Featured Publications
Biomechanical restoration of metastatic cancer-induced peri-acetabular bone defects by ablation-osteoplasty-reinforcement-internal fixation technique (AORIF): To screw or not to screw?
Morris MT, Alder KD, Moushey A, Munger AM, Milligan K, Toombs C, Conway D, Lee I, Chen F, Tommasini SM, Lee FY. Biomechanical restoration of metastatic cancer-induced peri-acetabular bone defects by ablation-osteoplasty-reinforcement-internal fixation technique (AORIF): To screw or not to screw? Clinical Biomechanics 2022, 92: 105565. PMID: 34999389, DOI: 10.1016/j.clinbiomech.2021.105565.Peer-Reviewed Original ResearchMeSH KeywordsAcetabulumBiomechanical PhenomenaBone CementsBone ScrewsFracture Fixation, InternalHumansNeoplasmsConceptsCyclic loadingEnergy absorptionFinite element analysisHigh energy absorptionElement analysisBone defectsComposite boneStress relaxationSkeletal reinforcementReinforcement techniquesCement augmentation proceduresCementLoadingBone cement augmentationNumerous clinical advantagesBiomechanical testingPeriacetabular defectsFracture locationOsteolytic metastasesIntraarticular fracturesJoint preservationAcetabular augmentationCombination of screwsBiomechanical restorationFixation groupEmerging Minimally Invasive Percutaneous Procedures for Periacetabular Osteolytic Metastases
Ibe I, Dussik C, Callan A, Barr J, Lee F. Emerging Minimally Invasive Percutaneous Procedures for Periacetabular Osteolytic Metastases. Journal Of Bone And Joint Surgery 2023, 105: 479-489. PMID: 36701566, DOI: 10.2106/jbjs.22.00694.Peer-Reviewed Original ResearchMeSH KeywordsBone CementsFracture Fixation, InternalHumansMinimally Invasive Surgical ProceduresNeoplasmsPolymethyl MethacrylateTreatment OutcomeConceptsInvasive percutaneous proceduresOsteolytic metastasesInvasive proceduresPercutaneous proceduresCancer ablationOsteolytic skeletal metastasesOpen surgical managementPercutaneous screw fixationSystemic cancer therapyOpen surgical proceduresRestoration of ambulationComplex open surgical proceduresPeriacetabular osteolytic lesionsBalloon osteoplastyAmbulatory functionTotal hip reconstructionBlood lossOsteolytic lesionsSkeletal metastasesSurgical managementInterventional oncologistsInternal fixationSurgical proceduresInvasive techniquesScrew fixationAblation, Osteoplasty, Reinforcement, and Internal Fixation for Percutaneous Endoskeletal Reconstruction of Periacetabular and Other Periarticular Osteolytic Metastases.
Toombs C, Conway D, Munger AM, Alder KD, Latich I, Lee FY. Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Percutaneous Endoskeletal Reconstruction of Periacetabular and Other Periarticular Osteolytic Metastases. Instructional Course Lectures 2021, 70: 503-514. PMID: 33438931.Peer-Reviewed Original ResearchMeSH KeywordsBone CementsBone NeoplasmsCementoplastyFracture Fixation, InternalHumansOsteolysisTreatment OutcomeConceptsInternal fixationLocal cancer controlBalloon osteoplastySurgical stabilizationCancer controlConventional open surgical proceduresLocal cancer progressionProgressive bone destructionFirst-line treatmentPercutaneous treatment optionsAmbulatory surgery settingProgressive bone lossSurgical reconstructive proceduresEarly clinical resultsImage-guided ablationNew effective therapiesOpen surgical proceduresInvasive surgical interventionOptimal internal fixationOsteolytic metastatic diseasePolymethyl methacrylate cementUncontrolled painMetastatic diseaseBone destructionOsteolytic metastases
2020
Minimally Invasive Image-Guided Ablation, Osteoplasty, Reinforcement, and Internal Fixation (AORIF) for Osteolytic Lesions in the Pelvis and Periarticular Regions of Weight-Bearing Bones
Lee FY, Latich I, Toombs C, Mungur A, Conway D, Alder K, Ibe I, Lindskog D, Friedlaender G. Minimally Invasive Image-Guided Ablation, Osteoplasty, Reinforcement, and Internal Fixation (AORIF) for Osteolytic Lesions in the Pelvis and Periarticular Regions of Weight-Bearing Bones. Journal Of Vascular And Interventional Radiology 2020, 31: 649-658.e1. PMID: 32139256, DOI: 10.1016/j.jvir.2019.11.029.Peer-Reviewed Original ResearchMeSH KeywordsAblation TechniquesAdultAgedAged, 80 and overBone CementsBone NeoplasmsBone RemodelingBone ScrewsCalcaneusCementoplastyFemaleFemoral NeoplasmsFemurFracture Fixation, InternalHumansMaleMiddle AgedOsteolysisPelvic BonesPostoperative ComplicationsProspective StudiesRecovery of FunctionTibiaTime FactorsTreatment OutcomeWeight-BearingConceptsOsteolytic lesionsInternal fixationVisual analog scale pain scoreMusculoskeletal Tumor Society scoreProspective clinical cohort studyFunctional ambulation scoreOsteolytic skeletal lesionsPainful osteolytic lesionsScale pain scoresClinical cohort studyInvasive percutaneous approachWeight-bearing boneInternal fixation screwsBalloon osteoplastyPain scoresCohort studyProphylactic stabilizationSevere painSociety ScoreConsecutive patientsSurgical treatmentEarly outcomesTreatment optionsPercutaneous approachFunctional improvement
2019
Bone Quality and Fracture-Healing in Type-1 and Type-2 Diabetes Mellitus.
Henderson S, Ibe I, Cahill S, Chung YH, Lee FY. Bone Quality and Fracture-Healing in Type-1 and Type-2 Diabetes Mellitus. Journal Of Bone And Joint Surgery 2019, 101: 1399-1410. PMID: 31393433, DOI: 10.2106/jbjs.18.01297.Peer-Reviewed Original ResearchConceptsType 2 diabetesPerioperative complicationsDiabetic patientsGlycemic controlBone healthType 1Type 2 diabetes mellitusNormal bone mineral densityPerioperative glycemic controlNon-diabetic patientsEarly bone lossSurgical site infectionAppropriate glycemic controlUnion of fractureRisk of fractureBone mineral densityType 1 diabetesAntiresorptive therapyOperative interventionDiabetes mellitusSclerostin antibodySite infectionMedical managementParathyroid hormonePostoperative management
2015
Optimal internal fixation of anatomically shaped synthetic bone grafts for massive segmental defects of long bones
Vorys GC, Bai H, Chandhanayingyong C, Lee CH, Compton JT, Caldwell JM, Gardner TR, Mao JJ, Lee FY. Optimal internal fixation of anatomically shaped synthetic bone grafts for massive segmental defects of long bones. Clinical Biomechanics 2015, 30: 1114-1118. PMID: 26386637, PMCID: PMC9004608, DOI: 10.1016/j.clinbiomech.2015.08.016.Peer-Reviewed Original ResearchConceptsTorsional stiffnessHydroxyapatite composite scaffoldsCyclic torsional testsNon-locking fixationMassive segmental defectsTissue engineering strategiesLarge segmental bone defectsComposite scaffoldsLoading cyclesTorque controlSynthetic bone graftAxial stiffnessAngular rotationAxial compressionTorsional testsNon-destructive mannerGeometry representativeOptimal screw fixationSegmental bone defectsSuch scaffoldsTorque levelsStiffnessBiomechanical testingHuman tibiaEngineering strategies
2006
Treatment of Congenital Pseudarthrosis of the Tibia with Recombinant Human Bone Morphogenetic Protein-7 (rhBMP-7)
Lee F, Sinicropi S, Lee F, Vitale M, Roye D, Choi I. Treatment of Congenital Pseudarthrosis of the Tibia with Recombinant Human Bone Morphogenetic Protein-7 (rhBMP-7). Journal Of Bone And Joint Surgery 2006, 88: 627-633. PMID: 16510831, DOI: 10.2106/jbjs.d.02201.Peer-Reviewed Original ResearchTREATMENT OF CONGENITAL PSEUDARTHROSIS OF THE TIBIA WITH RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-7 (RHBMP-7)
LEE FY, SINICROPI SM, LEE FS, VITALE MG, ROYE DP, CHOI IH. TREATMENT OF CONGENITAL PSEUDARTHROSIS OF THE TIBIA WITH RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-7 (RHBMP-7). Journal Of Bone And Joint Surgery 2006, 88: 627-633. DOI: 10.2106/00004623-200603000-00023.Peer-Reviewed Original Research
2001
Coronal Split Fracture of the Proximal Tibia Epiphysis Through a Partially Closed Physis: A New Fracture Pattern
Patari S, Lee F, Behrens F. Coronal Split Fracture of the Proximal Tibia Epiphysis Through a Partially Closed Physis: A New Fracture Pattern. Journal Of Pediatric Orthopaedics 2001, 21: 451. PMID: 11433155, DOI: 10.1097/01241398-200107000-00007.Peer-Reviewed Original ResearchMeSH KeywordsAccidental FallsAdolescentBicyclingBiomechanical PhenomenaEpiphysesExternal FixatorsFollow-Up StudiesFracture Fixation, InternalFracture HealingFractures, ComminutedGaitHumansMaleRange of Motion, ArticularRisk FactorsTibial FracturesTomography, X-Ray ComputedTreatment OutcomeWeight-BearingConceptsCoronal split fractureProximal tibial epiphysisTibial epiphysisSplit fractureDefinitive operative fixationProximal tibia epiphysisNew fracture patternClinical unionUncommon injuryOperative fixationEpiphyseal fracturesPlain radiographyTibial plateauTibia epiphysisEpiphysisFracture patternsFracturesPatientsThree-dimensional reconstructionInjuryPhysis