Yale Medical Renal Pathology & Electron Microscopy Laboratory

Medical Renal Pathology & Electron Microscopy

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The Yale Medical Renal Pathology and Electron Microscopy Laboratory is a nationally recognized center for diagnostic renal pathology and electron microscopy. It provides the most effective methodologies available for light microscopic, ultrastructural and immunological diagnosis of kidney biopsies and surgical pathology specimen. These include transmission electron microscopy, immunohistochemistry and standard and confocal immunofluorescence microscopy. There is special emphasis on the diagnosis of glomerular, tubulointerstitial and vascular kidney diseases, as well as evaluation of transplant kidney biopsies. Electron microscopy is further of value in the diagnosis of ciliary abnormalities, metabolic disorders, microbial identification, and tumor diagnosis. As one of the few clinical electron microscopy services with digital imaging capability in the nation, the Yale Renal Pathology Laboratory is well positioned to serve a wide geographic area with rapid turnaround time combined with expert consultative services.

Medical Renal Pathology & Electron Microscopy Service

The Yale Renal Pathology Service provides high quality electron micrographs/digital images for analysis of ultrastructural pathologic changes in organ tissue. We maintain the highest level of diagnostic accuracy coupled with rapid turnaround time for renal diseases, ciliary abnormalities, metabolic disorders, microbial identification, and tumor diagnosis. Diseases and conditions include but are not limited to: primary glomerular, tubulointerstitial, and vascular diseases of the kidney, renal genetic disease, lupus and systemic vasculitis, renal transplantation. 
Although patients with all varieties of renal parenchymal disease have undergone renal biopsy, the biopsy is of greatest value in patients with large amounts of proteinuria, patients with systemic disease that involve the kidneys, certain patients with acute renal failure, and patients with an active urinary sediment. Important clinical information such as serum creatinine, serologic studies, and the degree of proteinuria are useful in assisting the interpretation of the renal biopsy. The renal biopsy provides significant information relative to the risk of progression by examining the degree of tubulointerstitial scarring. The potential to respond to therapy is generally based on the presence or absence of acute inflammatory changes in the glomerulus and in the tubulointerstitial compartment. Important clinical information such as serum creatinine, serological studies for hepatitis and lupus, and the degree of proteinuria are generally useful in assisting in the interpretation of the renal biopsy.
The technique of a renal biopsy has been improved so that complications are very uncommon. It is relatively rare to have a serious complication, although it is not uncommon to have blood in the urine following a biopsy.

Complete electron microscopy and renal biopsy consultation services are available to departments and physicians within YNHH, as well as outside hospitals and groups.

Services and Expertise
Complete electron microscopy and renal biopsy consultation services are available to departments and physicians within YNHH, as well as outside hospitals and groups.
More information visit the Electron Microscopy Lab and Yale Pathology Labs side Box.

Yale Medical Renal Pathology and Electron Microscopy

Director

Bio Profile

Gilbert Moeckel, MD, PhD, FASN

Director

Professor of Pathology

Director of Mentoring Program, MED Pathology

Director, Renal, Cardiac & Transplant Pathology and Electron Microscopy Laboratory, MED Pathology

Director, Renal & Genitourinary Fellowship Program, MED Pathology

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Pathologists

Bio Profile

Michael Kashgarian, MD, FASN

Professor Emeritus of and Senior Research Scientist in Pathology

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Electron Microscopy Lab

Manager

Manager Pathology

Manager, Renal Pathology Lab

Research Associate Pathology

Associate In Research III in Pathology & the Yale Stem Cell Center

Clinical Technologist 2

Senior Administrative Assistant Pathology

The Medical Renal Pathology Laboratory at Yale is actively engaged in translational research in the areas of renal transplant pathology. A major focus is the evaluation of mechanisms of antibody mediated rejection (AMR) of the renal allograft. Translational studies conducted in the past have been focused on chronic antibody mediated rejection. A current collaboration with Transplant Nephrology at University of Hamburg is focused on the examination of differential epitope expression on endothelial cells in patients with AMR.
The Renal Pathology and Electron Microscopy Lab provides training to pathology residents, nephrology fellows and renal pathology and GU pathology fellows in the diagnostic skills of kidney biopsy interpretation.

Renal Pathology & Electron Microscopy Laboratory

Director:
Gilbert Moeckel, MD, PhD, FASN

Lab Manager:
Judith Mitnick, PhD

Yale School of Medicine 
Department of Pathology  
PO Box 208023  
310 Cedar St. LB20   
New Haven, CT 06520  
Tel: 203.785.2750  
Fax: 203.785.3348