Yale Researchers Take Stem Cells One Step Closer to Replacing Parathyroid Gland Function
Yale investigators have developed a multistep process that models the biological instructions to create parathyroid gland cells from pluripotent stem cells, a significant milestone along the path toward helping people who lack the hormones released by parathyroid glands.
Trainee-Led Study Seeks to Better Understand All-Cause Mortality in Schizophrenia Patients
A new study led by a Yale Department of Psychiatry trainee sought to better understand why people with schizophrenia have dramatically increased all-cause mortality, and whether living with severe mental illness accelerates the aging process.
Yale Researchers Crack the Code of a Rare, Inherited Anemia
Yale pediatrician and geneticist Patrick Gallagher, M.D., studies hereditary spherocytosis (HS), an inherited disease associated with hemolytic anemia, when red blood cells are destroyed faster than they are produced due to abnormal membranes. A novel mutation in the gene that encodes alpha-spectrin, a protein essential for normal red blood cell membranes, is responsible for many cases of recessive hereditary spherocytosis (rHS), the most severe form of the disease, reports Gallagher’s team
Researchers Identify Stem Cell Source of Key Process in Female Reproduction
Each month during women’s reproductive years, the uterus sheds and regenerates the tissue lining its walls in preparation for a pregnancy or the next cycle. The process behind this age-old and essential part of human reproduction is not well understood. But recent research led by Yale pathologist Wang Min identifies stem cells and a gene that contribute to this monthly event.
Lung Cancer Research Foundation Announces New Scientific Advisory Board Chair
NEW YORK, May 23, 2019 /PRNewswire/ -- The Lung Cancer Research Foundation (LCRF) today announced that Dr. Katerina Politi has been named the chair of its Scientific Advisory Board. Politi, an Associate Professor of Pathology and Internal Medicine (in the Section of Medical Oncology) at Yale School of Medicine, will be taking over the role from Dr. James B. Dougherty, who has held the chair position for 14 years.Source: Yahoo! Finance
Team finds biomarkers to diagnose serious kidney allergic reaction
A team led by Johns Hopkins Medicine researchers says it has identified two protein biomarkers in urine that may one day be used to better diagnose acute interstitial nephritis (AIN), an underdiagnosed but treatable kidney disorder that impairs renal function in the short term and can lead to chronic kidney disease, permanent damage or renal failure if left unchecked.Source: Eurekalert
Yale Cancer Center Scientists Receive Grant to Advance Lung Cancer Research
Katerina Politi, PhD and Don Nguyen, PhD, members of the Signal Transduction Research Program at Yale Cancer Center (YCC), have received a 5-year, nearly $4 million National Cancer Institute (NCI) grant to support Lung Cancer research.
Genetic Sequencing Uncovers Causes for Mysterious Liver Disease in Adults
In up to 30% of individuals with chronic liver disease, the cause is unknown. To test for possible genetic factors in such cases, Yale researchers conducted whole-exome sequencing for a small group of patients, finding specific mutations that would have otherwise been missed. The results led to accurate diagnoses and informed treatment for a subset of the patient participants, the researchers said.
New Center to Harness Burgeoning Data
The Center for Biomedical Data Science (CBDS) is one part clearinghouse for the newest data-related ideas; one part incubator for ways to educate students, trainees, and faculty on what data can offer; and one part an innovator of data techniques to advance biomedical science and data science. As CBDS matures, additional pursuits are sure to follow.Source: Medicine@Yale
How do hair follicles grow? A Yale-led study untangles the science
An outstanding question in dermatology that researchers have studied for decades is: How do hair follicles emerge from a sea of seemingly uniform skin cells during embryonic development? New research findings from a Yale-led team offer answers to that question, which may lead to strategies for regenerating lost hair follicles in adults.
Yale experts treat severe, disfiguring sarcoidosis with novel therapy
An all-Yale team of researchers successfully treated a patient with disfiguring sarcoidosis, a disease that can affect multiple organs, with a drug approved for rheumatoid arthritis. Successful treatment of two other patients with similarly severe disease suggests an effective treatment for an incurable, sometimes life-threatening illness is within reach.
Yale Cancer Center Scientists Advise Caution in Immunotherapy Research
In a new study, Yale Cancer Center scientists suggest that as the number of clinical trials in cancer immunotherapy grows exponentially, some caution should be exercised as we continue to better understand the biology of these new therapeutic targets.