2012
Intrarenal Dopamine Inhibits Progression of Diabetic Nephropathy
Zhang MZ, Yao B, Yang S, Yang H, Wang S, Fan X, Yin H, Fogo AB, Moeckel GW, Harris RC. Intrarenal Dopamine Inhibits Progression of Diabetic Nephropathy. Diabetes 2012, 61: 2575-2584. PMID: 22688335, PMCID: PMC3447896, DOI: 10.2337/db12-0046.Peer-Reviewed Original ResearchConceptsIntrarenal dopaminergic systemRenal dopamine productionDopaminergic systemDopamine productionDiabetic nephropathyDiabetic miceWild-type diabetic miceOxidative stressDiabetic kidney injuryIntrarenal dopamine productionRenin-angiotensin systemMarkers of inflammationType 1 diabetesAromatic amino acid decarboxylaseCyclooxygenase-2 expressionKidney injuryRenal hemodynamicsRenal transplantationUnderlying pathogenesisDopamine metabolismInhibition of expressionInhibits progressionAmino acid decarboxylaseFluid reabsorptionKidney structure
2011
Podocyte vascular endothelial growth factor (Vegf164) overexpression causes severe nodular glomerulosclerosis in a mouse model of type 1 diabetes
Veron D, Bertuccio CA, Marlier A, Reidy K, Garcia AM, Jimenez J, Velazquez H, Kashgarian M, Moeckel GW, Tufro A. Podocyte vascular endothelial growth factor (Vegf164) overexpression causes severe nodular glomerulosclerosis in a mouse model of type 1 diabetes. Diabetologia 2011, 54: 1227-1241. PMID: 21318407, PMCID: PMC3397150, DOI: 10.1007/s00125-010-2034-z.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternChromatography, High Pressure LiquidCreatinineDiabetes Mellitus, Type 1Diabetic NephropathiesDisease Models, AnimalEnzyme-Linked Immunosorbent AssayImmunohistochemistryMiceMice, TransgenicMicroscopy, Electron, TransmissionPodocytesPolymerase Chain ReactionSemaphorin-3ATandem Mass SpectrometryVascular Endothelial Growth Factor AConceptsDiabetic nephropathyNodular glomerulosclerosisDiabetic glomerulopathyMouse modelMassive proteinuriaExcessive vascular endothelial growth factorTransgenic miceStreptozotocin-induced mouse modelVascular endothelial growth factor overexpressionGlomerular basement membrane thickeningAdvanced diabetic glomerulopathyControl diabetic miceOnset of diabetesBasement membrane thickeningVascular endothelial growth factorType 1 diabetesGrowth factor overexpressionAdult transgenic miceEndothelial growth factorVEGF receptor 2Kimmelstiel-WilsonSystemic VEGFDiabetic micePathogenic roleRenal morphology