2025
Factors Associated With One-year Functional Decline After Elective Endovascular Abdominal Aortic Aneurysm Repair in Octogenarians
Li J, Bader J, Guzman R, Tonnessen B, Slade M, Gill T, Kuwayama D, Dardik A, Cardella J, Chaar C. Factors Associated With One-year Functional Decline After Elective Endovascular Abdominal Aortic Aneurysm Repair in Octogenarians. Journal Of Vascular Surgery 2025, 81: e138-e140. DOI: 10.1016/j.jvs.2025.03.277.Peer-Reviewed Original ResearchChanges in Lung Function and Mortality Risk in Patients With Idiopathic Pulmonary Fibrosis
Oldham J, Neely M, Wojdyla D, Gulati M, Li P, Patel D, Palmer S, Todd J, Investigators I. Changes in Lung Function and Mortality Risk in Patients With Idiopathic Pulmonary Fibrosis. CHEST Journal 2025 PMID: 40020995, DOI: 10.1016/j.chest.2025.02.018.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosisLung transplantationLung function declinePulmonary fibrosisAssociated with 1.8-foldProgressive fibrosing interstitial lung diseaseMedian follow-up timeFibrosing interstitial lung diseaseFollow-up timeInterstitial lung diseaseCox proportional hazards modelsRisk of deathFunctional declineRisk of mortalityProportional hazards modelAntifibrotic treatmentThreshold of declineAssociated with lung function declineOutcomes RegistryLung diseaseEnrolling centersDLCOSmoking statusDiffusing capacityLung functionThe PRO‐AGE Tool and Its Association With Post Discharge Outcomes in Older Adults Admitted From the Emergency Department
Cohen I, Curiati P, Morinaga C, Han L, Gandhi T, Araujo K, Avelino‐Silva T, Bianco L, Brandt C, Capelli S, Carpenter C, Cruz D, Dresden S, Fishman I, Gipson K, Gray E, Hastings S, Hung W, Kang R, Lockhart M, Meeker D, Ohuabunwa U, Ottilie‐Kovelman S, Platts‐Mills T, Sandoval J, Sifnugel N, Taylor Z, Tomasino D, Vaughan C, Aliberti M, Hwang U. The PRO‐AGE Tool and Its Association With Post Discharge Outcomes in Older Adults Admitted From the Emergency Department. Journal Of The American Geriatrics Society 2025, 73: 1419-1428. PMID: 39843218, PMCID: PMC12101947, DOI: 10.1111/jgs.19374.Peer-Reviewed Original ResearchActivities of daily livingEmergency departmentFunctional declineActivities of daily living disabilityInstrumental activities of daily livingRisk scorePro-agingPatients admitted to hospitalPost-discharge outcomesUnited StatesInstrumental ADLRisk of deathProportional hazards modelDaily livingAssociated with mortalityCharlson comorbidity scoreOlder adultsDischarge outcomesDecline outcomesDiverse populationsMultiple hospitalsComorbidity scoreHazards modelOlder patientsMulticenter observational study
2024
The Incidence and Impact of Cardiac Function Decline after Lower Extremity Revascularization
Jamil Y, Huttler J, Alameddine D, Wu Z, Mena-Hurtado C, Velazquez E, Guzman R, Ochoa Chaar C. The Incidence and Impact of Cardiac Function Decline after Lower Extremity Revascularization. Annals Of Vascular Surgery 2024, 110: 414-423. PMID: 39343374, DOI: 10.1016/j.avsg.2024.07.119.Peer-Reviewed Original ResearchCardiac functional declineStable cardiac functionLower extremity revascularizationPeripheral arterial diseaseCardiac functionFollow-upExtremity revascularizationFunctional declineElectronic records of patientsKaplan-Meier analysisRecords of patientsMode of revascularizationAdverse limb eventsLower-extremity revascularizationTransthoracic echocardiogramReintervention rateHeart failureDiabetes mellitusPeriprocedural bleedingPatient characteristicsArtery diseasePatientsLimb eventsIncreased mortalityRevascularizationPriority areas for outcomes improvement among older adults undergoing inpatient general surgery inclusive of geriatric‐pertinent complications
Kazaure H, Johnson K, Rosenthal R, Lagoo‐Deenadayalan S. Priority areas for outcomes improvement among older adults undergoing inpatient general surgery inclusive of geriatric‐pertinent complications. World Journal Of Surgery 2024, 48: 2646-2657. PMID: 39334312, DOI: 10.1002/wjs.12331.Peer-Reviewed Original ResearchFunctional declineInpatient general surgery proceduresMortality ratePostoperative functional declineWound-related complicationsThirty-day complicationsOutcome improvementGeneral surgery proceduresIndependent functional statusRescue rateSurgical morbidityComplication rateThirty-daySurgery outcomesProcedure groupOlder adultsSurgery proceduresComplicationsPressure ulcersInpatient surgeryPatientsFunctional statusMortalitySelf‐reported hearing loss is associated with faster cognitive and functional decline but not diagnostic conversion in the ADNI cohort
Miller A, Sharp E, Wang S, Zhao Y, Mecca A, van Dyck C, O'Dell R, Initiative F. Self‐reported hearing loss is associated with faster cognitive and functional decline but not diagnostic conversion in the ADNI cohort. Alzheimer's & Dementia 2024, 20: 7847-7858. PMID: 39324520, PMCID: PMC11567835, DOI: 10.1002/alz.14252.Peer-Reviewed Original ResearchSelf-reported hearing lossFunctional Activities QuestionnaireHearing lossMild cognitive impairmentModifiable risk factorsMild cognitive impairment participantsFunctional declineImpairment diagnosisModified Preclinical Alzheimer Cognitive CompositeRate of functional declineRate of cognitive declinePreclinical Alzheimer Cognitive CompositeRisk factorsCognitive impairmentSignificant longitudinal associationsActivity QuestionnaireLongitudinal associationsAlzheimer's Disease Neuroimaging InitiativeLongitudinal relationshipCognitive compositeCN participantsIncreased riskCognitive declineParticipantsDiagnostic conversion395 Altered hematopoiesis and functional decline of hematopoietic stem cells in cystic fibrosis mice
Braga C, Mancuso R, Thompson E, Oez H, Gudneppannavar R, Zhang P, Huang P, Egan M, Murray T, Krause D, Bruscia E. 395 Altered hematopoiesis and functional decline of hematopoietic stem cells in cystic fibrosis mice. Journal Of Cystic Fibrosis 2024, 23: s207-s208. DOI: 10.1016/s1569-1993(24)01235-9.Peer-Reviewed Original ResearchStudy Profile of the Tsuruoka Metabolomics Cohort Study (TMCS)
Harada S, Iida M, Miyagawa N, Hirata A, Kuwabara K, Matsumoto M, Okamura T, Edagawa S, Kawada Y, Miyake A, Toki R, Akiyama M, Kawai A, Sugiyama D, Sato Y, Takemura R, Fukai K, Ishibashi Y, Kato S, Kurihara A, Sata M, Shibuki T, Takeuchi A, Kohsaka S, Sawano M, Shoji S, Izawa Y, Katsumata M, Oki K, Takahashi S, Takizawa T, Maruya H, Nishiwaki Y, Kawasaki R, Hirayama A, Ishikawa T, Saito R, Sato A, Soga T, Sugimoto M, Tomita M, Komaki S, Ohmomo H, Ono K, Otsuka-Yamasaki Y, Shimizu A, Sutoh Y, Hozawa A, Kinoshita K, Koshiba S, Kumada K, Ogishima S, Sakurai-Yageta M, Tamiya G, Takebayashi T. Study Profile of the Tsuruoka Metabolomics Cohort Study (TMCS). Journal Of Epidemiology 2024, 34: 393-401. PMID: 38191178, PMCID: PMC11230875, DOI: 10.2188/jea.je20230192.Peer-Reviewed Original ResearchTsuruoka Metabolomics Cohort StudyCohort studyOngoing population-based cohort studyPrecision preventionPopulation-based cohort studySocial health determinantsHeated tobacco productsDisease sequelaeRisk stratificationAge-associated diseasesCancer incidenceDeep molecular profilingCardiovascular diseaseFunctional declinePhenotypic probeWomen's healthOngoing followHealth determinantsHealth statusDisease pathophysiologyPotential biomarkersTobacco productsMolecular profilingDiseaseHigh participation ratesFunctional decline in older breast cancer survivors treated with and without chemotherapy and non-cancer controls: results from the Hurria Older PatiEnts (HOPE) prospective study
Sedrak M, Sun C, Bae M, Freedman R, Magnuson A, O’Connor T, Moy B, Wildes T, Klepin H, Chapman A, Tew W, Dotan E, Fenton M, Kim H, Katheria V, Muss H, Cohen H, Gross C, Ji J. Functional decline in older breast cancer survivors treated with and without chemotherapy and non-cancer controls: results from the Hurria Older PatiEnts (HOPE) prospective study. Journal Of Cancer Survivorship 2024, 18: 1131-1143. PMID: 38678525, PMCID: PMC11324395, DOI: 10.1007/s11764-024-01594-3.Peer-Reviewed Original ResearchEarly-stage breast cancerPF-10 scorePF-10Physical functionNon-cancer controlsFunctional declineBC controlOlder breast cancer survivorsRAND 36-Item Short FormBreast cancerCohort of older adultsOlder womenBreast cancer survivorsImprove health outcomesPhysical function subscalePhysical function declineAccelerated functional declineBreast Cancer StudyCancer survivorsFunction subscaleHealth outcomesGroup of womenOlder adultsControl groupShort formCOVID-19−Associated Acute Kidney Injury and Longitudinal Kidney Outcomes
Aklilu A, Kumar S, Nugent J, Yamamoto Y, Coronel-Moreno C, Kadhim B, Faulkner S, O’Connor K, Yasmin F, Greenberg J, Moledina D, Testani J, Wilson F. COVID-19−Associated Acute Kidney Injury and Longitudinal Kidney Outcomes. JAMA Internal Medicine 2024, 184: 414-423. PMID: 38407862, PMCID: PMC10897825, DOI: 10.1001/jamainternmed.2023.8225.Peer-Reviewed Original ResearchCOVID-19-associated acute kidney injuryCOVID-19-associated AKIAcute kidney injuryMulticenter cohort studyKidney function declineKidney functionKidney injuryCohort studyKidney outcomes of patientsIncidence of acute kidney injuryLong-term kidney outcomesHistorical cohort of patientsMultivariate time-to-event analysesPositive influenza ALongitudinal multicenter cohort studyWorsening kidney functionOutcomes of patientsAdverse kidney eventsCohort of patientsComposite of mortalityMarkers of illness severityAdult hospitalized patientsBaseline comorbidity scoreTime-to-event analysisFunctional declinePulmonary Fibrosis Stakeholder Summit: A Joint NHLBI, Three Lakes Foundation, and Pulmonary Fibrosis Foundation Workshop Report
Montesi S, Gomez C, Beers M, Brown R, Chattopadhyay I, Flaherty K, Garcia C, Gomperts B, Hariri L, Hogaboam C, Jenkins R, Kaminski N, Kim G, Königshoff M, Kolb M, Kotton D, Kropski J, Lasky J, Magin C, Maher T, McCormick M, Moore B, Nickerson-Nutter C, Oldham J, Podolanczuk A, Raghu G, Rosas I, Rowe S, Schmidt W, Schwartz D, Shore J, Spino C, Craig J, Martinez F. Pulmonary Fibrosis Stakeholder Summit: A Joint NHLBI, Three Lakes Foundation, and Pulmonary Fibrosis Foundation Workshop Report. American Journal Of Respiratory And Critical Care Medicine 2024, 209: 362-373. PMID: 38113442, PMCID: PMC10878386, DOI: 10.1164/rccm.202307-1154ws.Peer-Reviewed Original ResearchConceptsSlow lung function declinePulmonary fibrosisLung function declineField of pulmonary fibrosisRisk factorsStudy pulmonary fibrosisProgressive pulmonary fibrosisIdiopathic pulmonary fibrosisPulmonary Fibrosis FoundationIdentification of risk factorsFunctional declineElucidation of disease mechanismsClinical trial designDisease risk factorsFibrosisImprove diagnosisTrial designBiomarker discoveryDisease mechanismsPulmonaryMedicationMorbidityTherapyExposome and Metabolome Analysis of Sugarcane Workers Reveals Predictors of Kidney Injury
Stem A, Brindley S, Rogers K, Salih A, Roncal-Jimenez C, Johnson R, Newman L, Butler-Dawson J, Krisher L, Brown J. Exposome and Metabolome Analysis of Sugarcane Workers Reveals Predictors of Kidney Injury. Kidney International Reports 2024, 9: 1458-1472. PMID: 38707825, PMCID: PMC11069010, DOI: 10.1016/j.ekir.2024.01.060.Peer-Reviewed Original ResearchKidney function declineChronic kidney diseaseKidney injuryIncreased incidence of CKDPredictor of kidney injuryKidney diseaseMetabolomic analysisIncidence of chronic kidney diseaseKidney injury marker-1Urine samplesPerturbing amino acid metabolismImpaired kidney functionInvestigate potential biomarkersRates of kidney diseaseUrine profilesKidney functionExposure to silicaIncreased incidencePotential biomarkersAmino acid metabolismUrineOccupational exposure to silicaElemental analysisMetabolomicsFunctional declineSustained effort network for treatment of status epilepticus/European academy of neurology registry on adult refractory status epilepticus (SENSE-II/AROUSE)
Damien C, Leitinger M, Kellinghaus C, Strzelczyk A, De Stefano P, Beier C, Sutter R, Kämppi L, Strbian D, Taubøll E, Rosenow F, Helbok R, Rüegg S, Damian M, Trinka E, Gaspard N. Sustained effort network for treatment of status epilepticus/European academy of neurology registry on adult refractory status epilepticus (SENSE-II/AROUSE). BMC Neurology 2024, 24: 19. PMID: 38178048, PMCID: PMC10765797, DOI: 10.1186/s12883-023-03505-y.Peer-Reviewed Original ResearchConceptsNonconvulsive status epilepticusRefractory status epilepticusStatus epilepticusEuropean AcademyCommon neurological emergencyMulticenter prospective registryLarge randomized trialsProspective multicenter observational registryMulticenter observational registryDeep general anesthesiaDifferent patient groupsDistinct EEG patternsConvulsive SEMulticenter registryObservational registryProspective registryConsecutive adultsNeurological emergencyRandomized trialsRefractory SEGeneral anesthesiaPatient groupTreatment modalitiesClinical trialsFunctional decline
2023
IMMUNOMETABOLIC CHECKPOINTS OF INFLAMMAGING
Dixit V. IMMUNOMETABOLIC CHECKPOINTS OF INFLAMMAGING. Innovation In Aging 2023, 7: 140-140. PMCID: PMC10735998, DOI: 10.1093/geroni/igad104.0458.Peer-Reviewed Original ResearchCaloric restrictionAnti-inflammatory effectsAnti-inflammatory responseAge-related functional declineNegative energy balanceTissue-resident macrophagesAge-associated degenerative diseasesThymic involutionMaintenance of homeostasisMetabolic dysfunctionFunctional declineAdipose tissueInflammationResident macrophagesStudy participantsDegenerative diseasesMacrophagesKey hallmarksRNA sequence analysisMitochondrial metabolismHuman physiologyUnique regulatorCellular quiescenceMetabolismTranscriptional programsFunctional decline during the COVID‐19 pandemic among U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Morse J, Fischer I, Na P, Afari N, Pietrzak R. Functional decline during the COVID‐19 pandemic among U.S. military veterans: Results from the National Health and Resilience in Veterans Study. International Journal Of Geriatric Psychiatry 2023, 38: e6040. PMID: 38072628, DOI: 10.1002/gps.6040.Peer-Reviewed Original ResearchConceptsAdverse childhood experiencesFunctional declineU.S. military veteransGreater adverse childhood experiencesNational HealthPhysical functioningVeterans StudyIdentification of veteransSubstantial health problemPhysical functional declineMilitary veteransMental functioningU.S. adult populationStress symptomsStrongest correlatePrevalence of veteransProtective psychosocial characteristicsMultivariable analysisPosttraumatic stress symptomsHealth problemsU.S. veteransAdult populationImprovement 1Coronavirus diseaseOlder ageProximal humerus fractures: Postoperative protocols and factors affecting treatment decisions among shoulder and elbow and orthopedic trauma surgeons
Fram B, Strony J, Chen R, Namdari S, Krieg J. Proximal humerus fractures: Postoperative protocols and factors affecting treatment decisions among shoulder and elbow and orthopedic trauma surgeons. Journal Of Orthopaedics 2023, 49: 75-80. PMID: 38130473, PMCID: PMC10730336, DOI: 10.1016/j.jor.2023.11.062.Peer-Reviewed Original ResearchOpen reduction internal fixationProximal humerus fracturesRange of motionPostoperative protocolReduction internal fixationIntramedullary nailingOrthopaedic traumaWeight bearingInternal fixationFunctional declineAcute proximal humerus fracturesStandard postoperative protocolTreatment of PHFUpper extremity injuriesPostoperative weight bearingOrthopaedic trauma surgeonsPolytraumatized patientsHumerus fracturesSurgical outcomesTreatment modalitiesExtremity injuriesTreatment decisionsShoulder arthroplastyTrauma surgeonsDaily livingR ealtime Diagnosis from E lectrocardiogram Artificial Intelligence- G uided Screening for A trial Fibrillation with L ong Follow-Up (REGAL): Rationale and design of a pragmatic, decentralized, randomized controlled trial
Yao X, Attia Z, Behnken E, Hart M, Inselman S, Weber K, Li F, Stricker N, Stricker J, Friedman P, Noseworthy P. R ealtime Diagnosis from E lectrocardiogram Artificial Intelligence- G uided Screening for A trial Fibrillation with L ong Follow-Up (REGAL): Rationale and design of a pragmatic, decentralized, randomized controlled trial. American Heart Journal 2023, 267: 62-69. PMID: 37913853, DOI: 10.1016/j.ahj.2023.10.005.Peer-Reviewed Original ResearchConceptsConsumer wearable devicesOlder adultsUnrecognized AFAssociated with increased risk of strokeApple WatchFollow-upAtrial fibrillationAssociated with increased riskEarly diagnosis of AFAll-cause mortalityRandomized controlled trialsCognitive function declineEarly diagnosisIntervention armPragmatic trialRisk of strokeDiagnosis of AFAI-ECGDisease preventionSecondary outcomesFunctional declineDisease burdenPrimary outcomeLong-term follow-upHigh-risk patientsElectrical impedance myography detects age-related skeletal muscle atrophy in adult zebrafish
Rutkove S, Callegari S, Concepcion H, Mourey T, Widrick J, Nagy J, Nath A. Electrical impedance myography detects age-related skeletal muscle atrophy in adult zebrafish. Scientific Reports 2023, 13: 7191. PMID: 37137956, PMCID: PMC10156759, DOI: 10.1038/s41598-023-34119-6.Peer-Reviewed Original ResearchConceptsAge-related skeletal muscle atrophyMuscle functionLoss of muscle massAssociated with fallsSkeletal muscle atrophyEvaluate potential therapeuticsSkeletal muscle functionTotal muscle areaMechanism of muscle degenerationClinical studiesMuscle atrophyMuscle degenerationMuscle healthMuscle massElectrical impedance myographyReplication cohortBioelectric propertiesFunctional declineNeuromuscular disordersSkeletal muscleDisease mechanismsImpedance myographySarcopeniaMuscle areaAge-related deficitsEffects of Electroconvulsive Therapy on Functional Outcomes Among Medicare Patients With Comorbid Depression and Dementia: A Nationwide 1-Year Follow-Up Study.
Wilkinson S, Sint K, Forester B, Rhee T. Effects of Electroconvulsive Therapy on Functional Outcomes Among Medicare Patients With Comorbid Depression and Dementia: A Nationwide 1-Year Follow-Up Study. The Journal Of Clinical Psychiatry 2023, 84 PMID: 36700843, DOI: 10.4088/jcp.22m14583.Peer-Reviewed Original ResearchConceptsElectroconvulsive therapyFunctional outcomeComorbid depressionPrincipal psychiatric diagnosisRandomized clinical trialsECT cohortECT patientsComparable cohortsSafe treatmentClinical trialsMedicare patientsCurrent treatmentFunctional declineLimited efficacyPropensity score methodsPsychiatric disordersSummary scoresPsychiatric diagnosisLarger sample sizeMultivariate analysisPsychological symptomsDementiaPatientsOlder adultsCohortBacteriophage Therapy for Pan-Drug-Resistant Pseudomonas aeruginosa in Two Persons With Cystic Fibrosis
Hahn A, Sami I, Chaney H, Koumbourlis A, Del Valle Mojica C, Cochrane C, Chan B, Koff J. Bacteriophage Therapy for Pan-Drug-Resistant Pseudomonas aeruginosa in Two Persons With Cystic Fibrosis. Journal Of Investigative Medicine High Impact Case Reports 2023, 11: 23247096231188243. PMID: 37515541, PMCID: PMC10387758, DOI: 10.1177/23247096231188243.Peer-Reviewed Original ResearchConceptsPulmonary exacerbationsCF transmembrane conductance regulator geneTransmembrane conductance regulator geneChronic bacterial colonizationRecurrent lung infectionsStructural lung damagePediatric clinical trialsLung function declineLung inflammationTreatment modalitiesLung infectionCystic fibrosisLung damageClinical trialsTherapeutic strategiesAntibiotic resistanceBacterial colonizationMonogenic diseasesBacteriophage therapyRegulated genesViscous secretionsReduced survivalFunctional declineExacerbationBacteriophage
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