Serotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction
Köhler-Forsberg K, Dam V, Ozenne B, Sankar A, Beliveau V, Landman E, Larsen S, Poulsen A, Ip C, Jørgensen A, Meyer M, Stenbæk D, Eiberg H, Madsen J, Svarer C, Jørgensen M, Frokjaer V, Knudsen G. Serotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction. JAMA Psychiatry 2023, 80: 296-304. PMID: 36753296, PMCID: PMC9909578, DOI: 10.1001/jamapsychiatry.2022.4539.Peer-Reviewed Original ResearchConceptsMemory dysfunctionUntreated MDDDepressive disorderReceptor bindingHealthy controlsModerate to severe depressive episodePositron emission tomographyMajor depressive disorderSevere depressive episodeVerbal memory performanceNeurobiological signatureDepressive episodeVerbal memoryMemory performanceCognitive domainsDepression trialsMDDDepressive stateBrain bindingCognitive testsCognitive functionGroup differencesAssociated with improved learningSerotonin-4Adult participantsAssociation of neurocognitive function with psychiatric hospitalization and socio-demographic conditions in individuals with bipolar and major depressive disorders
Sankar A, Ziersen S, Ozenne B, Beaman E, Dam V, Fisher P, Knudsen G, Kessing L, Frokjaer V, Miskowiak K. Association of neurocognitive function with psychiatric hospitalization and socio-demographic conditions in individuals with bipolar and major depressive disorders. EClinicalMedicine 2023, 58: 101927. PMID: 37007740, PMCID: PMC10050788, DOI: 10.1016/j.eclinm.2023.101927.Peer-Reviewed Original ResearchSocio-demographic conditionsPsychiatric hospitalAffective disordersNeurocognitive impairmentDepressive disorderExecutive functionVerbal memoryNeurocognitive functionNational population-based registersPopulation-based registersAssociation of neurocognitionVerbal memory domainSocio-demographic indicatorsStudies of neurocognitionClinically significant impairmentFuture hospitalsDepression severityMemory domainCox regression modelsIllness durationNeurocognitive assessmentEmployment outcomesSecondary outcomesSignificant impairmentStudy inclusion