2025
Prevalence and Phenotype of Food Allergy in Children with Cystic Fibrosis
Nguyen H, Shabanova V, McCollum S, Polk B, Lee T, Whittington K, Cunha P, Bruscia E, Egan M, Emmenegger M, Leeds S. Prevalence and Phenotype of Food Allergy in Children with Cystic Fibrosis. Annals Of Allergy Asthma & Immunology 2025 PMID: 40550267, DOI: 10.1016/j.anai.2025.06.024.Peer-Reviewed Original ResearchCystic fibrosisCF patientsFood allergyUS pediatric populationElectronic medical recordsPediatric populationPhenotypes of food allergyRetrospective pediatric cohort studyPrevalence of FAFA prevalenceCystic Fibrosis Foundation RegistryMale CF patientsUnited StatesPediatric CF patientsPancreatic enzyme replacementPediatric cohort studyIgE-mediated FACohort studyEstimated prevalenceInclusion criteriaMedical informationDevelopment of FAMedical recordsFA diagnosisPrevalenceGermline-encoded recognition of peanut underlies development of convergent antibodies in humans
Marini-Rapoport O, Andrieux L, Keswani T, Zong G, Duchen D, Yaari G, Min J, Lytle I, Rosenberg A, Fucile C, Kobie J, Piepenbrink M, Sun T, Martin V, Yuan Q, Shreffler W, Seppo A, Järvinen K, Loeffler J, Ward A, Kleinstein S, Pedersen L, Fernández-Quintero M, Mueller G, Patil S. Germline-encoded recognition of peanut underlies development of convergent antibodies in humans. Science Translational Medicine 2025, 17: eadw4148. PMID: 40498852, DOI: 10.1126/scitranslmed.adw4148.Peer-Reviewed Original ResearchConceptsGene rearrangementsAllergen-specific IgG antibodiesPeanut-allergic childrenContext of food allergyGermline antibody repertoireDietary antigensAntibody gene rearrangementsPublic epitopesFood allergySerum IgGIgG antibodiesAntibody specificityImmunoglobulin GDiverse cohortAntibodiesAntibody repertoireAra h 2IgG recognitionEpitope-paratope interactionH-2AntigenGermlineIgGPeanut allergen Ara h 2Antigenicity of food proteinsSkin damage signals mediate allergic sensitization to spatially unlinked antigen
Waizman D, Brown-Soler I, Martin A, Ma Y, Zhou K, Israni-Winger K, Zhang C, Medzhitov R, Launay P, Michieletto M, Henao-Mejia J, Palm N, Craft J, Eisenstein A, Wang A. Skin damage signals mediate allergic sensitization to spatially unlinked antigen. Science Immunology 2025, 10: eadn0688. PMID: 40184440, PMCID: PMC12100540, DOI: 10.1126/sciimmunol.adn0688.Peer-Reviewed Original ResearchThe LEARN (Learning Educator's Anaphylaxis Response Needs) Early Project
Kaman K, Lahoud A, Flessner C, Butler K, Lowery S, Hoyt A. The LEARN (Learning Educator's Anaphylaxis Response Needs) Early Project. Annals Of Allergy Asthma & Immunology 2025, 134: 694-699. PMID: 40164281, DOI: 10.1016/j.anai.2025.03.018.Peer-Reviewed Original ResearchSelf-reported preparednessHead Start centersFood allergy emergencyUnderserved communitiesImprove health care outcomesAllergy emergencyHealth care outcomesHealth care managementFeelings of preparednessPublic health problemCare outcomesFood allergy knowledgeIdentified multiple areasFood allergy trainingRates of food allergyPreparedness questionnaireCare managementFood allergyMultiple barriersCenter staffAllergy trainingKnowledge testAllergy knowledgeEarly childhood education centersHealth problemsMoving Beyond Desensitization to Tolerance in Food Allergy
Flom J, Shreffler W, Perrett K. Moving Beyond Desensitization to Tolerance in Food Allergy. The Journal Of Allergy And Clinical Immunology In Practice 2025, 13: 741-744. PMID: 40010566, DOI: 10.1016/j.jaip.2025.02.014.Peer-Reviewed Original ResearchManagement of IgE-mediated food allergyFood allergyIgE-mediated food allergyStages of clinical developmentSide effect profileMode of deliveryGoal of therapeuticsSustained unresponsivenessDosing regimensDose protocolProactive therapyAllergen-specificClinical developmentActive therapyPatient populationSide effectsTherapyPassive therapyPatient-specificDesensitizationClinical contextPatientsDoseAllergyDegree of protection
2024
Adverse Food Reactions: Physiological and Ecological Perspectives
Korn L, Kutyavin V, Bachtel N, Medzhitov R. Adverse Food Reactions: Physiological and Ecological Perspectives. Annual Review Of Nutrition 2024, 44: 155-178. PMID: 38724028, DOI: 10.1146/annurev-nutr-061021-022909.Peer-Reviewed Original ResearchAll roads lead to IgA: Mapping the many pathways of IgA induction in the gut
Siniscalco E, Williams A, Eisenbarth S. All roads lead to IgA: Mapping the many pathways of IgA induction in the gut. Immunological Reviews 2024, 326: 66-82. PMID: 39046160, DOI: 10.1111/imr.13369.Peer-Reviewed Original ResearchIgA inductionFood allergyFood-specific IgE.Food-specific IgEAntibody isotypesPrevalence of food allergyT cell helpIncreasing prevalence of food allergyRelease of histamineFoodFood antigensB cellsInduce toleranceAdverse reactionsCommensal bacteriaMast cellsIncreased prevalenceGut immunityIgAGutAllergyAntibodiesIsotypeInductionDendritic cells in food allergy, treatment, and tolerance
Liu E, Yin X, Siniscalco E, Eisenbarth S. Dendritic cells in food allergy, treatment, and tolerance. Journal Of Allergy And Clinical Immunology 2024, 154: 511-522. PMID: 38971539, PMCID: PMC11414995, DOI: 10.1016/j.jaci.2024.06.017.Peer-Reviewed Original ResearchAntigen presenting cellsDendritic cellsFood allergyOral tolerancePresenting cellsAllergic sensitizationPeripheral T regulatory cellsDevelopment of oral toleranceGut dendritic cellsT regulatory cellsDendritic cell subsetsLimited treatment optionsAdaptive immune responsesFood immunotherapyEpicutaneous immunotherapyCell subsetsTolerogenic programAlarmin releaseTreatment optionsLangerhans cellsFood toleranceInnocuous antigensSurface markersInflammatory conditionsImmune responseDOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells.
Williams A, Siniscalco E, Grassmann J, Craft J, Eisenbarth S, Uthaman G. DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells. The Journal Of Immunology 2024, 212: 0620_4120-0620_4120. DOI: 10.4049/jimmunol.212.supp.0620.4120.Peer-Reviewed Original ResearchPeanut-specific IgET cellsSpecific IgEFood allergyT follicular helper cellsCD4+ T cellsDOCK8-deficient patientsFood-specific IgEPeanut-specific IgE.Human T cellsCells in vitroDifferentiation in vivoSevere food allergyTfh cellsRegulatory populationsOvercome toleranceHelper cellsDeficient patientsSpecific IgE.DOCK8IgE productionSTAT3 mutationsMiceCholera toxinIgECD23+IgG1+ memory B cells are poised to switch to pathogenic IgE production in food allergy
Ota M, Hoehn K, Fernandes-Braga W, Ota T, Aranda C, Friedman S, Miranda-Waldetario M, Redes J, Suprun M, Grishina G, Sampson H, Malbari A, Kleinstein S, Sicherer S, Curotto de Lafaille M. CD23+IgG1+ memory B cells are poised to switch to pathogenic IgE production in food allergy. Science Translational Medicine 2024, 16: eadi0673. PMID: 38324641, PMCID: PMC11008013, DOI: 10.1126/scitranslmed.adi0673.Peer-Reviewed Original ResearchConceptsMemory B cellsB cellsIgE-producing cellsPeanut allergySerum peanut-specific IgEFood allergyInterleukin-4 (IL-4)-B cell memoryPeanut-specific IgEAllergen-specific immunoglobulin EHigh-affinity B cellsPersistent IgE responsesConcentration of IgESingle-cell RNA sequencing experimentsMemory populationRNA sequencing experimentsIgE productionImmune responseImmunoglobulin ECirculating concentrationsIgE responseAllergySequencing experimentsAra h 2Long-term persistenceDe-labeling of Food Allergy in Electronic Medical Records for Cystic Fibrosis Patients to Avoid Unnecessary Food Restriction
Nguyen H, Bruscia E, Young J, Egan M, Leeds S. De-labeling of Food Allergy in Electronic Medical Records for Cystic Fibrosis Patients to Avoid Unnecessary Food Restriction. Journal Of Allergy And Clinical Immunology 2024, 153: ab114. DOI: 10.1016/j.jaci.2023.11.376.Peer-Reviewed Original ResearchNovel and emerging tests for food allergy
Liu E, Eisenbarth S. Novel and emerging tests for food allergy. 2024, 698-709. DOI: 10.1016/b978-0-323-96018-2.00081-x.Peer-Reviewed Original ResearchFood allergyActivation testingSkin prick testingRisk of developmentAvailable clinical testsSkin barrier permeabilityLow predictive valueInflammatory markersPrick testingIgE testingImmunoglobulin EBarrier permeabilityAllergyPromising biomarkerPredictive valueClinical testsGenetic testingLack of testingCellular profilingMarkersWidespread useTestingImmunoglobulinBiomarkersSeverity
2023
SOMETHING'S FISHY WITH THE FEED: AN IGE-MEDIATED ALLERGIC REACTION TO HUMAN MILK
Halperin-Goldstein S, Soffer G. SOMETHING'S FISHY WITH THE FEED: AN IGE-MEDIATED ALLERGIC REACTION TO HUMAN MILK. Annals Of Allergy Asthma & Immunology 2023, 131: s170. DOI: 10.1016/j.anai.2023.08.523.Peer-Reviewed Original ResearchAssociated with allergen exposureHuman milkAllergic reactionsCase description ARare case reportFood proteinsSkin prick testAllergy to peanutIgE-mediated reactionsIgE-mediated allergic reactionsIntermittent pruritusBreastfed infantsCase reportRespiratory distressPrick testLaboratory evidenceChildren's dietsFood allergyMother's dietAllergen exposureComplementary foodsDiet modificationInduce sensitizationFin fishAllergic symptomatologyImmune sensing of food allergens promotes avoidance behaviour
Florsheim E, Bachtel N, Cullen J, Lima B, Godazgar M, Carvalho F, Chatain C, Zimmer M, Zhang C, Gautier G, Launay P, Wang A, Dietrich M, Medzhitov R. Immune sensing of food allergens promotes avoidance behaviour. Nature 2023, 620: 643-650. PMID: 37437602, PMCID: PMC10432274, DOI: 10.1038/s41586-023-06362-4.Peer-Reviewed Original ResearchConceptsMast cellsImmune systemBALB/c miceAllergen-specific IgEDifferentiation factor 15Behavioral modificationAllergen avoidanceAllergic sensitizationAllergic inflammationFood allergyTractus solitariusC miceCysteinyl leukotrienesParabrachial nucleusAllergen ingestionE antibodiesCentral amygdalaFactor 15Mouse modelFood allergensBrain areasImmune sensingAvoidance behaviorAversive stimuliGenetic backgroundRacial, Ethnic, and Socioeconomic Differences in Food Allergies in the US
Jiang J, Warren C, Brewer A, Soffer G, Gupta R. Racial, Ethnic, and Socioeconomic Differences in Food Allergies in the US. JAMA Network Open 2023, 6: e2318162. PMID: 37314805, PMCID: PMC10267771, DOI: 10.1001/jamanetworkopen.2023.18162.Peer-Reviewed Original ResearchConceptsNon-Hispanic Black individualsNon-Hispanic white individualsParent-reported food allergyFood allergyWhite individualsBlack individualsEpinephrine autoinjector useFood allergy outcomesSurvey-weighted proportionsEmergency department visitsCommon food allergensFood allergy reactionsPopulation-based surveyCross-sectional survey studySimilar symptom presentationsLower ratesAutoinjector useDepartment visitsClinical outcomesPhysician diagnosisAllergy outcomesRepresentative sampleAllergy reactionsMAIN OUTCOMEPrevalence ratesValidated anxiety assessments among pediatric patients with peanut allergy on oral immunotherapy
Kaman K, Dhodapkar M, Shabanova V, McCollum S, Factor J, Leeds S. Validated anxiety assessments among pediatric patients with peanut allergy on oral immunotherapy. Annals Of Allergy Asthma & Immunology 2023, 130: 657-663. PMID: 36738780, DOI: 10.1016/j.anai.2023.01.028.Peer-Reviewed Original ResearchConceptsPeanut oral immunotherapyOral immunotherapyNon-white racePeanut allergyAnxiety scoresOlder cohortProspective cross-sectional cohort studyCross-sectional cohort studyHigher mean anxiety scoresMean anxiety scoreDiagnosable anxietyCohort studyMale patientsPediatric patientsFemale patientsFood allergySimilar patientsHigh prevalenceHigher scoresLife measuresLow prevalencePatientsSeparation anxiety scoresElectronic survey questionnaireAllergy
2022
Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens
Liu E, Zhang B, Martin V, Anthonypillai J, Kraft M, Grishin A, Grishina G, Catanzaro J, Chinthrajah S, Sindher T, Manohar M, Quake A, Nadeau K, Burks A, Kim E, Kulis M, Henning A, Jones S, Leung D, Sicherer S, Wood R, Yuan Q, Shreffler W, Sampson H, Shabanova V, Eisenbarth S. Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens. Science Translational Medicine 2022, 14: eabq0599. PMID: 36383680, PMCID: PMC10219469, DOI: 10.1126/scitranslmed.abq0599.Peer-Reviewed Original ResearchConceptsPeanut allergyFood allergyEpitope specificityPredominant antibody isotypePeanut-specific IgEDifferent epitope specificitiesSimilar epitope specificityAtopic childrenEgg allergyOral toleranceAllergic infantsImmune exclusionEgg toleranceAntibody isotypesImmunoglobulin ACommensal floraSeparate cohortAllergyEgg allergensInfant stoolHealthy adultsIgAProtective roleOlder childrenChildrenTHE LEARN EARLY PROJECT: LEARNING EDUCATORS ANAPHYLAXIS RESPONSE NEEDS
Kaman K, Hoyt A. THE LEARN EARLY PROJECT: LEARNING EDUCATORS ANAPHYLAXIS RESPONSE NEEDS. Annals Of Allergy Asthma & Immunology 2022, 129: s68-s69. DOI: 10.1016/j.anai.2022.08.697.Peer-Reviewed Original ResearchHead Start centersFood allergyIndividual needs assessmentEarly childcare centersFood allergy emergencyIncidence of food allergySafe careFood allergy knowledgeFood allergy trainingNeeds assessmentFocus groupsInvestigate barriersHispanic childrenAllergy trainingKnowledge testAllergy knowledgeStock epinephrineAllergy emergencyPrevent anaphylaxisCenter directorsImplement appropriate solutionsChildcare centersAllergyDisproportionate impactEarly learning centersA practical focus on sesame allergy and a brief review of other seed allergies
Kaman K, Factor J. A practical focus on sesame allergy and a brief review of other seed allergies. Journal Of Food Allergy 2022, 4: 151-157. PMID: 39021852, PMCID: PMC11250203, DOI: 10.2500/jfa.2022.4.220008.Peer-Reviewed Original ResearchHealth disparities in pediatric food allergy
Tepler E, Wong KH, Soffer GK. Health disparities in pediatric food allergy. Annals Of Allergy Asthma & Immunology 2022, 129: 417-423. PMID: 35476967, DOI: 10.1016/j.anai.2022.04.022.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPediatric food allergyFood allergyHealth disparitiesSocioeconomic disparitiesSocioeconomic statusOutcome of childrenLow socioeconomic statusGoogle Scholar databasesAllergen-free foodsLong-term managementAcute managementAllergy careOverall prevalenceFood assistance programsAllergyHealth outcomesScholar databasesGreater riskLiterature searchOriginal research articlesChildrenPossible interventionsPrevalenceCurrent literatureDiagnosis
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