Jose Costa, MD, FACP

Professor Emeritus of Pathology; DIrector, Autopsy Service; Director, Bone & Soft Tissue Pathology

Research Interests

Bone Neoplasms; Medical Oncology; Musculoskeletal Diseases; Orthopedics; Pathology; Molecular Diagnostic Techniques; Translational Medical Research

Research Organizations

Pathology: Pathology Research

Gene Regulation and Functional Genomics

Molecular Diagnostics Laboratory

Yale Cancer Center: Genomics, Genetics, and Epigenetics

Research Summary

I am interested in understanding the forces driving tumor formation and tumor progression. Using clues from clinical observation, experimental models and in silico simulations, I formulate hypotheses that can then be tested either in the laboratory or in the clinic. For example, the theory that carcinogenesis is a micro-evolutionary process best described by metapopulation dynamics provides a framework for understanding the origins of tumor heterogeneity and explains the reason for the long term failures of some therapies. It also demonstrates how intermediate disturbance can favor the emergence and progression of tumors without significant increase in mutational rate. Theory also suggests that inhibiting the so-called capacitors of evolution may be a useful intervention to increase the therapeutic effect of some of the anticancer agents used in the clinic.

Specialized Terms: Oncology; Carcinogenesis; Tumor development and progression; Advanced diagnostics; Molecular diagnostics; Diagnosed genetic alterations in tumors; Cancer risk detection by mutational load distribution analysis

Full List of PubMed Publications

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Contact Info

Jose Costa, MD, FACP
Patient Care Location
Yale PathologyYale New Haven Hospital
20 York Street, Ste East Pavilion 2-631

New Haven, CT 06510
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Office Location
Department of PathologyBrady Memorial Laboratory
310 Cedar Street, Ste BML 254A

New Haven, CT 06510
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Mailing Address
Pathology310 Cedar Street
PO Box 208023

New Haven, CT 06520-8023