GYN Translational Research Interests
Our team has a broad academic interest in the pathogenesis, diagnosis, therapeutic markers of neoplastic and pre-neoplastic lesions of gynecological organs - ovary, uterus, cervix, vulva and vagina. With available state-of-the-art molecular and genetic technology, we are currently undertaking focused investigations of the disease entities including gestational trophoblastic disease, endometrial cancers, uterine smooth muscle neoplasms and cervical glandular lesions. These research endeavors involve highly committed faculty and enthusiastic pathology trainees. A major effort in the gestational trophoblastic disease research program is to improve diagnostic accuracy by incorporating ancillary techniques including DNA genotyping and immunohistochemistry. Studies of endometrial cancers are aimed at identifying (1) early precursor lesions and (2) diagnostic, prognostic and predictive biomarkers. Many of the projects are designed and tailored to the long-term academic career development of individual members and frequently in close collaboration with the Yale Gynecologic Oncology group.