2025
Cardiovascular risk factors in myeloproliferative neoplasms: associations with survival and thrombotic outcomes
How J, Leiva O, Redd R, Marneth A, DeAngelo D, Dieli-Conwright C, El-Jawahri A, Kamaz B, Kim C, Lindsley R, Luskin M, Stahl M, Wazir M, Weeks L, Hobbs G. Cardiovascular risk factors in myeloproliferative neoplasms: associations with survival and thrombotic outcomes. Blood Vessels Thrombosis & Hemostasis 2025, 2: 100051. DOI: 10.1016/j.bvth.2025.100051.Peer-Reviewed Original ResearchMyeloproliferative neoplasm patientsCardiovascular risk factorsEssential thrombocythemiaMyeloproliferative neoplasmsPolycythemia veraThrombotic outcomesThrombotic riskRisk factorsDiagnosis of hematological malignanciesMyeloproliferative neoplasm subtypeIncreased risk of deathType 2 diabetes mellitusMyeloproliferative neoplasms diagnosisRetrospective cohort analysisSex-matched controlsManaging cardiovascular risk factorsAssociated with survivalImprove patient morbidityRisk of deathMF patientsHematologic malignanciesMPN diagnosisPatient morbidityDana-FarberArterial/venous thrombosisTirzepatide for reduction of morbidity and mortality in adults with obesity: rationale and design of the SURMOUNT‐MMO trial
Lam C, Rodriguez A, Aminian A, Ferrannini E, Heerspink H, Jastreboff A, Laffin L, Pandey A, Ray K, Ridker P, Sanyal A, Yki‐Jarvinen H, Mason D, Strzelecki M, Bartee A, Cui C, Hurt K, Linetzky B, Bunck M, Nissen S. Tirzepatide for reduction of morbidity and mortality in adults with obesity: rationale and design of the SURMOUNT‐MMO trial. Obesity 2025 PMID: 40545827, DOI: 10.1002/oby.24332.Peer-Reviewed Original ResearchSecondary cardiovascular disease preventionCardiovascular disease preventionCardiovascular diseaseGlucagon-like peptide-1 receptor agonistsGlucose-dependent insulinotropic polypeptide receptorPeptide-1 receptor agonistsMultiple cardiovascular risk factorsCardiovascular risk factorsHeart failure eventsNonfatal myocardial infarctionType 2 diabetesReduction of morbidityDisease preventionDouble-blindPrimary endpointReceptor agonistsClinical benefitImprove morbidityObesityCoronary revascularizationRisk factorsOutcome trialsTirzepatideMultiple outcomesSubstantial weight reductionThoracic aortic aneurysm
Berger T, Dumfarth J, Kreibich M, Minatoya K, Ziganshin B, Czerny M. Thoracic aortic aneurysm. Nature Reviews Disease Primers 2025, 11: 34. PMID: 40341396, DOI: 10.1038/s41572-025-00617-2.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmAortic diseasePathophysiological mechanismsTreatment of aortic diseaseThoracic aortic diseaseVascular smooth muscle cellsGold standard diagnostic toolSmooth muscle cellsCardiovascular risk factorsStandard diagnostic toolAortic medicineAdvanced imaging techniquesEmbryological factorsCT angiographyArterial hypertensionDiagnostic challengeAortic aneurysmAbnormal dilatationThoracic aortaAsymptomatic natureGenetic predispositionTreatment outcomesMuscle cellsMedical managementRisk factorsAlcohol use, heavy episodic drinking, and associated cardiovascular risk in Guyana
Motilal M, Gobin R, Khan R, Maharaj R. Alcohol use, heavy episodic drinking, and associated cardiovascular risk in Guyana. BULL PAN AM HEALTH ORGAN 2025, 49: 1. PMID: 40206567, PMCID: PMC11980521, DOI: 10.26633/rpsp.2025.30.Peer-Reviewed Original ResearchHeavy episodic drinkingAlcohol useWorld Health OrganizationSecondary analysisIndo-GuyaneseCardiovascular riskSecondary analysis of dataRisk factor surveyRisk of heavy episodic drinkingEpisodic drinkingPublic health interventionsOdds of alcohol useOdds of heavy episodic drinkingElevated blood pressureCardiovascular risk factorsBinary logistic regressionFactor surveyMaximum educational levelHealth interventionsYoung malesLinear regression modelsElevated triglyceridesDescriptive statisticsEducation levelAdjusted modelsAssociation Between Hippocampal Volume on Portable Magnetic Resonance Imaging and Cognitive Ability in Patients with Cardiovascular Risk Factors (P4-3.020)
Peasley E, Johnson I, Brigger H, Smith J, Lalwani D, Zabinska J, Sze G, Payabvash S, Sorby-Adams A, Gonzalez J, Rosen M, Kimberly W, De Havenon A, Sheth K. Association Between Hippocampal Volume on Portable Magnetic Resonance Imaging and Cognitive Ability in Patients with Cardiovascular Risk Factors (P4-3.020). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000211834.Peer-Reviewed Original ResearchHippocampal volumeCognitive abilitiesMagnetic resonance imagingResonance imagingCardiovascular risk factorsHippocampalPredictive value of tibial and coronary artery calcification scores for cardiac and lower extremity events
Schwartz A, Maahs E, Berezowitz A, Mojibian H, Guzman R. Predictive value of tibial and coronary artery calcification scores for cardiac and lower extremity events. Journal Of Vascular Surgery 2025 PMID: 40158754, DOI: 10.1016/j.jvs.2025.03.196.Peer-Reviewed Original ResearchCoronary artery calcificationTibial artery calcificationAssociated with increased MACEArtery calcificationCardiovascular risk factor dataCoronary calcificationIschemic eventsLower extremity eventsSevere coronary artery calcificationCoronary arteryRisk factorsCoronary artery calcification scorePredictive valueInfluence of cardiovascular risk factorsAssociated with advanced ageRetrospectively reviewed imagesLog-rank testAdverse cardiac eventsComputed tomography scanHistory of smokingData of patientsArtery calcification scoreCardiovascular risk factorsOrdinal logistic regressionLower extremity ischemiaThe Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review
Mahabamunuge J, Sekula N, Lepore C, Kudrimoti M, Upadhyay A, Alshowaikh K, Li H, Seifer D, AlAshqar A. The Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review. Biomedicines 2025, 13: 709. PMID: 40149685, PMCID: PMC11940587, DOI: 10.3390/biomedicines13030709.Peer-Reviewed Original ResearchPolycystic ovary syndromeType 2 diabetes mellitusCardiometabolic morbidityIncreased cardiovascular riskDevelopment of hypertensionCardiovascular risk factorsNarrative reviewPotential clinical implicationsAndrogen excessEndothelial dysfunctionCardiovascular riskClinical conditionsPredisposed individualsTherapeutic strategiesAdipokine secretionRisk factorsInsulin resistanceCardiometabolic diseasesCardiovascular diseaseClinical implicationsMorbidityMellitusSyndromeMolecular mechanismsDisease16 Metabolic Syndrome and Obesity
Alonso W, Canapari C. 16 Metabolic Syndrome and Obesity. 2025, 175-184. DOI: 10.1016/b978-0-323-75566-5.00016-2.Peer-Reviewed Original ResearchMetabolic syndromeComponents of metabolic syndromeInvolvement of adipocytokinesSleep-disordered breathingIncreased sympathetic activityElevated blood pressureCardiovascular risk factorsRates of obesityIntermittent hypoxemiaTruncal obesityDysregulation of glucose metabolismSleep fragmentationSympathetic activityBlood pressureSleep curtailmentRisk factorsSyndromeObesityShort sleepGlucose metabolismCircadian factorsSleepHypoxemiaDyslipidemiaAdipocytokines
2024
Health status outcomes after acute myocardial infarction in patients without standard modifiable risk factors
Ikemura N, Chan P, Gosch K, Nguyen D, Iv C, Khan M, Lu Y, Sawano M, Krumholz H, Spertus J. Health status outcomes after acute myocardial infarction in patients without standard modifiable risk factors. American Heart Journal 2024, 281: 123-132. PMID: 39638274, PMCID: PMC11810589, DOI: 10.1016/j.ahj.2024.11.018.Peer-Reviewed Original ResearchSeattle Angina QuestionnaireModifiable risk factorsHealth status outcomesBaseline SAQ scoresAcute myocardial infarctionStatus outcomesHealth statusRisk factorsSequential adjustmentSAQ scoresModifiable cardiovascular risk factorsHistory of coronary diseaseSAQ Summary ScoreHierarchical linear mixed modelsAcute myocardial infarction patientsCardiovascular risk factorsMyocardial infarctionSummary scoreSociodemographic characteristicsAngina QuestionnaireLinear mixed modelsDepressive symptomsU.S. hospitalsLong-term mortalitySecondary preventionAPOE4 moderates the association between cerebral small vessel disease and cortical tau accumulation in midlife
Espinoza L, Scott M, Beiser A, Banh A, Philip V, Ghosh S, Thibault E, Maillard P, Decarli C, Fakhri G, Johnson K, Seshadri S, Satizabal C. APOE4 moderates the association between cerebral small vessel disease and cortical tau accumulation in midlife. Alzheimer's & Dementia 2024, 20: e091824. PMCID: PMC11714429, DOI: 10.1002/alz.091824.Peer-Reviewed Original ResearchAPOE-e4 genotypeAPOE-e4APOE-e4 carriersBiomarkers of cerebral small vessel diseaseIncreased risk of ADSignificant associationFramingham Heart StudyThird Generation cohortsRegional tauCerebral small vessel diseaseCognitively healthy participantsRisk of ADMiddle-aged adultsBorderline significant associationCardiovascular risk factorsSmall vessel diseaseDementia onsetNo significant associationHeart StudyPotential confoundersAlzheimer's diseaseLinear regression modelsE4 genotypeTau accumulationIncreased riskPrevalent Atherosclerotic Cardiovascular Disease Among Veterans by Sexual Orientation
Streed C, Duncan M, Heier K, Workman T, Beach L, Caceres B, O'Leary J, Skanderson M, Goulet J. Prevalent Atherosclerotic Cardiovascular Disease Among Veterans by Sexual Orientation. Journal Of The American Heart Association 2024, 13: e036898. PMID: 39508159, PMCID: PMC11681393, DOI: 10.1161/jaha.124.036898.Peer-Reviewed Original ResearchPrevalent atherosclerotic cardiovascular diseasesAtherosclerotic cardiovascular diseaseIndex dateCardiovascular diseaseVeterans Health Administration dataPoor cardiovascular healthHealth administrative dataPrimary care appointmentsLGB veteransCardiovascular risk factorsCare appointmentsLogistic regression analysisSexual orientationCardiovascular healthVeteran populationHispanic ethnicityAdministrative dataNationwide cohortVeteransBaseline dateNatural language processing algorithmsSubstance useRisk factorsRegression analysisLanguage processing algorithmsLife's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, Hawkes M, de Havenon A, Schwamm L, Sheth K, Gill T, Falcone G. Life's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults. Neurology 2024, 103: e209990. PMID: 39442069, PMCID: PMC11498939, DOI: 10.1212/wnl.0000000000209990.Peer-Reviewed Original ResearchConceptsLife's Essential 8Poor cardiovascular healthCardiovascular healthBrain healthLife's Essential 8 scoreUnadjusted riskEssential 8Determinants of cardiovascular healthUK Biobank (UKBCardiovascular health profileModifiable cardiovascular risk factorsBrain health outcomesRisk factorsComposite outcomePublic health constructsPopulation studiesMiddle-aged adultsCox modelLate-life depressionCox proportional hazards modelsBrain health benefitsMultivariate Cox modelCardiovascular risk factorsFollow-up timeAoU participantsAmerican Radium Society Appropriate Use Criteria on Cardiac Toxicity Prevention and Management After Thoracic Radiotherapy
Amini A, Zaha V, Hamad E, Woodard P, Rimner A, Chang J, Chun S, Donington J, Edelman M, Gubens M, Higgins K, Iyengar P, Juloori A, Movsas B, Ning M, Park H, Rodrigues G, Wolf A, Simone C. American Radium Society Appropriate Use Criteria on Cardiac Toxicity Prevention and Management After Thoracic Radiotherapy. Journal Of Thoracic Oncology 2024, 19: 1654-1667. PMID: 39313150, PMCID: PMC11665043, DOI: 10.1016/j.jtho.2024.09.1433.Peer-Reviewed Original ResearchConceptsCardiac toxicityCardiac comorbiditiesThoracic radiotherapyToxicity preventionAmerican Radium Society Appropriate Use CriteriaAbsence of cardiovascular risk factorsLow riskHigh riskMultidisciplinary consensus guidelinesTreatment-related risksAppropriate Use CriteriaCardiovascular risk factorsVariants of patientsThoracic malignanciesModified Delphi methodologyCardiac substructuresConsensus guidelinesRadiotherapyRisk factorsCardiac imagingComorbiditiesDose exposurePatientsSystematic reviewThoracicSystolic Blood Pressure, Cardiovascular Health, and Neurocognition in Adolescents
Hooper S, Lande M, Flynn J, Hanevold C, Meyers K, Samuels J, Becker R, Daniels S, Falkner B, Ferguson M, Ingelfinger J, Martin L, Mitsnefes M, Khoury P, Seo J, Urbina E. Systolic Blood Pressure, Cardiovascular Health, and Neurocognition in Adolescents. Hypertension 2024, 81: 2444-2453. PMID: 39291378, PMCID: PMC11578784, DOI: 10.1161/hypertensionaha.124.22834.Peer-Reviewed Original ResearchParent ratings of executive functioningRatings of executive functionSystolic blood pressureLow nonverbal IQCardiovascular risk factorsNonverbal IQVerbal attentionCardiovascular healthExecutive functionParent ratingsRisk factorsAssociated with parent ratingsAmbulatory systolic blood pressureHealth risk indicatorsNeurocognitive outcomesCross-sectional studyAcademic medical centerAssociated with neurocognitionHigh school degreeElevated systolic blood pressureAssociated with neurocognitive outcomesBlood pressureBlood pressure measurementsClinical carePrimary exposureAssociations of Physical Activity Engagement with Cerebral Amyloid-β and Tau from Midlife
Gonzales M, Kojis D, Spartano N, Thibault E, DeCarli C, Fakhri G, Johnson K, Beiser A, Seshadri S. Associations of Physical Activity Engagement with Cerebral Amyloid-β and Tau from Midlife. Journal Of Alzheimer’s Disease 2024, 100: 935-943. PMID: 39031362, PMCID: PMC12050109, DOI: 10.3233/jad-240322.Peer-Reviewed Original ResearchConceptsPhysical activity indexPhysical activity engagementAssociated with lower dementia riskPhysical activity index scoreAssociation of physical activityActive engagementPhysical activity levelsFramingham Heart StudyCross-sectional associationsCommunity-based cohortCardiovascular risk factorsDementia riskPhysical activityLifestyle interventionHeart StudyLinear regression modelsStratified analysisTau-PET retentionSelf-reportSex disparitiesActivity levelsLate lifeTau positron emission tomographyRisk factorsAge groupsImpact of Multiarterial Revascularization on Long-term Major Adverse Cardiovascular Events After Coronary Bypass in 23,798 Patients
Jameie M, Valinejad K, Pashang M, Jameie M, Bagheri J, Soleimani H, Jalali A, Mehrabanian M, Nayebirad S, Abbasi K, Masoudkabir F, Tajdini M, Mehrani M, Movahedi N, Hameed I, Hosseini K, Gaudino M. Impact of Multiarterial Revascularization on Long-term Major Adverse Cardiovascular Events After Coronary Bypass in 23,798 Patients. The Annals Of Thoracic Surgery 2024, 118: 863-872. PMID: 39009058, DOI: 10.1016/j.athoracsur.2024.06.034.Peer-Reviewed Original ResearchInverse probability weightingRisks of study outcomesAssociated with reduced riskRisk factorsCovariate-adjusted modelsPatient subgroupsAll-cause mortalitySingle-center retrospective cohort studyCardiovascular risk factorsLong-term major adverse cardiovascular eventsAdverse cardiocerebrovascular eventsMajor adverse cardiovascular eventsRetrospective cohort studyRisk of adverse eventsAdverse cardiovascular eventsArtery bypass graftingCohort studyPost-surgery outcomesSaphenous vein graftsStudy outcomesStudy populationCrude mortalityCardiocerebrovascular eventsProbability weightingUnivariate levelA Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression
Oikonomou E, Holste G, Yuan N, Coppi A, McNamara R, Haynes N, Vora A, Velazquez E, Li F, Menon V, Kapadia S, Gill T, Nadkarni G, Krumholz H, Wang Z, Ouyang D, Khera R. A Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression. JAMA Cardiology 2024, 9: 534-544. PMID: 38581644, PMCID: PMC10999005, DOI: 10.1001/jamacardio.2024.0595.Peer-Reviewed Original ResearchCardiac magnetic resonanceAortic valve replacementCardiac magnetic resonance imagingAV VmaxSevere ASAortic stenosisCohort studyPeak aortic valve velocityCohort study of patientsAortic valve velocityCohort of patientsTraditional cardiovascular risk factorsAssociated with faster progressionStudy of patientsCedars-Sinai Medical CenterAssociated with AS developmentCardiovascular risk factorsCardiovascular imaging modalitiesIndependent of ageModerate ASEjection fractionEchocardiographic studiesValve replacementRisk stratificationCardiac structureCharacterizing genetic profiles for high triglyceride levels in U.S. patients of African ancestry
Jiang L, Gangireddy S, Dickson A, Xin Y, Yan C, Kawai V, Cox N, Linton M, Wei W, Stein C, Feng Q. Characterizing genetic profiles for high triglyceride levels in U.S. patients of African ancestry. Journal Of Lipid Research 2024, 65: 100569. PMID: 38795861, PMCID: PMC11231545, DOI: 10.1016/j.jlr.2024.100569.Peer-Reviewed Original ResearchIndividuals of AAElectronic health recordsMild-to-moderate HTGGenetic risk factorsAfrican ancestryEuropean ancestryGenetic profileIndividuals of European ancestryRisk factorsNormal TGLongitudinal electronic health recordsSevere hypertriglyceridemiaPolygenic risk scoresCohort of AA patientsPatients of African ancestryAPOA5 p.Metabolic genesFunctional variantsCardiovascular risk factorsHigher triglyceride levelsHealth recordsVariant allelesAncestryRisk scoreAA patientsInterleukin-16 is increased in dialysis patients but is not a cardiovascular risk factor
Brösecke F, Pfau A, Ermer T, Dein Terra Mota Ribeiro A, Rubenbauer L, Rao V, Burlein S, Genser B, Reichel M, Aronson P, Coca S, Knauf F. Interleukin-16 is increased in dialysis patients but is not a cardiovascular risk factor. Scientific Reports 2024, 14: 11323. PMID: 38760468, PMCID: PMC11101424, DOI: 10.1038/s41598-024-61808-7.Peer-Reviewed Original ResearchConceptsIL-16 levelsIL-16Dialysis patientsCardiovascular eventsConcentrations of IL-16Kidney failureUremic toxinsCardiovascular diseaseCompared to healthy individualsPlasma oxalate concentrationActivated immune cellsAssociated with cardiovascular diseaseIL-16 concentrationCytokine IL-16Cardiovascular risk factorsNo significant associationPlasma oxalateInflammatory markersImmune cellsCytokine concentrationsInterleukin-16US patientsCohort 1Cardiovascular outcomesHealthy individualsASSOCIATION OF LONG-TERM TIME IN TARGET RANGE FOR SYSTOLIC BLOOD PRESSURE SINCE CHILDHOOD WITH ARTERIAL STIFFNESS IN MIDLIFE: A 36-YEAR PROSPECTIVE COHORT STUDY
Wang Y, Qi H, Jia H, Wang D, Sun Y, Du M, Hu G, Man Z, Chu C, Chang J, Delles C, Zhang L, Mu J. ASSOCIATION OF LONG-TERM TIME IN TARGET RANGE FOR SYSTOLIC BLOOD PRESSURE SINCE CHILDHOOD WITH ARTERIAL STIFFNESS IN MIDLIFE: A 36-YEAR PROSPECTIVE COHORT STUDY. Journal Of Hypertension 2024, 42: e54. DOI: 10.1097/01.hjh.0001019768.43096.d1.Peer-Reviewed Original ResearchRisk of arterial stiffnessSystolic blood pressureOdds ratioDecreased riskArterial stiffness in adulthoodAssociated with adult hypertensionRisk factorsModifiable risk factorsAdolescents aged 6Arterial stiffnessBlood pressureYears of follow-upCardiovascular risk factorsTraditional cardiovascular risk factorsAssociated with arterial stiffnessElevated blood pressureLowest quartileSystolic blood pressure variabilityCohort studyAged 6MidlifeTarget rangeCardiovascular diseaseAdult hypertensionTime-in-target
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