2025
Prevalence of Hypertension in the Late Postpartum Period by Hypertensive Status in Pregnancy
Sinnott C, Culhane J, Lundsberg L, Partridge C, Denoble A. Prevalence of Hypertension in the Late Postpartum Period by Hypertensive Status in Pregnancy. O&G Open 2025, 2: e093. DOI: 10.1097/og9.0000000000000093.Peer-Reviewed Original ResearchElevated blood pressureLate postpartum periodBlood pressurePostpartum periodAcademic health care systemHypertension statusDelivery hospitalization dischargeWeeks of gestationRetrospective cohort studyHealth care systemNormal blood pressureDiastolic blood pressureElectronic medical recordsPrevalence of hypertensionSystolic blood pressureRates of hypertensionPostpartum hypertensionMm HgCare systemCohort studyMonths postpartumPregnancyLate postpartumPatient attributesMedical recordsNexfin versus conventional oscillometric cuff for blood pressure monitoring during neuro-endovascular procedures
Chen H, Njonkou-Tchoquessi R, Colasurdo M, Cobb C, Payabvash S, Malhotra A, Gandhi D. Nexfin versus conventional oscillometric cuff for blood pressure monitoring during neuro-endovascular procedures. Brain Circulation 2025 DOI: 10.4103/bc.bc_146_24.Peer-Reviewed Original ResearchNeuro-endovascular proceduresBlood pressureSystolic BPArterial lineNeurological injurySingle-center retrospective studyPredictive valueNegative predictive valuePositive predictive valueAcute neurological injuryBlood pressure monitoringArterial line measurementsConsecutive patientsRelative hypotensionRetrospective studyNeuro-endovascular treatmentNeuroendovascular interventionsNeuroendovascular proceduresSBP dropNexfinClinical scenariosNoninvasive blood pressureBP monitoringPatientsConventional cuffHarnessing HIV clinics to deliver integrated hypertension care for People living with HIV in Uganda: A formative mixed methods study
Semitala F, Ayebare F, Kiggundu J, Kiwala C, Senfuma J, Mutungi G, Ssinabulya I, Kayima J, Muddu M, Spiegelman D, Schwartz J, Longenecker C, Katahoire A. Harnessing HIV clinics to deliver integrated hypertension care for People living with HIV in Uganda: A formative mixed methods study. PLOS Global Public Health 2025, 5: e0004701. PMID: 40465676, PMCID: PMC12136366, DOI: 10.1371/journal.pgph.0004701.Peer-Reviewed Original ResearchFragmented care deliveryHypertension careQualitative dataHIV clinicSub-Saharan AfricaCare deliveryConsolidated Framework for Implementation ResearchAnalyzed qualitative dataQualitative interviewsInterruptions due to side effectsSub-SaharanHIV servicesBlood pressureHealthcare accessNon-communicable diseasesMixed methods studyUgandaPeri-urban UgandaChronic careSystolic blood pressureHIV careImplementation researchPocket costsMedication accessAnalyzed quantitative dataPrevalence, Awareness, and Factors Associated with Hypertension Among Adults in Rural Southwestern Uganda: A Baseline Survey
Kansiime G, Nuwagira E, Obwoya P, Baluku J, Kanyesigye M, Twesiime C, Ssebutinde P, Muhindo R, Muyingo A, Kananura K, Tusingwire P, Atukunda E, Kalyesubula R, Bajunirwe F, Muiru A. Prevalence, Awareness, and Factors Associated with Hypertension Among Adults in Rural Southwestern Uganda: A Baseline Survey. International Journal Of General Medicine 2025, 18: 3289-3300. PMID: 40575767, PMCID: PMC12199733, DOI: 10.2147/ijgm.s522911.Peer-Reviewed Original ResearchFactors associated with hypertensionRural southwestern UgandaSouthwestern UgandaBaseline surveyWHO STEPS questionnaireServings of fruitsCommunity health workersPhysically active populationFactors of hypertensionBlood pressureRisk factorsRural sub-Saharan AfricaSTEPS questionnaireLifestyle behaviorsPhysical activityHealth workersHypertension prevalenceTargeted interventionsMbarara districtResearch assistantsPreventable deathsAntihypertensive useLogistic regressionSub-Saharan AfricaRural communitiesImpact of Mean Blood Pressure Profiles in Percutaneous Left Ventricular Assist Device‐Supported High‐Risk Percutaneous Coronary Intervention: The PROTECT III Study
Bonnet G, Rommel K, Falah B, Lansky A, Zhang Y, Schonning M, Redfors B, Burkhoff D, Cohen D, Basir M, O'Neill W, Granada J. Impact of Mean Blood Pressure Profiles in Percutaneous Left Ventricular Assist Device‐Supported High‐Risk Percutaneous Coronary Intervention: The PROTECT III Study. Journal Of The American Heart Association 2025, 14: e036367. PMID: 40371603, PMCID: PMC12184586, DOI: 10.1161/jaha.124.036367.Peer-Reviewed Original ResearchConceptsIn-hospital outcomesBP categoriesPercutaneous coronary interventionHigh-risk percutaneous coronary interventionMean blood pressureBaseline BP levelsCoronary interventionIn-hospital deathAssociated with higher ratesVentricular assist device supportStroke/transient ischemic attackLeft ventricular assist device supportCerebrovascular eventsAssist device supportPercutaneous left ventricular assist device supportHistory of heart failureIn-hospitalInterventionHemodynamic profileAdverse outcomesBP levelsPrevent hypotensionPercutaneous left ventricular assist deviceMyocardial infarctionBlood pressure[The mediating effect of electrocardiographic indicators in the association between exposure to fine particulate matter and its element constituents and blood pressure].
Wang Y, Zhang W, Liu Q, Ling H, Xiang C, Qiu Y, Chen C, Wang J, Fang J, Shi X. [The mediating effect of electrocardiographic indicators in the association between exposure to fine particulate matter and its element constituents and blood pressure]. Chinese Preventive Medicine 2025, 59: 621-627. PMID: 40374351, DOI: 10.3760/cma.j.cn112150-20241028-00852.Peer-Reviewed Original ResearchConceptsExposure to PM<sub>2.5</sub>Short-term exposure to PM<sub>2.5</sub>Effects of short-term exposure to PM<sub>2.5</sub> anConcentrations of PM<sub>2.5</sub>Short-term exposure to fine particulate matterExposure to fine particulate matterFine particulate matterBeijing-Tianjin-Hebei regionElemental constituentsExposure to PbExposure to KParticulate matterDiastolic blood pressureZnMultivariate linear regressionSystolic blood pressureSeLinear regressionBlood pressureCross-sectional surveyExposurePbCOCuStudy periodCombined androgen excess polycystic ovary syndrome and obesity are associated with elevated blood pressure variability in adult women
Young B, Colburn A, Fadel P, Stachenfeld N. Combined androgen excess polycystic ovary syndrome and obesity are associated with elevated blood pressure variability in adult women. Physiology 2025, 40: 0392. DOI: 10.1152/physiol.2025.40.s1.0392.Peer-Reviewed Original ResearchDiastolic blood pressureSystolic blood pressureBlood pressure variabilityAverage real variabilityObese womenLean controlsLean womenCardiovascular disease riskPolycystic ovary syndromeAE-PCOSBlood pressureMarkers of cardiovascular disease riskWomen of reproductive ageCompared to lean controlsAssociated with elevated cardiovascular disease riskIncreased BPVHealthy control womenDBP SDMeasures of blood pressure variabilityElevated cardiovascular disease riskPressure variabilityKruskal-Wallis one-way ANOVAResting blood pressureBeat-to-beat BPElevated blood pressure variabilityMaternal Cardiometabolic Risk Factors in Pregnancy and Offspring Blood Pressure at Age 2 to 18 Years
Niu Z, Ako A, Geiger S, Howe C, Perng W, Singh R, Karagas M, Elliott A, Cassidy-Bushrow A, Camargo C, Sanderson K, McEvoy C, Oken E, Dabelea D, Hartert T, Carter B, Stroustrup A, Lampland A, O’Connor T, Gogcu S, Hudak M, Shorey-Kendrick L, Zhao Q, Ni Y, VanWormer J, Ferrara A, Hedderson M, Zhu Y, Alshawabkeh A, Cordero J, Koinis-Mitchell D, Carnell S, Breton C, Bastain T, Farzan S, Smith P, Newby L, Adair L, Jacobson L, Catellier D, McGrath M, Douglas C, Duggal P, Knapp E, Kress A, Blackwell C, Mansolf M, Lai J, Ho E, Cella D, Gershon R, Macy M, Das S, Freedman J, Mallal S, McLean J, Shah R, Shilts M, Meeker J, Trasande L, Hasegawa K, Zhu Z, Sullivan A, Bekelman T, Wilkening G, Magzamen S, Moore B, Starling A, Rinehart D, D'Sa V, Deoni S, Mueller H, Duarte C, Monk C, Canino G, Posner J, Murray T, Lugo-Candelas C, Dunlop A, Brennan P, Hockett C, Croen L, Ainsworth J, Bacharier L, Bendixsen C, Gern J, Gold D, Jackson D, Johnson C, Joseph C, Kattan M, Khurana Hershey G, Lemanske, Jr. R, Lynch S, Miller R, Ober C, Ownby D, Rivera-Spoljaric K, Ryan P, Seroogy C, Singh A, Wood R, Zoratti E, Habre R, Farzan S, Gilliland F, Hertz-Picciotto I, Bennett D, Schweitzer J, Schmidt R, LaSalle J, Hipwell A, Karr C, Bush N, LeWinn K, Sathyanarayana S, Tylavsky F, Carroll K, Loftus C, Leve L, Ganiban J, Neiderhiser J, Weiss S, Litonjua A, Spindel E, Tepper R, Newschaffer C, Lyall K, Volk H, Landa R, Ozonoff S, Piven J, Hazlett H, Pandey J, Schultz R, Dager S, Botteron K, Messinger D, Stone W, Ames J, O'Connor T, Miller R, Hacker M, James-Todd T, O'Shea T, Fry R, Frazier J, Rollins C, Montgomery A, Vaidya R, Joseph R, Washburn L, Bear K, Rollins J, Hooper S, Taylor G, Jackson W, Thompson A, Daniels J, Hernandez M, Lu K, Msall M, Lenski M, Obeid R, Pastyrnak S, Jensen E, Sakai C, Santos H, Kerver J, Paneth N, Barone C, Elliott M, Ruden D, Fussman C, Herbstman J, Margolis A, Schantz S, Aguiar A, Tabb K, Strakovsky R, Woodruff T, Morello-Frosch R, Padula A, Stanford J, Porucznik C, Giardino A, Wright R, Wright R, Collett B, Baumann-Blackmore N, Gangnon R, McKennan C, Wilson J, Altman M, Aschner J, Merhar S, Moore P, Pryhuber G, Reynolds Lyndaker A, Rochelson B, Jan S, Blitz M, Katzow M, Brown Z, Chiuzan C, Rafael T, Lewis D, Meirowitz N, Poindexter B, Gebretsadik T, Osmundson S, Straughen J, Eapen A, Wegienka G, Sitarik A, Woodcroft K, Urquhart A, Levin A, Johnson-Hooper T, Davidson B, Ma T, Barrett E, Blaser M, Dominguez-Bello M, Horton D, Jimenez M, Rosen T, Palomares K, Avalos L, Hunt K, Newman R, Bloom M, Alkis M, Roberts J, Mumford S, Burris H, DeMauro S, Yee L, Hamvas A, Olidipo A, Haddad A, Eiland L, Spillane N, Suri K, Fisher S, Goldstein J, Mithal L, DeRegnier R, Maitre N, Nguyen R, JaKa M, Sidebottom A, Paidas M, Potter J, Ruby N, Duthely L, Jayakumar A, Young K, Maldonado I, Miller M, Slaughter J, Keim S, Lynch C, Venkatesh K, Whitworth K, Symanski E, Northrup T, Mendez-Figueroa H, Mosquera R, Madan J, MacKenzie D, Lewis J, Rennie B, Leventhal B, Kim Y, Bishop S, Nozadi S, Luo L, Lester B, Marsit C, Everson T, Loncar C, McGowan E, Sheinkopf S, Check J, Helderman J, Neal C, Smith L. Maternal Cardiometabolic Risk Factors in Pregnancy and Offspring Blood Pressure at Age 2 to 18 Years. JAMA Network Open 2025, 8: e259205. PMID: 40338548, PMCID: PMC12062903, DOI: 10.1001/jamanetworkopen.2025.9205.Peer-Reviewed Original ResearchConceptsMaternal cardiometabolic risk factorsCardiometabolic risk factorsOffspring blood pressurePrepregnancy obesitySystolic blood pressureDiastolic blood pressureRisk factorsBlood pressure measurementsAssociated with higher offspring blood pressureGestational diabetesAged 2Cohort study analyzed dataHypertensive disordersOffspring systolic blood pressureChild Health Outcomes programBlood pressureHealthy blood pressureHigher systolic blood pressureHigher diastolic blood pressureHypertensive disorders of pregnancyStudy analyzed dataMother-offspring pairsHigh blood pressureDisorders of pregnancyMain OutcomesConversion Therapy Exposure and Elevated Cardiovascular Disease Risk
Gibb J, Schrock J, Smith M, D’Aquila R, McDade T, Mustanski B. Conversion Therapy Exposure and Elevated Cardiovascular Disease Risk. JAMA Network Open 2025, 8: e258745. PMID: 40327341, PMCID: PMC12056572, DOI: 10.1001/jamanetworkopen.2025.8745.Peer-Reviewed Original ResearchConceptsHigh blood pressureSystolic blood pressureDiastolic blood pressureSelf-reported high blood pressureCohort studyCardiovascular health dataCardiovascular health indicatorsSelf-reported hypertensionSGM health disparitiesMental health impactsCardiovascular health consequencesCardiovascular disease riskBlood pressureElevated diastolic blood pressureHealth disparitiesCare approachElevated systolic blood pressureHealth indicatorsMain OutcomesIncreased DBPBehavioral covariatesHealth dataSGM individualsDisease riskHealth consequencesChemically Induced Hypertension: Antineoplastic Agents Associated with High Blood Pressure
Moss E, Shirali A. Chemically Induced Hypertension: Antineoplastic Agents Associated with High Blood Pressure. Updates In Hypertension And Cardiovascular Protection 2025, 79-91. DOI: 10.1007/978-3-031-81292-7_5.Peer-Reviewed Original ResearchVascular endothelial growth factor signal pathway inhibitorsAdverse effects of anticancer therapyEffects of anticancer therapySystemic adverse effectsTyrosine kinase inhibitorsExacerbation of hypertensionTreatment of malignanciesDevelopment of hypertensionAssociated with hypertensionDrug-drug interactionsBlood pressure monitoringSignaling pathway inhibitorsCalcineurin inhibitorsHigh blood pressureAdjuvant medicationsAntineoplastic therapyProteosome inhibitorKinase inhibitorsIncreased riskSubsequent treatmentAnticancer therapyPathway inhibitorBlood pressureAntineoplastic drugsHypertensionBLOOD PRESSURE AND MORTALITY IN THE ADULTS AGED 80 OR OLDER: A COMPREHENSIVE ANALYSIS OF NATIONAL SURVEYS IN THE UNITED STATES
Yang H, Huang C, Sawano M, Herrin J, Li Z, Spatz E, Krumholz H, Lu Y. BLOOD PRESSURE AND MORTALITY IN THE ADULTS AGED 80 OR OLDER: A COMPREHENSIVE ANALYSIS OF NATIONAL SURVEYS IN THE UNITED STATES. Journal Of The American College Of Cardiology 2025, 85: 436. DOI: 10.1016/s0735-1097(25)00920-9.Peer-Reviewed Original ResearchBlood pressureCurrent Practices in Monitoring Children and Adults With X-linked Hypophosphatemia: A Global Survey of Expert Experience
Ali D, Alsarraf F, Abu Alrob H, Alexander R, Almoulia A, Appelman-Dijkstra N, Beck-Nielsen S, Biosse-Duplan M, Brandi M, Carpenter T, Chaussain C, Cohen-Solal M, Crowley R, Dandurand K, Florenzano P, Gagnon C, Goodyer P, Grimbly C, Hussein S, Imel E, de Beur S, Javaid M, Lehman A, Lems W, Lewiecki E, McDonnell C, Mirza R, Morgante E, Portale A, Rhee Y, Siggelkow H, Tosi L, Ward L, Guyatt G, Khan A. Current Practices in Monitoring Children and Adults With X-linked Hypophosphatemia: A Global Survey of Expert Experience. The Journal Of Clinical Endocrinology & Metabolism 2025, 110: e2347-e2361. PMID: 40111179, PMCID: PMC12190797, DOI: 10.1210/clinem/dgaf180.Peer-Reviewed Original ResearchConceptsX-linked hypophosphatemiaFollow-upManagement of "X-linked hypophosphatemiaPresence of bone painBlood pressureHistory of fractureSkeletal deformitiesEvaluation of childrenBone painDental infectionsRenal ultrasoundDental assessmentLaboratory profileChild follow-upRenal functionPHEX geneSerum phosphorusAssess painClinical examinationLactating womenFamily historyHypophosphatemiaAdult follow-upJoint involvementPatientsSystolic Blood Pressure and Cardiovascular Mortality in U.S. Adults Aged 80+ Taking Antihypertensive Medications
Yang H, Huang C, Sawano M, Herrin J, Chen G, Li Z, Spatz E, Krumholz H, Lu Y. Systolic Blood Pressure and Cardiovascular Mortality in U.S. Adults Aged 80+ Taking Antihypertensive Medications. Journal Of The American College Of Cardiology 2025, 85: 1455-1458. PMID: 40100170, PMCID: PMC12045553, DOI: 10.1016/j.jacc.2025.01.033.Peer-Reviewed Original ResearchPerceived Discrimination, Trauma, Mental Health, and Blood Pressure Outcomes Among Young African American/Black Mothers in the InterGEN Study.
Nyembwe A, Zhao Y, Millender E, Hall K, Caceres B, Taylor B, Morrison M, Prescott L, Potts-Thompson S, Aziz A, Aruleba F, Crusto C, Taylor J. Perceived Discrimination, Trauma, Mental Health, and Blood Pressure Outcomes Among Young African American/Black Mothers in the InterGEN Study. The Journal Of Cardiovascular Nursing 2025 PMID: 40052829, DOI: 10.1097/jcn.0000000000001190.Peer-Reviewed Original ResearchDepressive symptomsSecondary data analysis of dataAssociation of discriminationPresentation of depressive symptomsFactors associated with BPLongitudinal cohort studySecondary data analysisAssociated with blood pressureBlood pressure outcomesExperiences of discriminationInfluence of discriminationChildren aged 3InterGEN StudyMother-child dyadsPsychosocial measuresAA womenBlood pressureMental healthPressure outcomesCohort studyLinear regression analysisCulturally sensitive screening toolsScreening toolMaternal BPSensitive screening toolBiomarkers in Autosomal Dominant Tubulointerstitial Kidney Disease
Li M, Jiang L, Liu Z, You R, Li Y, Xiang C, Yang L, Zhang H, Zhou X. Biomarkers in Autosomal Dominant Tubulointerstitial Kidney Disease. Integrative Medicine In Nephrology And Andrology 2025, 12 DOI: 10.1097/imna-d-24-00050.Peer-Reviewed Original ResearchAutosomal dominant tubulointerstitial kidney diseaseChronic kidney diseaseTubulointerstitial kidney diseaseKidney diseaseProgressive chronic kidney diseaseDelay kidney failureVariable clinical featuresUric acid levelsControl blood pressureRenal interstitial fibrosisImprove patient outcomesPotential therapeutic targetClinical featuresClinical manifestationsTreatment optionsInterstitial fibrosisInsidious onsetClinical indicationsDisease progressionTubular proteinuriaEarly diagnosisBlood pressurePathological featuresAdvanced stageKidney failureI Brazilian guideline on hypertension in dialysis of the Brazilian Society of Nephrology
Rodrigues C, Ferreira-Filho S, de Souza Moura A, Poli-de-Figueiredo C, da Silva D, Polacchini F, de Almeida F, Pinheiro M, Bezerra R, de Paula R, Peixoto A, Figueiredo A, Feitosa A, Machado C, Amodeo C, Mion D, Muxfeldt E, da Silva G, Moura-Neto J, Pazeli J, Lotaif L, Drager L, Martín L, Bortolotto L, Bastos M, Malachias M, Moreira M, Canziani M, Miranda R, da Silva Franco R, Pecoits R, Mulinari R, Elias R, Barroso W, Nadruz W. I Brazilian guideline on hypertension in dialysis of the Brazilian Society of Nephrology. Brazilian Journal Of Nephrology 2025, 47: e20240033. PMID: 40009791, PMCID: PMC11864789, DOI: 10.1590/2175-8239-jbn-2024-0033en.Peer-Reviewed Original ResearchConceptsBrazilian Society of NephrologyPeritoneal dialysisSociety of NephrologyBlood pressureRecommended blood pressureDepartment of HypertensionBlood pressure targetsNon-pharmacological treatmentContext of hemodialysisAntihypertensive drugsLifestyle changesReduce morbidityAntihypertensive medicationsDialysis patientsPressure targetsDialysis settingBrazilian guidelinesHypertensionDialysis centersComplementary assessmentPatientsBP measurementsDialysisNephrology practiceCardiovascular onesIndividualized Net Benefit of Intensive Blood Pressure Lowering Among Community‐Dwelling Older Adults in SPRINT
Jamshidian M, Scherzer R, Estrella M, Kravitz R, Boxer R, Tancredi D, Berry J, de Lemos J, Ginsberg C, Ix J, Shlipak M, Ascher S. Individualized Net Benefit of Intensive Blood Pressure Lowering Among Community‐Dwelling Older Adults in SPRINT. Journal Of The American Geriatrics Society 2025, 73: 1441-1453. PMID: 39967308, PMCID: PMC12100678, DOI: 10.1111/jgs.19395.Peer-Reviewed Original ResearchSystolic Blood Pressure Intervention TrialCommunity-dwelling older adultsIntensive blood pressureSystolic BP targetOlder adultsBlood pressureIndividual net benefitsIntensive BPBP targetsAdvanced ageSystolic Blood Pressure Intervention Trial participantsBenefits of BPOptimal blood pressureTreatment-related harmsCategories of ageAdverse eventsPositive net benefitsFrailty statusCardiovascular outcomesCognitive outcomesIntervention trialsCox modelRisk differenceSystolicPolypharmacyShort-term disruption of TGFβ signaling in adult mice renders the aorta vulnerable to hypertension-induced dissection
Jiang B, Ren P, He C, Wang M, Murtada S, Ruiz-Rodríguez M, Chen Y, Ramachandra A, Li G, Qin L, Assi R, Schwartz M, Humphrey J, Tellides G. Short-term disruption of TGFβ signaling in adult mice renders the aorta vulnerable to hypertension-induced dissection. JCI Insight 2025, 10 PMID: 39932797, PMCID: PMC11949005, DOI: 10.1172/jci.insight.182629.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsBlood pressureAortic dissectionAdult miceInherited connective tissue disorderConnective tissue disordersTGF-b signalingAccumulation of bloodHigh blood pressureAortic phenotypeTissue disordersMolecule expressionTGFB signalingMuscle cellsRisk factorsSynthesis of extracellular matrixSustained increaseTransient increaseBlood extravasationDissectionMedial injuryExtracellular matrix productionVascular degenerationExperimental modelMicePower and Sample Size Calculations for Cluster Randomized Hybrid Type 2 Effectiveness‐Implementation Studies
Owen M, Curran G, Smith J, Tedla Y, Cheng C, Spiegelman D. Power and Sample Size Calculations for Cluster Randomized Hybrid Type 2 Effectiveness‐Implementation Studies. Statistics In Medicine 2025, 44: e70015. PMID: 39930740, DOI: 10.1002/sim.70015.Peer-Reviewed Original ResearchConceptsHybrid type 2 effectiveness-implementation studySample size calculationCluster randomized trialCluster randomized designSize calculationImplementation research outcomesReduce cardiovascular diseaseIssue of multiple testingEffective outcomesImplementation outcomesCommunity interventionsControl blood pressureBinary outcomesOutcomes approachLiterature searchMultiple testingCardiovascular diseaseInterventionRandomized trialsStandard statistical methodsBlood pressureOutcomesType 2 studiesThe metabolic and cardiovascular effects of amphetamine are partially mediated by the central melanocortin system
Simonds S, Pryor J, Lam B, Dowsett G, Mustafa T, Munder A, Elysee K, Balland E, Cowley L, Yeo G, Lawrence A, Spanswick D, Cowley M. The metabolic and cardiovascular effects of amphetamine are partially mediated by the central melanocortin system. Cell Reports Medicine 2025, 6: 101936. PMID: 39914386, PMCID: PMC11866487, DOI: 10.1016/j.xcrm.2025.101936.Peer-Reviewed Original ResearchConceptsEffects of amphetamineCentral melanocortin systemCardiovascular effectsMelanocortin systemFood intakeInhibition of POMC neuronsAMPH-induced anorexiaMelanocortin 4 receptor-deficientNoradrenergic neurotransmitter systemsHeart rateBrown adipose tissueElevated blood pressureBody weightNoradrenergic inhibitionPOMC neuronsAMPH-inducedSerotonergic activityPresynaptic mechanismsNeurotransmitter systemsMC4R pathwayAmphetamineBlood pressureCardiovascular functionIncreased brown adipose tissueAdipose tissue
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