Yale Head, Neck & Endocrine Pathology

Head, Neck & Endocrine Pathology

bladder cancer image
The Endocrine, Head and Neck Pathology Service specializes in the evaluation of thyroid, parathyroid and adrenal glands, head and neck diseases including those of the oral cavity, larynx and pharynx, eye & ear, salivary glands, jaw & skull bones, and soft tissue. The team renders diagnoses on a little over 6000 cases each year. The practice strongly leans toward oncologic pathology due to referral bias and the tertiary nature of the hospital. The practice is supported by a well-appointed immunohistochemistry and molecular pathology laboratories, the former carrying a repertoire of more than 200 antibodies for diagnosis and prognosis. We offer HPV testing by PCR, and EBV testing by in-situ hybridization on formalin-fixed paraffin embedded cancer tissues.

Head, Neck & Endocrine Pathology Service

  • Evaluation of tissue biopsies to rule out/confirm cancer
  • Evaluation of resections for tumor staging, prognostication, adequacy of resection and to guide further treatment
  • Evaluation of biological markers of prognosis 
  • Evaluation of HPV and EBV related cancers
  • Special expertise in thyroid cancers, adrenal tumors, head and neck cancers
Services and Expertise
In addition to providing diagnostic service to Yale’s Smilow Cancer Center, we are the only Endocrine, Head & Neck subspecialty pathology practice in the state of Connecticut providing consultancy services to surrounding hospitals, including Bridgeport Hospital, Greenwich Hospital, Milford Hospital, Griffin Hospital, and the Saint Raphael Campus of Yale New Haven and other regional hospitals.

Yale Pathology Head, Neck & Endocrine Service

Director

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Manju Prasad, MD, MBBS

Director

Professor of Pathology

Director, Endocrine, Head & Neck Pathology

Director, Immunohistochemistry Laboratory

Director, Endocrine, Head and Neck Pathology Fellowship

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Pathologists

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Andrea Lynne Barbieri, MD

Assistant Professor of Pathology

Co-Chair, Dean's Advisory Council for LGBTQI+ Affairs, Yale Medicine Outlist

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John H. Sinard, MD, PhD

Professor of Pathology and of Ophthalmology and Visual Science

Vice Chair Pathology

Director, Anatomic Pathology

Medical Director, Pathology Informatics

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Stephen Michael Smith, MD

Clinical Fellow

Clinical Fellow, Endocrine, Head & Neck Pathology

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Faculty engage in a wide range of clinical and translational research that include genotype-phenotype correlation in thyroid carcinomas, viral-associated head and neck cancers, genetic abnormalities in adrenal tumors and in pediatric thyroid cancers.
Publications (selected recent):
  • Hardee S, Prasad ML, Hui P, Dinauer CA, Morotti RA. Pathologic Characteristics, natural history, and prognostic implications of BRAFV600E mutation in pediatric papillary thyroid carcinoma. Pediatr Dev Pathol. 2017;20:206-212. PMID:28521635
  • Prasad ML, Franchi A, Thompson LDR. Nasopharyngeal angiofibroma. in WHO Classification of Head and Neck Tumours. Ed El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. 4th ed. 2017
  • Prasad ML, Cardessa A, Helliwell T, Hille J, Nadal A. Adenosquamous carcinoma. in WHO Classification of Head and Neck Tumours. Ed El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. 4th ed. 2017
  • Prasad ML, Chiosea S, Ihrler S, Skalova A. Lymphadenoma. in WHO Classification of Head and Neck Tumours. Ed El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. 4th ed. 2017
  • Prasad ML, Nelson B, Tilakaratne WM. Melanotic neuroectodermal tumour of infancy. in WHO Classification of Head and Neck Tumours. Ed El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. 4th ed. 2017
  • Prasad ML, Bell D, Gnepp DR, Richardson M. Thyroglossal duct cyst. in WHO Classification of Head and Neck Tumours. Ed El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. 4th ed. 2017
  • Prasad ML, Vyas M, Horne MJ, Virk RK, Morotti R, Liu Z, Tallini G, Nikiforova MN, Christison-Lagay ER, Udelsman R, Dinauer CA, Nikiforov YE.  NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States.  Cancer. 2016;122:1097-107. PMID: 26784937
  • Abi-Raad R, Virk RK, Dinauer CA, Prasad A, Morotti RA, Breuer CK, Sosa JA, Udelsman R, Rivkees SA, Prasad ML. C-cell neoplasia in asymptomatic carriers of RET mutation in extracellular cysteine-rich and intracellular tyrosine kinase domain. Hum Pathol. 2015;46:1121-8. PMID: 26033033
  • Goh G, Scholl UI, Healy JM, Choi M, Prasad ML, Nelson-Williams C, Kuntsman JW, Korah R, Suttorp AC, Dietrich D, Haase M, Willenberg HS, Stahlberg, Hellman P, Akerstrom G, Bjorklund P, Carling T, Lifton RP. Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors. Nature Genetics, 2014,46:613-7. PMID 24747643
  • Virk RK, Theoharis CGA, Prasad A, Chhieng D, Prasad ML.  Morphology predicts BRAFV600E Mutation in Papillary Thyroid Carcinoma: An Interobserver Reproducibility Study. Virchows Archiv 2014,464:435-42. PMID 24549591
  • Korah R, Healy JM, Kunstman JW, Fonseca AL, Ameri A, Prasad ML, Carling T. Epigenetic silencing of RASSF1A deregulates cytoskeleton and promotes malignant behavior of adrenocortical carcinoma. Molecular Cancer 2013, 12:87. PMID: 23915220
Faculty in Endocrine, Head & Neck Pathology Division are engaged in and lead educational efforts within: 
  • Yale School of Medicine: Endocrinology Course
  • Pathology Residency Programs: AP/CP lecturers and instructors in practical microscopy sessions 
  • Fellowship Program: Endocrine, Head & Neck Pathology fellowship
  • American Society of Clinical Pathology: Courses and Seminars in Head & Neck Pathology (2015, 2016)