2024
Research Priorities in Pediatric Asthma Morbidity: Addressing the Impacts of Systemic Racism on Children with Asthma in the United States. An Official American Thoracic Society Workshop Report
Lovinsky-Desir S, Riley I, Bryant-Stephens T, De Keyser H, Forno E, Kozik A, Louisias M, Matsui E, Sheares B, Thakur N, Apter A, Beck A, Bentley-Edwards K, Berkowitz C, Braxton C, Dean J, Jones C, Koinis-Mitchell D, Okelo S, Taylor-Cousar J, Teach S, Wechsler M, Gaffin J, Federico M. Research Priorities in Pediatric Asthma Morbidity: Addressing the Impacts of Systemic Racism on Children with Asthma in the United States. An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2024, 21: 1349-1364. PMID: 39352175, PMCID: PMC11451894, DOI: 10.1513/annalsats.202407-767st.Peer-Reviewed Original ResearchConceptsImpact of systemic racismAsthma morbidityChildhood asthmaSocial determinants of healthAsthma health outcomesPediatric asthma morbidityDeterminants of healthSystemic racismCommunity engagementDrivers of disparitiesEmergency department visitsResearch teamChildhood asthma outcomesImpact of interventionsMultidisciplinary research teamEffects of systemic racismInnovative study designsImpact of racismAsthma disparitiesSocial determinantsHealthcare accessAsthma outcomesHealth outcomesDepartment visitsEvaluate interventions
2022
Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial
Gent JF, Holford TR, Bracken MB, Plano JM, McKay LA, Sorrentino KM, Koutrakis P, Leaderer BP. Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial. Journal Of Asthma 2022, 60: 744-753. PMID: 35796019, PMCID: PMC10162040, DOI: 10.1080/02770903.2022.2093219.Peer-Reviewed Original ResearchConceptsLevels of NOPersistent asthmaAsthma symptomsIntervention trialsNumber of asthmaDays of treatmentSymptom daysAsthma morbidityChildhood asthmaTreatment periodAsthmaCrossover designHousehold exposureSymptomsModest reductionTreatment effectsTreatmentGas stovesTrialsExposureTriple crossoverInterventionChildrenMixed modelsFurther researchAssociation of fractional exhaled nitric oxide with asthma morbidity in urban minority children
Chen L, Agalliu I, Roth A, Rastogi D. Association of fractional exhaled nitric oxide with asthma morbidity in urban minority children. Journal Of Asthma 2022, 60: 553-564. PMID: 35499408, PMCID: PMC10170416, DOI: 10.1080/02770903.2022.2073549.Peer-Reviewed Original ResearchConceptsPulmonary function testsFractional exhaled nitric oxideHigher FeNO levelsFeNO levelsExhaled nitric oxideAssociated with higher BMI z-scoreHispanic childrenHigher BMI z-scoreClinical characteristicsAirway obstructionUrban minority childrenBMI z-scoreAsthma-related morbidityMinority childrenLow FeNO levelsAllergic airway inflammationAssociation of baselineRetrospective chart reviewBaseline FeNO levelsProportion of childrenLower airway obstructionFollow-up visitAsthma morbidityNitric oxideDisease management tool
2016
An Analysis of Obesity and Asthma Morbidity in Patients Managed at the Children's Hospital at Montefiore's Asthma Center
Soffer G, Toh J, Jariwala S, Rastogi D. An Analysis of Obesity and Asthma Morbidity in Patients Managed at the Children's Hospital at Montefiore's Asthma Center. Journal Of Allergy And Clinical Immunology 2016, 137: ab7. DOI: 10.1016/j.jaci.2015.12.023.Peer-Reviewed Original Research
2014
Effect of vitamin D–binding protein genotype on the development of asthma in children
Navas-Nazario A, Li FY, Shabanova V, Weiss P, Cole DE, Carpenter TO, Bazzy-Asaad A. Effect of vitamin D–binding protein genotype on the development of asthma in children. Annals Of Allergy Asthma & Immunology 2014, 112: 519-524. PMID: 24745702, PMCID: PMC4070170, DOI: 10.1016/j.anai.2014.03.017.Peer-Reviewed Original ResearchMeSH KeywordsAsthmaChild, PreschoolCholestanetriol 26-MonooxygenaseConnecticutCytochrome P450 Family 2FemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHispanic or LatinoHumansInfantMalePolymorphism, Single NucleotideReceptors, CalcitriolRetrospective StudiesVitamin DVitamin D-Binding ProteinConceptsDevelopment of asthmaVitamin DGC genotypeVitamin D metabolite levelsRetrospective medical record reviewVitamin D insufficiencyMedical record reviewCurrent clinical dataSingle nucleotide polymorphismsVitamin D metabolitesGC single nucleotide polymorphismsHispanic populationPotential vitamin DMonths of ageD insufficiencyAsthma morbidityHealthy infantsRecord reviewD metabolitesHealthy childrenInflammatory diseasesNucleotide polymorphismsClinical dataProtective effectAsthma
2013
Household Levels of Nitrogen Dioxide and Pediatric Asthma Severity
Belanger K, Holford TR, Gent JF, Hill ME, Kezik JM, Leaderer BP. Household Levels of Nitrogen Dioxide and Pediatric Asthma Severity. Epidemiology 2013, 24: 320-330. PMID: 23337243, PMCID: PMC3686297, DOI: 10.1097/ede.0b013e318280e2ac.Peer-Reviewed Original ResearchConceptsAsthma severityNight symptomsAsthma morbiditySeverity scoreNO2 exposureHigher asthma severity scoresFrequency of wheezeIndoor NO2 exposurePediatric asthma severityRescue medication useIndoor allergen exposureAsthma severity scoreAdverse respiratory effectsDose-dependent increaseYears of ageInner-city childrenLogistic regression modelsRescue medicationActive asthmaAllergen exposureAsthmatic childrenMedication useRespiratory effectsChildren 5Health outcomes
2012
Household mold and dust allergens: Exposure, sensitization and childhood asthma morbidity
Gent JF, Kezik JM, Hill ME, Tsai E, Li DW, Leaderer BP. Household mold and dust allergens: Exposure, sensitization and childhood asthma morbidity. Environmental Research 2012, 118: 86-93. PMID: 22863552, PMCID: PMC3604733, DOI: 10.1016/j.envres.2012.07.005.Peer-Reviewed Original ResearchConceptsRisk of wheezeSpecific allergen sensitizationRescue medication useChildhood asthma morbidityAsthma severity scoreMedication useAllergen sensitizationPersistent coughAsthma morbiditySeverity scoreHigher asthma severity scoresCommon household allergensCommon indoor allergensFel d 1Der p 1Asthma exacerbationsAllergen exposureLevel of exposureAsthmatic childrenDer pAllergy testingIndoor allergensSchool-aged childrenPet allergensDust allergens
2011
Association of daily asthma emergency department visits and hospital admissions with ambient air pollutants among the pediatric Medicaid population in Detroit: Time-series and time-stratified case-crossover analyses with threshold effects
Li S, Batterman S, Wasilevich E, Wahl R, Wirth J, Su F, Mukherjee B. Association of daily asthma emergency department visits and hospital admissions with ambient air pollutants among the pediatric Medicaid population in Detroit: Time-series and time-stratified case-crossover analyses with threshold effects. Environmental Research 2011, 111: 1137-1147. PMID: 21764049, DOI: 10.1016/j.envres.2011.06.002.Peer-Reviewed Original ResearchConceptsAmbient air pollutionGeneralized additive modelCase-crossover designConditional logistic regressionPediatric Medicaid populationAir pollutionAsthma morbidityAssociated with ambient air pollutionMedicaid populationEffects of air pollutionAsthma emergency department visitsAdditive modelLogistic regressionConditional logistic regression modelsAcute asthma eventsAssociations of SO2Interquartile range increaseCase-crossover analysisEmergency department visitsCase-crossover studyPM2.5 concentrationsPM2.5 thresholdLogistic regression modelsStrong effect sizesPM2.5
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