Extensive Research Description
Hippocampal sclerosis (neuronal loss and gliosis) plays a complicated role in epilepsy: hippocampal sclerosis occurs due to epilepsy, but, in turn, the sclerotic hippocampus appears to be responsible for epileptogenesis. We are looking into the role of hippocampal neurons and glial cells in epilepy through neuronal and glial density studies in surgically resected hippocampi from intractable epilepsy patients. My second research interest is the role of calpains in CNS degenerative disorders, epilepsy and AIDS. All three conditions just mentioned are believed to have neuronal damages, at least in part, due to excitotoxicity, which may acitivate calpains, a family of Ca++ dependant proteases. Calpains, once activated, cleave spectrin, generating the spectrin breakdown product (BDP), and involvement of calpains is determined by detecting spectrin BDP in the CNS tissue.
- Kim, J.H. Pathology of Epilepsy. Review. Experimental and Molecular Pathology 70:345-367, 2001
- Hatanpaa, KJ, Kim JH. Neuropathology of Viral Infections (Chapter 8) in Handbook of Clinical Neurology, Vol. 123 (3rd Series), Aminoff, M, Boller, R and Swaab, D (eds), Tselis AC & Booss, J. (Volume Eds) Elsevier, 175-192, 2014
- de Lanerolle, NC, Bandak, F, Kang,D, Li, AY, Du, F, Swauger,P, Parks,S, Lin, G, and Kim, JH. Characteristics of an Explosive Blast-Induced Brain Injury in an Experimental Model. J. Neuropathol. Exp. Neurol. 70:1046-1057, 2011
- Huh, G-Y, Glantz, SB, Je, S, Morrow, JS, Kim, JH. Calpain proteolysis of alpha II spectrin in the normal adult human brain. Neurosci. Lett. 316:41-44, 2001.
- Uranish, R, Baev, NI, Ng, P-Y, Kim, JH, Awad, IA. Expression of endothelial cell angiogenesis receptors in human cerebral vascular malformations. Neurosurgery 48:359-368. 2001
- Spencer SS, Kim J, deLanerolle N, Spencer DD. Differential neuronal and glial relations with parameters of ictal discharge in mesial temporal lobe epilepsy. Epilepsia 1999 Jun40(6):708-12
- Wong, J.H., Kim, J.H., Awad, I.A. Pathological features of spinal vascular malformations. (Chapter 2). In:Spinal vascular malformations. Barrow, D.L. and Awad, I.A. (eds). Am. Assoc. Neurol. Surgeons, Park Ridge, pp9-22, 1999.