2017
βIII Spectrin Is Necessary for Formation of the Constricted Neck of Dendritic Spines and Regulation of Synaptic Activity in Neurons
Efimova N, Korobova F, Stankewich MC, Moberly AH, Stolz DB, Wang J, Kashina A, Ma M, Svitkina T. βIII Spectrin Is Necessary for Formation of the Constricted Neck of Dendritic Spines and Regulation of Synaptic Activity in Neurons. Journal Of Neuroscience 2017, 37: 6442-6459. PMID: 28576936, PMCID: PMC5511878, DOI: 10.1523/jneurosci.3520-16.2017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCells, CulturedDendritic SpinesMaleNeurogenesisNeuronsRatsRats, Sprague-DawleySpectrinSynaptic TransmissionConceptsDendritic spinesSynaptic activitySpinocerebellar ataxia type 5Spine neckAberrant spine morphologyMushroom-shaped spinesType 5Autosomal recessive cerebellar ataxia type 1Spiny synapsesPostsynaptic excitationMiniature EPSCsShaft synapsesDamage neuronsNeuronal pathologyCortical neuronsSomatodendritic compartmentPresynaptic terminalsNeurodegenerative syndromePostsynaptic structuresSpine headsNeuropsychiatric disordersSynaptic strengthType 1Spine morphologyBrain function
2011
Schwann cell spectrins modulate peripheral nerve myelination
Susuki K, Raphael AR, Ogawa Y, Stankewich MC, Peles E, Talbot WS, Rasband MN. Schwann cell spectrins modulate peripheral nerve myelination. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 8009-8014. PMID: 21518878, PMCID: PMC3093478, DOI: 10.1073/pnas.1019600108.Peer-Reviewed Original ResearchConceptsSchwann cell cytoskeletonCell cytoskeletonΒII spectrinSubmembranous cytoskeletal proteinsNeuron-glia interactionsEfficient action potential propagationSchwann cellsMembrane proteinsCytoskeletal rearrangementsLoss of spectrinCytoskeletal proteinsNectin-like proteinsCell shapeContact sitesF-actinPeripheral nerve myelinationSpectrinPeripheral nerve developmentΑII-spectrinCytoskeletonProteinNerve myelinationNerve developmentMotor nervesCells
2002
Regulation of TGF-β ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia
Vicencio AG, Eickelberg O, Stankewich MC, Kashgarian M, Haddad GG. Regulation of TGF-β ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia. Journal Of Applied Physiology 2002, 93: 1123-1130. PMID: 12183510, DOI: 10.1152/japplphysiol.00031.2002.Peer-Reviewed Original ResearchConceptsRat lungChronic hypoxiaArrest of alveolarizationTGF-beta levelsPostnatal day 14 ratsBronchoalveolar lavage fluidTGF-beta receptor INeonatal rat lungSprague-Dawley ratsPostnatal day 14Day 14 ratsTGF-beta activityWk of lifeTGF-beta systemEffects of hypoxiaHypoxic adultsWestern blot analysisLavage fluidReceptor expressionLong-term effectsAdult ratsAlveolar epitheliumImmunohistochemical analysisModulatory effectsDay 14