2025
Carcinogenic Industrial Air Emissions and Lung Cancer Risk in a Cohort of 440,000 Americans.
Madrigal J, Fisher J, Pruitt C, Liao L, Graubard B, Ward M, Silverman D, Jones R. Carcinogenic Industrial Air Emissions and Lung Cancer Risk in a Cohort of 440,000 Americans. American Journal Of Respiratory And Critical Care Medicine 2025, 211: 1241-1252. PMID: 40315142, DOI: 10.1164/rccm.202409-1738oc.Peer-Reviewed Original ResearchConceptsLung cancer riskCancer riskAssociated with riskNIH-AARP DietEvaluate lung cancer riskLung carcinogensAssociated with lung cancerCox proportional hazards modelsNIH-AARPHealth StudyProportional hazards modelSquamous cell carcinomaStrong associationsAssociated with benzeneHazards modelIndustrial air emissionsEnrollment residenceCell carcinomaOverall riskLung cancer developmentSmokingAssociationRiskHistological subtypesLung cancerAPOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, de Havenon A, Hawkes M, Gilmore E, Schwamm L, Sheth K, Gill T, Falcone G. APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban. JAMA Neurology 2025, 82 PMID: 40549373, PMCID: PMC12186128, DOI: 10.1001/jamaneurol.2025.0182.Peer-Reviewed Original ResearchRisk of intracranial hemorrhagePopulation-based studyYears of follow-up dataApo E4Cox proportional hazards modelsAPOE e4 alleleIntracranial hemorrhageRisk prediction scoreCerebral amyloid angiopathyClinical decision-makingProportional hazards modelAtrial fibrillationIncreased risk of ICHMultivariate Cox proportional hazards modelMain OutcomesIncident intracranial hemorrhageEuropean ancestryCohort studyInclusion criteriaHistory of ischemic strokeAmyloid angiopathyE4 variantHazards modelIncreased riskE4 allele779-P: Cardiovascular Outcomes Associated with Dulaglutide, Exenatide, Liraglutide, and Semaglutide in Adults with Type 2 Diabetes at Moderate Cardiovascular Risk
SKLEPINSKI S, HERRIN J, SINDHU SWARNA K, NEUMILLER J, GALINDO R, UMPIERREZ G, ROSS J, DENG Y, POLLEY E, MARON B, MCCOY R. 779-P: Cardiovascular Outcomes Associated with Dulaglutide, Exenatide, Liraglutide, and Semaglutide in Adults with Type 2 Diabetes at Moderate Cardiovascular Risk. Diabetes 2025, 74 DOI: 10.2337/db25-779-p.Peer-Reviewed Original ResearchModerate CVD riskCVD riskType 2 diabetesCardiovascular diseaseAssociated with lower hazardRisk of cardiovascular outcomesCardiovascular disease outcomesCox proportional hazards modelsCardiovascular outcomesGlucagon-like peptide-1 receptor agonistsModerate cardiovascular riskCardiovascular risk reductionDigestive and Kidney DiseasesPeptide-1 receptor agonistsPropensity score inverse probabilityProportional hazards modelHazard of deathDepartment visitsNational Institute of DiabetesHazard of MACETrial emulationMedicare AdvantageMedicare plansComparative riskHazards modelEnhancing prognostic accuracy in lung cancer brain metastases through histopathologic feature integration and AI-based image analysis.
Breuer G, Sritharan D, Chadha S, Hager T, Fu D, Aneja S. Enhancing prognostic accuracy in lung cancer brain metastases through histopathologic feature integration and AI-based image analysis. Journal Of Clinical Oncology 2025, 43: e13608-e13608. DOI: 10.1200/jco.2025.43.16_suppl.e13608.Peer-Reviewed Original ResearchTumor-infiltrating lymphocytesCox proportional hazards modelsClinical featuresHistopathological featuresProportional hazards modelLung adenocarcinoma metastasisWhole slide imagesBrain metastasesAdenocarcinoma metastasisManagement of brain metastasesLung cancer brain metastasisBrain metastasis diagnosisCancer brain metastasesHazards modelEstimate overall survivalSystemic disease controlOverall survival estimatesGround-truth labelsAttention-based modelAttention-based networkMetastasis biopsiesSlide imagesNeural network-based modelOverall survivalAI-based image analysisManagement and Outcomes in Confirmed or Suspected Acute Symptomatic Seizure: Role of Structured Outpatient Care
Punia V, Byrnes M, Thompson N, Ayub N, Rubinos C, Zafar S, Sivaraju A, Ying Z, Fesler J, Hantus S, investigators P. Management and Outcomes in Confirmed or Suspected Acute Symptomatic Seizure: Role of Structured Outpatient Care. Annals Of Clinical And Translational Neurology 2025, 12: 1225-1239. PMID: 40244869, PMCID: PMC12172096, DOI: 10.1002/acn3.70039.Peer-Reviewed Original ResearchConceptsAcute symptomatic seizuresSymptomatic seizuresUnprovoked seizuresASyS patientsEpileptiform abnormalitiesMedian 14-month follow-upContinuous EEGRetrospective study of adultsCox proportional hazards modelsCause-specific Cox proportional hazards modelsProportional hazards modelRisk of unprovoked seizuresOutpatient EEGAlive patientsStudy of adultsOutpatient careSingle-centerRetrospective studyFollow-upPatientsCumulative incidence functionHazards modelSeizuresPost-discharge managementAbnormalitiesLong-term mortality from imaging-diagnosed pulmonary embolism in women and men
Sosner E, Mathai B, Bordon A, Ye K, Moadel R, Haramati L, Lazarus M. Long-term mortality from imaging-diagnosed pulmonary embolism in women and men. Clinical Imaging 2025, 122: 110469. PMID: 40273669, DOI: 10.1016/j.clinimag.2025.110469.Peer-Reviewed Original ResearchConceptsElectronic health recordsOne-year mortalityIncreased one-year mortalityCox proportional hazards modelsCharlson Comorbidity IndexProportional hazards modelLong-term mortalityUrban academic medical centerNational Death IndexMortality of womenHazards modelAcademic medical centerStudy of adultsHigher hazard ratioHealth recordsDeath IndexHealth statusInclusion of ageImpact of PEHazard ratioRetrospective study of adultsMedical CenterRisk factorsComorbidity indexPulmonary embolismAssociation of social relationships and genetic risk with frailty
Song W, Zhong W, Yan H, Li Z, Gao J, Wang X, Chen P, You F, Li C, Chen H, Xie J, Lv Y, Shi X, Mao C. Association of social relationships and genetic risk with frailty. American Journal Of Geriatric Psychiatry 2025 PMID: 40155233, DOI: 10.1016/j.jagp.2025.02.015.Peer-Reviewed Original ResearchPolygenic risk scoresFrailty riskGenetic riskMendelian randomizationOlder adultsChinese Longitudinal Healthy Longevity SurveyTwo-sample Mendelian randomizationAssociations of social relationshipsSocial relationshipsEffects of social relationshipsSocial activitiesCox proportional hazards modelsIncreased frailty riskLongevity SurveyHigh frailty riskProportional hazards modelUnfavorable relationshipSocial supportTwo-time pointsRisk scoreFrailtyHazards modelGenetic susceptibilityAdditive interactionSingle-nucleotidePrescribing methadone in prison predicts linkage to HIV care after release from prison: A randomized and patient preference trial
Mobley A, Wegman M, Bazazi A, Shenoi S, Bromberg D, Ahmad A, Kamarulzaman A, Altice F. Prescribing methadone in prison predicts linkage to HIV care after release from prison: A randomized and patient preference trial. International Journal Of Drug Policy 2025, 137: 104733. PMID: 39923270, PMCID: PMC11875876, DOI: 10.1016/j.drugpo.2025.104733.Peer-Reviewed Original ResearchConceptsLinkage to HIV careHIV careIncrease linkage to HIV careTreatment-as-prevention strategiesHIV treatment cascadeHIV treatment outcomesOpen-label trialCox proportional hazards modelsPatient preference trialOpioid use disorderMalaysia’s largest prison.Impact of methadoneProportional hazards modelTreatment cascadeInverse probability weighted Cox proportional hazards modelAnalytic sampleStudy participantsCareTreatment outcomesPrescribed methadoneOpioidConfounding variablesHIVUse disorderHazards modelUtilisation of nursing home care before and after the 2015 Dutch national reform: an interrupted time series analysis
Vroomen J, Wammes J, Wouterse B, Smalbrugge M, Murphy T. Utilisation of nursing home care before and after the 2015 Dutch national reform: an interrupted time series analysis. Age And Ageing 2025, 54: afaf018. PMID: 39902847, PMCID: PMC11791781, DOI: 10.1093/ageing/afaf018.Peer-Reviewed Original ResearchConceptsInterrupted time series analysisLong-term careNH admissionNursing homesOlder adultsAdmission ratesMortality riskAdmitted older adultsNursing home careIncreased mortality riskCox proportional hazards modelsAdmitted residentsAging-in-placePopulation-level studiesProportional hazards modelHome carePromote aging-in-placeStatistics NetherlandsTime series analysisHazards modelPopulation dataCareAdultsFollow-upAdmissionEvaluation of naturally occurring IgG anti-Vi antibody titers as predictors and correlates of typhoid fever in Dhaka, Bangladesh
Khanam F, Rickett N, Ahmmed F, Islam M, Mbae C, Im J, Aziz A, Ongadi B, Chowdhury F, Khan A, Akter A, Firoj M, Rahman S, Haile K, Park S, Mwebia M, Mwangi M, Ngugi B, Behute M, Kering K, Agampodi S, Kanungo S, Liu X, Pollard A, Zaman K, Kim D, Kariuki S, Qadri F, Clemens J. Evaluation of naturally occurring IgG anti-Vi antibody titers as predictors and correlates of typhoid fever in Dhaka, Bangladesh. BMC Infectious Diseases 2025, 25: 149. PMID: 39891051, PMCID: PMC11786536, DOI: 10.1186/s12879-025-10548-8.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntibodies, BacterialBangladeshChildChild, PreschoolCohort StudiesEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoglobulin GIncidenceInfantMaleMiddle AgedPolysaccharides, BacterialSalmonella typhiSeroepidemiologic StudiesTyphoid FeverTyphoid-Paratyphoid VaccinesYoung AdultConceptsAnti-Vi antibodiesTyphoid feverReceiver operating characteristicTyphoid riskIncidence of typhoid feverCulture-confirmed typhoid feverAntibody titersResultsThe ROC analysisCox proportional hazards modelsRisk of typhoidTyphoid infectionEnzyme-linked immunosorbent assayProportional hazards modelMethodsWe analyzed dataPresence of antibodiesTyphoidCohort studyTyphoid vaccineROC analysisAntibody levelsCrude analysisIncreased seroprevalenceFeverHazards modelNatural immunitySex-Specific Clinical and Genetic Factors Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy
Butters A, Arnott C, Sweeting J, Claggett B, Cuomo A, Abrams D, Ashley E, Day S, Helms A, Lampert R, Lin K, Michels M, Miller E, Olivotto I, Owens A, Parikh V, Pereira A, Rossano J, Ryan T, Saberi S, Stendahl J, Ware J, Atherton J, Semsarian C, Lakdawala N, Ho C, Ingles J. Sex-Specific Clinical and Genetic Factors Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy. Circulation Genomic And Precision Medicine 2025, 18: e004641. PMID: 39851041, DOI: 10.1161/circgen.124.004641.Peer-Reviewed Original ResearchConceptsRisk of heart failureSex-specific hazard ratiosHazard ratioHypertrophic cardiomyopathyAdverse outcomesHeart failureSex interaction termsFactors associated with adverse outcomesRisk of atrial fibrillationVentricular arrhythmiasCox proportional hazards modelsSarcomeric Human Cardiomyopathy RegistryManagement of hypertrophic cardiomyopathyProportional hazards modelInvestigate sex-related differencesSex differencesHeart failure riskRisk scoreHigher heart failureModerate riskHazards modelRisk factorsCardiomyopathy RegistryDeath riskImprove outcomesThe PRO‐AGE Tool and Its Association With Post Discharge Outcomes in Older Adults Admitted From the Emergency Department
Cohen I, Curiati P, Morinaga C, Han L, Gandhi T, Araujo K, Avelino‐Silva T, Bianco L, Brandt C, Capelli S, Carpenter C, Cruz D, Dresden S, Fishman I, Gipson K, Gray E, Hastings S, Hung W, Kang R, Lockhart M, Meeker D, Ohuabunwa U, Ottilie‐Kovelman S, Platts‐Mills T, Sandoval J, Sifnugel N, Taylor Z, Tomasino D, Vaughan C, Aliberti M, Hwang U. The PRO‐AGE Tool and Its Association With Post Discharge Outcomes in Older Adults Admitted From the Emergency Department. Journal Of The American Geriatrics Society 2025, 73: 1419-1428. PMID: 39843218, PMCID: PMC12101947, DOI: 10.1111/jgs.19374.Peer-Reviewed Original ResearchActivities of daily livingEmergency departmentFunctional declineActivities of daily living disabilityInstrumental activities of daily livingRisk scorePro-agingPatients admitted to hospitalPost-discharge outcomesUnited StatesInstrumental ADLRisk of deathProportional hazards modelDaily livingAssociated with mortalityCharlson comorbidity scoreOlder adultsDischarge outcomesDecline outcomesDiverse populationsMultiple hospitalsComorbidity scoreHazards modelOlder patientsMulticenter observational studyQuantitative Pupillometry Predicts Neurologic Deterioration in Patients with Large Middle Cerebral Artery Stroke
Du Y, Pohlmann J, Chatzidakis S, Brush B, Malinger L, Stafford R, Cervantes‐Arslanian A, Benjamin E, Gilmore E, Dupuis J, Greer D, Smirnakis S, Mohammed S, Ong C. Quantitative Pupillometry Predicts Neurologic Deterioration in Patients with Large Middle Cerebral Artery Stroke. Annals Of Neurology 2025, 97: 930-941. PMID: 39825740, PMCID: PMC12011534, DOI: 10.1002/ana.27178.Peer-Reviewed Original ResearchNeurological Pupil indexMiddle cerebral arteryQuantitative pupillometryNeurological deteriorationMiddle cerebral artery strokeDilation velocitySingle-center observational cohort studyAlberta Stroke Program Early CT ScoreCox proportional hazards modelsObservational cohort studyIntensive care unitProportional hazards modelCT scoreCohort studyYouden indexCerebral arteryCare unitHazards modelTukey testLinear mixed-effects modelsPatientsArtery strokeDilatationOptimal thresholdMixed-effects modelsAssociation of delayed asthma diagnosis with asthma exacerbations in children
Wi C, Ryu E, King K, Kwon J, Bublitz J, Park M, Chiarella S, Greenwood J, Pongdee T, Myers L, Nordlund B, Sohn S, Sagheb E, Kshatriya B, Watson D, Liu H, Sheares B, Davis C, Schulz W, Juhn Y. Association of delayed asthma diagnosis with asthma exacerbations in children. Journal Of Allergy And Clinical Immunology Global 2025, 4: 100409. PMID: 40008091, PMCID: PMC11851198, DOI: 10.1016/j.jacig.2025.100409.Peer-Reviewed Original ResearchElectronic health recordsDiagnosis of asthmaAsthma diagnosisAsthma exacerbationsRisk of AEPredetermined Asthma CriteriaDiagnosis of childhood asthmaChildhood asthma managementIncreased riskCox proportional hazards modelsIncreased risk of AECare qualityAsthma outcomesHealth recordsProportional hazards modelAsthma managementChildhood asthmaBirth cohortAsthma severityDiagnosis statusIndex dateIdentifying childrenPrimary outcomeNatural language processing algorithmsHazards modelTiming of depression in relation to risk of ovarian cancer
Roberts A, Townsend M, Chibnik L, Kubzansky L, Tworoger S. Timing of depression in relation to risk of ovarian cancer. Journal Of The National Cancer Institute 2025, 117: 989-996. PMID: 39745894, PMCID: PMC12058258, DOI: 10.1093/jnci/djae348.Peer-Reviewed Original ResearchRisk of ovarian cancerAssociation of depressionAscertainment periodIncident cancerAssociated with greater cancer riskAssociated with increased risk of ovarian cancerAssociated with elevated riskTime of depressionAssociated with increased riskP-value thresholdCox proportional hazards modelsCancer ascertainmentProportional hazards modelCancer riskTests of statistical significanceStatistical significanceExamined depressionOvarian cancerElevated riskProspective cohortBehavioral factorsAscertainmentHazards modelConsecutive two-year periodDepression
2024
Occurrence of Opioid-Related Neurocognitive Symptoms Associated With Long-term Opioid Therapy
León C, Sung M, Reisman J, Liu W, Kerns R, Gordon K, Mitra A, Kwon S, Yu H, Becker W, Li W. Occurrence of Opioid-Related Neurocognitive Symptoms Associated With Long-term Opioid Therapy. The Clinical Journal Of Pain 2024, 41: e1266. PMID: 39682036, PMCID: PMC11729567, DOI: 10.1097/ajp.0000000000001266.Peer-Reviewed Original ResearchLong-term opioid therapyElectronic health recordsIncidence rate ratiosOpioid-related harmsSubstance use disordersNeurocognitive symptomsHazard ratioPatients prescribed long-term opioid therapyVeterans Health AdministrationCalculated incidence ratesAssociated with increased likelihoodChronic obstructive pulmonary diseasePost-traumatic stress disorderHealth recordsProportional hazards modelRetrospective cohort studyObstructive pulmonary diseaseHealth AdministrationRate ratiosIncidence rateCohort studyTraumatic brain injuryClinical notesExtract dataHazards modelMigraine May Represent an Independent Risk Factor for Retinal Stroke: A Population-Based Cohort Study
Lusk J, Song A, Unnithan S, Al-Khalidi H, de Havenon A, Biousse V, Schrag M, Solopova E, Poli S, Osazuwa-Peters N, Xian Y, O'Brien E, Mac Grory B. Migraine May Represent an Independent Risk Factor for Retinal Stroke: A Population-Based Cohort Study. Clinical Neurology And Neurosurgery 2024, 246: 108587. PMID: 39405806, PMCID: PMC11527560, DOI: 10.1016/j.clineuro.2024.108587.Peer-Reviewed Original ResearchRetinal artery occlusionRetinal strokeRisk factorsCohort studyPopulation-based cohort studyState Emergency Department DatabasesPopulation-based dataEmergency Department DatabasesCause-specific hazard modelBurden of atrial fibrillationCongestive cardiac failureIndependent risk factorChronic kidney diseasePrimary exposureDepartment databasePrimary endpointSecondary endpointsCardiac failureAtrial fibrillationHazards modelRobust associationsArtery occlusionKidney diseaseMigraineDiagnostic positionsAssociation of health status and hospitalization risk for peripheral artery disease in the PORTRAIT registry
Cleman J, Romain G, Scierka L, Labrosciano C, Bradley B, Fitridge R, Beltrame J, Shishehbor M, Spertus J, Mena-Hurtado C, Smolderen K. Association of health status and hospitalization risk for peripheral artery disease in the PORTRAIT registry. Vascular Medicine 2024, 29: 664-674. PMID: 39319857, DOI: 10.1177/1358863x241274758.Peer-Reviewed Original ResearchPeripheral Artery QuestionnairePeripheral arterial diseaseED visitsHealth statusHospital admissionHealthcare utilizationPAD-specific health statusEmergency departmentCause-specific hospital admissionsAssociation of health statusPatient-reported outcome measuresPatient's risk of hospitalizationBaseline health statusAll-cause hospital admissionsCox proportional hazards modelsRisk of hospitalizationOverall summary scorePAQ scoresProportional hazards modelSummary scoreOutcome measuresHospitalization riskArtery diseaseVisitsHazards modelLeisure-time activities and disability among Chinese community-dwelling oldest old: evidence from the Chinese Longitudinal Healthy Longevity Study
Zhong W, Wang X, Liang F, Song W, Chen Z, Li Z, Shen Q, Shen D, Nan Y, Xiang J, Li C, Ye Z, Huang H, Wang J, Lv Y, Shi X, Mao C. Leisure-time activities and disability among Chinese community-dwelling oldest old: evidence from the Chinese Longitudinal Healthy Longevity Study. European Journal Of Public Health 2024, 34: 1177-1183. PMID: 39254527, PMCID: PMC11631485, DOI: 10.1093/eurpub/ckae129.Peer-Reviewed Original ResearchLeisure-time activitiesRisk of disabilityOlder adultsChinese Longitudinal Healthy Longevity StudyChinese Longitudinal Healthy Longevity SurveyActivities of daily livingChinese community-dwellingCox proportional hazards modelsPublic health problemLeisure-timeLongevity SurveyAcceleration of population agingCommunity-dwellingProportional hazards modelDaily livingPhysical performanceWatching TVHealth problemsFrequent engagementDaily activitiesAffecting disabilityDisabilityHazards modelPopulation agingLongevity StudyAssociation Between Exercise Program Participation and Hospitalization of Older Adults
Wright D, Zhou B, Wright C, Axtell R, Mangi A, Safdar B. Association Between Exercise Program Participation and Hospitalization of Older Adults. American Journal Of Preventive Medicine 2024, 68: 83-90. PMID: 39218409, DOI: 10.1016/j.amepre.2024.08.017.Peer-Reviewed Original ResearchExercise program participationNon-participantsPersonalized exercise programProgram participantsBaseline physical assessmentNational mortality databaseAssociated with decreased riskCox proportional hazards modelsExercise programAll-cause hospitalizationsMortality DatabaseProportional hazards modelRetrospective cohort studyExercise centersOlder AdultsPhysical assessmentHospital dataCohort studySustained participationDecreased hospitalizationBaseline measurementsHazards modelAssess sexMeasures of fitnessHospital
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