2025
Acute inflammation induces acute megakaryopoiesis with impaired platelet production during fetal hematopoiesis.
Hu X, He Y, Li S, Jiang Y, Yu R, Wu Y, Fu X, Song Y, Lin C, Shi J, Li H, Gao Y. Acute inflammation induces acute megakaryopoiesis with impaired platelet production during fetal hematopoiesis. Development 2025, 152 PMID: 39817838, DOI: 10.1242/dev.204226.Peer-Reviewed Original ResearchFetal hematopoiesisMegakaryocyte-erythroid progenitorsAcute inflammationInterferon-stimulated genesDouble-stranded RNAMegakaryocyte maturationPlatelet productionImpaired platelet productionFormation of double-stranded RNADownstream interferon-stimulated genesCell fate determinationRNA m6A modificationPhosphorylation of STAT1Hematopoietic progenitorsMegakaryocyte progenitorsHematopoietic cellsM6A methyltransferase METTL3Hematopoietic developmentGene expression analysisImmune responseMegakaryopoiesisHematopoiesisInflammationFate determinationIGF1 expression
2024
The dynamics of hematopoiesis over the human lifespan
Li H, Côté P, Kuoch M, Ezike J, Frenis K, Afanassiev A, Greenstreet L, Tanaka-Yano M, Tarantino G, Zhang S, Whangbo J, Butty V, Moiso E, Falchetti M, Lu K, Connelly G, Morris V, Wang D, Chen A, Bianchi G, Daley G, Garg S, Liu D, Chou S, Regev A, Lummertz da Rocha E, Schiebinger G, Rowe R. The dynamics of hematopoiesis over the human lifespan. Nature Methods 2024, 22: 422-434. PMID: 39639169, PMCID: PMC11908799, DOI: 10.1038/s41592-024-02495-0.Peer-Reviewed Original ResearchConceptsHematopoietic stem cellsHematopoietic stemProgenitor cellsClassification of acute myeloid leukemiaDifferentiation of hematopoietic stem cellsAssociated with poor prognosisAcute myeloid leukemiaHuman hematopoietic stemWave of hematopoiesisGene expression networksMyeloid leukemiaPoor prognosisLineage outputMultilineage capacityDynamics of hematopoiesisCell ontogenyStem cellsLineage primingFate decisionsModel organismsTranscriptomic statesExpression networksHuman lifespanTranscriptional programsHematopoiesis395 Altered hematopoiesis and functional decline of hematopoietic stem cells in cystic fibrosis mice
Braga C, Mancuso R, Thompson E, Oez H, Gudneppannavar R, Zhang P, Huang P, Egan M, Murray T, Krause D, Bruscia E. 395 Altered hematopoiesis and functional decline of hematopoietic stem cells in cystic fibrosis mice. Journal Of Cystic Fibrosis 2024, 23: s207-s208. DOI: 10.1016/s1569-1993(24)01235-9.Peer-Reviewed Original Research
2023
Ten-Eleven-Translocation Genes in Cancer
Wang Y, Wang X, Lu J. Ten-Eleven-Translocation Genes in Cancer. Cancer Treatment And Research 2023, 190: 363-373. PMID: 38113007, DOI: 10.1007/978-3-031-45654-1_11.Peer-Reviewed Original ResearchConceptsTET mutationsTen-ElevenBiochemical functionsTranslocation (TET) familyTranslocation geneHematopoietic malignanciesHematopoietic expansionGenesHuman cancersMutationsCritical roleImmune responseTET2Clonal hematopoiesisSolid cancersEpigenomeTET1TET3RNABiologyUnanswered questionsDNAHematopoiesisCooperateTETsMassively parallel base editing to map variant effects in human hematopoiesis
Martin-Rufino J, Castano N, Pang M, Grody E, Joubran S, Caulier A, Wahlster L, Li T, Qiu X, Riera-Escandell A, Newby G, Al'Khafaji A, Chaudhary S, Black S, Weng C, Munson G, Liu D, Wlodarski M, Sims K, Oakley J, Fasano R, Xavier R, Lander E, Klein D, Sankaran V. Massively parallel base editing to map variant effects in human hematopoiesis. Cell 2023, 186: 2456-2474.e24. PMID: 37137305, PMCID: PMC10225359, DOI: 10.1016/j.cell.2023.03.035.Peer-Reviewed Original ResearchConceptsHuman hematopoiesisVariant effectsNon-coding variantsDisease-associated variantsSingle-cell genotypingHuman hematopoietic stemFetal hemoglobin expressionHigh-throughput variantGenome engineeringSequencing readoutHematopoietic differentiationFunctional screenHemoglobin expressionDifferentiation stateDefines mechanismsHematopoietic stemPrimary cellsGenetic variantsProgenitor cellsSpecific mutationsDiverse diseasesHuman physiologyRich phenotypingHematopoiesisImmunotherapy approachesSpectrum From Clonal Hematopoiesis to Myelodysplastic Neoplasm/Syndromes and Other Myeloid Neoplasms
Xie Z, Chen E, Mendez L, Komrokji R, Zeidan A. Spectrum From Clonal Hematopoiesis to Myelodysplastic Neoplasm/Syndromes and Other Myeloid Neoplasms. The Cancer Journal 2023, 29: 130-137. PMID: 37195768, DOI: 10.1097/ppo.0000000000000656.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsClonal hematopoiesisHigh-risk patientsRisk of progressionSuch patientsUndetermined significanceAge-related diseasesHematologic malignanciesClonal cytopeniaMyeloid neoplasmsHigh riskUnmet needMyeloid malignanciesNatural historyCH managementPatientsMalignancySignificant knowledge gapsRiskHematopoiesisCytopeniasNeoplasmsSyndrome
2022
CHIPing away the progression potential of CHIP: A new reality in the making
Xie Z, Zeidan AM. CHIPing away the progression potential of CHIP: A new reality in the making. Blood Reviews 2022, 58: 101001. PMID: 35989137, DOI: 10.1016/j.blre.2022.101001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsClonal hematopoiesisEffective preventive strategiesEvidence-based recommendationsClinical sequelaeInterventional trialsClinical outcomesClinical trialsPreventive strategiesInterventional strategiesProgression potentialClinical implicationsIndeterminate potentialTrialsMolecular mechanismsLatest updatesHematopoiesisUrgent needThe Coming of Age of Preclinical Models of MDS
Liu W, Teodorescu P, Halene S, Ghiaur G. The Coming of Age of Preclinical Models of MDS. Frontiers In Oncology 2022, 12: 815037. PMID: 35372085, PMCID: PMC8966105, DOI: 10.3389/fonc.2022.815037.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsTranscription factorsEpigenetic modifiersComplex molecular landscapeXenograft modelHematopoietic cellsDeletions/additionsMolecular landscapeRecurrent mutationsCell linesGenetic abnormalitiesMDS cellsXenograft murine modelChromosomal abnormalitiesCellsIneffective hematopoiesisTransgenicHematopoiesisMutationsPreclinical modelsWide spectrumMurine modelHeterogeneous groupLandscapeComing of age
2021
MRTFA: A critical protein in normal and malignant hematopoiesis and beyond
Reed F, Larsuel ST, Mayday MY, Scanlon V, Krause DS. MRTFA: A critical protein in normal and malignant hematopoiesis and beyond. Journal Of Biological Chemistry 2021, 296: 100543. PMID: 33722605, PMCID: PMC8079280, DOI: 10.1016/j.jbc.2021.100543.Peer-Reviewed Original ResearchConceptsMalignant hematopoiesisActin cytoskeleton dynamicsCritical cellular functionsResponse factorSerum response factorTranscription factor ACellular rolesImmediate early genesProtein partnersTranscriptional regulationCytoskeleton dynamicsCellular functionsTranscriptional targetsTranscription factorsCytoskeletal proteinsCritical proteinsMRTFAEarly genesCell typesChromosomal translocationsHematopoietic cellsCell growthFactor AHematopoiesisMuscle cells
2019
From clonal hematopoiesis to myeloid leukemia and what happens in between: Will improved understanding lead to new therapeutic and preventive opportunities?
Bewersdorf JP, Ardasheva A, Podoltsev NA, Singh A, Biancon G, Halene S, Zeidan AM. From clonal hematopoiesis to myeloid leukemia and what happens in between: Will improved understanding lead to new therapeutic and preventive opportunities? Blood Reviews 2019, 37: 100587. PMID: 31400824, DOI: 10.1016/j.blre.2019.100587.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMyeloid neoplasmsClonal hematopoiesisTherapy-related myeloid neoplasmsAnnual progression rateHealthy elderly individualsGenetic testing resultsCardiovascular mortalityHematologic disordersMyeloid leukemiaClinical significanceProgression ratePremalignant stateElderly individualsDiagnostic criteriaPreventive opportunitiesSolid tumorsClinical settingNatural historyFurther studiesPatientsSomatic mutationsRiskHematopoiesisCurrent understandingICUs
2018
Concise Review: Bipotent Megakaryocytic-Erythroid Progenitors: Concepts and Controversies
Xavier-Ferrucio J, Krause DS. Concise Review: Bipotent Megakaryocytic-Erythroid Progenitors: Concepts and Controversies. Stem Cells 2018, 36: 1138-1145. PMID: 29658164, PMCID: PMC6105498, DOI: 10.1002/stem.2834.Peer-Reviewed Original ResearchConceptsMegakaryocytic-erythroid progenitorsProgenitor cellsDifferent functional outputsVariety of speciesProgenitor stageIntermediate progenitor stageErythroid cellsHuman hematopoiesisBlood formationMegakaryocytic lineageMurine cellsHematopoietic stemHematopoietic progenitorsFunctional outputStem cellsDifferentiation capabilityHematopoiesis processProgenitorsLineagesHematopoiesisCell sourceCellsDiscrete stepsRecent advancesSpecies
2017
Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders
Puleo DE, Kucera K, Hammarén H, Ungureanu D, Newton AS, Silvennoinen O, Jorgensen WL, Schlessinger J. Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders. ACS Medicinal Chemistry Letters 2017, 8: 618-621. PMID: 28626521, PMCID: PMC5467198, DOI: 10.1021/acsmedchemlett.7b00153.Peer-Reviewed Original ResearchSmall molecule bindersJAK2 pseudokinase domainKinase foldTyrosine kinase domainNovel pharmacological opportunitiesPseudokinase domainKinase domainJAK-STATJAK2 proteinTop hitsMicromolar affinityPharmacological opportunitiesHyperactivation stateProteinATPJH2JAK2 V617FRecent evidencePseudokinaseMutantsJAKDomainHematopoiesisPathwayStructural approachPulmonary extra‐medullary hematopoiesis and pulmonary hypertension from underlying polycythemia vera: a case series
Singh I, Mikita G, Green D, Risquez C, Sanders A. Pulmonary extra‐medullary hematopoiesis and pulmonary hypertension from underlying polycythemia vera: a case series. Pulmonary Circulation 2017, 7: 261-267. PMID: 28680586, PMCID: PMC5448544, DOI: 10.1177/2045893217702064.Peer-Reviewed Original ResearchExtra-medullary hematopoiesisPulmonary hypertensionPolycythemia veraCase seriesJanus kinase 2 mutationRecent clinical classificationKinase 2 mutationRadiological featuresRare complicationHematopoietic precursor cellsClinical classificationIdiopathic myelofibrosisEssential thrombocytosisMyeloproliferative neoplasiaMyeloid phenotypeHeterogeneous groupPrecursor cellsHypertensionGroup fiveDisordersMyelofibrosisVeraHematopoiesisPrimary expressionComplications
2015
Neural Regulation of Hematopoiesis, Inflammation, and Cancer
Hanoun M, Maryanovich M, Arnal-Estapé A, Frenette P. Neural Regulation of Hematopoiesis, Inflammation, and Cancer. Neuron 2015, 86: 360-373. PMID: 25905810, PMCID: PMC4416657, DOI: 10.1016/j.neuron.2015.01.026.Peer-Reviewed Original ResearchConceptsAutonomic nervous systemStem cell niche homeostasisRegulation of hematopoiesisStromal constituentsHematopoietic homeostasisHematopoietic systemTherapeutic strategiesInflammatory responseNiche homeostasisCancer cellsNeural regulationFlight-or-fight responsePeripheral innervationNervous systemCancerNeural circuitryRegulate cell behaviorInflammationHomeostasisCell behaviorHematopoiesisInnervationResponseMicroenvironment
2013
An Extensive Network of TET2-Targeting MicroRNAs Regulates Malignant Hematopoiesis
Cheng J, Guo S, Chen S, Mastriano SJ, Liu C, D’Alessio A, Hysolli E, Guo Y, Yao H, Megyola CM, Li D, Liu J, Pan W, Roden CA, Zhou XL, Heydari K, Chen J, Park IH, Ding Y, Zhang Y, Lu J. An Extensive Network of TET2-Targeting MicroRNAs Regulates Malignant Hematopoiesis. Cell Reports 2013, 5: 471-481. PMID: 24120864, PMCID: PMC3834864, DOI: 10.1016/j.celrep.2013.08.050.Peer-Reviewed Original ResearchConceptsKey tumor suppressorMyeloid differentiation biasTET2 expressionTranslocation 2 (TET2) geneMolecular regulationDifferentiation biasHematopoietic malignanciesTen-ElevenMalignant hematopoiesisTumor suppressorHematopoietic expansionActivity screenMiR-7MiRNAsExpression of TET2Normal hematopoiesisOncogenic potentialTET2Important pathogenic mechanismMiR-101Extensive roleMiR-29cHematopoiesisExpressionRegulationPiwi Genes Are Dispensable for Normal Hematopoiesis in Mice
Nolde MJ, Cheng EC, Guo S, Lin H. Piwi Genes Are Dispensable for Normal Hematopoiesis in Mice. PLOS ONE 2013, 8: e71950. PMID: 24058407, PMCID: PMC3751959, DOI: 10.1371/journal.pone.0071950.Peer-Reviewed Original ResearchConceptsPiwi genesHematopoietic stem cellsNormal adult hematopoiesisPIWI protein familyStem cellsStem/progenitor cellsDiverse organismsAdult hematopoiesisProtein familyLong-term hematopoiesisMyeloablative stressCompetitive transplantationTransient expressionHuman leukemia cell linesHSC compartmentLeukemia cell linesGenesProliferative stateNormal hematopoiesisCell typesMIWI2Progenitor cellsLineage reconstitutionHematopoiesisCell proliferation
2012
Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells
MacLean GA, Menne TF, Guo G, Sanchez DJ, Park IH, Daley GQ, Orkin SH. Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 17567-17572. PMID: 23045682, PMCID: PMC3491455, DOI: 10.1073/pnas.1215468109.Peer-Reviewed Original ResearchConceptsHuman embryonic stemPluripotent cellsHuman pluripotent cellsFetal liver stageEffects of trisomyPluripotent stem cellsDefinitive hematopoiesisIsogenic originColony-forming potentialColony-forming assaysΓ-globinEmbryonic stemIPS linesDifferentiation conditionsAltered hematopoiesisClonal variationHematopoietic cellsStem cellsHematopoiesisHematopoietic abnormalitiesChromosome 21Two- to fivefold increaseFetal liverTrisomic cellsMyeloid hematopoiesis
1998
Extramedullary hematopoiesis mimicking metastatic lung carcinoma
Hsu F, Filippa D, Castro-Malaspina H, Downey R. Extramedullary hematopoiesis mimicking metastatic lung carcinoma. The Annals Of Thoracic Surgery 1998, 66: 1411-1413. PMID: 9800847, DOI: 10.1016/s0003-4975(98)00785-1.Peer-Reviewed Case Reports and Technical NotesConceptsExtramedullary hematopoiesisPleural massLung carcinomaMetastatic lung carcinomaInoperable metastatic diseaseChronic myeloproliferative disordersCongenital hemolytic anemiaRight paravertebralMetastatic diseaseRare conditionHemolytic anemiaMyeloproliferative disordersBone marrowHematopoietic elementsPatientsCarcinomaHematopoiesisParavertebralBiopsyAnemiaNeoplasmsMarrowDiseaseCD34 expression by embryonic hematopoietic and endothelial cells does not require c-Myb.
Krause DS, Mucenski ML, Lawler AM, May WS. CD34 expression by embryonic hematopoietic and endothelial cells does not require c-Myb. Experimental Hematology 1998, 26: 1086-92. PMID: 9766450.Peer-Reviewed Original ResearchConceptsC-MybDevelopmental hematopoiesisES cellsPromoter activityHematopoietic cellsD3 embryonic stem cellsStage-specific mannerES cell differentiationEmbryonic stem cellsPrimitive hematopoietic cellsDefinitive hematopoiesisBone marrow stemCell surface glycoproteinBlood islandsEmbryoid bodiesEndothelial cellsTransient transfectionCell differentiationEmbryosStem cellsProgenitor cellsYolk sacHematopoiesisNonhematopoietic cellsCD34 expression
1997
Gotta find GATA a friend
Krause D, Perkins A. Gotta find GATA a friend. Nature Medicine 1997, 3: 960-961. PMID: 9288719, DOI: 10.1038/nm0997-960.Commentaries, Editorials and Letters
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