationDaytime fatigueMovement sleepEffective treatmentTreatment approachesHypoxemiaHypoventilationHypercapniaScoliosisSleepTreatmentGas exchangeHeadachePatientsCliniciansEpidemiologyFindingsImpairment
2020
Progressive Dyspnea and Hypoxemia With Diffuse Pulmonary Infiltrates in a Previously Healthy Woman
Mainardi AS, Siddon AJ, Bader AS, Hilbert J. Progressive Dyspnea and Hypoxemia With Diffuse Pulmonary Infiltrates in a Previously Healthy Woman. CHEST Journal 2020, 158: e327-e334. PMID: 33280778, DOI: 10.1016/j.chest.2020.07.009.Peer-Reviewed Case Reports and Technical NotesConceptsAdmission laboratory test resultsMonths of coughMild respiratory distressViolaceous maculesAcneiform rashProgressive dyspneaAxillary adenopathyNight sweatsHealthy womenNew feverRespiratory distressDiffuse pulmonaryPhysical examinationWBC countPlatelet levelsConjunctival edemaFurther managementOxygen saturationPulmonary cracklesLaboratory test resultsDyspneaRashWomenAdenopathyHypoxemiaA 62-Year-Old Woman With Lung Cancer, Ulcerating Rash, and Rapidly Progressive Hypoxemia
Kunitomo Y, Young G, Datta R, Korn LL, Tanoue L, Gautam S. A 62-Year-Old Woman With Lung Cancer, Ulcerating Rash, and Rapidly Progressive Hypoxemia. CHEST Journal 2020, 158: e191-e196. PMID: 33036118, PMCID: PMC7533682, DOI: 10.1016/j.chest.2020.06.020.Peer-Reviewed Case Reports and Technical Notes
2019
Oxygen Therapy and Pulmonary Hypertension in Preterm Infants
Gentle S, Abman S, Ambalavanan N. Oxygen Therapy and Pulmonary Hypertension in Preterm Infants. Clinics In Perinatology 2019, 46: 611-619. PMID: 31345551, DOI: 10.1016/j.clp.2019.05.009.Peer-Reviewed Original ResearchConceptsOxygen saturation targetsPulmonary hypertensionPreterm infantsSaturation targetsOxygen therapyHigher oxygen saturation targetsDevelopment of pulmonary hypertensionOptimal oxygen saturation targetsGoal of oxygen therapyEvaluating infantsCo-morbiditiesPretermHypertensionInfantsTherapyTrialsOutcomesNeOProMPrematurityHypoxemiaHyperoxemia
2018
Environmental or Nasal Cannula Supplemental Oxygen for Preterm Infants: A Randomized Cross-Over Trial
Travers C, Carlo W, Nakhmani A, Bhatia S, Gentle S, Amperayani V, Indic P, Aban I, Ambalavanan N. Environmental or Nasal Cannula Supplemental Oxygen for Preterm Infants: A Randomized Cross-Over Trial. The Journal Of Pediatrics 2018, 200: 98-103. PMID: 29705116, PMCID: PMC6109600, DOI: 10.1016/j.jpeds.2018.03.010.Peer-Reviewed Original ResearchConceptsEpisodes of intermittent hypoxemiaPreterm infantsNasal cannulaIntermittent hypoxemiaSupplemental oxygenRandomized cross-over trialCross-over trialGestational agePostnatal dayBirth weightPretermHypoxemiaDecreased episodesInfantsOxygen saturationCannulaHoursPatient monitoringPatientsBirthWeeksTrialsCase 1-2018: A 39-Year-Old Woman with Rapidly Progressive Respiratory Failure
Hibbert KA, Shepard JO, Lane RJ, Azar MM. Case 1-2018: A 39-Year-Old Woman with Rapidly Progressive Respiratory Failure. New England Journal Of Medicine 2018, 378: 182-190. PMID: 29320657, DOI: 10.1056/nejmcpc1712222.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAdenoviridaeAdenoviridae InfectionsAdultAntiviral AgentsCidofovirCytosineDiagnosis, DifferentialFemaleHumansImmunocompromised HostLeukemia, Myeloid, AcuteLungNasopharynxOpportunistic InfectionsOrganophosphonatesRadiography, ThoracicRenal InsufficiencyRespiratory InsufficiencyStem Cell TransplantationTomography, X-Ray ComputedViral Load
2017
Case 26-2017
Letourneau AR, Price MC, Azar MM. Case 26-2017. New England Journal Of Medicine 2017, 377: 770-778. PMID: 28834480, DOI: 10.1056/nejmcpc1616402.Peer-Reviewed Case Reports and Technical Notes
2014
Sleep in Patients with Restrictive Lung Disease
Won CH, Kryger M. Sleep in Patients with Restrictive Lung Disease. Clinics In Chest Medicine 2014, 35: 505-512. PMID: 25156766, DOI: 10.1016/j.ccm.2014.06.006.ChaptersConceptsRestrictive lung diseaseLung diseaseObesity hypoventilation syndromeInterstitial lung diseasePathophysiology of sleepImpact of treatmentOverall prognosisVentilatory defectHypoventilation syndromeImpaired ventilationDaytime fatigueSleep disruptionRelated symptomsSleep disordersSleep qualityDiffusion impairmentNeuromuscular diseaseDiseasePatientsPathophysiologySleepHypoxemiaHypercarbiaPrognosisDysfunction
2012
Anesthesia and Pulmonary Hypertension
McGlothlin D, Ivascu N, Heerdt PM. Anesthesia and Pulmonary Hypertension. Progress In Cardiovascular Diseases 2012, 55: 199-217. PMID: 23009916, DOI: 10.1016/j.pcad.2012.08.002.Peer-Reviewed Original ResearchConceptsPulmonary hypertensionNon-cardiothoracic surgeryThorough multidisciplinary planningOperative risk factorsRight ventricular failurePulmonary arterial hypertensionPreoperative risk assessmentCareful intraoperative managementArterial hypertensionPostoperative complicationsPostoperative hypoxemiaVentricular failureCardiac surgeryIntraoperative managementAnesthetic approachEarly recognitionMyocardial ischemiaRisk factorsMultidisciplinary planningHypertensionPatientsSurgerySuccessful managementAnesthesiaHypoxemia
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