2025
Moving Beyond Desensitization to Tolerance in Food Allergy
Flom J, Shreffler W, Perrett K. Moving Beyond Desensitization to Tolerance in Food Allergy. The Journal Of Allergy And Clinical Immunology In Practice 2025, 13: 741-744. PMID: 40010566, DOI: 10.1016/j.jaip.2025.02.014.Peer-Reviewed Original ResearchManagement of IgE-mediated food allergyFood allergyIgE-mediated food allergyStages of clinical developmentSide effect profileMode of deliveryGoal of therapeuticsSustained unresponsivenessDosing regimensDose protocolProactive therapyAllergen-specificClinical developmentActive therapyPatient populationSide effectsTherapyPassive therapyPatient-specificDesensitizationClinical contextPatientsDoseAllergyDegree of protection
2024
A corneal neuralgia TRPV1 mutation increases response to acidic pH and alters agonist sensitization and desensitization
Gualdani R, Gailly P, Barbeau S, Jacobs D, Dib-Hajj S, Waxman S. A corneal neuralgia TRPV1 mutation increases response to acidic pH and alters agonist sensitization and desensitization. Biophysical Journal 2024, 123: 391a. DOI: 10.1016/j.bpj.2023.11.2378.Peer-Reviewed Original Research
2020
HIPEC with cisplatin in a patient with a prior hypersensitivity reaction to systemic oxaliplatin
Morgan R, Parsad S, Turaga K, Eng O. HIPEC with cisplatin in a patient with a prior hypersensitivity reaction to systemic oxaliplatin. Basic & Clinical Pharmacology & Toxicology 2020, 127: 551-553. PMID: 32623784, DOI: 10.1111/bcpt.13464.Peer-Reviewed Original ResearchConceptsHyperthermic intraperitoneal chemotherapyHypersensitivity reactionsSystemic oxaliplatinDiscontinued due to toxicityPlatinum-based chemotherapeutic agentsAlternative routes of administrationPlatinum-based agentsRoute of administrationIntraperitoneal chemotherapySystemic therapyDesensitization protocolCross-reactivityCase reportChemotherapeutic agentsSkin testPatientsCisplatinTherapyOxaliplatinAdverse effectsSafety parametersHypersensitivityPlatinum saltsDesensitizationAgents
2015
ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton Ligand
Peng Z, Li W, Huang C, Jiang Y, Wang X, Zhu M, Cheng X, Xu T. ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton Ligand. Cell Reports 2015, 13: 387-398. PMID: 26440887, DOI: 10.1016/j.celrep.2015.09.002.Peer-Reviewed Original ResearchConceptsAcid-sensing ion channel 3Itch sensationPrimary sensory neuronsIon channel 3ASIC3 geneSL-NH2Concomitant inflammationScratching behaviorPathological changesCoincident stimulationTissue acidosisASIC3 channelsSensory neuronsAcidosisNonproton ligandPruritogensSensationIle-GlyChannel 3Arg-LeuInflammationItchMiceNeuronsDesensitization
2010
Drug Desensitizations in the Management of Allergy and Anaphylaxis to Chemotherapeutic Agents and Monoclonal Antibodies
Banerji A, Brennan P, Hesterberg P, Oren E, Hsu F. Drug Desensitizations in the Management of Allergy and Anaphylaxis to Chemotherapeutic Agents and Monoclonal Antibodies. 2010, 297-311. DOI: 10.1007/978-1-60327-951-2_19.ChaptersDrug hypersensitivity reactionsDrug desensitizationManagement of allergyChemotherapeutic agentsHypersensitivity reactionsMonoclonal antibodiesLife-threatening infectious diseaseDrug-allergic individualsIgE-mediated drug hypersensitivity reactionsMast cell degranulationImmunology specialistsDesensitization protocolRheumatologic diseasesIncremental dosesCautious administrationCell degranulationSensitized individualsInfectious diseasesSmall molecule therapeuticsAllergyDesensitizationNumerous cancersAntibodiesDiseaseDrugs
2009
Comparative Case Study of Diffusion of Eye Movement Desensitization and Reprocessing in Two Clinical Settings: Empirically Supported Treatment Status Is Not Enough
Cook JM, Biyanova T, Coyne JC. Comparative Case Study of Diffusion of Eye Movement Desensitization and Reprocessing in Two Clinical Settings: Empirically Supported Treatment Status Is Not Enough. Professional Psychology Research And Practice 2009, 40: 518-524. PMID: 25360060, PMCID: PMC4211075, DOI: 10.1037/a0015144.Peer-Reviewed Original Research
2008
Successful desensitization with cetuximab (CET) after hypersensitivity reaction (HSR) to panitumumab (PAN) and CET in patients (pts) with metastatic colorectal cancer (mCRC)
Shah M, Hotchkiss S, Shanley J, Davies M, Ferencz T, Syrigos K, Syrigos K, Saif M. Successful desensitization with cetuximab (CET) after hypersensitivity reaction (HSR) to panitumumab (PAN) and CET in patients (pts) with metastatic colorectal cancer (mCRC). Journal Of Clinical Oncology 2008, 26: 15092-15092. DOI: 10.1200/jco.2008.26.15_suppl.15092.Peer-Reviewed Original Research
2007
It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood
Picciotto MR, Addy NA, Mineur YS, Brunzell DH. It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood. Progress In Neurobiology 2007, 84: 329-342. PMID: 18242816, PMCID: PMC2390914, DOI: 10.1016/j.pneurobio.2007.12.005.Peer-Reviewed Original ResearchConceptsDesensitization of nAChRsNicotinic acetylcholine receptorsNicotine addictionDrug reinforcementAcetylcholine receptorsAntidepressant-like effectsActivation of nAChRsEffects of nicotineNicotine-mediated behaviorsRecent electrophysiological studiesNicotine administrationTobacco smokingAffective modulationNicotine resultsElectrophysiological studiesSmoking behaviorNicotinic agentsReceptor desensitizationDrug rewardBehavioral consequencesAffective behaviorBehavioral processesBehavioral effectsNAChRsDesensitization
2000
Science and pseudoscience in the development of eye movement desensitization and reprocessing Implications for clinical psychology
Herbert J, Lilienfeld S, Lohr J, Montgomery R, O'Donohue W, Rosen G, Tolin D. Science and pseudoscience in the development of eye movement desensitization and reprocessing Implications for clinical psychology. Clinical Psychology Review 2000, 20: 945-971. PMID: 11098395, DOI: 10.1016/s0272-7358(99)00017-3.Peer-Reviewed Original ResearchMenthol desensitization of capsaicin irritation Evidence of a short-term anti-nociceptive effect
Green B, McAuliffe B. Menthol desensitization of capsaicin irritation Evidence of a short-term anti-nociceptive effect. Physiology & Behavior 2000, 68: 631-639. PMID: 10764892, DOI: 10.1016/s0031-9384(99)00221-8.Peer-Reviewed Original ResearchConceptsInterstimulus intervalFinal experimentPrevious researchSecond experimentCapsaicin stimuliCapsaicin-sensitive fibersAnti-nociceptive effectsStimuliSelfSecond exposureAntinociceptive effectTopical analgesicsSensory irritationCapsaicinPerceptionExposureDesensitizationCrossdesensitizationStimulationImplicationsMin
1999
Eye Movement Desensitization and Reprocessing An Analysis of Specific versus Nonspecific Treatment Factors
Lohr J, Lilienfeld S, Tolin D, Herbert J. Eye Movement Desensitization and Reprocessing An Analysis of Specific versus Nonspecific Treatment Factors. Journal Of Anxiety Disorders 1999, 13: 185-207. PMID: 10225508, DOI: 10.1016/s0887-6185(98)00047-4.Peer-Reviewed Original ResearchConceptsEye movement desensitizationIncremental validityIncremental efficacyNonspecific treatment factorsEffects of EMDRNonspecific treatment effectsPsychological assessmentEMDREye movementsIntervention proceduresTreatment featuresExperimental controlTreatment effectsNovel measureNonspecific featuresNovel treatmentsEfficacy studiesTreatment factorsValidityEfficacyIndividual studiesDesensitizationInterventionMeasuresControl procedures
1998
Temporal characteristics of capsaicin desensitization and stimulus-induced recovery in the oral cavity
Green B, Rentmeister-Bryant H. Temporal characteristics of capsaicin desensitization and stimulus-induced recovery in the oral cavity. Physiology & Behavior 1998, 65: 141-149. PMID: 9811376, DOI: 10.1016/s0031-9384(98)00162-0.Peer-Reviewed Original ResearchConceptsCapsaicin desensitizationIntermittent stimulationMicroM capsaicinTopical analgesicsOral cavitySignificant desensitizationCapsaicinClinical useRecurrent stimulationDesensitizationStimulationBlock recoveryExposureMinutesRapid exposureTest stimuliStimuliTongueCandy formulationChemonociceptionAnalgesicsSecond testTreatment stimuliIrritation
1996
An intensive design investigation of eye movement desensitization and reprocessing of claustrophobia
Lohr J, Tolin D, Kleinknecht R. An intensive design investigation of eye movement desensitization and reprocessing of claustrophobia. Journal Of Anxiety Disorders 1996, 10: 73-88. DOI: 10.1016/0887-6185(95)00036-4.Peer-Reviewed Original Research
1995
The empirical status of the clinical application of eye movement desensitization and reprocessing
Lohr J, Kleinknecht R, Tolin D, Barrett R. The empirical status of the clinical application of eye movement desensitization and reprocessing. Journal Of Behavior Therapy And Experimental Psychiatry 1995, 26: 285-302. PMID: 8675716, DOI: 10.1016/0005-7916(95)00041-0.Peer-Reviewed Original ResearchConceptsEye movement desensitizationClinical applicationEffect of treatmentClinical problemClassification of disordersClinical disordersNonspecific effectsPsychophysiologic measuresEye movementsTreatment fidelityComparative effectsTreatmentIndependent observer ratingsDesensitizationDisordersBehavioral indicesSingle-subject experimentsReportMethodological controlsEye movement desensitization of medical phobias: Two case studies
Lohr J, Tolin D, Kleinknecht R. Eye movement desensitization of medical phobias: Two case studies. Journal Of Behavior Therapy And Experimental Psychiatry 1995, 26: 141-151. PMID: 7593687, DOI: 10.1016/0005-7916(95)00011-n.Peer-Reviewed Original Research
1994
Mechanism of desensitization of the cloned vasopressin V1a receptor expressed in Xenopus oocytes
Nathanson MH, Burgstahler AD, Orloff JJ, Mani A, Moyer MS. Mechanism of desensitization of the cloned vasopressin V1a receptor expressed in Xenopus oocytes. American Journal Of Physiology 1994, 267: c94-c103. PMID: 8048495, DOI: 10.1152/ajpcell.1994.267.1.c94.Peer-Reviewed Original ResearchConceptsVasopressin V1a receptorV1a receptorReceptor desensitizationXenopus oocytesCyclic monophosphateMechanism of desensitizationG protein-mediated increasesProtein-mediated increasePretreatment of oocytesSubsequent microinjectionReceptor binding sitesMin of exposureProtein kinase C.Protein kinase CCytosolic Ca2Maximal stimulationDesensitizationReceptorsPhorbol dibutyrateKinase C.Inositol trisphosphateKinase CVasopressinOocytesConfocal microscopyAutoactive peptides act at three distinct receptors to depolarize the bag cell neurons of Aplysia
Loechner K, Kaczmarek L. Autoactive peptides act at three distinct receptors to depolarize the bag cell neurons of Aplysia. Journal Of Neurophysiology 1994, 71: 195-203. PMID: 8158229, DOI: 10.1152/jn.1994.71.1.195.Peer-Reviewed Original Research
1993
The sensory response to capsaicin during repeated topical exposures: differential effects on sensations of itching and pungency
Green B, Shaffer G. The sensory response to capsaicin during repeated topical exposures: differential effects on sensations of itching and pungency. Pain 1993, 53: 323-334. PMID: 8351161, DOI: 10.1016/0304-3959(93)90228-h.Peer-Reviewed Original ResearchConceptsInter-stimulus intervalTopical exposureIntensity of itchingUse of capsaicinApplication of capsaicinHand-held dynamometerDuration of sensitizationSensations of itchingTest 24 hFifth exposureDay 1Day 2Sensory irritationCapsaicinItchingOverall sensitivityDesensitizationLess sensitizationSensitizationSensory responsesMarked individual differencesTime courseDifferential effectsItchPungent sensationEvidence that removal of capsaicin accelerates desensitization on the tongue
Green B. Evidence that removal of capsaicin accelerates desensitization on the tongue. Neuroscience Letters 1993, 150: 44-48. PMID: 8469401, DOI: 10.1016/0304-3940(93)90104-s.Peer-Reviewed Original Research
1992
Desensitization of GABA-activated currents and channels in cultured cortical neurons
Frosch M, Lipton, Dichter M. Desensitization of GABA-activated currents and channels in cultured cortical neurons. Journal Of Neuroscience 1992, 12: 3042-3053. PMID: 1379634, PMCID: PMC6575652, DOI: 10.1523/jneurosci.12-08-03042.1992.Peer-Reviewed Original ResearchConceptsRate of desensitizationPresence of agonistInhibitory synaptic activationCultured cortical neuronsWhole-cell recording modeApplication of GABAWhole-cell modeDesensitization of GABACortical inhibitionCortical neuronsGABA responsesNeocortical neuronsSynaptic activationSame neuronsGABASingle-channel responsesDesensitizationDesensitization processNeuronsTrue declineAgonistsMembrane conductanceCell culturesRecording modeDose dependence
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