2017
βIII Spectrin Is Necessary for Formation of the Constricted Neck of Dendritic Spines and Regulation of Synaptic Activity in Neurons
Efimova N, Korobova F, Stankewich MC, Moberly AH, Stolz DB, Wang J, Kashina A, Ma M, Svitkina T. βIII Spectrin Is Necessary for Formation of the Constricted Neck of Dendritic Spines and Regulation of Synaptic Activity in Neurons. Journal Of Neuroscience 2017, 37: 6442-6459. PMID: 28576936, PMCID: PMC5511878, DOI: 10.1523/jneurosci.3520-16.2017.Peer-Reviewed Original ResearchConceptsDendritic spinesSynaptic activitySpinocerebellar ataxia type 5Spine neckAberrant spine morphologyMushroom-shaped spinesType 5Autosomal recessive cerebellar ataxia type 1Spiny synapsesPostsynaptic excitationMiniature EPSCsShaft synapsesDamage neuronsNeuronal pathologyCortical neuronsSomatodendritic compartmentPresynaptic terminalsNeurodegenerative syndromePostsynaptic structuresSpine headsNeuropsychiatric disordersSynaptic strengthType 1Spine morphologyBrain function
2010
Targeted deletion of βIII spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes
Stankewich MC, Gwynn B, Ardito T, Ji L, Kim J, Robledo RF, Lux SE, Peters LL, Morrow JS. Targeted deletion of βIII spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 6022-6027. PMID: 20231455, PMCID: PMC2851889, DOI: 10.1073/pnas.1001522107.Peer-Reviewed Original ResearchConceptsBetaIII spectrinSpinocerebellar ataxia type 5Spectrin membrane skeletonTargeted gene disruptionAmino acid transportersExcitatory amino acid transportersImpairs synaptogenesisProtein traffickingSeizure disorderGene disruptionDark Purkinje cellsMembrane skeletonAlphaII-spectrinAcid transportersMechanistic basisPurkinje cellsMembrane channelsGlutamate receptor deltaIntracellular pathwaysSpectrin bindsSynaptic proteinsSpectrinReceptor deltaProteinGolgi profiles