1998
Generation of mucosal cytotoxic T cells against soluble protein by tissue-specific environmental and costimulatory signals
Kim S, Reed D, Olson S, Schnell M, Rose J, Morton P, Lefrançois L. Generation of mucosal cytotoxic T cells against soluble protein by tissue-specific environmental and costimulatory signals. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 10814-10819. PMID: 9724787, PMCID: PMC27978, DOI: 10.1073/pnas.95.18.10814.Peer-Reviewed Original ResearchConceptsCD8 T cellsT cellsT lymphocytesPrimary CD8 T cell responseCD8 T cell responsesMucosal cytotoxic T lymphocytesPeripheral CD8 T cellsMajor histocompatibility complex class IActivation of peripheralMucosal T cellsT cell responsesHistocompatibility complex class ICytotoxic T cellsCytotoxic T lymphocytesT cell generationComplex class IInflammatory mediatorsPeripheral toleranceAntigen administrationCostimulatory requirementsMucosal sitesAdjuvant effectB7-1B7-2Inflammatory signals
1986
N protein is the predominant antigen recognized by vesicular stomatitis virus-specific cytotoxic T cells
Puddington L, Bevan M, Rose J, Lefrançois L. N protein is the predominant antigen recognized by vesicular stomatitis virus-specific cytotoxic T cells. Journal Of Virology 1986, 60: 708-717. PMID: 3022003, PMCID: PMC288945, DOI: 10.1128/jvi.60.2.708-717.1986.Peer-Reviewed Original ResearchConceptsN proteinCell linesAnti-vesicular stomatitis virusEL4 cell linePlasma membraneG proteinsVSV genesCompetition assaysProteinNucleocapsid proteinInfected cellsStomatitis virusSodium butyrateGenesEfficient competitorsVSVEL4 cellsCold target competition assaysCellsT cellsCompetition studiesTarget cellsCytotoxic T cellsAssaysImmunoprecipitation