2025
Ensuring Timely Pulmonary Follow-up after an Inpatient Asthma Hospitalization: A Quality Improvement Initiative
Chandrasekar L, Schaffer H, Godse S, Grossman M, Chen L, Brumer E. Ensuring Timely Pulmonary Follow-up after an Inpatient Asthma Hospitalization: A Quality Improvement Initiative. Pediatric Quality And Safety 2025, 10: e815. PMID: 40371048, PMCID: PMC12077554, DOI: 10.1097/pq9.0000000000000815.Peer-Reviewed Original ResearchQuality improvement initiativesFollow-up appointmentsImprovement initiativesAttendance ratesAsthma exacerbationsTimely outpatient follow-upAppointment attendance ratesAsthma care guidelinesDays of hospital dischargeFollow-upPulmonary follow-upInconsistent careAcute asthma exacerbationAsthma hospitalizationsCare guidelinesVisit attendanceOutpatient follow-upPediatric intensive care unitActivity remindersAsthma controlOutcome measuresMultidisciplinary teamHospital dischargePrevent future episodesPulmonary consultationReal-World Evidence of Administration of Biologic Agents in Patients with Severe Asthma: An Analysis of the Respiratory Department of University Hospital of Patras Asthma Registry
Papaioannou O, Christopoulos I, Tsiri P, Sampsonas F, Karkoulias K, Lykouras D, Sotiropoulou V, Theohari E, Papalexatos D, Komninos D, Christopoulos A, Tzouvelekis A. Real-World Evidence of Administration of Biologic Agents in Patients with Severe Asthma: An Analysis of the Respiratory Department of University Hospital of Patras Asthma Registry. Journal Of Clinical Medicine 2025, 14: 2174. PMID: 40217624, PMCID: PMC11989620, DOI: 10.3390/jcm14072174.Peer-Reviewed Original ResearchTime of diagnosisOral corticosteroidsSevere asthmaFollow-upBiological agentsBlood eosinophilsAdministration of biological agentsInitiation of biologic treatmentMedian valueTreated with biologic agentsTreated with omalizumabUncontrolled severe asthmaUse of corticosteroidsSevere asthma exacerbationsAsthma outpatient clinicLongitudinal useConsecutive patientsMedian ageDisease phenotypic characteristicsRetrospective studyNever smokersCorticosteroidsAsthma exacerbationsAsthma flaresLung functionProspective REALITI-A Study 2-Year Real-World Benefits of Mepolizumab in Severe Asthma
Caruso C, Canonica G, Patel M, Smith A, Liu M, Alfonso-Cristancho R, Price R, Jakes R, Demetriou L, Valero A, Köhler T, Pilette C, Chupp G, Brusselle G, Howarth P. Prospective REALITI-A Study 2-Year Real-World Benefits of Mepolizumab in Severe Asthma. CHEST Pulmonary 2025, 3: 100107. DOI: 10.1016/j.chpulm.2024.100107.Peer-Reviewed Original ResearchFollow-up periodMepolizumab treatmentAdverse eventsSevere asthmaRate of clinically significant asthma exacerbationsFollow-upMonoclonal antibodies targeting interleukin-5Clinically significant asthma exacerbationsMaintenance oral corticosteroidsAssociated with sustained reductionsProportion of patientsACQ-5 scoresAsthma Control QuestionnaireForced expiratory volumeOral corticosteroidsWell-toleratedACQ-5Clinical benefitMepolizumabProspective studyWeeks 0Asthma exacerbationsInterleukin-5Expiratory volumeSustained reductionβ-Ionone facilitates ex vivo airway smooth muscle relaxation via extraocular opsin-3 light receptor activation
Uribe S, Shany E, Zhang Y, Wu A, Dan W, Perez-Zoghbi J, Emala C, Yim P. β-Ionone facilitates ex vivo airway smooth muscle relaxation via extraocular opsin-3 light receptor activation. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2025, 328: l526-l537. PMID: 39937635, DOI: 10.1152/ajplung.00227.2024.Peer-Reviewed Original ResearchConceptsAirway smooth muscle relaxationOpsin 3Severity of asthma exacerbationsAirway smooth muscle cellsDose-dependent relaxationTherapeutic agentsAirways in vitroPrecision-cut lung slicesSmooth muscle relaxationSmooth muscle cellsAttenuated relaxationWire myographyDietary intakeDecreased relaxationAirway pathologyIncreased riskReceptor activationAsthma exacerbationsMuscle cellsLower airwaysLung slicesMRNA expressionMuscle relaxationTracheal ringsAirwayAssociation of delayed asthma diagnosis with asthma exacerbations in children
Wi C, Ryu E, King K, Kwon J, Bublitz J, Park M, Chiarella S, Greenwood J, Pongdee T, Myers L, Nordlund B, Sohn S, Sagheb E, Kshatriya B, Watson D, Liu H, Sheares B, Davis C, Schulz W, Juhn Y. Association of delayed asthma diagnosis with asthma exacerbations in children. Journal Of Allergy And Clinical Immunology Global 2025, 4: 100409. PMID: 40008091, PMCID: PMC11851198, DOI: 10.1016/j.jacig.2025.100409.Peer-Reviewed Original ResearchElectronic health recordsDiagnosis of asthmaAsthma diagnosisAsthma exacerbationsRisk of AEPredetermined Asthma CriteriaDiagnosis of childhood asthmaChildhood asthma managementIncreased riskCox proportional hazards modelsIncreased risk of AECare qualityAsthma outcomesHealth recordsProportional hazards modelAsthma managementChildhood asthmaBirth cohortAsthma severityDiagnosis statusIndex dateIdentifying childrenPrimary outcomeNatural language processing algorithmsHazards model
2024
Neighborhood Socioeconomic Context Predicts Pediatric Asthma Exacerbation
Kranjac A, Kain Z, Ehwerhemuepha L, Weiss M, Jenkins B. Neighborhood Socioeconomic Context Predicts Pediatric Asthma Exacerbation. Clinical Pediatrics 2024, 64: 310-318. PMID: 39044420, DOI: 10.1177/00099228241262997.Peer-Reviewed Original ResearchNon-Hispanic Black residentsAsthma exacerbationsElectronic medical record dataLevels of ambient air pollutionNeighborhood-level factorsAssociated with greater oddsMedical record dataAmbient air pollutionIndividual-level factorsPlace-based initiativesProportion of female-headed householdsAsthma managementNeighborhood characteristicsGreater oddsAsthma controlUncontrolled asthmaBlack residentsFemale-headed householdsRecord dataInadequate disease controlMultilevel modeling techniquesPediatric patientsResidential characteristicsAsthmaIndividual levelAdoption and implementation of maintenance and reliever therapy for adults with moderate-to-severe asthma
Zaeh S, Zimmerman Z, Eakin M, Chupp G. Adoption and implementation of maintenance and reliever therapy for adults with moderate-to-severe asthma. Annals Of Allergy Asthma & Immunology 2024, 133: 318-324. PMID: 38897404, PMCID: PMC11344662, DOI: 10.1016/j.anai.2024.06.011.Peer-Reviewed Original ResearchAcademic health care systemHealth care systemClinician characteristicsCare systemCross-sectional studySevere asthmaModerate to severe asthmaRetrospective cross-sectional studyClinician dataLong-acting bronchodilatorsAsthma guidelinesAsthma managementPrescribed to patientsSubspecialty cliniciansShort-acting bronchodilatorsReliever therapyAsthma exacerbationsChart reviewPatient demographicsOlder patientsCliniciansAllergy practiceAsthma groupAsthmaPatients
2023
A SMART Shift in Pediatric Asthma
Banasiak N, Keil Heinonen S, Filippelli A. A SMART Shift in Pediatric Asthma. The Journal For Nurse Practitioners 2023, 19: 104641. DOI: 10.1016/j.nurpra.2023.104641.Peer-Reviewed Original ResearchReliever therapyPatients 4 yearsOral corticosteroid useSevere persistent asthmaSingle maintenanceQuality of lifeNational AsthmaSingle inhalerAsthma exacerbationsCorticosteroid usePersistent asthmaPediatric asthmaClinical practiceAsthmaPrevention programsExpert panelTherapyNew recommendationsRelevant evidenceExacerbationInhalerEffect of tezepelumab on healthcare utilization in patients with severe, uncontrolled asthma The NAVIGATOR study
Menzies-Gow A, Bourdin A, Chupp G, Israel E, Hellqvist Å, Hunter G, Roseti S, Ambrose C, Llanos J, Cook B, Corren J, Colice G. Effect of tezepelumab on healthcare utilization in patients with severe, uncontrolled asthma The NAVIGATOR study. Annals Of Allergy Asthma & Immunology 2023, 131: 343-348.e2. PMID: 37263380, DOI: 10.1016/j.anai.2023.05.028.Peer-Reviewed Original ResearchConceptsExacerbation-related hospitalizationsHealthcare utilizationUncontrolled asthmaNAVIGATOR studyAsthma-related healthcare utilizationEffect of tezepelumabPatient healthcare utilizationRecipients of placeboThymic stromal lymphopoietinHealth-related qualityIntensive care daysHuman monoclonal antibodySubcutaneous tezepelumabAsthma controlAsthma exacerbationsLung functionSpecialist visitsEmergency departmentCare daysOverall burdenTezepelumabMAIN OUTCOMEPlaceboAmbulance transportHospitalizationLow CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity.
Li X, Guerra S, Ledford JG, Kraft M, Li H, Hastie AT, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Zein J, Kaminski N, Wenzel SE, Woodruff PG, Meyers DA, Bleecker ER. Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 438-451. PMID: 36066606, PMCID: PMC9940145, DOI: 10.1164/rccm.202206-1230oc.Peer-Reviewed Original ResearchConceptsBronchial epithelial cellsMRNA expression levelsAsthma severityT2 biomarkersAsthma susceptibilityT2 inflammationExpression levelsSevere Asthma Research ProgramSystemic corticosteroid useLower pulmonary functionEpithelial cellsAsthma-related phenotypesCorticosteroid useAsthma exacerbationsPulmonary functionAsthma developmentAsthma endotypesAsthma progressionInflammation biomarkersInflammation genesHost defenseCC16Th2 genesSeverityBiomarkersPaired Indoor and Outdoor Nitrogen Dioxide Associated With Childhood Asthma Outcomes in a Mixed Rural-Urban Setting: A Feasibility Study
Wi C, Gent J, Bublitz J, King K, Ryu E, Sorrentino K, Plano J, McKay L, Porcher J, Wheeler P, Chiarella S, DeWan A, Pollitt K, Sheares B, Leaderer B, Juhn Y. Paired Indoor and Outdoor Nitrogen Dioxide Associated With Childhood Asthma Outcomes in a Mixed Rural-Urban Setting: A Feasibility Study. Journal Of Primary Care & Community Health 2023, 14: 21501319231173813. PMID: 37243352, PMCID: PMC10226331, DOI: 10.1177/21501319231173813.Peer-Reviewed Original ResearchConceptsAsthma control statusControl statusAsthma diaryRural-urban settingOutdoor NOChildhood asthma outcomesProspective cohort studySocioeconomic statusLow socioeconomic statusSmall feasibility studyAsthma exacerbationsOlmsted CountyPersistent asthmaAsthma outcomesCohort studyChildhood asthmaRural-urban communityLarger sample sizeAsthmaStudy periodHealth effectsFeasibility studyWeeksStatusLow threshold
2022
Asthma exacerbations during the pandemic: Time to rethink clinical markers
Ortega H, Katz L, Chupp G. Asthma exacerbations during the pandemic: Time to rethink clinical markers. Journal Of Allergy And Clinical Immunology Global 2022, 2: 97-100. PMID: 36281240, PMCID: PMC9581642, DOI: 10.1016/j.jacig.2022.09.003.Peer-Reviewed Original ResearchPrimary end pointAsthma exacerbationsClinical studiesClinical markersEnd pointCOVID-19 pandemicClinical trial enrollmentCoronavirus disease 2019 (COVID-19) pandemicNitric oxide levelsRecent clinical reportsDisease 2019 pandemicPrior exacerbationsPlacebo armFuture exacerbationsTrial enrollmentClinical trialsOxide levelsExacerbationClinical reportsClinical practiceCOVID-19Prior yearPandemicEnrollmentBest predictorReducing asthma exacerbations in vulnerable children through a medical–legal partnership
Mainardi AS, Harris D, Rosenthal A, Redlich CA, Hu B, Fenick AM. Reducing asthma exacerbations in vulnerable children through a medical–legal partnership. Journal Of Asthma 2022, 60: 262-269. PMID: 35188437, DOI: 10.1080/02770903.2022.2045307.Peer-Reviewed Original ResearchConceptsMedical-legal partnershipsAsthma exacerbationsEmergency departmentHealth disparitiesAsthma exacerbation ratePrimary care officesAcademic children's hospitalAsthma health disparitiesExacerbation rateHealthcare utilizationPediatric populationChildren's HospitalCare officesPrimary careWorse outcomesChronic illnessInpatient settingStudy populationAsthmaTotal encountersSocial determinantsHospitalizationExacerbationStatistical significanceIntervention
2021
E-cigarette use and adverse respiratory symptoms among adolescents and Young adults in the United States
Chaffee BW, Barrington-Trimis J, Liu F, Wu R, McConnell R, Krishnan-Sarin S, Leventhal AM, Kong G. E-cigarette use and adverse respiratory symptoms among adolescents and Young adults in the United States. Preventive Medicine 2021, 153: 106766. PMID: 34418439, PMCID: PMC8595821, DOI: 10.1016/j.ypmed.2021.106766.Peer-Reviewed Original ResearchConceptsShortness of breathE-cigarette useAdverse respiratory symptomsRespiratory symptomsE-cigarette usersAsthma exacerbationsYoung adultsFrequent e-cigarette usersSymptoms of bronchitisSymptoms of asthmaCross-sectional studyDays/monthTobacco use behaviorsBronchitic symptomsRespiratory outcomesAdjusted oddsMultivariable modelingStudy populationHealth statusSymptomsE-cigarette devicesBronchitisShortnessExacerbationBreath
2020
Asthma Exacerbation Prediction and Risk Factor Analysis Based on a Time-Sensitive, Attentive Neural Network: Retrospective Cohort Study
Xiang Y, Ji H, Zhou Y, Li F, Du J, Rasmy L, Wu S, Zheng W, Xu H, Zhi D, Zhang Y, Tao C. Asthma Exacerbation Prediction and Risk Factor Analysis Based on a Time-Sensitive, Attentive Neural Network: Retrospective Cohort Study. Journal Of Medical Internet Research 2020, 22: e16981. PMID: 32735224, PMCID: PMC7428917, DOI: 10.2196/16981.Peer-Reviewed Original ResearchConceptsAttentive Neural NetworkAsthma exacerbationsRisk factorsNeural networkAdvanced deep learning modelsClinical variablesDeep learning modelsCerner Health Facts databaseLarge electronic health recordNeural network modelRetrospective cohort studyHealth Facts databasePotential risk factorsRisk factor analysisPersonalized risk factorsElectronic health recordsBaseline methodsLearning modelPersonalized risk scoreProgressive asthmaAsthma symptomsEsophageal refluxAdult patientsCohort studyTime-SensitiveUnconventional oil and gas development and health outcomes: A scoping review of the epidemiological research
Deziel NC, Brokovich E, Grotto I, Clark CJ, Barnett-Itzhaki Z, Broday D, Agay-Shay K. Unconventional oil and gas development and health outcomes: A scoping review of the epidemiological research. Environmental Research 2020, 182: 109124. PMID: 32069745, DOI: 10.1016/j.envres.2020.109124.Peer-Reviewed Original ResearchConceptsHealth outcomesLow birth weightAdverse birth outcomesAdverse health outcomesFull-text evaluationOutcomes of interestHuman health outcomesAsthma exacerbationsPreterm deliveryPregnancy outcomesBirth outcomesPotential confoundersBirth weightBody of evidenceCancer incidenceEligible studiesExposure assessment methodologyPotential environmental health hazardInclusion criteriaStudy populationEpidemiological studiesExposure assessment approachHealth problemsEnvironmental health hazardsSignificant association
2018
Influence of viral infection on the relationships between airway cytokines and lung function in asthmatic children
Lewis T, Metitiri E, Mentz G, Ren X, Carpenter A, Goldsmith A, Wicklund K, Eder B, Comstock A, Ricci J, Brennan S, Washington G, Owens K, Mukherjee B, Robins T, Batterman S, Hershenson M. Influence of viral infection on the relationships between airway cytokines and lung function in asthmatic children. Respiratory Research 2018, 19: 228. PMID: 30463560, PMCID: PMC6249926, DOI: 10.1186/s12931-018-0922-9.Peer-Reviewed Original ResearchConceptsViral infectionLung functionAbsence of viral infectionIL-13IL-4Viral-induced asthma exacerbationsRespiratory illnessRespiratory viral infectionsAssociated with increased cytokinesPro-inflammatory cytokinesLung function declineSelf-reported respiratory illnessInfluence of viral infectionAirway cytokinesMDA5 mRNACXCL10 mRNACytokine levelsAirway responsivenessNasal lavageAirflow obstructionAssociated with FVCAsthma exacerbationsAssociated with decreased lung functionInflammatory responseNasal samplesAn Initiative to Reduce Routine Viral Diagnostic Testing in Pediatric Patients Admitted with Bronchiolitis
Emerson BL, Tenore C, Grossman M. An Initiative to Reduce Routine Viral Diagnostic Testing in Pediatric Patients Admitted with Bronchiolitis. The Joint Commission Journal On Quality And Patient Safety 2018, 44: 751-756. PMID: 30197306, DOI: 10.1016/j.jcjq.2018.05.006.Peer-Reviewed Original ResearchConceptsPediatric emergency departmentViral diagnostic testingViral lower respiratory tract infectionsDiagnostic testingLower respiratory tract infectionsNon-ICU patientsRespiratory tract infectionsSpecific viral pathogensQuality improvement projectLow-cost interventionAsthma exacerbationsTract infectionsPediatric patientsPediatric populationSignificant morbidityChildren's HospitalEmergency departmentOutpatient careCurrent guidelinesUnit settingBronchiolitisStaff educationPatientsVDT useNational ratesAsthma, Environment and Pollution: Where the Rubber Hits the Road
Krishnan S, Panacherry S. Asthma, Environment and Pollution: Where the Rubber Hits the Road. Indian Journal Of Pediatrics 2018, 85: 893-898. PMID: 29845404, DOI: 10.1007/s12098-018-2691-3.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseOmnipresent environmental pollutantObstructive pulmonary diseaseRate of hospitalizationPublic health consequencesAsthma exacerbationsAcute illnessPulmonary diseaseAsthma pathophysiologyOncologic implicationsCardiovascular diseaseChronic exposureRespiratory systemHealth consequencesNumber of outcomesReproductive systemDiseaseResultant increaseEnvironmental pollutantsDetrimental effectsAmbient air levelsExacerbationHospitalizationMorbidityAsthmaImpaired type I interferon regulation in the blood transcriptome of recurrent asthma exacerbations
Gomez JL, Diaz MP, Nino G, Britto CJ. Impaired type I interferon regulation in the blood transcriptome of recurrent asthma exacerbations. BMC Medical Genomics 2018, 11: 21. PMID: 29486764, PMCID: PMC5830339, DOI: 10.1186/s12920-018-0340-3.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsAsthma exacerbationsInterferon-stimulated genesRespiratory infectionsIL-15Vivo cohortToll-like receptor 2STAT1 responseRecurrent asthma exacerbationsAcute asthma exacerbationPro-inflammatory moleculesType I interferon regulationBlood mononuclear cellsPro-inflammatory signatureTranscriptomic signaturesType I interferonFold changeAdult asthmaAcute phaseMononuclear cellsImmunologic genesExacerbationIndependent cohortReceptor 2I interferon
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