2014
Renalase
Guo X, Wang L, Velazquez H, Safirstein R, Desir GV. Renalase. Current Opinion In Nephrology & Hypertension 2014, 23: 513-518. PMID: 24992568, PMCID: PMC4383282, DOI: 10.1097/mnh.0000000000000044.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsEnzymatic functionType 1 diabetesMitogen-activated protein kinase pathwayNucleotide polymorphismsProtein kinase BProtein kinase pathwayCellular actionsPlasma membraneKinase pathwayKinase BPotential therapeutic utilityCertain single nucleotide polymorphismsEnzymatic propertiesIschemic strokeImmune modulatorsRenalase geneTherapeutic utilityCytoprotective effectsClinical implicationsRenalaseConsistent associationPotential roleDiabetesCytokines
2009
Endothelial and Smooth Muscle-derived Neuropilin-like Protein Regulates Platelet-derived Growth Factor Signaling in Human Vascular Smooth Muscle Cells by Modulating Receptor Ubiquitination*
Guo X, Nie L, Esmailzadeh L, Zhang J, Bender JR, Sadeghi MM. Endothelial and Smooth Muscle-derived Neuropilin-like Protein Regulates Platelet-derived Growth Factor Signaling in Human Vascular Smooth Muscle Cells by Modulating Receptor Ubiquitination*. Journal Of Biological Chemistry 2009, 284: 29376-29382. PMID: 19696027, PMCID: PMC2785569, DOI: 10.1074/jbc.m109.049684.Peer-Reviewed Original ResearchMeSH KeywordsCells, CulturedDown-RegulationHumansMembrane ProteinsMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Muscle, Smooth, VascularMyocytes, Smooth MusclePhosphorylationPlatelet-Derived Growth FactorProto-Oncogene Proteins c-cblReceptor, Platelet-Derived Growth Factor betaSignal TransductionSrc-Family KinasesUbiquitinationUbiquitin-Protein LigasesConceptsPlatelet-derived growth factorSmooth muscle cell-derived neuropilin-like proteinPDGF receptorPlatelet-derived growth factor signalingPrototypic growth factorsE3 ubiquitin ligaseGrowth factor signalingExpression levelsPrimary human VSMCsHuman vascular smooth muscle cellsVascular smooth muscle cell growthReceptor ubiquitinationGrowth factorUbiquitin ligaseFactor signalingRNA interferenceC-CblVascular smooth muscle cellsSmooth muscle cell growthMuscle cell growthVSMC DNA synthesisUbiquitinationESDNHuman VSMCsSmooth muscle cells