2025
Acquired angio-oedema as a mimicker of drug allergy
Liao J, Mathew M, Elmansy L, Hsu F, Belmont A. Acquired angio-oedema as a mimicker of drug allergy. BMJ Case Reports 2025, 18: e265525. PMID: 40389294, DOI: 10.1136/bcr-2025-265525.Peer-Reviewed Original ResearchConceptsAcquired angio-oedemaAngio-oedemaSplenic marginal zone lymphomaBradykinin-mediated diseaseSevere angio-oedemaMarginal zone lymphomaLocal anaesthetic allergyDrug allergy testingDental proceduresAcute therapyCase reportClinical historyDrug allergyAllergy centresAllergy testingClinical pearlsClinical diagnosisEmergency departmentMultiple physiciansDiagnosisAllergyLymphomaTherapyPatientsAetiologyMoving Beyond Desensitization to Tolerance in Food Allergy
Flom J, Shreffler W, Perrett K. Moving Beyond Desensitization to Tolerance in Food Allergy. The Journal Of Allergy And Clinical Immunology In Practice 2025, 13: 741-744. PMID: 40010566, DOI: 10.1016/j.jaip.2025.02.014.Peer-Reviewed Original ResearchManagement of IgE-mediated food allergyFood allergyIgE-mediated food allergyStages of clinical developmentSide effect profileMode of deliveryGoal of therapeuticsSustained unresponsivenessDosing regimensDose protocolProactive therapyAllergen-specificClinical developmentActive therapyPatient populationSide effectsTherapyPassive therapyPatient-specificDesensitizationClinical contextPatientsDoseAllergyDegree of protection
2024
All roads lead to IgA: Mapping the many pathways of IgA induction in the gut
Siniscalco E, Williams A, Eisenbarth S. All roads lead to IgA: Mapping the many pathways of IgA induction in the gut. Immunological Reviews 2024, 326: 66-82. PMID: 39046160, DOI: 10.1111/imr.13369.Peer-Reviewed Original ResearchIgA inductionFood allergyFood-specific IgE.Food-specific IgEAntibody isotypesPrevalence of food allergyT cell helpIncreasing prevalence of food allergyRelease of histamineFoodFood antigensB cellsInduce toleranceAdverse reactionsCommensal bacteriaMast cellsIncreased prevalenceGut immunityIgAGutAllergyAntibodiesIsotypeInductionCD23+IgG1+ memory B cells are poised to switch to pathogenic IgE production in food allergy
Ota M, Hoehn K, Fernandes-Braga W, Ota T, Aranda C, Friedman S, Miranda-Waldetario M, Redes J, Suprun M, Grishina G, Sampson H, Malbari A, Kleinstein S, Sicherer S, Curotto de Lafaille M. CD23+IgG1+ memory B cells are poised to switch to pathogenic IgE production in food allergy. Science Translational Medicine 2024, 16: eadi0673. PMID: 38324641, PMCID: PMC11008013, DOI: 10.1126/scitranslmed.adi0673.Peer-Reviewed Original ResearchConceptsMemory B cellsB cellsIgE-producing cellsPeanut allergySerum peanut-specific IgEFood allergyInterleukin-4 (IL-4)-B cell memoryPeanut-specific IgEAllergen-specific immunoglobulin EHigh-affinity B cellsPersistent IgE responsesConcentration of IgESingle-cell RNA sequencing experimentsMemory populationRNA sequencing experimentsIgE productionImmune responseImmunoglobulin ECirculating concentrationsIgE responseAllergySequencing experimentsAra h 2Long-term persistenceNovel and emerging tests for food allergy
Liu E, Eisenbarth S. Novel and emerging tests for food allergy. 2024, 698-709. DOI: 10.1016/b978-0-323-96018-2.00081-x.Peer-Reviewed Original ResearchFood allergyActivation testingSkin prick testingRisk of developmentAvailable clinical testsSkin barrier permeabilityLow predictive valueInflammatory markersPrick testingIgE testingImmunoglobulin EBarrier permeabilityAllergyPromising biomarkerPredictive valueClinical testsGenetic testingLack of testingCellular profilingMarkersWidespread useTestingImmunoglobulinBiomarkersSeverity
2023
2191. An Assessment of Penicillin Allergy Documentation among Patients undergoing Elective Surgeries and Ambulatory Procedures
Banach D, Zavez K, Schramm C, Zolla M, Baron K, Carter E. 2191. An Assessment of Penicillin Allergy Documentation among Patients undergoing Elective Surgeries and Ambulatory Procedures. Open Forum Infectious Diseases 2023, 10: ofad500.1813. PMCID: PMC10678576, DOI: 10.1093/ofid/ofad500.1813.Peer-Reviewed Original ResearchPenicillin allergy recordsSymptoms of allergyElective surgeryAmbulatory proceduresPenicillin allergyAllergy recordsAntibiotic prescribingRisk stratificationMedical assistantsPost-operative adverse eventsPenicillin allergy historyRetrospective chart reviewPenicillin class antibioticsFuture antibiotic prescribingAllergy assessmentGastrointestinal symptomsAdverse eventsChart reviewAllergy historyAllergy documentationCommon symptomsAllergySurgeryPatient reactionsPatientsDevelopment of an innovative curriculum for paediatricians on peanut allergy prevention: How do we address current guidelines?
Leeds S, Slade M, Hafler J, Samady W, Jiang J, Bilaver L, Gupta R. Development of an innovative curriculum for paediatricians on peanut allergy prevention: How do we address current guidelines? The Clinical Teacher 2023, 21: e13689. PMID: 37935587, PMCID: PMC12199709, DOI: 10.1111/tct.13689.Peer-Reviewed Original ResearchPeanut allergy preventionAllergy preventionNeeds assessmentBroad clinical practiceSpecialty-specific guidelinesBaseline knowledge scoresPrimary preventionProspective studyPeanut allergyClinical guidelinesRisk infantsCurrent guidelinesClinical practiceKnowledge scoreClinical casesPediatriciansMajority of respondentsPreventionVariable evidenceEarly introductionKnowledge surveyAllergyKnowledge questionsInteractive curriculumGuidelinesThe Role of B Cells in Skin Inflammation
Frank A, Belperron A, Bockenstedt L. The Role of B Cells in Skin Inflammation. Journal Of Student Research 2023, 11 DOI: 10.47611/jsr.v11i3.1684.Commentaries, Editorials and LettersValidated anxiety assessments among pediatric patients with peanut allergy on oral immunotherapy
Kaman K, Dhodapkar M, Shabanova V, McCollum S, Factor J, Leeds S. Validated anxiety assessments among pediatric patients with peanut allergy on oral immunotherapy. Annals Of Allergy Asthma & Immunology 2023, 130: 657-663. PMID: 36738780, DOI: 10.1016/j.anai.2023.01.028.Peer-Reviewed Original ResearchConceptsPeanut oral immunotherapyOral immunotherapyNon-white racePeanut allergyAnxiety scoresOlder cohortProspective cross-sectional cohort studyCross-sectional cohort studyHigher mean anxiety scoresMean anxiety scoreDiagnosable anxietyCohort studyMale patientsPediatric patientsFemale patientsFood allergySimilar patientsHigh prevalenceHigher scoresLife measuresLow prevalencePatientsSeparation anxiety scoresElectronic survey questionnaireAllergy
2022
Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens
Liu E, Zhang B, Martin V, Anthonypillai J, Kraft M, Grishin A, Grishina G, Catanzaro J, Chinthrajah S, Sindher T, Manohar M, Quake A, Nadeau K, Burks A, Kim E, Kulis M, Henning A, Jones S, Leung D, Sicherer S, Wood R, Yuan Q, Shreffler W, Sampson H, Shabanova V, Eisenbarth S. Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens. Science Translational Medicine 2022, 14: eabq0599. PMID: 36383680, PMCID: PMC10219469, DOI: 10.1126/scitranslmed.abq0599.Peer-Reviewed Original ResearchConceptsPeanut allergyFood allergyEpitope specificityPredominant antibody isotypePeanut-specific IgEDifferent epitope specificitiesSimilar epitope specificityAtopic childrenEgg allergyOral toleranceAllergic infantsImmune exclusionEgg toleranceAntibody isotypesImmunoglobulin ACommensal floraSeparate cohortAllergyEgg allergensInfant stoolHealthy adultsIgAProtective roleOlder childrenChildrenTHE LEARN EARLY PROJECT: LEARNING EDUCATORS ANAPHYLAXIS RESPONSE NEEDS
Kaman K, Hoyt A. THE LEARN EARLY PROJECT: LEARNING EDUCATORS ANAPHYLAXIS RESPONSE NEEDS. Annals Of Allergy Asthma & Immunology 2022, 129: s68-s69. DOI: 10.1016/j.anai.2022.08.697.Peer-Reviewed Original ResearchHead Start centersFood allergyIndividual needs assessmentEarly childcare centersFood allergy emergencyIncidence of food allergySafe careFood allergy knowledgeFood allergy trainingNeeds assessmentFocus groupsInvestigate barriersHispanic childrenAllergy trainingKnowledge testAllergy knowledgeStock epinephrineAllergy emergencyPrevent anaphylaxisCenter directorsImplement appropriate solutionsChildcare centersAllergyDisproportionate impactEarly learning centersSafety Considerations for Natural Products Commonly Used By Patients with Allergic Disease
Soffer G, Shroff P, Horwitz R. Safety Considerations for Natural Products Commonly Used By Patients with Allergic Disease. The Journal Of Allergy And Clinical Immunology In Practice 2022, 10: 3131-3138. PMID: 36174919, DOI: 10.1016/j.jaip.2022.09.025.Peer-Reviewed Original ResearchConceptsConventional medical therapyHealth care providersMedical therapyAllergic diseasesClinical commentaryAdverse reactionsDrug Administration requirementsCare providersSide effectsAlternative medicinePatientsDietary supplementsU.S. FoodAllergyAdministration requirementsMedicinal plantsNatural productsTherapyCliniciansSafety considerationsDiseaseA practical focus on sesame allergy and a brief review of other seed allergies
Kaman K, Factor J. A practical focus on sesame allergy and a brief review of other seed allergies. Journal Of Food Allergy 2022, 4: 151-157. PMID: 39021852, PMCID: PMC11250203, DOI: 10.2500/jfa.2022.4.220008.Peer-Reviewed Original ResearchHealth disparities in pediatric food allergy
Tepler E, Wong KH, Soffer GK. Health disparities in pediatric food allergy. Annals Of Allergy Asthma & Immunology 2022, 129: 417-423. PMID: 35476967, DOI: 10.1016/j.anai.2022.04.022.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPediatric food allergyFood allergyHealth disparitiesSocioeconomic disparitiesSocioeconomic statusOutcome of childrenLow socioeconomic statusGoogle Scholar databasesAllergen-free foodsLong-term managementAcute managementAllergy careOverall prevalenceFood assistance programsAllergyHealth outcomesScholar databasesGreater riskLiterature searchOriginal research articlesChildrenPossible interventionsPrevalenceCurrent literatureDiagnosisCharacteristics and prevalence of antibiotic allergies in patients with sickle cell disease: A single‐center retrospective study
Wong KH, Soffer GK. Characteristics and prevalence of antibiotic allergies in patients with sickle cell disease: A single‐center retrospective study. American Journal Of Hematology 2022, 97: e247-e249. PMID: 35358357, DOI: 10.1002/ajh.26555.Peer-Reviewed Original ResearchContact Dermatitis and Topical Agents
Milam E, Price A, Ramachandran S, Cohen D. Contact Dermatitis and Topical Agents. 2022, 57-71. DOI: 10.1002/9781119676881.ch6.Peer-Reviewed Original ResearchContact dermatitisSkin reactionsAdverse skin reactionsIrritant contact dermatitisAllergic contact dermatitisSun-damaged skinForeign body reactionInvasive cosmetic proceduresTopical agentsContact urticariaThorough historyCommon causePreservative allergyDermatitisDermatologic practiceClinical settingContact dermatosesOphthalmic preparationsAllergyPhototoxic dermatitisCosmetic proceduresIrritant propertiesBody reactionEnvironmental exposuresCosmetic treatment
2021
Tylenol or acetaminophen: a recurrent fixed drug eruption perpetuated through the use of inconsistent drug terminology
Federman D, Gruen JA, Merchant N. Tylenol or acetaminophen: a recurrent fixed drug eruption perpetuated through the use of inconsistent drug terminology. BMJ Case Reports 2021, 14: e241908. PMID: 34344644, PMCID: PMC8336122, DOI: 10.1136/bcr-2021-241908.Peer-Reviewed Case Reports and Technical NotesAn integrative medicine review of primary prevention of allergy in pediatrics
Boolchandani H, Horwitz R, Soffer G. An integrative medicine review of primary prevention of allergy in pediatrics. Complementary Therapies In Medicine 2021, 58: 102695. PMID: 33636296, DOI: 10.1016/j.ctim.2021.102695.Peer-Reviewed Original ResearchConceptsAtopic diseasesAllergic diseasesPrimary preventionIntegrative medicineIntegrative medicine approachesLong-term outcomesNarrative review articlePrevention of diseaseMedicine ReviewsCounseling patientsPediatric populationAllergy preventionMedicine approachDiseasePreventionAllergyMedicineReview articlePatientsPregnancyPediatricsPrevalenceSensitizationAntigen-Presenting Cells in Food Tolerance and Allergy
Liu EG, Yin X, Swaminathan A, Eisenbarth SC. Antigen-Presenting Cells in Food Tolerance and Allergy. Frontiers In Immunology 2021, 11: 616020. PMID: 33488627, PMCID: PMC7821622, DOI: 10.3389/fimmu.2020.616020.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsDendritic cellsOral toleranceFood allergyT cellsDifferent antigen-presenting cellsB cell antibody responseLife-threatening anaphylaxisT cell responsesImmunoglobulin E antibodiesVariety of symptomsAPC subsetsFood antigensFood toleranceAntibody responseE antibodiesAntigen presentationImmune responseMouse modelFood allergensAllergyInitial primingCell responsesPatient samplesAntigen
2020
Food Allergy: Searching for the Modern Environmental Culprit.
Eisenstein AS, Hilliard B, Silwal S, Wang A. Food Allergy: Searching for the Modern Environmental Culprit. The Yale Journal Of Biology And Medicine 2020, 93: 733-747. PMID: 33380935, PMCID: PMC7757057.Peer-Reviewed Original Research
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