Thoracic / GU Translational Research Interests

In the area of genitourinary pathology, our research interests focus on diagnosis, particularly tissue diagnosis, of urologic malignancies, including prostate cancer, kidney cancer, testis cancer, and bladder cancer. Investigations are also directed toward discovery and development of immunophenotypic and molecular genetic markers of these malignancies. Specific areas of interest include: Active surveillance in kidney and prostate malignancies, evaluation of vascularity and expression of drug targets in renal cell carcinoma, and diagnostic and prognostic markers in renal cell carcinoma

 

 

 

In the area of thoracic pathology, our research interests focus on histologic and molecular characterization of non-small cell lung cancers. Specific areas of interest include:

Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers, Role of Angiogenic Agents in Alveolar Maturations and injury 

Novel Immunologic Effects of Semaphorin 7A in IPF, YKL-40 In Idiopathic Pulmonary Fibrosis and Kidney Transplantation 

Significance of Circulating Semaphorin 7a+ve cells in Pulmonary Sarcoidosis 

and Generation of a molecular atlas of lung development

Bio Profile

Robert Homer, MD, PhD

Directory, Thoracic Pathology

Professor of Pathology

Director, Thoracic Pathology

Director of Medical Studies

Director, Medical Student Course Module

Research Interests

Acute Lung Injury; Asthma; Education, Medical; Emphysema; Lung; Lung Diseases, Interstitial; Pathology; Pulmonary Fibrosis

My major interests are in diagnostic and experimental lung pathology.

I entered the MD-PhD program at Yale School of Medicine in 1979. My PhD was with Donal Murphy on a novel antigenic structure within the murine MHC. Upon graduation I trained in Anatomic Pathology under the supervision of Dr. Juan Rosai and simultaneously completed a post-doctoral fellowship with Richard Flavell, Chair of the section of Immunobiology, with a focus on T cell tolerance.

For many years, I worked on various murine...

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Bio Profile

Guoping Cai, MD

Associate Professor of Pathology

Research Interests

Lung Neoplasms; Male Urogenital Diseases; Pancreas

Dr. Cai completed his residency in Pathology and Laboratory Medicine at New York University Medical Center, where he also completed a fellowship in cytopathology. He is a board-certified pathologist and cytopathologist.

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Bio Profile

Paul Jay Cohen, MD

Assistant Professor of Pathology

Chair, Bridgeport Hospital Pathology

Site Director, Yale Pathology Residency Program at Bridgeport Hospital

Research Interests

Allergy and Immunology; Pathology, Surgical; Quality of Health Care; Respiratory Tract Diseases

Paul Cohen earned his MD at Columbia University in 1981. He completed his residency in anatomic pathology at Massachusetts General Hospital and the National Cancer Institute, where he also completed a pathology fellowship. Dr. Cohen is board certified in anatomic pathology. He is the Chair of Pathology at Bridgeport Hospital, and an Assistant Professor of Pathology at Yale School of Medicine. Dr. Cohen is the Director of the Yale Pathology residency program at Bridgeport Hospital.

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Bio Profile

John Sinard, MD, PhD

Professor of Pathology and of Ophthalmology and Visual Science

Vice Chair Pathology

Director, Anatomic Pathology

Medical Director, Pathology Informatics

Research Interests

Informatics; Ophthalmology; Pathology

John Sinard is a board-certified anatomic pathologist. He received his bachelor's degree from Harvard University, and his M.D. and Ph.D. degrees from Johns Hopkins. His residency training was at Yale-New Haven Hospital. He is the Vice Chair of Pathology and Director of Anatomic Pathology and is active on the autopsy and surgical pathology services, with a specialty interest in ophthalmic pathology. He founded the Pathology Informatics Program, and has been developing software for over 30 years....

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Bio Profile

Xuchen Zhang, MD, PhD

Associate Professor of Pathology

Research Interests

Barrett Esophagus; Chemical and Drug Induced Liver Injury; Esophageal Neoplasms; Esophagitis; Fatty Liver; Gastritis; Gastrointestinal Diseases; Gastrointestinal Neoplasms; Intestinal Neoplasms; Liver Diseases; Liver Neoplasms; Lung Diseases; Lung Injury; Pancreatic Diseases; Pathology; Stomach Neoplasms

Xuchen Zhang, MD, PhD, is an Associate Professor of Pathology who is board-certified in both anatomic and clinical pathology. He has clinical interests and expertise in liver/gastrointestinal pathology; liver transplant pathology; and neoplastic and non-neoplastic pulmonary pathology. His research interests are acute and chronic oxidant-induced lung injury, liver neoplasms, alcoholic and non-alcoholic liver diseases, colorectal cancer and underlying molecular mechanisms.

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Collaborators

  • Bhandari, Vineet - Yale
  • Choi, Augustine - Cornell
  • Colberg, John - Yale, Urology
  • Elias, Jack - Brown
  • Gettinger, Scott - Yale, Medical Oncology
  • Herbst, Roy - Yale  
  • Herzog, Erica - Yale
  • Hui, Pei - Yale, Pathology
  • Kaminski, Naftali - Yale
  • Kluger, Harriet - Yale, Medical Oncology
  • Niklason, Laura - Yale
  • Politi, Katerina - Yale
  • Puchalski, Jonathan - Yale
  • Shin, Myung - Yale, Diagnostic Radiology
  • Shuch, Brian - Yale, Urology
  • Singh, Dinesh - Yale, Urology