2025
Bidirectional relationship between epigenetic age and stroke, dementia, and late-life depression
Rivier C, Szejko N, Renedo D, Clocchiatti-Tuozzo S, Huo S, de Havenon A, Zhao H, Gill T, Sheth K, Falcone G. Bidirectional relationship between epigenetic age and stroke, dementia, and late-life depression. Nature Communications 2025, 16: 1261. PMID: 39893209, PMCID: PMC11787333, DOI: 10.1038/s41467-024-54721-0.Peer-Reviewed Original ResearchThis study shows a bidirectional link between accelerated epigenetic aging and brain health events like stroke, dementia, and depression, supporting new prevention strategies for aging-related conditions.
2024
Estimates of intra-cluster correlation coefficients from 2018 USA Medicare data to inform the design of cluster randomized trials in Alzheimer’s and related dementias
Ouyang Y, Li F, Li X, Bynum J, Mor V, Taljaard M. Estimates of intra-cluster correlation coefficients from 2018 USA Medicare data to inform the design of cluster randomized trials in Alzheimer’s and related dementias. Trials 2024, 25: 732. PMID: 39478608, PMCID: PMC11523597, DOI: 10.1186/s13063-024-08404-2.Peer-Reviewed Original ResearchConceptsIntra-cluster correlation coefficientIntra-cluster correlation coefficient estimationSample size calculationED visitsMedicare dataMedicare fee-for-service beneficiariesEmergency departmentFee-for-service beneficiariesSize calculationDiagnosis of ADRDNational Medicare dataCluster randomized trialHospital referral regionsHospital service areasHealth care systemBackgroundCluster randomized trialsPopulation-level dataRandomized trialsDesign of cluster randomized trialsEvaluate interventionsReferral regionsCare systemICC estimatesADRDCorrelation coefficientResearch Priorities in Pediatric Asthma Morbidity: Addressing the Impacts of Systemic Racism on Children with Asthma in the United States. An Official American Thoracic Society Workshop Report
Lovinsky-Desir S, Riley I, Bryant-Stephens T, De Keyser H, Forno E, Kozik A, Louisias M, Matsui E, Sheares B, Thakur N, Apter A, Beck A, Bentley-Edwards K, Berkowitz C, Braxton C, Dean J, Jones C, Koinis-Mitchell D, Okelo S, Taylor-Cousar J, Teach S, Wechsler M, Gaffin J, Federico M. Research Priorities in Pediatric Asthma Morbidity: Addressing the Impacts of Systemic Racism on Children with Asthma in the United States. An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2024, 21: 1349-1364. PMID: 39352175, PMCID: PMC11451894, DOI: 10.1513/annalsats.202407-767st.Peer-Reviewed Original ResearchConceptsImpact of systemic racismAsthma morbidityChildhood asthmaSocial determinants of healthAsthma health outcomesPediatric asthma morbidityDeterminants of healthSystemic racismCommunity engagementDrivers of disparitiesEmergency department visitsResearch teamChildhood asthma outcomesImpact of interventionsMultidisciplinary research teamEffects of systemic racismInnovative study designsImpact of racismAsthma disparitiesSocial determinantsHealthcare accessAsthma outcomesHealth outcomesDepartment visitsEvaluate interventionsIntensive care unit interventions to promote sleep and circadian biology in reducing incident delirium: a scoping review
Wilcox M, Burry L, Englesakis M, Coman B, Daou M, van Haren F, Ely E, Bosma K, Knauert M. Intensive care unit interventions to promote sleep and circadian biology in reducing incident delirium: a scoping review. Thorax 2024, 79: 988-997. PMID: 38350730, DOI: 10.1136/thorax-2023-220036.Peer-Reviewed Original ResearchSeverity of deliriumIntensive care unitIncident deliriumCare bundleReducing incident deliriumSensitive search of electronic databasesSearch of electronic databasesEnglish-language studiesPromote sleepPromotion interventionsEvaluate interventionsIntensive care unit interventionsElectronic databasesNon-pharmacologicalInclusion criteriaIntervention strategiesDeliriumInterventionCare unitEye maskConference proceedingsVariable reportingSleepPharmacological interventionsAssociation
2023
The importance of investing in data, models, experiments, team science, and public trust to help policymakers prepare for the next pandemic
Grieve R, Yang Y, Abbott S, Babu G, Bhattacharyya M, Dean N, Evans S, Jewell N, Langan S, Lee W, Molenberghs G, Smeeth L, Williamson E, Mukherjee B. The importance of investing in data, models, experiments, team science, and public trust to help policymakers prepare for the next pandemic. PLOS Global Public Health 2023, 3: e0002601. PMID: 38032861, PMCID: PMC10688710, DOI: 10.1371/journal.pgph.0002601.Peer-Reviewed Original Research
2016
A Novel Tool for Assessment of Emergency Medicine Resident Skill in Determining Diagnosis and Management for Emergent Electrocardiograms: A Multicenter Study
Hartman N, Wheaton N, Williamson K, Quattromani E, Branzetti J, Aldeen A. A Novel Tool for Assessment of Emergency Medicine Resident Skill in Determining Diagnosis and Management for Emergent Electrocardiograms: A Multicenter Study. Journal Of Emergency Medicine 2016, 51: 697-704. PMID: 27618476, DOI: 10.1016/j.jemermed.2016.06.054.Peer-Reviewed Original ResearchConceptsEmergency electrocardiogramEmergency medicineResident competencyResidents' skillsPGY-2Residency programsPGY-1Residency trainingAssessment toolEM residency programsLevel of trainingImproved ECG interpretationMeasuring resident competenceEM residentsAssess residents' performanceEvaluate interventionsResident physiciansAssociated with improved abilityMulticenter studyProspective studyAssessment surveyPostgraduate yearResident performanceImprove competenceMulti-center
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