2025
Serum kynurenine metabolites and cytokine levels: diagnostic and predictive implications in acute manic episodes of bipolar disorder
Li W, Liu Z, Wang J, Wang X, Chen W, Li N, Huang J, Gou M, Zhang P, Liu R, Deng H, Yang K, Chen S, Xie T, Tian L, Yang F, Tian B, Li C, Li Y, Tan Y. Serum kynurenine metabolites and cytokine levels: diagnostic and predictive implications in acute manic episodes of bipolar disorder. Brain Behavior And Immunity 2025, 129: 485-493. PMID: 40578536, DOI: 10.1016/j.bbi.2025.06.033.Peer-Reviewed Original ResearchYoung Mania Rating ScaleKynurenine metabolitesHealthy controlsTreatment outcomesCytokine levelsKynurenine metabolite levelsManic episodes of bipolar disorderBipolar disorderAcute manic episodeMania Rating ScaleEpisodes of bipolar disorderWeeks of treatmentInterleukin (IL)-10Predicting treatment outcomePredictors of treatment outcomeManic symptom severitySerum cytokinesSerum levelsTreatment responseIL-4Diagnostic accuracyIL-10Cytokine systemManic episodesIL-8Phenotyping extracellular vesicles and their serotonin transporter cargo in major depressive disorder
Zadka Ł, Eggerstorfer B, Buzalewicz I, Vraka C, Rusak A, Godbersen G, Opalińska A, Unterholzner J, Ulatowska-Jarża A, Philippe C, Haczkiewicz-Leśniak K, Silberbauer L, Murgaš M, Nics L, Hahn A, Hacker M, Gomułkiewicz A, Rujescu D, Podhorska-Okołów M, Lanzenberger R, Gryglewski G. Phenotyping extracellular vesicles and their serotonin transporter cargo in major depressive disorder. Journal Of Affective Disorders 2025, 389: 119740. PMID: 40550277, DOI: 10.1016/j.jad.2025.119740.Peer-Reviewed Original ResearchSerotonin transporterDepressive disorderPresence of serotonin transporterAntidepressant treatment responseSerotonin transporter levelsMDD patientsNanoparticle tracking analysisMood disordersPsychiatric disordersMDDBinding potentialExtracellular vesiclesTreatment response predictionPositron emission tomographyTreatment responseDisordersHealthy controlsExosome markers CD63Blood-brain barrierEmission tomographyStudy intercellular communicationPrognostic valueConcentration of extracellular vesiclesPatient stratificationExosomal markersNetwork-wide aberrancies in neuronal activity during working memory in a large cohort of patients with mood disorders: associations with cognitive impairment and functional disability
Damgaard V, Schandorff J, Macoveanu J, Sankar A, Zarp J, Fisher P, Jørgensen M, Kessing L, Knudsen G, Frokjaer V, Miskowiak K. Network-wide aberrancies in neuronal activity during working memory in a large cohort of patients with mood disorders: associations with cognitive impairment and functional disability. Molecular Psychiatry 2025, 1-9. PMID: 40527901, DOI: 10.1038/s41380-025-03078-x.Peer-Reviewed Original ResearchCognitive control networkFunctional magnetic resonance imagingMood disordersCognitive performanceHypo-activityCross-sectional functional magnetic resonance imagingWorking memory n-back taskCognitive impairmentHyper-activityRight middle frontal gyrusLeft dorsolateral prefrontal cortexDaily functioningHealthy controlsDorsolateral prefrontal cortexFrontal medial cortexN-back taskMiddle frontal gyrusAssociated with cognitive impairmentAssociated with cognitionComprehensive neurocognitive testingAssessment of daily functionCognitive controlDMN abnormalitiesPrefrontal cortexFrontal gyrusCommon neural patterns of substance use disorder: a seed-based resting-state functional connectivity meta-analysis
Zhang X, Zhang H, Shao Y, Li Y, Zhang F, Zhang H. Common neural patterns of substance use disorder: a seed-based resting-state functional connectivity meta-analysis. Translational Psychiatry 2025, 15: 190. PMID: 40467551, PMCID: PMC12137653, DOI: 10.1038/s41398-025-03396-2.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexSuperior frontal gyrusMedian cingulate gyrusInferior frontal gyrusResting-state functional connectivityBrain reward circuitsReward circuitSUD patientsPrefrontal cortexFamily-wise errorFrontal gyrusUse disorderCortical-striatal-thalamic-cortical circuitWhole-brain rs-fMRI studiesReduced resting-state functional connectivityDorsal anterior cingulate cortexResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingHealthy controlsPatterns of substance use disordersAssociated with impulsivityStages of addictionSubstance use disordersRs-fMRI studiesBackgroundSubstance use disordersImproved detection of circulating tumor DNA in patients with leiomyosarcoma with fragment size restriction.
Ruzgar N, Klega K, Ricker C, Tanhaemami M, Shafer A, Reinke D, Siontis B, Schuetze S, Crompton B. Improved detection of circulating tumor DNA in patients with leiomyosarcoma with fragment size restriction. Journal Of Clinical Oncology 2025, 43: 3046-3046. DOI: 10.1200/jco.2025.43.16_suppl.3046.Peer-Reviewed Original ResearchCell-free DNADetection of ctDNADetection of circulating tumor DNACycles of chemotherapyShort fragmentsDetectable ctDNACtDNA detectionTumor DNAHealthy controlsWhole-genome sequencingCopy number alterationsDiagnosis of leiomyosarcomaCell-free DNA samplesLiquid biopsy assayFragments of cell-free DNASequence dataRestriction analysisCtDNA levelsLeiomyosarcoma samplesNon-tumor originAssociated with lower likelihoodDNA samplesPrognostic valueFragment lengthBiopsy assayCognitive–Emotional Impairments in Euthymic Bipolar Disorder—New Insights Into Emotion Regulation and Cognitive Control Deficits
Seelig E, Joormann J, Wolkenstein L. Cognitive–Emotional Impairments in Euthymic Bipolar Disorder—New Insights Into Emotion Regulation and Cognitive Control Deficits. Emotion 2025, 25: 1044-1059. PMID: 40402635, DOI: 10.1037/emo0001479.Peer-Reviewed Original ResearchBipolar disorderCognitive controlER strategiesCC deficitsStrategy useResponse to negative affectSelf-reported habitual useHabitual useDown-regulate positive emotionsHealthy controlsDeficient cognitive controlCognitive control deficitsER strategy useMaladaptive ER strategiesSpontaneous strategy useNo group differencesEuthymic patientsMood inductionER deficitsEmotion regulationNegative affectImpaired CCPositive affectControl deficitsCompetence deficitsBrain Age Disparities in Psychosis Across DSM Diagnoses and B-SNIP Biotypes
Promet L, Meda S, Alliey-Rodriguez N, Clementz B, Gershon E, Hill S, Ivleva E, Keedy S, Keshavan M, McDowell J, Parker D, Tamminga C, Pearlson G. Brain Age Disparities in Psychosis Across DSM Diagnoses and B-SNIP Biotypes. Schizophrenia Bulletin 2025, sbaf022. PMID: 40448350, DOI: 10.1093/schbul/sbaf022.Peer-Reviewed Original ResearchBrain age gapBipolar-Schizophrenia NetworkDSM diagnosesBrain agingPRS-SZComorbid disordersNon-psychotic first-degree relativesHealthy controlsAssociated with symptom severityPsychotic bipolar disorderSubtypes of psychosisStructural T1-weighted imagesBrain structural differencesPsychotropic medication useSchizoaffective disorderPsychosis probandsPsychotic disordersBipolar disorderPolygenic risk scoresSymptom severityFirst-degree relativesPsychosisAge gapDSMIntermediate phenotypesPrediction of longitudinal synaptic loss in Alzheimer's disease using tau PET and plasma biomarkers
Wang J, Huang Q, Chen X, You Z, He K, Mao X, Huang Y, Franzmeier N, Schöll M, Guo T, Zhao J, Guan Y, Ni R, Li B, Xie F. Prediction of longitudinal synaptic loss in Alzheimer's disease using tau PET and plasma biomarkers. Alzheimer's & Dementia 2025, 21: e70333. PMID: 40432308, PMCID: PMC12117192, DOI: 10.1002/alz.70333.Peer-Reviewed Original ResearchConceptsAssociated with longitudinal cognitive declineLongitudinal cognitive declineSynaptic lossCognitive declineSynapse lossPositron emission tomographyTau depositionTau positron emission tomographyTau burdenHealthy controlsAlzheimer's diseaseSynaptic densityMedial temporal lobePlasma glial fibrillary acidic proteinIncreased tau burdenPhosphorylated tau181Longitudinal changesCognitively impaired individualsAcidic proteinTau pathologyTemporal lobeAmyloid positron emission tomographyGlial fibrillary acidic proteinPlasma phosphorylated tau181CI groupChanges in the FXR-cistrome and alterations in bile acid physiology in Wilson disease
Wooton-Kee C, Yalamanchili H, Mohamed I, Hassan M, Setchell K, Rivas M, Coskun A, Putluri V, Putluri N, Jalal P, Schilsky M, Moore D. Changes in the FXR-cistrome and alterations in bile acid physiology in Wilson disease. Hepatology Communications 2025, 9: e0707. PMID: 40408300, PMCID: PMC12106221, DOI: 10.1097/hc9.0000000000000707.Peer-Reviewed Original ResearchConceptsWild-type miceFarnesoid X receptorWilson's diseaseNon-parenchymal cellsDistal intergenic regionsLiver bile acid concentrationWD patientsHealthy controlsMetabolic target genesFarnesoid X Receptor RegulationBile salt export pumpIntergenic regionFXR activationAutosomal recessive disorderBile acid homeostasisBile acid physiologyFarnesoid X receptor activationPromoter regionHomeostasis pathwaysBile acid metabolismDecreasing FXR activityTarget genesBile acid profilesMarker genesStress pathwaysSex differences in event-related potentials and their clinical predictive value in first-episode antipsychotic-naïve schizophrenia
Qin Q, Lu C, Li S, Liu N, Li Y, Li T, Dong Y, Wang X, Li S, Li J, Zhang X. Sex differences in event-related potentials and their clinical predictive value in first-episode antipsychotic-naïve schizophrenia. European Archives Of Psychiatry And Clinical Neuroscience 2025, 1-10. PMID: 40397181, DOI: 10.1007/s00406-025-02020-0.Peer-Reviewed Original ResearchPositive and Negative Syndrome ScaleHamilton Depression ScaleHamilton Anxiety ScaleReduced P3 amplitudeHamilton Anxiety Scale scoresEvent-related potentialsSex differencesP3 amplitudeP3a latencyHealthy controlsN1 amplitudeAntipsychotic-naive schizophreniaGeneral psychopathology scoreNegative Syndrome ScaleHamilton Depression Scale scoresAuditory oddball paradigmSyndrome ScaleCompare sex differencesProlonged latencyPsychopathology scoresP3 componentN100 amplitudeAnxiety ScaleOddball paradigmCognitive impairmentHippocampal and amygdala subfield volumes in obsessive–compulsive disorder by medication status
Ntwatwa Z, Lochner C, Roos A, Sevenoaks T, van Honk J, Batistuzzo M, Choi S, Hoexter M, Kim M, Kwon J, Mataix-Cols D, Menchón J, Miguel E, Nakamae T, Soriano-Mas C, Veltman D, Groenewold N, van den Heuvel O, Stein D, Ipser J. Hippocampal and amygdala subfield volumes in obsessive–compulsive disorder by medication status. Journal Of Psychiatry And Neuroscience 2025, 50: e170-e180. PMID: 40398928, PMCID: PMC12114122, DOI: 10.1503/jpn.230119.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSubfield volumesMedical statusSymptom severityNeuroimaging studies of obsessive-compulsive disorderObsessive-compulsive disorder symptom severityStudies of obsessive-compulsive disorderNeurobiology of obsessive-compulsive disorderHealthy controlsObsessive-compulsive disorder severityBrain volumetric alterationsPsychotropic medication useHippocampal dentate gyrusQuadratic effects of ageAssess between-group differencesComorbid anxietyUnmedicated peopleNeuroimaging studiesPsychotropic medicationsVolumetric findingsBetween-group differencesVolumetric alterationsHippocampal subfieldsAmygdalaBrain volumePlasma CHI3L1 associates with brain volume loss and glial activation in multiple sclerosis
Ahola V, Saraste M, Nylund M, Matilainen M, Luoma A, Vuorimaa A, Lehto J, Laaksonen S, Brockmann E, Kuhle J, Leppert D, Soukka T, Lamminmäki U, Airas L. Plasma CHI3L1 associates with brain volume loss and glial activation in multiple sclerosis. Journal Of Neurology Neurosurgery & Psychiatry 2025, jnnp-2025-336063. PMID: 40379482, DOI: 10.1136/jnnp-2025-336063.Peer-Reviewed Original ResearchDistribution volume ratioBrain volume lossHealthy controlsPositron emission tomographyPlasma CHI3L1Smoldering inflammationMultiple sclerosisGlial activationInnate immune cell activationAssociated with Expanded Disability Status ScaleImmune cell activationChitinase-3-like protein 1Expanded Disability Status ScaleAssociated with smaller brain volumesDisability Status ScaleCHI3L1 concentrationsIndependent of relapsesVolume lossStudy cohortCell activationImaging outcomesTSPO-PETCHI3L1Emission tomographyStatus ScaleHigh rates of suicidality and parasuicidal behavior in individuals at clinical high-risk for psychosis: Implications for suicide risk assessment and suicide prevention
Trujillo T, Mirzakhanian H, Addington J, Bearden C, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Cadenhead K. High rates of suicidality and parasuicidal behavior in individuals at clinical high-risk for psychosis: Implications for suicide risk assessment and suicide prevention. Schizophrenia Research 2025, 281: 1-9. PMID: 40300257, DOI: 10.1016/j.schres.2025.04.030.Peer-Reviewed Original ResearchConceptsClinical high riskCalgary Depression Scale for SchizophreniaClinical high-risk youthSuicide risk assessmentParasuicidal behaviorSuicidal ideationLife eventsSelf-harmNorth American Prodrome Longitudinal StudyClinical high-risk participantsStructured Assessment of Violence RiskAssessment of Violence RiskClinical high-risk groupHealthy controlsRates of suicidal ideationHistory of self-harmHistory of SILevels of suicidalityStressful life eventsPredictors of SIRates of suicideAssociated with worse symptomsCHR participantsPsychotic conversionDSM diagnosesCerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum
Sritharan J, Zeng V, Petr J, Mutsaerts H, Hoang D, Bolo N, Ivleva E, Dai W, Gershon E, Keedy S, Parker D, Trotti R, McDowell J, Clementz B, Tamminga C, Pearlson G, Keshavan M, Lizano P. Cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum. Frontiers In Psychiatry 2025, 16: 1566184. PMID: 40365009, PMCID: PMC12069394, DOI: 10.3389/fpsyt.2025.1566184.Peer-Reviewed Original ResearchPsychosis spectrum disordersFusiform gyrusSchizoaffective disorderPseudo-continuous arterial spin-labeling scansCerebral blood flowOccipital lobeOverall cognitive performanceArterial spin labeling scansGray matter cerebral blood flowPsychosis spectrumBipolar disorderCognitive measuresCognitive performancePsychosisSpectrum disorderDiagnostic groupsPerfusion differencesVisual processingCognitive impairmentVisual hallucinationsCytoarchitectonic subregionsPerfusion alterationsLabeling scansSchizophreniaHealthy controlsCultural variables influence performance on the MATRICS Consensus Cognitive Battery among people at clinical high risk for psychosis
Guest R, Aberizk K, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Walker E. Cultural variables influence performance on the MATRICS Consensus Cognitive Battery among people at clinical high risk for psychosis. Schizophrenia Research 2025, 280: 60-68. PMID: 40250131, PMCID: PMC12169887, DOI: 10.1016/j.schres.2025.04.019.Peer-Reviewed Original ResearchConceptsMATRICS Consensus Cognitive BatteryConsensus Cognitive BatteryClinical high riskCognitive batteryCHR-PHopkins Verbal Learning Test-RevisedNorth American Prodrome Longitudinal StudyEnglish speakersHealthy controlsLetter-Number SpanPsychosis-Risk SyndromesMultigroup structural equation modelingInfluence cognitive performanceCultural variablesNative English speakersSample of peopleLetter-NumberNeuropsychological measuresVariables influencing performanceTest-RevisedCognitive performanceStructural equation modelingAnimal namesDiagnostic groupsCanadian sampleT cells of patients with systemic sclerosis or Sjögren’s disease display an aberrant metabolic state and memory phenotype in blood and lungs
Ehlers C, Biermann H, Thiele T, Schupp J, Villa M, Jänke C, Risser L, Witte T, Kalinke U, Seeliger B, Graalmann T. T cells of patients with systemic sclerosis or Sjögren’s disease display an aberrant metabolic state and memory phenotype in blood and lungs. Rheumatology 2025, keaf198. PMID: 40244816, DOI: 10.1093/rheumatology/keaf198.Peer-Reviewed Original ResearchInterstitial lung diseaseCD8+ T cellsT cells of patientsBronchoalveolar lavage of patientsSystemic sclerosisBronchoalveolar lavageT cellsSjogren's diseaseHealthy controlsBlood CD8+ T cellsBlood T cells of patientsLevels of HLA-DRIncreased expression of CD25Involvement of T cellsExpression of CD25Increased CD4+T cell responsesT cell receptor engagementLungs of patientsT cell characterizationExpressed increased levelsCell type 2Aberrant metabolic stateExpressed significant levelsSpectral flow cytometryDLG2 rs11607886 polymorphism associated with schizophrenia and precuneus functional changes
Zhu H, Wu Z, Wang J, Zhang E, Zhang S, Yang Y, Li W, Shi H, Yang G, Lv L, Zhang Y. DLG2 rs11607886 polymorphism associated with schizophrenia and precuneus functional changes. Schizophrenia Research 2025, 280: 50-58. PMID: 40220608, DOI: 10.1016/j.schres.2025.04.004.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingSZ patientsPrecuneus gyrusRight middle temporal gyrusHealthy controlsMiddle temporal gyrusIncreased risk of SZSevere mental disordersRisk of SZPathogenesis of SZAssociated with SZClinical symptom assessmentSignificant main effectLeft precuneus gyrusTemporal gyrusBrain regionsMental disordersSchizophreniaCognitive functionBrain functionSZ susceptibilityMain effectGyrusMagnetic resonance imagingSingle nucleotide polymorphismsSimplified methods for SERT occupancy estimation measured with [11C]DASB PET bolus plus infusion
Ponce de León M, Murgaš M, Silberbauer L, Hacker M, Gryglewski G, Hahn A, Lanzenberger R. Simplified methods for SERT occupancy estimation measured with [11C]DASB PET bolus plus infusion. NeuroImage 2025, 311: 121208. PMID: 40221064, DOI: 10.1016/j.neuroimage.2025.121208.Peer-Reviewed Original ResearchSerotonin transporterBolus plus constant infusionSerotonin transporter occupancyDepressive disorderBinding potentialBolus plus infusionReference regionCitalopramHealthy controlsArterial blood samplesPET/MRI scansPET scansOccupational valuesIntravenous applicationConstant infusionBlood samplesIn vivoAntidepressantsInfusionSaline solutionSerotoninHighest agreementDisordersRadioligandPlaceboDiurnal changes of salivary oxytocin in healthy and psychiatric adolescents
Gizuterman A, Zgoory-Sharon O, Avirame K, Mevorach T, Foul Y, Feldman R, Eitan R. Diurnal changes of salivary oxytocin in healthy and psychiatric adolescents. Journal Of Psychiatric Research 2025, 186: 273-279. PMID: 40267842, DOI: 10.1016/j.jpsychires.2025.04.007.Peer-Reviewed Original ResearchConceptsSalivary oxytocinMeasures of emotion regulationCompleted self-report questionnairesPsychiatric inpatient wardsSelf-report questionnairesMental health stateEmotion regulationPsychiatric adolescentsYouth mental healthPsychiatric assessmentOxytocin levelsInterpersonal relationshipsDiurnal rhythmMental healthPsychopathologyOxytocin productionHealthy controlsOxytocinDaily time pointsHealthy peersAdolescent patientsAdolescentsBaseline levelsConsecutive daysPatient groupSerum type I interferon score as a disease activity biomarker in patients with diffuse cutaneous systemic sclerosis: a retrospective cohort study
Hinchcliff M, Khanna D, De Lorenzis E, Di Donato S, Carriero A, Ross R, Huang S, Aren K, Bernstein E, Carns M, Castelino F, Domsic R, Frech T, Gordon J, Hant F, Shah A, Shanmugam V, Steen V, Assassi S, Del Galdo F. Serum type I interferon score as a disease activity biomarker in patients with diffuse cutaneous systemic sclerosis: a retrospective cohort study. The Lancet Rheumatology 2025, 7: e403-e414. PMID: 40179922, PMCID: PMC12107440, DOI: 10.1016/s2665-9913(24)00403-x.Peer-Reviewed Original ResearchConceptsDiffuse cutaneous systemic sclerosisCutaneous systemic sclerosisHealth Assessment Questionnaire-Disability IndexForced vital capacitySystemic sclerosisRetrospective cohort studyHealthy controlsIFN scoreIncident cohortDisease activityCohort studyModified Rodnan skin scoreCumulative 5-year mortalityEarly systemic sclerosisRodnan skin scoreSevere systemic sclerosisBaseline forced vital capacityMedian disease durationCohort of patientsDisease activity biomarkersHigh disease activityShorter median disease durationMinimal clinically important differenceKennedy Trust for Rheumatology ResearchConcentrations of CCL2
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply