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Nelli Mnatsakanyan, PhD

Assistant Professor

Contact Information

Nelli Mnatsakanyan, PhD

Mailing Address

  • Endocrinology

    PO Box 208020 333 Cedar Street

    New Haven, CT, 06520-8056

    United States

Appointments

Biography

Dr. Mnatsakanyan obtained her PhD from Yerevan State University and performed her postdoctoral work at Texas Tech University Health Sciences Center. As a postdoctoral fellow, she studied the catalytic mechanism of the ATP synthase and characterized the important structural unit, beta DELSEED loop region of the ATP synthase that couples ATP synthesis with subunit rotation. Dr. Mnatsakanyan's current research focuses on understanding the molecular mechanism and regulation of the enigmatic cell death channel located in the mitochondrial ATP synthase and its role in mitochondrial permeability transition (mPTP). The goals in the lab are threefold: 1) Identify and structurally characterize the molecular components of mPTP by using cryo-electron microscopy and cryo-electron tomography. 2) Functionally characterize the ATP synthase leak channel and its regulation by using electrophysiology techniques, patch-clamp and planar lipid bilayer recordings. 3) Generate CRISPR/Cas9-edited mice with the low probability of ATP synthase leak channel/mPTP opening and introduce these mutations in transgenic Alzheimer's disease (AD) mice to study if they will protect the mice from the onset of AD-like features. We hypothesize that this mouse will be protected from degenerative diseases of heart and brain. These studies may lead to the structure-based drug design of specific therapeutic compounds for the treatment of mPTP-related neurodegenerative disorders, aging and cancer.

Education & Training

  • PhD
    Yerevan State University, Biophysics (2003)
  • MS
    Yerevan State University (1999)
  • BS
    Yerevan State University (1999)

Activities

  • Invited Speaker, Biophysical Society Annual Meeting "Bioenergetics, Mitochondria and Metabolism" Subgroup
    San Diego, United States 2020
  • Selected Speaker, Biophysical Society Annual Meeting
    Baltimore, United States 2019
  • Selected Speaker Biophysical Society "Bioenergetics" Subgroup Symposium
    San Francisco, United States 2018

Honors & Recognition

AwardAwarding OrganizationDate
RF1 AwardNational Institute on Aging2021
Young Bioenergeticist AwardBiophysical Society2018
K01 Research Scientist Development AwardNational Institute on Aging2017

Professional Service

OrganizationRoleDate
Biophysical Society "Bioenergetics, Mitochondria and Metabolism" SubgroupExecutive Council Member2020 - Present
Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART)Member2019 - Present
"Biomedicine & Pharmacotherapy" Elsevier JournalAssociate Editor2018 - Present
Biophysical SocietyCo-organizer and co-chair of the Biophysical Society "Bioenergetics" Subgroup Symposium "High-resolution structure, function and dynamics of mitochondrial proteins".2017
"Bioenergetics, Mitochondria and Metabolism" Subgroup, Biophysical SocietyMember2015 - Present
Society of NeuroscienceMember2011 - Present
Biophysical SocietyMember2011 - Present

Departments & Organizations