Covid-19 Blood Clotting Cause Identified in Study Led by Yale Cancer Center Researchers
New findings led by Yale Cancer Center researchers and experts across several medical specialties at Yale identify a leading mechanism behind the pathophysiology of Covid-19 and pinpoint a biological marker for the mechanism that may aid in treating these patients.
Yale Cancer Center Study Validates Combination Therapy for Aggressive Endometrial Cancer
Yale Cancer Center (YCC) scientists have found that combining the targeted drug trastuzumab with chemotherapy significantly improves survival rates for women with a rare, aggressive form of endometrial cancer. These results may help to change the standard of care worldwide for the disease. The findings are published today in the journal Clinical Cancer Research.
Blocking a ‘Jamming Signal’ Can Unleash Immune System to Fight Tumors
Yale researchers have discovered a “jamming signal” that blocks a powerful immune system stimulant called interleukin-18 (IL-18) from reaching tumors, including in cancers that are resistant to conventional immunotherapy treatments, they report June 24 in the journal Nature.
Yale Cancer Center Tumor Study Shows Triple-Negative Breast Cancer Has Different Biology in African Americans
In a new study of tumor microenvironment led by Yale Cancer Center, researchers showed that triple-negative breast cancer which has a worse overall outcome in African American compared to Caucasian patients actually has a different Tumor Microenvironment in the two mentioned groups.
Gift from Ludwig Family Foundation Funds Urgent COVID Research by School of Medicine Scientists
The donation will fund the laboratories of at least six scientists on the Yale School of Medicine faculty, for work on vaccine development to prevent future outbreaks as well as treatments for people who are already infected.
Carefully, Yale Labs Stir to Life Across Campus
Since June 1, the start of a broad, three-phase reactivation of campus, an estimated 4,000 faculty members, graduate students, and staff representing more than 500 labs around Yale have fired up microscopes, opened fume hoods, or dusted off other essential research equipment.Source: YaleNews
Researchers at Yale Pursuing COVID-19 Vaccine Based on Powerful Yale Platform
Yale pathologist John “Jack” Rose believes a proven vaccine platform he pioneered decades ago using a livestock virus called vesicular stomatitis virus (VSV) could produce better immunity than other vaccine candidates, and be scaled up quickly to meet global demand.Source: YaleNews
Yale Launches Clinical Trial for Drug to Treat Severe COVID-19 Patients
Yale researchers will begin a clinical trial at Yale-New Haven Hospital to test the effectiveness of a drug called ibudilast (MN-166) for treating acute respiratory distress syndrome (ARDS), a life-threatening lung condition developed by some of the most seriously ill COVID-19 patients.Source: YaleNews
Rothberg family donates $2 million for Yale COVID-19 response
Acclaimed bioscience inventor and entrepreneur Jonathan Rothberg GRD ’87 ’91 and his wife Bonnie Gould Rothberg MED ’94 SPH ’05 GRD ’09 donated $2 million to strengthen Yale’s clinical and research efforts to combat COVID-19.Source: Yale News
New cancer drug shrinks tumors, reduces side effects, in animal studies
A class of experimental cancer drugs called BET inhibitors have shown promise for treating cancers of the blood, but can induce toxic side effects. Now Yale researchers have found a new inhibitor that in animal studies demonstrates greater potency against a wider variety of cancers, as well as against solid tumors, and also produces fewer side effects compared to others in the class.