2025
Association of delayed asthma diagnosis with asthma exacerbations in children
Wi C, Ryu E, King K, Kwon J, Bublitz J, Park M, Chiarella S, Greenwood J, Pongdee T, Myers L, Nordlund B, Sohn S, Sagheb E, Kshatriya B, Watson D, Liu H, Sheares B, Davis C, Schulz W, Juhn Y. Association of delayed asthma diagnosis with asthma exacerbations in children. Journal Of Allergy And Clinical Immunology Global 2025, 4: 100409. PMID: 40008091, PMCID: PMC11851198, DOI: 10.1016/j.jacig.2025.100409.Peer-Reviewed Original ResearchElectronic health recordsDiagnosis of asthmaAsthma diagnosisAsthma exacerbationsRisk of AEPredetermined Asthma CriteriaDiagnosis of childhood asthmaChildhood asthma managementIncreased riskCox proportional hazards modelsIncreased risk of AECare qualityAsthma outcomesHealth recordsProportional hazards modelAsthma managementChildhood asthmaBirth cohortAsthma severityDiagnosis statusIndex dateIdentifying childrenPrimary outcomeNatural language processing algorithmsHazards model
2024
Research Priorities in Pediatric Asthma Morbidity: Addressing the Impacts of Systemic Racism on Children with Asthma in the United States. An Official American Thoracic Society Workshop Report
Lovinsky-Desir S, Riley I, Bryant-Stephens T, De Keyser H, Forno E, Kozik A, Louisias M, Matsui E, Sheares B, Thakur N, Apter A, Beck A, Bentley-Edwards K, Berkowitz C, Braxton C, Dean J, Jones C, Koinis-Mitchell D, Okelo S, Taylor-Cousar J, Teach S, Wechsler M, Gaffin J, Federico M. Research Priorities in Pediatric Asthma Morbidity: Addressing the Impacts of Systemic Racism on Children with Asthma in the United States. An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2024, 21: 1349-1364. PMID: 39352175, PMCID: PMC11451894, DOI: 10.1513/annalsats.202407-767st.Peer-Reviewed Original ResearchConceptsImpact of systemic racismAsthma morbidityChildhood asthmaSocial determinants of healthAsthma health outcomesPediatric asthma morbidityDeterminants of healthSystemic racismCommunity engagementDrivers of disparitiesEmergency department visitsResearch teamChildhood asthma outcomesImpact of interventionsMultidisciplinary research teamEffects of systemic racismInnovative study designsImpact of racismAsthma disparitiesSocial determinantsHealthcare accessAsthma outcomesHealth outcomesDepartment visitsEvaluate interventions
2023
Paired Indoor and Outdoor Nitrogen Dioxide Associated With Childhood Asthma Outcomes in a Mixed Rural-Urban Setting: A Feasibility Study
Wi C, Gent J, Bublitz J, King K, Ryu E, Sorrentino K, Plano J, McKay L, Porcher J, Wheeler P, Chiarella S, DeWan A, Pollitt K, Sheares B, Leaderer B, Juhn Y. Paired Indoor and Outdoor Nitrogen Dioxide Associated With Childhood Asthma Outcomes in a Mixed Rural-Urban Setting: A Feasibility Study. Journal Of Primary Care & Community Health 2023, 14: 21501319231173813. PMID: 37243352, PMCID: PMC10226331, DOI: 10.1177/21501319231173813.Peer-Reviewed Original ResearchConceptsAsthma control statusControl statusAsthma diaryRural-urban settingOutdoor NOChildhood asthma outcomesProspective cohort studySocioeconomic statusLow socioeconomic statusSmall feasibility studyAsthma exacerbationsOlmsted CountyPersistent asthmaAsthma outcomesCohort studyChildhood asthmaRural-urban communityLarger sample sizeAsthmaStudy periodHealth effectsFeasibility studyWeeksStatusLow threshold
2022
Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial
Gent JF, Holford TR, Bracken MB, Plano JM, McKay LA, Sorrentino KM, Koutrakis P, Leaderer BP. Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial. Journal Of Asthma 2022, 60: 744-753. PMID: 35796019, PMCID: PMC10162040, DOI: 10.1080/02770903.2022.2093219.Peer-Reviewed Original ResearchConceptsLevels of NOPersistent asthmaAsthma symptomsIntervention trialsNumber of asthmaDays of treatmentSymptom daysAsthma morbidityChildhood asthmaTreatment periodAsthmaCrossover designHousehold exposureSymptomsModest reductionTreatment effectsTreatmentGas stovesTrialsExposureTriple crossoverInterventionChildrenMixed modelsFurther research
2020
Decreased sphingolipid synthesis in children with 17q21 asthma–risk genotypes
Ono JG, Kim BI, Zhao Y, Christos PJ, Tesfaigzi Y, Worgall TS, Worgall S. Decreased sphingolipid synthesis in children with 17q21 asthma–risk genotypes. Journal Of Clinical Investigation 2020, 130: 921-926. PMID: 31929190, PMCID: PMC6994114, DOI: 10.1172/jci130860.Peer-Reviewed Original ResearchConceptsSphingolipid de novo synthesisNonallergic asthmaPeripheral blood cellsDe novo synthesisAirway hyperreactivityAllergic asthmaHuman asthmaAsthma pathogenesisChildhood asthmaAsthma riskAsthmaORMDL3 expressionAsthma susceptibilityBlood cellsNovo synthesisSphingolipid synthesisFuture therapeuticsDe novo sphingolipid synthesisChildrenORMDL3 overexpressionRiskDihydroceramideCeramideGenotypesHyperreactivity
2019
Epigenetics in Asthma
Gomez JL. Epigenetics in Asthma. Current Allergy And Asthma Reports 2019, 19: 56. PMID: 31776749, PMCID: PMC6986424, DOI: 10.1007/s11882-019-0886-y.BooksConceptsChildhood asthmaCommon chronic respiratory diseasePurpose of ReviewAsthmaChronic respiratory diseasesUnderlying pathophysiological processesHuman asthmaAllergic inflammationAsthma endotypesHealthcare utilizationAsthma pathogenesisEpigenetic mechanismsImmune cellsRespiratory diseaseAsthmaHuman studiesPathophysiological processesSummaryThis reviewSpecific methylation signaturesNovel findingsMethylation signaturesCurrent literatureAdditional researchFuture studiesRegulatory roleEndotypes
2017
NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma—implications for home environmental intervention in asthma prevention and management
Gold DR, Adamkiewicz G, Arshad SH, Celedón JC, Chapman MD, Chew GL, Cook DN, Custovic A, Gehring U, Gern JE, Johnson CC, Kennedy S, Koutrakis P, Leaderer B, Mitchell H, Litonjua AA, Mueller GA, O'Connor GT, Ownby D, Phipatanakul W, Persky V, Perzanowski MS, Ramsey CD, Salo PM, Schwaninger JM, Sordillo JE, Spira A, Suglia SF, Togias A, Zeldin DC, Matsui EC. NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma—implications for home environmental intervention in asthma prevention and management. Journal Of Allergy And Clinical Immunology 2017, 140: 933-949. PMID: 28502823, PMCID: PMC5632590, DOI: 10.1016/j.jaci.2017.04.024.Peer-Reviewed Original ResearchMeSH KeywordsAir Pollution, IndoorAnimalsAsthmaBiomedical ResearchChildConsensus Development Conferences, NIH as TopicDrug IndustryEnvironmental HealthFund RaisingHumansNational Heart, Lung, and Blood Institute (U.S.)National Institute of Allergy and Infectious Diseases (U.S.)National Institute of Environmental Health Sciences (U.S.)Organizations, NonprofitUnited StatesConceptsEnvironmental exposuresCommon chronic childhood diseaseEnvironmental interventionsMerck Childhood Asthma NetworkControl of asthmaExacerbation of asthmaManagement of asthmaChronic childhood diseaseHome environmental interventionsExposure reduction techniquesNational InstituteAirway allergyAsthma preventionAsthma managementAsthma NetworkBlood InstituteChildhood asthmaNational HeartChildhood diseasesAsthmaEnvironmental Health SciencesInfectious diseasesStudy designBiologic propertiesIndoor exposure
2013
Maternal Infection in Pregnancy and Risk of Asthma in Offspring
Collier CH, Risnes K, Norwitz ER, Bracken MB, Illuzzi JL. Maternal Infection in Pregnancy and Risk of Asthma in Offspring. Maternal And Child Health Journal 2013, 17: 1940-1950. PMID: 23338127, DOI: 10.1007/s10995-013-1220-2.Peer-Reviewed Original ResearchConceptsUrinary tract infectionRisk of asthmaChildhood asthmaMaternal infectionTract infectionsMaternal urinary tract infectionMultivariable logistic regression modelAdjusted odds ratioChildren of womenYears of lifeLogistic regression modelsAntepartum infectionChart reviewPhysician diagnosisPregnant womenStreptococcus colonizationHospital visitsOdds ratioAsthmaPregnancyInfectionWomenRiskStructured interviewsAge six
2012
An environmental epigenetic study of ADRB2 5′‐UTR methylation and childhood asthma severity
Fu A, Leaderer BP, Gent JF, Leaderer D, Zhu Y. An environmental epigenetic study of ADRB2 5′‐UTR methylation and childhood asthma severity. Clinical & Experimental Allergy 2012, 42: 1575-1581. PMID: 22862293, PMCID: PMC3673701, DOI: 10.1111/j.1365-2222.2012.04055.x.Peer-Reviewed Original ResearchConceptsChildhood asthma severityAsthma severitySevere asthmaSignificant associationSevere childhood asthmaBeta-agonist treatmentBeta-2 adrenergic receptorsImportant environmental exposuresAsthma exacerbationsAsthma medicationsMild asthmaChildhood asthmaSurrogate biomarkerMethylation-specific PCRPotential joint effectsClinical relevanceAdrenergic receptorsAsthmaADRB2SeverityEnvironmental exposuresIndoor exposureChildrenAssociationBlood
2011
Association of variants in innate immune genes with asthma and eczema
Sharma S, Poon A, Himes BE, Lasky‐Su J, Sordillo JE, Belanger K, Milton DK, Bracken MB, Triche EW, Leaderer BP, Gold DR, Litonjua AA. Association of variants in innate immune genes with asthma and eczema. Pediatric Allergy And Immunology 2011, 23: 315-323. PMID: 22192168, PMCID: PMC3412627, DOI: 10.1111/j.1399-3038.2011.01243.x.Peer-Reviewed Original ResearchConceptsInnate immune genesPathogenesis of asthmaInnate immune pathwaysSingle nucleotide polymorphismsAsthma StudyImmune genesImmune pathwaysChildhood Asthma StudyPolymorphisms of genesAssociation of variantsChildhood asthmaEczema riskAsthmaCase controlEczemaImmune variantsAdditional single nucleotide polymorphismsBayesian network analysisHome allergensScreening algorithmDifferent genetic determinantsTop single nucleotide polymorphismsPathogenesisMultiple comparisonsDisease susceptibilityHLA‐DR polymorphism modulates response to house dust mites in a transgenic mouse model of airway inflammation
Rajagopalan G, Tilahun A, Iijima K, David C, Kita H, Juhn Y. HLA‐DR polymorphism modulates response to house dust mites in a transgenic mouse model of airway inflammation. HLA 2011, 77: 589-592. PMID: 21447115, DOI: 10.1111/j.1399-0039.2010.01617.x.Peer-Reviewed Original ResearchConceptsHLA-DR3 transgenic miceHouse dust miteDust miteTransgenic miceTh2-predominant immune responseHouse dust mite extractInterleukin-13 levelsInflammatory cell countsBronchoalveolar lavage fluidTh2-type inflammationTransgenic mouse modelHLA-DR polymorphismAirway inflammationCytokine levelsBAL fluidEosinophil countHLA-DR3Childhood asthmaHLA-DR2Lavage fluidMite extractHLA-DRB1Immune responseInterleukin-4Mouse modelAssociation of maternal anemia with increased wheeze and asthma in children
Triche EW, Lundsberg LS, Wickner PG, Belanger K, Leaderer BP, Bracken MB. Association of maternal anemia with increased wheeze and asthma in children. Annals Of Allergy Asthma & Immunology 2011, 106: 131-139.e1. PMID: 21277514, PMCID: PMC3073499, DOI: 10.1016/j.anai.2010.11.007.Peer-Reviewed Original ResearchConceptsMaternal anemiaEarly-onset transientRespiratory health outcomesChildren of womenOffspring of mothersRespiratory disease developmentChildren of mothersYears of ageEarly childhoodAge 3Delivery hospitalizationsRecurrent wheezeCurrent asthmaAsthma diagnosisChildhood asthmaInfant wheezeMaternal nutritionRespiratory healthWheezeAsthmaAnemiaHealth outcomesPregnancyAnemia diagnosisMicronutrient status
2005
Barriers to effective pediatric asthma care
Swartz MK, Banasiak NC, Meadows-Oliver M. Barriers to effective pediatric asthma care. Journal Of Pediatric Health Care 2005, 19: 71-79. PMID: 15750551, DOI: 10.1016/j.pedhc.2004.10.006.Peer-Reviewed Original ResearchConceptsAsthma carePediatric primary care centerYale-New Haven Children's HospitalAsthma outreach programQuality asthma carePediatric asthma carePathophysiology of asthmaPrimary care centersPediatric nurse practitionersEnvironmental risk factorsChildhood asthmaChildren's HospitalRisk factorsCare centerNurse practitionersEffective asthmaAsthmaCareHealth careHospitalOutreach programsPathophysiologyCliniciansDisparitiesPrevalence
2002
Impact of Site of Care, Race, and Hispanic Ethnicity on Medication Use for Childhood Asthma
Ortega AN, Gergen PJ, Paltiel AD, Bauchner H, Belanger KD, Leaderer BP. Impact of Site of Care, Race, and Hispanic Ethnicity on Medication Use for Childhood Asthma. 2002, 109: e1-e1. PMID: 11773569, DOI: 10.1542/peds.109.1.e1.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Asthmatic AgentsAsthmaBlack or African AmericanChild, PreschoolConnecticutDrug UtilizationFemaleHealth Care SurveysHealth Services AccessibilityHispanic or LatinoHumansInsurance, Physician ServicesMaleMassachusettsMultivariate AnalysisPractice Patterns, Physicians'Private PracticeQuality of Health CareRetrospective StudiesSocioeconomic FactorsWhite PeopleConceptsSite of careHispanic ethnicityMedication useInsurance statusPatient raceSymptom severityAsthma medication useBeta2-agonist usePrimary care contactsHispanic childrenPrimary care visitsPrivate practiceParent-reported questionnaire dataSystemic steroidsCare contactsCare visitsUrgent visitsChildhood asthmaSteroid useRegular providerPatient levelNational guidelinesMultivariate analysisMaternal educationSignificant association
2001
Safety of inhaled corticosteroids in children with asthma
Bazzy-Asaad A. Safety of inhaled corticosteroids in children with asthma. Current Opinion In Pediatrics 2001, 13: 523-527. PMID: 11753100, DOI: 10.1097/00008480-200112000-00005.Peer-Reviewed Original ResearchConceptsModerate dosesChronic childhood asthmaUltimate adult heightMainstay of therapyUse of ICSAdrenal suppressionAsthma controlAdrenal functionChildhood asthmaGrowth retardationAdult heightAsthmaLong-term studiesDrugsCorticosteroidsChildrenDosesInitial decreaseGrowth velocitySafetyProper monitoringComplicationsGlucocorticoidsTherapyMainstayPredictors of airborne endotoxin in the home.
Park JH, Spiegelman DL, Gold DR, Burge HA, Milton DK. Predictors of airborne endotoxin in the home. Environmental Health Perspectives 2001, 109: 859-864. PMID: 11564624, PMCID: PMC1240416, DOI: 10.1289/ehp.01109859.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutantsAir Pollution, IndoorAllergensAnimalsAnimals, DomesticAsthmaCatsDogsDustEndotoxinsEnvironmental MonitoringEpidemiological MonitoringHousingHumansHumidityHypersensitivityInfantLongitudinal StudiesMassachusettsMiceModels, StatisticalMultivariate AnalysisPredictive Value of TestsRegression AnalysisSeasonsTobacco Smoke Pollution
1996
Asthma among Puerto Rican Hispanics: a multi-ethnic comparison study of risk factors.
Beckett W, Belanger K, Gent J, Holford T, Leaderer B. Asthma among Puerto Rican Hispanics: a multi-ethnic comparison study of risk factors. American Journal Of Respiratory And Critical Care Medicine 1996, 154: 894-899. PMID: 8887582, DOI: 10.1164/ajrccm.154.4.8887582.Peer-Reviewed Original ResearchConceptsRisk factorsPuerto Rican HispanicsSocioeconomic statusHispanic ethnicityHispanic mothersEnvironmental tobacco smoke exposureIndependent risk factorPhysician-diagnosed asthmaPrevalence of asthmaTobacco smoke exposureStrong risk factorAfrican American ethnicityEnvironmental risk factorsYr of ageLow socioeconomic statusStudy of asthmaNon-Hispanic whitesMo of ageActive smokingAsthmatic childrenSmoke exposureChildhood asthmaCigarette smokersMaternal ageMaternal history
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